Details of the Target

General Information of Target

Target ID LDTP14838
Target Name Cyclin-I (CCNI)
Gene Name CCNI
Gene ID 10983
Synonyms
Cyclin-I
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSLPRFQRVNFGPYDNYIPVSELSKKSWNQQHFALLFPKPQRPGTKRRSKPSQIRDNTVS
IIDEEQLRGDRRQPLWMYRSLMRISERPSVYLAARRQPLKPTRTVEVDSKAAEIGKKGED
KTTQKDTTDSESELKQGKKDSKKGKDIEKGKEEKLDAKKDSKKGKKDAEKGKDSATESED
EKGGAKKDNKKDKKDSNKGKDSATESEGEKGGTEKDSKKGKKDSKKGKDSAIELQAVKAD
EKKDEDGKKDANKGDESKDAKKDAKEIKKGKKDKKKPSSTDSDSKDDVKKESKKDATKDA
KKVAKKDTEKESADSKKDAKKNAKKDAKKDAKKNAKKDEKKDAKKKGK
Target Bioclass
Other
Family
Cyclin family
Subcellular location
Nucleus membrane
Uniprot ID
Q14094
Ensemble ID
ENST00000237654.9
HGNC ID
HGNC:1595

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.L194R .
HGC27 SNV: p.E362Q .
IGROV1 SNV: p.C191Y .
IM95 SNV: p.Q196H .
SNU308 SNV: p.N342T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C272(3.73)  LDD3332  [1]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C120(0.84); C122(0.84)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C120(1.02); C122(1.02)  LDD0813  [3]
 LDCM0226  AC11 HEK-293T C120(0.97); C122(0.97)  LDD0824  [3]
 LDCM0237  AC12 HEK-293T C120(0.95); C122(0.95)  LDD0835  [3]
 LDCM0246  AC128 HEK-293T C120(1.10); C122(1.10)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C120(0.91); C122(0.91)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C120(0.72); C122(0.72)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C120(0.84); C122(0.84)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C120(0.97); C122(0.97)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C120(0.77); C122(0.77)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C120(1.14); C122(1.14)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C120(0.95); C122(0.95)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C120(1.13); C122(1.13)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C120(1.14); C122(1.14)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C120(1.12); C122(1.12)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C120(1.26); C122(1.26)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C120(0.98); C122(0.98)  LDD0857  [3]
 LDCM0260  AC140 HEK-293T C120(1.14); C122(1.14)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C120(1.15); C122(1.15)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C120(1.02); C122(1.02)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C120(0.89); C122(0.89)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C120(0.74); C122(0.74)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C120(0.82); C122(0.82)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C120(0.89); C122(0.89)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C120(0.77); C122(0.77)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C120(0.73); C122(0.73)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C120(0.92); C122(0.92)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C120(0.98); C122(0.98)  LDD0868  [3]
 LDCM0271  AC150 HEK-293T C120(0.88); C122(0.88)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C120(0.84); C122(0.84)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C120(0.85); C122(0.85)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C120(0.88); C122(0.88)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C120(0.80); C122(0.80)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C120(0.89); C122(0.89)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C120(0.83); C122(0.83)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C120(0.91); C122(0.91)  LDD2165  [3]
 LDCM0276  AC17 HEK-293T C120(0.85); C122(0.85)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C120(0.77); C122(0.77)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C120(0.79); C122(0.79)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C120(1.09); C122(1.09)  LDD0877  [3]
 LDCM0280  AC20 HEK-293T C120(0.74); C122(0.74)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C120(0.78); C122(0.78)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C120(0.77); C122(0.77)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C120(0.93); C122(0.93)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C120(0.92); C122(0.92)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C120(0.89); C122(0.89)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C120(0.87); C122(0.87)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C120(0.84); C122(0.84)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C120(0.94); C122(0.94)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C120(0.78); C122(0.78)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C120(0.95); C122(0.95)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C120(0.84); C122(0.84)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C120(0.82); C122(0.82)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C120(0.81); C122(0.81)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C120(0.92); C122(0.92)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C120(0.99); C122(0.99)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C120(1.05); C122(1.05)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C120(1.08); C122(1.08)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C120(0.86); C122(0.86)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C120(1.09); C122(1.09)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C120(1.45); C122(1.45)  LDD0898  [3]
 LDCM0301  AC4 HEK-293T C120(1.08); C122(1.08)  LDD0899  [3]
 LDCM0302  AC40 HEK-293T C120(1.27); C122(1.27)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C120(1.64); C122(1.64)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C120(0.94); C122(0.94)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C120(0.96); C122(0.96)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C120(1.12); C122(1.12)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C120(1.22); C122(1.22)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C120(0.97); C122(0.97)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C120(1.12); C122(1.12)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C120(0.99); C122(0.99)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C120(1.20); C122(1.20)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C120(1.19); C122(1.19)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C120(1.22); C122(1.22)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C120(1.03); C122(1.03)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C120(0.88); C122(0.88)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C120(1.09); C122(1.09)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C120(1.02); C122(1.02)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C120(1.37); C122(1.37)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C120(1.21); C122(1.21)  LDD0917  [3]
 LDCM0323  AC6 HEK-293T C120(1.11); C122(1.11)  LDD0921  [3]
 LDCM0334  AC7 HEK-293T C120(0.92); C122(0.92)  LDD0932  [3]
 LDCM0345  AC8 HEK-293T C120(0.87); C122(0.87)  LDD0943  [3]
 LDCM0248  AKOS034007472 HEK-293T C120(1.06); C122(1.06)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C120(0.96); C122(0.96)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C120(1.06); C122(1.06)  LDD0873  [3]
 LDCM0369  CL100 HEK-293T C120(0.89); C122(0.89)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C120(1.04); C122(1.04)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C120(1.84); C122(1.84)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C120(0.98); C122(0.98)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C120(1.10); C122(1.10)  LDD0971  [3]
 LDCM0374  CL105 HEK-293T C120(0.94); C122(0.94)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C120(0.97); C122(0.97)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C120(0.89); C122(0.89)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C120(0.64); C122(0.64)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C120(1.27); C122(1.27)  LDD0976  [3]
 LDCM0380  CL110 HEK-293T C120(0.99); C122(0.99)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C120(1.28); C122(1.28)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C120(1.43); C122(1.43)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C120(1.03); C122(1.03)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C120(2.03); C122(2.03)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C120(0.89); C122(0.89)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C120(0.85); C122(0.85)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C120(1.17); C122(1.17)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C120(0.98); C122(0.98)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C120(1.06); C122(1.06)  LDD0987  [3]
 LDCM0391  CL120 HEK-293T C120(1.19); C122(1.19)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C120(1.11); C122(1.11)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C120(1.39); C122(1.39)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C120(1.30); C122(1.30)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C120(1.01); C122(1.01)  LDD0993  [3]
 LDCM0403  CL16 HEK-293T C120(1.06)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C120(1.87)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C120(1.06)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C120(0.95)  LDD1004  [3]
 LDCM0408  CL20 HEK-293T C120(1.26)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C120(1.30)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C120(1.39)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C120(0.92)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C120(1.21)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C120(1.58)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C120(1.26)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C120(1.31)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C120(1.16)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C120(1.15)  LDD1015  [3]
 LDCM0419  CL30 HEK-293T C120(1.80)  LDD1017  [3]
 LDCM0469  CL76 HEK-293T C120(1.01); C122(1.01)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C120(1.65); C122(1.65)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C120(1.10); C122(1.10)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C120(1.50); C122(1.50)  LDD1070  [3]
 LDCM0474  CL80 HEK-293T C120(0.92); C122(0.92)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C120(0.97); C122(0.97)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C120(0.84); C122(0.84)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C120(1.20); C122(1.20)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C120(1.08); C122(1.08)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C120(0.95); C122(0.95)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C120(1.07); C122(1.07)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C120(1.12); C122(1.12)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C120(1.14); C122(1.14)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C120(1.06); C122(1.06)  LDD1081  [3]
 LDCM0485  CL90 HEK-293T C120(1.88); C122(1.88)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C120(0.90); C122(0.90)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C120(1.98); C122(1.98)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C120(1.12); C122(1.12)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C120(1.31); C122(1.31)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C120(2.59); C122(2.59)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C120(1.09); C122(1.09)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C120(1.70); C122(1.70)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C120(1.51); C122(1.51)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C120(0.99); C122(0.99)  LDD1092  [3]
 LDCM0022  KB02 AU565 C272(2.45)  LDD2265  [1]
 LDCM0023  KB03 AU565 C272(3.88)  LDD2682  [1]
 LDCM0024  KB05 MKN45 C272(3.73)  LDD3332  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-dependent kinase 3 (CDK3) CMGC Ser/Thr protein kinase family Q00526
Cyclin-dependent kinase 5 (CDK5) CMGC Ser/Thr protein kinase family Q00535
Cyclin-dependent kinase 6 (CDK6) CMGC Ser/Thr protein kinase family Q00534
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger MYND domain-containing protein 19 (ZMYND19) . Q96E35

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.