Details of the Target

General Information of Target

Target ID LDTP14811
Target Name Zinc finger protein 92 (ZNF92)
Gene Name ZNF92
Gene ID 168374
Synonyms
Zinc finger protein 92; Zinc finger protein HTF12
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MMERIRKEMILMERGLHSPTAGKRFSNLSNSAGNAVLEALENSQHPARLSPRLPSAPLHS
ALGELPAKGKFEIDTLFNLQHTGSESTVSSEISSAAESRKKPGHYSEAAAEADMSSDVEV
GCSALRSPGGLGAAQLKENNGKGYAESGSAAGTTTSASGSGLGSLHGGSGGSGGSAALGG
SGSGADQVRRYRTAFTREQIARLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRR
MKDKRQRLAMSWPHPADPSFYTYMMTHAAATGSLPYPFHSHVPLHYYPHVGVTAAAAAAA
ASGAAAAASSPFATSIRPLDTFRALSHPYSRPELLCSFRHPGLYQAPAAAAGLNSAASAA
AAAAAAAAAASSAAAAGAPPSGGSAPCSCLSCHSSQSAAAAAAAAAAALGSRGGGGGGGG
GGGGGGGGAGAGGGSDFGCSAAAPRSESGFLPYSAAVLSKTAVSPPDQRDEAPLTR
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q03936
Ensemble ID
ENST00000328747.12
HGNC ID
HGNC:13168

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.G487D .
EFO27 SNV: p.Y537C .
HCC15 SNV: p.T140I .
HCT116 SNV: p.G403V .
HEC1 SNV: p.L40P .
MFE319 Insertion: p.H331TfsTer2 .
NCIH1299 SNV: p.Y481F .
RKO SNV: p.Y341C .
RL952 SNV: p.I99K; p.K432N .
SUPT1 SNV: p.K510T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C20(0.78)  LDD1512  [1]
HHS-465
 Probe Info  		K227(0.00); K230(0.00); Y229(0.00)  LDD2240  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C20(0.78)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C78(1.07)  LDD1513  [1]
 LDCM0282  AC22 HEK-293T C20(0.74)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C78(1.09)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C20(0.84)  LDD1523  [1]
 LDCM0291  AC30 HEK-293T C20(1.15)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C78(1.06)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C20(0.89)  LDD1532  [1]
 LDCM0299  AC38 HEK-293T C20(0.89)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C78(1.03)  LDD1539  [1]
 LDCM0302  AC40 HEK-293T C20(1.11)  LDD1541  [1]
 LDCM0308  AC46 HEK-293T C20(0.94)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C78(0.92)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C20(1.09)  LDD1549  [1]
 LDCM0317  AC54 HEK-293T C20(1.19)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C78(1.10)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C20(0.97)  LDD1558  [1]
 LDCM0323  AC6 HEK-293T C20(1.06)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C20(1.06)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C78(1.02)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C20(0.83)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C78(1.02)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C20(1.32)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C20(0.92)  LDD1514  [1]
 LDCM0368  CL10 HEK-293T C20(1.17)  LDD1572  [1]
 LDCM0371  CL102 HEK-293T C20(0.90)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C20(0.85)  LDD1576  [1]
 LDCM0375  CL106 HEK-293T C20(1.14)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C20(0.81)  LDD1580  [1]
 LDCM0379  CL11 HEK-293T C78(0.94)  LDD1583  [1]
 LDCM0380  CL110 HEK-293T C20(1.17)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C20(0.94)  LDD1585  [1]
 LDCM0384  CL114 HEK-293T C20(1.11)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C20(0.87)  LDD1589  [1]
 LDCM0388  CL118 HEK-293T C20(1.13)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C20(0.94)  LDD1593  [1]
 LDCM0390  CL12 HEK-293T C20(1.32)  LDD1594  [1]
 LDCM0393  CL122 HEK-293T C20(0.88)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C20(1.05)  LDD1598  [1]
 LDCM0397  CL126 HEK-293T C20(1.10)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C20(0.99)  LDD1602  [1]
 LDCM0401  CL14 HEK-293T C20(1.12)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C20(1.27)  LDD1606  [1]
 LDCM0407  CL2 HEK-293T C20(0.93)  LDD1611  [1]
 LDCM0410  CL22 HEK-293T C20(0.98)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C78(1.00)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C20(1.11)  LDD1616  [1]
 LDCM0414  CL26 HEK-293T C20(0.98)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C20(0.94)  LDD1619  [1]
 LDCM0418  CL3 HEK-293T C20(1.08)  LDD1622  [1]
 LDCM0423  CL34 HEK-293T C20(1.72)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C78(1.00)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C20(0.94)  LDD1629  [1]
 LDCM0428  CL39 HEK-293T C20(0.90)  LDD1632  [1]
 LDCM0436  CL46 HEK-293T C20(1.47)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C78(0.99)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C20(1.18)  LDD1642  [1]
 LDCM0441  CL50 HEK-293T C20(1.29)  LDD1645  [1]
 LDCM0449  CL58 HEK-293T C20(1.61)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C78(0.98)  LDD1653  [1]
 LDCM0452  CL60 HEK-293T C20(1.09)  LDD1655  [1]
 LDCM0454  CL62 HEK-293T C20(0.87)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C20(0.98)  LDD1658  [1]
 LDCM0463  CL70 HEK-293T C20(0.87)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C78(1.02)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C20(0.79)  LDD1668  [1]
 LDCM0467  CL74 HEK-293T C20(1.09)  LDD1670  [1]
 LDCM0476  CL82 HEK-293T C20(1.27)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C78(0.96)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C20(0.57)  LDD1681  [1]
 LDCM0480  CL86 HEK-293T C20(1.26)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C20(1.08)  LDD1684  [1]
 LDCM0489  CL94 HEK-293T C20(1.33)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C78(1.22)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C20(0.91)  LDD1694  [1]
 LDCM0493  CL98 HEK-293T C20(1.00)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C20(0.71)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C20(1.15)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C20(0.85)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C20(1.28)  LDD1631  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010