Details of the Target

General Information of Target

Target ID LDTP13907
Target Name Axin-2 (AXIN2)
Gene Name AXIN2
Gene ID 8313
Synonyms
Axin-2; Axin-like protein; Axil; Axis inhibition protein 2; Conductin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAACTARRALAVGSRWWSRSLTGARWPRPLCAAAGAGAFSPASTTTTRRHLSSRNRPEGK
VLETVGVFEVPKQNGKYETGQLFLHSIFGYRGVVLFPWQARLYDRDVASAAPEKAENPAG
HGSKEVKGKTHTYYQVLIDARDCPHISQRSQTEAVTFLANHDDSRALYAIPGLDYVSHED
ILPYTSTDQVPIQHELFERFLLYDQTKAPPFVARETLRAWQEKNHPWLELSDVHRETTEN
IRVTVIPFYMGMREAQNSHVYWWRYCIRLENLDSDVVQLRERHWRIFSLSGTLETVRGRG
VVGREPVLSKEQPAFQYSSHVSLQASSGHMWGTFRFERPDGSHFDVRIPPFSLESNKDEK
TPPSGLHW
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Uniprot ID
Q9Y2T1
Ensemble ID
ENST00000307078.10
HGNC ID
HGNC:904
ChEMBL ID
CHEMBL1255167

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C716(0.96)  LDD0531  [1]
IPM
 Probe Info  		C452(0.00); C497(0.00)  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C716(0.96)  LDD0531  [1]
 LDCM0279  AC2 HCT 116 C716(1.15)  LDD0596  [1]
 LDCM0290  AC3 HCT 116 C716(1.11)  LDD0607  [1]
 LDCM0301  AC4 HCT 116 C716(1.26)  LDD0618  [1]
 LDCM0312  AC5 HCT 116 C716(1.84)  LDD0629  [1]
 LDCM0332  AC68 HCT 116 C716(1.09)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C716(0.98)  LDD0650  [1]
 LDCM0335  AC70 HCT 116 C716(1.34)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C716(1.04)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C716(1.02)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C716(1.50)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C716(1.09)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C716(1.90)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C716(1.11)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C716(0.81)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C716(1.08)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C716(0.89)  LDD0661  [1]
 LDCM0346  AC80 HCT 116 C716(0.82)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C716(0.87)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C716(1.55)  LDD0665  [1]
 LDCM0020  ARS-1620 HCC44 C222(0.91); C236(0.91)  LDD2171  [1]
 LDCM0369  CL100 HCT 116 C716(1.34)  LDD0686  [1]
 LDCM0403  CL16 HCT 116 C716(1.04)  LDD0720  [1]
 LDCM0421  CL32 HCT 116 C716(0.84)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C716(0.70)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C716(0.80)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C716(1.10)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C716(0.76)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C716(1.34)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C716(0.78)  LDD0745  [1]
 LDCM0430  CL40 HCT 116 C716(0.68)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C716(0.76)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C716(0.51)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C716(0.63)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C716(0.64)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C716(0.65)  LDD0752  [1]
 LDCM0453  CL61 HCT 116 C716(0.90)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C716(1.06)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C716(0.84)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C716(0.71)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C716(0.89)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C716(0.81)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C716(0.99)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C716(0.83)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C716(1.25)  LDD0778  [1]
 LDCM0463  CL70 HCT 116 C716(0.74)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C716(0.72)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C716(1.11)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C716(1.03)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C716(1.12)  LDD0784  [1]
 LDCM0486  CL91 HCT 116 C716(0.83)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C716(1.14)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C716(0.99)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C716(1.07)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C716(1.24)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C716(1.65)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C716(1.63)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C716(1.48)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C716(0.97)  LDD0811  [1]
 LDCM0468  Fragment33 HCT 116 C716(0.84)  LDD0785  [1]
 LDCM0427  Fragment51 HCT 116 C716(1.12)  LDD0744  [1]
 LDCM0022  KB02 HCT 15 C452(2.09)  LDD2347  [3]
 LDCM0023  KB03 HCT 15 C452(2.97)  LDD2764  [3]
 LDCM0024  KB05 TFK-1 C452(2.60)  LDD3472  [3]
 LDCM0021  THZ1 HCT 116 C222(0.91); C236(0.91)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calpain-7 (CAPN7) Peptidase C2 family Q9Y6W3
Proteasome subunit beta type-2 (PSMB2) Peptidase T1B family P49721
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PPP2R5A) Phosphatase 2A regulatory subunit B56 family Q15172
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PPP2CB) PPP phosphatase family P62714
Serine/threonine-protein kinase PLK1 (PLK1) Ser/Thr protein kinase family P53350
DNA topoisomerase 3-beta-1 (TOP3B) Type IA topoisomerase family O95985
BRCA1-associated RING domain protein 1 (BARD1) . Q99728
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B5 (HOXB5) Antp homeobox family P09067
Zinc finger protein 124 (ZNF124) Krueppel C2H2-type zinc-finger protein family Q15973
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Zinc finger protein 648 (ZNF648) Krueppel C2H2-type zinc-finger protein family Q5T619
Homeobox protein TGIF1 (TGIF1) TALE/TGIF homeobox family Q15583
Other
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
APC membrane recruitment protein 3 (AMER3) Amer family Q8N944
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Bystin (BYSL) Bystin family Q13895
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Cysteine-rich hydrophobic domain-containing protein 2 (CHIC2) CHIC family Q9UKJ5
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
Protein FAM161A (FAM161A) FAM161 family Q3B820
Keratin-associated protein 10-10 (KRTAP10-10) KRTAP type 10 family P60014
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 4-5 (KRTAP4-5) KRTAP type 4 family Q9BYR2
Keratin-associated protein 9-2 (KRTAP9-2) KRTAP type 9 family Q9BYQ4
Syntaxin-11 (STX11) Syntaxin family O75558
Alpha-taxilin (TXLNA) Taxilin family P40222
Beta-taxilin (TXLNB) Taxilin family Q8N3L3
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
UPF0561 protein C2orf68 (C2orf68) UPF0561 family Q2NKX9
Elongin-A (ELOA) . Q14241
F-box/WD repeat-containing protein 1A (BTRC) . Q9Y297
Microspherule protein 1 (MCRS1) . Q96EZ8

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840