Details of the Target

General Information of Target

Target ID LDTP13645
Target Name Transcription factor SOX-13 (SOX13)
Gene Name SOX13
Gene ID 9580
Synonyms
Transcription factor SOX-13; Islet cell antigen 12; SRY; Sex determining region Y)-box 13; Type 1 diabetes autoantigen ICA12
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDKLKCPSFFKCREKEKVSASSENFHVGENDENQDRGNWSKKSDYLLSMIGYAVGLGNVW
RFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGIT
MVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCSSWSDKNCSRSPIVTHCNVSTVNK
GIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLA
LCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGATLEGASKGISYYIGAQ
SNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVF
AGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPFWSILFFFMLLTLG
LDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHF
CAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAI
FIWSLVQFHRPNYGAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCC
RPASNWGPYLEQHRGERYKDMVDPKKEADHEIPTVSGSRKPE
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3'. Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor. Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells. Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells. Promotes brown adipocyte differentiation. Inhibitor of WNT signaling.
Uniprot ID
Q9UN79
Ensemble ID
ENST00000367204.6
HGNC ID
HGNC:11192

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C501(1.71)  LDD3323  [2]
NAIA_5
 Probe Info  		C33(1.31)  LDD2227  [3]
AHL-Pu-1
 Probe Info  		C396(2.08)  LDD0170  [4]
NAIA_4
 Probe Info  		C33(0.00); C578(0.00)  LDD2226  [3]
WYneN
 Probe Info  		N.A.  LDD0021  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C396(2.08)  LDD0170  [4]
 LDCM0259  AC14 HEK-293T C33(1.00)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C33(0.95)  LDD1513  [7]
 LDCM0281  AC21 HEK-293T C33(1.46)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C33(0.79)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C33(1.22)  LDD1522  [7]
 LDCM0289  AC29 HEK-293T C33(1.39)  LDD1528  [7]
 LDCM0291  AC30 HEK-293T C33(1.19)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C33(0.87)  LDD1531  [7]
 LDCM0298  AC37 HEK-293T C33(0.97)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C33(1.40)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C33(1.05)  LDD1539  [7]
 LDCM0307  AC45 HEK-293T C33(1.07)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C33(1.36)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C33(1.11)  LDD1548  [7]
 LDCM0312  AC5 HEK-293T C33(1.28)  LDD1551  [7]
 LDCM0316  AC53 HEK-293T C33(1.51)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C33(1.17)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C33(1.07)  LDD1557  [7]
 LDCM0323  AC6 HEK-293T C33(0.96)  LDD1562  [7]
 LDCM0325  AC61 HEK-293T C33(1.51)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C33(1.17)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C33(0.89)  LDD1566  [7]
 LDCM0334  AC7 HEK-293T C33(0.86)  LDD1568  [7]
 LDCM0248  AKOS034007472 HEK-293T C33(1.37)  LDD1511  [7]
 LDCM0632  CL-Sc Hep-G2 C33(1.31)  LDD2227  [3]
 LDCM0368  CL10 HEK-293T C33(1.07)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C33(1.12)  LDD1573  [7]
 LDCM0373  CL104 HEK-293T C33(1.06)  LDD1577  [7]
 LDCM0377  CL108 HEK-293T C33(0.86)  LDD1581  [7]
 LDCM0379  CL11 HEK-293T C33(1.10)  LDD1583  [7]
 LDCM0382  CL112 HEK-293T C33(1.11)  LDD1586  [7]
 LDCM0386  CL116 HEK-293T C33(1.51)  LDD1590  [7]
 LDCM0391  CL120 HEK-293T C33(1.37)  LDD1595  [7]
 LDCM0395  CL124 HEK-293T C33(1.12)  LDD1599  [7]
 LDCM0399  CL128 HEK-293T C33(1.14)  LDD1603  [7]
 LDCM0403  CL16 HEK-293T C33(0.84)  LDD1607  [7]
 LDCM0409  CL21 HEK-293T C33(1.36)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C33(1.60)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C33(1.26)  LDD1615  [7]
 LDCM0416  CL28 HEK-293T C33(1.07)  LDD1620  [7]
 LDCM0422  CL33 HEK-293T C33(1.09)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C33(1.04)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C33(0.99)  LDD1628  [7]
 LDCM0429  CL4 HEK-293T C33(0.89)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C33(1.10)  LDD1634  [7]
 LDCM0435  CL45 HEK-293T C33(1.23)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C33(1.79)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C33(1.22)  LDD1641  [7]
 LDCM0443  CL52 HEK-293T C33(1.22)  LDD1646  [7]
 LDCM0448  CL57 HEK-293T C33(2.10)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C33(1.30)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C33(1.20)  LDD1653  [7]
 LDCM0456  CL64 HEK-293T C33(0.94)  LDD1659  [7]
 LDCM0461  CL69 HEK-293T C33(1.32)  LDD1664  [7]
 LDCM0463  CL70 HEK-293T C33(0.85)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C33(1.11)  LDD1667  [7]
 LDCM0469  CL76 HEK-293T C33(0.87)  LDD1672  [7]
 LDCM0475  CL81 HEK-293T C33(1.08)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C33(1.06)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C33(1.03)  LDD1680  [7]
 LDCM0482  CL88 HEK-293T C33(0.88)  LDD1685  [7]
 LDCM0484  CL9 HEK-293T C33(1.60)  LDD1687  [7]
 LDCM0488  CL93 HEK-293T C33(0.84)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C33(1.42)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C33(0.95)  LDD1693  [7]
 LDCM0022  KB02 A375.S2 C33(1.63)  LDD2256  [2]
 LDCM0023  KB03 A375.S2 C33(1.32)  LDD2673  [2]
 LDCM0024  KB05 SKMEL24 C501(1.71)  LDD3323  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-terminal-binding protein 2 (CTBP2) D-isomer specific 2-hydroxyacid dehydrogenase family P56545
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vascular endothelial zinc finger 1 (VEZF1) Krueppel C2H2-type zinc-finger protein family Q14119
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-taxilin (TXLNB) Taxilin family Q8N3L3
INO80 complex subunit B (INO80B) . Q9C086

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402