Details of the Target

General Information of Target

Target ID LDTP13585
Target Name Activator of basal transcription 1 (ABT1)
Gene Name ABT1
Gene ID 29777
Synonyms
Activator of basal transcription 1; hABT1; Basal transcriptional activator
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQRPGPRLWLVLQVMGSCAAISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHEN
QREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPI
MEQFNFKWPDSLDCRKLPNKNDPNYLCMEAPNNGSDEPTRGSGLFPPLFRPQRPHSAQEH
PLKDGGPGRGGCDNPGKFHHVEKSASCAPLCTPGVDVYWSREDKRFAVVWLAIWAVLCFF
SSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACDRDSGQLYVI
QEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWA
IPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVAL
FHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHK
CKMNNQTKTLDCLMAASIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSRRLK
KKSRRKPASVITSGGIYKKAQHPQKTHHGKYEIPAQSPTCV
Target Bioclass
Other
Family
ESF2/ABP1 family
Subcellular location
Nucleus
Function Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes.
Uniprot ID
Q9ULW3
Ensemble ID
ENST00000274849.3
HGNC ID
HGNC:17369

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
IA-alkyne
 Probe Info  		C37(1.05)  LDD0304  [2]
AHL-Pu-1
 Probe Info  		C37(4.76)  LDD0171  [3]
DBIA
 Probe Info  		C37(1.17)  LDD1492  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
W1
 Probe Info  		D241(0.00); N246(0.00); Q240(0.00); R244(0.00)  LDD0236  [6]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C37(4.76)  LDD0171  [3]
 LDCM0259  AC14 HEK-293T C37(1.01)  LDD1512  [4]
 LDCM0282  AC22 HEK-293T C37(1.21)  LDD1521  [4]
 LDCM0291  AC30 HEK-293T C37(1.04)  LDD1530  [4]
 LDCM0299  AC38 HEK-293T C37(1.21)  LDD1538  [4]
 LDCM0308  AC46 HEK-293T C37(1.00)  LDD1547  [4]
 LDCM0317  AC54 HEK-293T C37(1.01)  LDD1556  [4]
 LDCM0323  AC6 HEK-293T C37(0.97)  LDD1562  [4]
 LDCM0326  AC62 HEK-293T C37(0.99)  LDD1565  [4]
 LDCM0156  Aniline NCI-H1299 12.64  LDD0403  [1]
 LDCM0368  CL10 HEK-293T C37(0.96)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C37(0.92)  LDD1573  [4]
 LDCM0371  CL102 HEK-293T C37(0.88)  LDD1575  [4]
 LDCM0373  CL104 HEK-293T C37(0.89)  LDD1577  [4]
 LDCM0375  CL106 HEK-293T C37(0.93)  LDD1579  [4]
 LDCM0377  CL108 HEK-293T C37(1.36)  LDD1581  [4]
 LDCM0380  CL110 HEK-293T C37(0.89)  LDD1584  [4]
 LDCM0382  CL112 HEK-293T C37(1.01)  LDD1586  [4]
 LDCM0384  CL114 HEK-293T C37(0.92)  LDD1588  [4]
 LDCM0386  CL116 HEK-293T C37(0.94)  LDD1590  [4]
 LDCM0388  CL118 HEK-293T C37(0.95)  LDD1592  [4]
 LDCM0391  CL120 HEK-293T C37(0.86)  LDD1595  [4]
 LDCM0393  CL122 HEK-293T C37(0.98)  LDD1597  [4]
 LDCM0395  CL124 HEK-293T C37(0.91)  LDD1599  [4]
 LDCM0397  CL126 HEK-293T C37(1.08)  LDD1601  [4]
 LDCM0399  CL128 HEK-293T C37(0.80)  LDD1603  [4]
 LDCM0401  CL14 HEK-293T C37(0.99)  LDD1605  [4]
 LDCM0403  CL16 HEK-293T C37(1.16)  LDD1607  [4]
 LDCM0407  CL2 HEK-293T C37(1.16)  LDD1611  [4]
 LDCM0410  CL22 HEK-293T C37(0.90)  LDD1614  [4]
 LDCM0414  CL26 HEK-293T C37(1.07)  LDD1618  [4]
 LDCM0416  CL28 HEK-293T C37(1.17)  LDD1620  [4]
 LDCM0423  CL34 HEK-293T C37(0.98)  LDD1627  [4]
 LDCM0429  CL4 HEK-293T C37(0.98)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C37(0.88)  LDD1634  [4]
 LDCM0436  CL46 HEK-293T C37(1.06)  LDD1640  [4]
 LDCM0441  CL50 HEK-293T C37(1.02)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C37(0.76)  LDD1646  [4]
 LDCM0449  CL58 HEK-293T C37(0.97)  LDD1652  [4]
 LDCM0454  CL62 HEK-293T C37(0.90)  LDD1657  [4]
 LDCM0456  CL64 HEK-293T C37(0.93)  LDD1659  [4]
 LDCM0463  CL70 HEK-293T C37(1.11)  LDD1666  [4]
 LDCM0467  CL74 HEK-293T C37(0.84)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C37(1.03)  LDD1672  [4]
 LDCM0476  CL82 HEK-293T C37(1.11)  LDD1679  [4]
 LDCM0480  CL86 HEK-293T C37(0.99)  LDD1683  [4]
 LDCM0482  CL88 HEK-293T C37(1.11)  LDD1685  [4]
 LDCM0489  CL94 HEK-293T C37(1.02)  LDD1692  [4]
 LDCM0493  CL98 HEK-293T C37(0.84)  LDD1696  [4]
 LDCM0427  Fragment51 HEK-293T C37(0.91)  LDD1631  [4]
 LDCM0022  KB02 HEK-293T C37(1.17)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C37(0.81)  LDD1497  [4]
 LDCM0024  KB05 HEK-293T C37(1.24)  LDD1502  [4]
 LDCM0131  RA190 MM1.R C37(1.05)  LDD0304  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein mab-21-like 3 (MAB21L3) Mab-21 family Q8N8X9
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Nesprin-4 (SYNE4) Nesprin family Q8N205
Testis-specific Y-encoded-like protein 2 (TSPYL2) Nucleosome assembly protein (NAP) family Q9H2G4
Cell division cycle-associated 7-like protein (CDCA7L) . Q96GN5
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Emerin (EMD) . P50402
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
PRKCA-binding protein (PICK1) . Q9NRD5
RING finger protein 151 (RNF151) . Q2KHN1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
7 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.