Details of the Target

General Information of Target

Target ID LDTP13517
Target Name Paraneoplastic antigen Ma2 (PNMA2)
Gene Name PNMA2
Gene ID 10687
Synonyms
KIAA0883; MA2; Paraneoplastic antigen Ma2; 40 kDa neuronal protein; Onconeuronal antigen Ma2; Paraneoplastic neuronal antigen MM2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPLTLLQDWCRGEHLNTRRCMLILGIPEDCGEDEFEETLQEACRHLGRYRVIGRMFRREE
NAQAILLELAQDIDYALLPREIPGKGGPWEVIVKPRNSDGEFLNRLNRFLEEERRTVSDM
NRVLGSDTNCSAPRVTISPEFWTWAQTLGAAVQPLLEQMLYRELRVFSGNTISIPGALAF
DAWLEHTTEMLQMWQVPEGEKRRRLMECLRGPALQVVSGLRASNASITVEECLAALQQVF
GPVESHKIAQVKLCKAYQEAGEKVSSFVLRLEPLLQRAVENNVVSRRNVNQTRLKRVLSG
ATLPDKLRDKLKLMKQRRKPPGFLALVKLLREEEEWEATLGPDRESLEGLEVAPRPPARI
TGVGAVPLPASGNSFDARPSQGYRRRRGRGQHRRGGVARAGSRGSRKRKRHTFCYSCGED
GHIRVQCINPSNLLLVKQKKQAAVESGNGNWAWDKSHPKSKAK
Target Bioclass
Other
Family
PNMA family
Subcellular location
Nucleus, nucleolus
Uniprot ID
Q9UL42
Ensemble ID
ENST00000522362.7
HGNC ID
HGNC:9159

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C310(1.30)  LDD0080  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C285
 Probe Info  		19.84  LDD1955  [4]
C288
 Probe Info  		6.87  LDD1958  [4]
C289
 Probe Info  		33.36  LDD1959  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HCT 116 C310(1.30)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C310(1.17)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C310(1.27)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
E3 ubiquitin-protein ligase RNF8 (RNF8) RNF8 family O76064
DNA topoisomerase 3-beta-1 (TOP3B) Type IA topoisomerase family O95985
Peptidyl-prolyl cis-trans isomerase G (PPIG) . Q13427
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Metal transporter CNNM3 (CNNM3) ACDP family Q8NE01
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Zinc finger protein 669 (ZNF669) Krueppel C2H2-type zinc-finger protein family Q96BR6
Zinc finger protein 785 (ZNF785) Krueppel C2H2-type zinc-finger protein family A8K8V0
THAP domain-containing protein 7 (THAP7) . Q9BT49
Zinc finger protein 408 (ZNF408) . Q9H9D4
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hyaluronan and proteoglycan link protein 2 (HAPLN2) HAPLN family Q9GZV7
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bystin (BYSL) Bystin family Q13895
Protein FAM161A (FAM161A) FAM161 family Q3B820
Mitotic interactor and substrate of PLK1 (MISP) MISP family Q8IVT2
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
Large ribosomal subunit protein uL6 (RPL9; RPL9P7; RPL9P8; RPL9P9) Universal ribosomal protein uL6 family P32969
Chromobox protein homolog 8 (CBX8) . Q9HC52
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Inactive polyglycylase TTLL10 (TTLL10) . Q6ZVT0
INO80 complex subunit B (INO80B) . Q9C086
Leucine-rich repeat protein 1 (LRR1) . Q96L50
Mortality factor 4-like protein 2 (MORF4L2) . Q15014
Receptor-transporting protein 5 (RTP5) . Q14D33
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587