Details of the Target

General Information of Target

Target ID LDTP13342
Target Name Bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
Gene Name BAZ2B
Gene ID 29994
Synonyms
KIAA1476; Bromodomain adjacent to zinc finger domain protein 2B; hWALp4
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MTPLVSRLSRLWAIMRKPRAAVGSGHRKQAASQEGRQKHAKNNSQAKPSACDGMIAECPG
APAGLARQPEEVVLQASVSSYHLFRDVAEVTAFRGSLLSWYDQEKRDLPWRRRAEDEMDL
DRRAYAVWVSEVMLQQTQVATVINYYTGWMQKWPTLQDLASASLEEVNQLWAGLGYYSRG
RRLQEGARKVVEELGGHMPRTAETLQQLLPGVGRYTAGAIASIAFGQATGVVDGNVARVL
CRVRAIGADPSSTLVSQQLWGLAQQLVDPARPGDFNQAAMELGATVCTPQRPLCSQCPVE
SLCRARQRVEQEQLLASGSLSGSPDVEECAPNTGQCHLCLPPSEPWDQTLGVVNFPRKAS
RKPPREESSATCVLEQPGALGAQILLVQRPNSGLLAGLWEFPSVTWEPSEQLQRKALLQE
LQRWAGPLPATHLRHLGEVVHTFSHIKLTYQVYGLALEGQTPVTTVPPGARWLTQEEFHT
AAVSTAMKKVFRVYQGQQPGTCMGSKRSQVSSPCSRKKPRMGQQVLDNFFRSHISTDAHS
LNSAAQ
Target Type
Literature-reported
Target Bioclass
Other
Family
WAL family
Subcellular location
Nucleus
Function
Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template. The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex. Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI. Involved in positively modulating the rate of age-related behavioral deterioration. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1.
TTD ID
T15745
Uniprot ID
Q9UIF8
DrugMap ID
TT6K8YG
Ensemble ID
ENST00000392782.5
HGNC ID
HGNC:963
ChEMBL ID
CHEMBL1741220

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.K1838NfsTer25 DBIA    Probe Info 
CAL27 SNV: p.M197V .
CASKI SNV: p.R1384C .
DU145 SNV: p.I1182V; p.G1532C DBIA    Probe Info 
HCT116 SNV: p.E750V .
HCT15 SNV: p.G702C DBIA    Probe Info 
HELA SNV: p.A1146S .
HUH7 SNV: p.E1276K .
JURKAT SNV: p.Q562H .
K562 SNV: p.F130L .
LNCaP clone FGC SNV: p.S1667Ter DBIA    Probe Info 
LS123 SNV: p.D266G .
MDAMB453 SNV: p.S2019C .
MDST8 Substitution: p.L1085P DBIA    Probe Info 
MFE319 SNV: p.T378M .
MIAPACA2 SNV: p.G32A .
NCIH1299 SNV: p.L980F .
NCIH661 SNV: p.D148Y .
OPM2 SNV: p.P137S .
OZ SNV: p.Q1358K DBIA    Probe Info 
RKO SNV: p.Y789H DBIA    Probe Info 
RL952 SNV: p.E1448Ter DBIA    Probe Info 
SNU5 SNV: p.S176N .
SUPT1 SNV: p.V915F; p.R1385W .
SW1573 SNV: p.E1850G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1956(0.95); C1960(0.95)  LDD0078  [1]
CY4
 Probe Info  		D1723(0.00); D1726(0.00)  LDD0247  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]
Phosphinate-6
 Probe Info  		C212(0.00); C48(0.00)  LDD0018  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C1975(1.45); C1978(1.45)  LDD1093  [1]
 LDCM0279  AC2 PaTu 8988t C1975(1.35); C1978(1.35)  LDD1158  [1]
 LDCM0284  AC24 HEK-293T C212(0.96)  LDD1523  [6]
 LDCM0285  AC25 PaTu 8988t C1975(0.92); C1978(0.92)  LDD1164  [1]
 LDCM0286  AC26 PaTu 8988t C1975(0.89); C1978(0.89)  LDD1165  [1]
 LDCM0287  AC27 PaTu 8988t C1975(0.94); C1978(0.94)  LDD1166  [1]
 LDCM0288  AC28 PaTu 8988t C1975(0.93); C1978(0.93)  LDD1167  [1]
 LDCM0289  AC29 PaTu 8988t C1975(0.84); C1978(0.84)  LDD1168  [1]
 LDCM0290  AC3 PaTu 8988t C1975(1.14); C1978(1.14)  LDD1169  [1]
 LDCM0291  AC30 PaTu 8988t C1975(0.77); C1978(0.77)  LDD1170  [1]
 LDCM0292  AC31 PaTu 8988t C1975(0.83); C1978(0.83)  LDD1171  [1]
 LDCM0293  AC32 PaTu 8988t C1975(1.11); C1978(1.11)  LDD1172  [1]
 LDCM0294  AC33 PaTu 8988t C1975(1.03); C1978(1.03)  LDD1173  [1]
 LDCM0295  AC34 PaTu 8988t C1975(1.15); C1978(1.15)  LDD1174  [1]
 LDCM0301  AC4 PaTu 8988t C1975(1.54); C1978(1.54)  LDD1180  [1]
 LDCM0302  AC40 HEK-293T C212(0.87)  LDD1541  [6]
 LDCM0308  AC46 PaTu 8988t C1975(0.87); C1978(0.87)  LDD1187  [1]
 LDCM0309  AC47 PaTu 8988t C1975(0.99); C1978(0.99)  LDD1188  [1]
 LDCM0310  AC48 PaTu 8988t C1975(0.98); C1978(0.98)  LDD1189  [1]
 LDCM0311  AC49 PaTu 8988t C1975(1.11); C1978(1.11)  LDD1190  [1]
 LDCM0312  AC5 PaTu 8988t C1975(1.62); C1978(1.62)  LDD1191  [1]
 LDCM0313  AC50 PaTu 8988t C1975(1.16); C1978(1.16)  LDD1192  [1]
 LDCM0314  AC51 PaTu 8988t C1975(0.56); C1978(0.56)  LDD1193  [1]
 LDCM0315  AC52 PaTu 8988t C1975(0.94); C1978(0.94)  LDD1194  [1]
 LDCM0316  AC53 PaTu 8988t C1975(1.23); C1978(1.23)  LDD1195  [1]
 LDCM0317  AC54 PaTu 8988t C1975(1.31); C1978(1.31)  LDD1196  [1]
 LDCM0318  AC55 PaTu 8988t C1975(1.14); C1978(1.14)  LDD1197  [1]
 LDCM0319  AC56 PaTu 8988t C1975(1.14); C1978(1.14)  LDD1198  [1]
 LDCM0320  AC57 PaTu 8988t C1975(1.01); C1978(1.01)  LDD1199  [1]
 LDCM0321  AC58 PaTu 8988t C1975(1.38); C1978(1.38)  LDD1200  [1]
 LDCM0322  AC59 PaTu 8988t C1975(1.09); C1978(1.09)  LDD1201  [1]
 LDCM0324  AC60 PaTu 8988t C1975(0.94); C1978(0.94)  LDD1203  [1]
 LDCM0325  AC61 PaTu 8988t C1975(0.92); C1978(0.92)  LDD1204  [1]
 LDCM0326  AC62 PaTu 8988t C1975(1.09); C1978(1.09)  LDD1205  [1]
 LDCM0327  AC63 PaTu 8988t C1975(1.22); C1978(1.22)  LDD1206  [1]
 LDCM0328  AC64 PaTu 8988t C1975(1.08); C1978(1.08)  LDD1207  [1]
 LDCM0329  AC65 PaTu 8988t C1975(1.20); C1978(1.20)  LDD1208  [1]
 LDCM0330  AC66 PaTu 8988t C1975(0.97); C1978(0.97)  LDD1209  [1]
 LDCM0331  AC67 PaTu 8988t C1975(1.15); C1978(1.15)  LDD1210  [1]
 LDCM0332  AC68 PaTu 8988t C1975(0.86); C1978(0.86)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C1975(0.79); C1978(0.79)  LDD1212  [1]
 LDCM0335  AC70 PaTu 8988t C1975(0.96); C1978(0.96)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C1975(1.11); C1978(1.11)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C1975(0.79); C1978(0.79)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C1975(0.90); C1978(0.90)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C1975(0.78); C1978(0.78)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C1975(0.97); C1978(0.97)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C1975(0.89); C1978(0.89)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C1975(1.03); C1978(1.03)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C1975(0.96); C1978(0.96)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C1975(0.82); C1978(0.82)  LDD1223  [1]
 LDCM0345  AC8 HEK-293T C212(0.89)  LDD1569  [6]
 LDCM0346  AC80 PaTu 8988t C1975(0.86); C1978(0.86)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C1975(0.79); C1978(0.79)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C1975(0.81); C1978(0.81)  LDD1227  [1]
 LDCM0275  AKOS034007705 HEK-293T C212(0.87)  LDD1514  [6]
 LDCM0020  ARS-1620 HCC44 C1956(0.95); C1960(0.95)  LDD0078  [1]
 LDCM0632  CL-Sc Hep-G2 C212(0.77)  LDD2227  [4]
 LDCM0369  CL100 PaTu 8988t C1975(1.35); C1978(1.35)  LDD1248  [1]
 LDCM0382  CL112 PaTu 8988t C1975(0.86); C1978(0.86)  LDD1261  [1]
 LDCM0383  CL113 PaTu 8988t C1975(0.85); C1978(0.85)  LDD1262  [1]
 LDCM0384  CL114 PaTu 8988t C1975(1.00); C1978(1.00)  LDD1263  [1]
 LDCM0385  CL115 PaTu 8988t C1975(0.97); C1978(0.97)  LDD1264  [1]
 LDCM0386  CL116 PaTu 8988t C1975(1.01); C1978(1.01)  LDD1265  [1]
 LDCM0390  CL12 HEK-293T C212(0.91)  LDD1594  [6]
 LDCM0392  CL121 PaTu 8988t C1975(1.26); C1978(1.26)  LDD1271  [1]
 LDCM0393  CL122 PaTu 8988t C1975(1.14); C1978(1.14)  LDD1272  [1]
 LDCM0394  CL123 PaTu 8988t C1975(1.20); C1978(1.20)  LDD1273  [1]
 LDCM0395  CL124 PaTu 8988t C1975(1.16); C1978(1.16)  LDD1274  [1]
 LDCM0396  CL125 PaTu 8988t C1975(1.15); C1978(1.15)  LDD1275  [1]
 LDCM0397  CL126 PaTu 8988t C1975(1.25); C1978(1.25)  LDD1276  [1]
 LDCM0398  CL127 PaTu 8988t C1975(1.23); C1978(1.23)  LDD1277  [1]
 LDCM0399  CL128 PaTu 8988t C1975(1.28); C1978(1.28)  LDD1278  [1]
 LDCM0412  CL24 HEK-293T C212(1.00)  LDD1616  [6]
 LDCM0425  CL36 HEK-293T C212(0.84)  LDD1629  [6]
 LDCM0436  CL46 PaTu 8988t C1975(0.96); C1978(0.96)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C1975(1.22); C1978(1.22)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C1975(1.32); C1978(1.32)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C1975(1.21); C1978(1.21)  LDD1318  [1]
 LDCM0441  CL50 PaTu 8988t C1975(0.71); C1978(0.71)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C1975(0.90); C1978(0.90)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C1975(1.18); C1978(1.18)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C1975(1.16); C1978(1.16)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C1975(1.33); C1978(1.33)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C1975(1.11); C1978(1.11)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C1975(0.46); C1978(0.46)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C1975(1.42); C1978(1.42)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C1975(1.11); C1978(1.11)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C1975(1.60); C1978(1.60)  LDD1329  [1]
 LDCM0452  CL60 PaTu 8988t C1975(1.72); C1978(1.72)  LDD1331  [1]
 LDCM0465  CL72 HEK-293T C212(1.06)  LDD1668  [6]
 LDCM0478  CL84 HEK-293T C212(0.90)  LDD1681  [6]
 LDCM0486  CL91 PaTu 8988t C1975(1.29); C1978(1.29)  LDD1365  [1]
 LDCM0487  CL92 PaTu 8988t C1975(1.36); C1978(1.36)  LDD1366  [1]
 LDCM0488  CL93 PaTu 8988t C1975(1.66); C1978(1.66)  LDD1367  [1]
 LDCM0489  CL94 PaTu 8988t C1975(1.62); C1978(1.62)  LDD1368  [1]
 LDCM0490  CL95 PaTu 8988t C1975(1.58); C1978(1.58)  LDD1369  [1]
 LDCM0491  CL96 PaTu 8988t C1975(1.70); C1978(1.70)  LDD1370  [1]
 LDCM0492  CL97 PaTu 8988t C1975(1.15); C1978(1.15)  LDD1371  [1]
 LDCM0493  CL98 PaTu 8988t C1975(1.69); C1978(1.69)  LDD1372  [1]
 LDCM0494  CL99 PaTu 8988t C1975(1.43); C1978(1.43)  LDD1373  [1]
 LDCM0022  KB02 HCT 116 C1975(2.21); C1978(2.21)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C1975(1.52); C1978(1.52)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C1975(1.27); C1978(1.27)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Methylthioribulose-1-phosphate dehydratase (APIP) Aldolase class II family Q96GX9
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Basic immunoglobulin-like variable motif-containing protein (BIVM) BIVM family Q86UB2
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Heat shock factor 2-binding protein (HSF2BP) . O75031
SH3 and cysteine-rich domain-containing protein 3 (STAC3) . Q96MF2

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Baz2-icr Small molecular drug D0I4FP
Gsk2801 Small molecular drug D0T3WL
Pmid25719566c1 Small molecular drug D07HET
Pmid25719566c7 Small molecular drug D02KSN

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402