Details of the Target

General Information of Target

Target ID LDTP12833
Target Name TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB2)
Gene Name TAB2
Gene ID 23118
Synonyms
KIAA0733; MAP3K7IP2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAK1-binding protein 2; TAB-2; TGF-beta-activated kinase 1-binding protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVSPRMSGLLSQTVILALIFLPQTRPAGVFELQIHSFGPGPGPGAPRSPCSARLPCRLFF
RVCLKPGLSEEAAESPCALGAALSARGPVYTEQPGAPAPDLPLPDGLLQVPFRDAWPGTF
SFIIETWREELGDQIGGPAWSLLARVAGRRRLAAGGPWARDIQRAGAWELRFSYRARCEP
PAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCL
EGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTC
PRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQ
PCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALG
FGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGASALPAAP
PGLRPGDPQRYLLPPALGLLVAAGVAGAALLLVHVRRRGHSQDAGSRLLAGTPEPSVHAL
PDALNNLRTQEGSGDGPSSSVDWNRPEDVDPQGIYVISAPSIYAREVATPLFPPLHTGRA
GQRQHLLFPYPSSILSVK
Target Bioclass
Other
Subcellular location
Membrane
Function
Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) . Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1. Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Involved in heart development.
Uniprot ID
Q9NYJ8
Ensemble ID
ENST00000367456.5
HGNC ID
HGNC:17075
ChEMBL ID
CHEMBL4295965

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.N150K .
JURKAT Deletion: p.G4EfsTer57 .
OVK18 SNV: p.V514M .
PATU8988T SNV: p.P494R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0223  [1]
DBIA
 Probe Info  		C31(0.99); C42(0.99); C43(0.99); C608(0.94)  LDD0078  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
AOyne
 Probe Info  		10.60  LDD0443  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C608(1.03)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C608(0.89)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C608(1.01)  LDD1509  [5]
 LDCM0237  AC12 HEK-293T C608(0.98)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C608(1.02)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C608(1.00)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C608(1.01)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C608(0.93)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C608(1.01)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C608(0.99)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C608(1.01)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C608(1.00)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C608(1.02)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C608(1.09)  LDD1522  [5]
 LDCM0285  AC25 HEK-293T C608(0.90)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C608(0.97)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C608(0.98)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C608(1.02)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C608(0.98)  LDD1528  [5]
 LDCM0290  AC3 HEK-293T C608(1.01)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C608(1.02)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C608(0.92)  LDD1531  [5]
 LDCM0294  AC33 HEK-293T C608(0.98)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C608(0.95)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C608(1.02)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C608(0.98)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C608(0.98)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C608(0.99)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C608(1.05)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C608(1.01)  LDD1540  [5]
 LDCM0303  AC41 HEK-293T C608(0.94)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C608(1.10)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C608(0.98)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C608(0.98)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C608(1.12)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C608(1.07)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C608(0.98)  LDD1548  [5]
 LDCM0311  AC49 HEK-293T C608(1.03)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C608(1.03)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C608(0.98)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C608(1.05)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C608(0.97)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C608(1.06)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C608(1.04)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C608(0.96)  LDD1557  [5]
 LDCM0320  AC57 HEK-293T C608(1.07)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C608(0.97)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C608(0.98)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C608(1.06)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C608(0.96)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C608(1.03)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C608(1.04)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C608(0.91)  LDD1566  [5]
 LDCM0334  AC7 HEK-293T C608(0.93)  LDD1568  [5]
 LDCM0248  AKOS034007472 HEK-293T C608(0.99)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C608(0.98)  LDD1570  [5]
 LDCM0020  ARS-1620 HCC44 C31(0.99); C42(0.99); C43(0.99); C608(0.94)  LDD0078  [2]
 LDCM0367  CL1 HEK-293T C608(1.03)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C608(0.89)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C608(0.99)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C608(1.06)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C608(0.99)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C608(1.03)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C608(0.98)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C608(0.96)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C608(0.94)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C608(1.05)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C608(0.92)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C608(0.96)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C608(0.98)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C608(0.91)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C608(0.91)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C608(0.96)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C608(0.96)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C608(0.97)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C608(1.22)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C608(0.92)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C608(1.05)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C608(0.98)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C608(1.08)  LDD1593  [5]
 LDCM0391  CL120 HEK-293T C608(0.96)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C608(0.98)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C608(0.99)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C608(1.12)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C608(1.06)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C608(1.20)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C608(1.14)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C608(1.36)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C608(1.00)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C608(1.07)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C608(1.03)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C608(1.06)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C608(1.15)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C608(1.18)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C608(1.07)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C608(1.08)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C608(1.03)  LDD1611  [5]
 LDCM0408  CL20 HEK-293T C608(1.00)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C608(0.94)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C608(0.97)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C608(0.98)  LDD1615  [5]
 LDCM0413  CL25 HEK-293T C608(0.98)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C608(0.93)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C608(1.13)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C608(0.98)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C608(1.09)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C608(1.09)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C608(0.96)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C608(0.99)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C608(0.93)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C608(0.88)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C608(1.02)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C608(0.94)  LDD1628  [5]
 LDCM0426  CL37 HEK-293T C608(0.98)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C608(0.97)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C608(1.07)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C608(0.99)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C608(0.98)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C608(1.12)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C608(1.05)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C608(0.90)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C608(0.92)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C608(0.97)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C608(1.01)  LDD1641  [5]
 LDCM0439  CL49 HEK-293T C608(1.10)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C608(1.16)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C608(1.09)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C608(0.96)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C608(0.98)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C608(0.92)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C608(1.00)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C608(0.88)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C608(0.99)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C608(0.95)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C608(0.95)  LDD1653  [5]
 LDCM0451  CL6 HEK-293T C608(0.92)  LDD1654  [5]
 LDCM0453  CL61 HEK-293T C608(1.15)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C608(0.91)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C608(1.11)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C608(0.94)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C608(1.06)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C608(0.99)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C608(1.05)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C608(1.05)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C608(0.97)  LDD1664  [5]
 LDCM0462  CL7 HEK-293T C608(1.10)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C608(1.02)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C608(0.89)  LDD1667  [5]
 LDCM0466  CL73 HEK-293T C608(0.99)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C608(0.40)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C608(1.04)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C608(0.91)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C608(1.07)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C608(0.97)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C608(0.85)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C608(1.00)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C608(1.02)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C608(0.98)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C608(0.85)  LDD1680  [5]
 LDCM0479  CL85 HEK-293T C608(1.12)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C608(1.05)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C608(1.13)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C608(1.05)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C608(0.95)  LDD1686  [5]
 LDCM0484  CL9 HEK-293T C608(1.06)  LDD1687  [5]
 LDCM0485  CL90 HEK-293T C608(0.84)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C608(0.99)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C608(0.89)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C608(0.97)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C608(1.00)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C608(0.85)  LDD1693  [5]
 LDCM0492  CL97 HEK-293T C608(0.96)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C608(1.06)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C608(1.14)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C608(1.18)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C608(1.06)  LDD1671  [5]
 LDCM0427  Fragment51 HEK-293T C608(0.97)  LDD1631  [5]
 LDCM0022  KB02 769-P C608(1.30)  LDD2246  [6]
 LDCM0023  KB03 769-P C608(1.94)  LDD2663  [6]
 LDCM0024  KB05 HMCB C608(2.39)  LDD3312  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [1]
 LDCM0021  THZ1 HCT 116 C684(1.68); C687(1.68); C31(1.02); C43(1.02)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) STE Ser/Thr protein kinase family O43318
TRAF2 and NCK-interacting protein kinase (TNIK) STE Ser/Thr protein kinase family Q9UKE5
TNF receptor-associated factor 6 (TRAF6) TNF receptor-associated factor family Q9Y4K3
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) . Q15750
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beclin-1 (BECN1) Beclin family Q14457
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fos-related antigen 1 (FOSL1) BZIP family P15407
Zinc finger protein 143 (ZNF143) GLI C2H2-type zinc-finger protein family P52747
Zinc finger and BTB domain-containing protein 16 (ZBTB16) Krueppel C2H2-type zinc-finger protein family Q05516
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Keratin, type II cuticular Hb5 (KRT85) Intermediate filament family P78386
Tropomyosin alpha-3 chain (TPM3) Tropomyosin family P06753
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
Heat shock factor 2-binding protein (HSF2BP) . O75031

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840