General Information of Target

Target ID LDTP12778
Target Name Palmitoyltransferase ZDHHC7 (ZDHHC7)
Gene Name ZDHHC7
Gene ID 55625
Synonyms
Palmitoyltransferase ZDHHC7; EC 2.3.1.225; Acyltransferase ZDHHC7; EC 2.3.1.-; Zinc finger DHHC domain-containing protein 7; DHHC-7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGGGDLNLKKSWHPQTLRNVEKVWKAEQKHEAERKKIEELQRELREERAREEMQRYAEDV
GAVKKKEEKLDWMYQGPGGMVNRDEYLLGRPIDKYVFEKMEEKEAGCSSETGLLPGSIFA
PSGANSLLDMASKIREDPLFIIRKKEEEKKREVLNNPVKMKKIKELLQMSLEKKEKKKKK
EKKKKHKKHKHRSSSSDRSSSEDEHSAGRSQKKMANSSPVLSKVPGYGLQVRNSDRNQGL
QGPLTAEQKRGHGMKNHSRSRSSSHSPPRHASKKSTREAGSRDRRSRSLGRRSRSPRPSK
LHNSKVNRRETGQTRSPSPKKEVYQRRHAPGYTRKLSAEELERKRQEMMENAKWREEERL
NILKRHAKDEEREQRLEKLDSRDGKFIHRMKLESASTSSLEDRVKRNIYSLQRTSVALEK
NFMKR
Target Bioclass
Enzyme
Family
DHHC palmitoyltransferase family
Subcellular location
Golgi apparatus membrane
Function
Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA. Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones. Palmitoylates GNAQ, a heterotrimeric G protein, regulating its dynamic localization at the plasma membrane and is thereby involved in GNAQ-dependent G protein-coupled receptor signaling pathways. Functions also in ligand-induced cell death by regulating the FAS signaling pathway through the palmitoylation and stabilization of the receptor at the plasma membrane. In epithelial cells, palmitoylates SCRIB and regulates its localization to the plasma membrane, regulating indirectly cell polarity and differentiation. Also palmitoylates JAM3 and promotes its expression at tight junctions and regulates its function in cell migration. Palmitoylates the glucose transporter GLUT4/SLC2A4 and controls the insulin-dependent translocation of GLUT4 to the plasma membrane. In brain, could also palmitoylate SNAP25 and DLG4/PSD95. Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane. Could also palmitoylate NCDN. May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells.
Uniprot ID
Q9NXF8
Ensemble ID
ENST00000313732.9
HGNC ID
HGNC:18459

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.S280HfsTer5 .
NCIH1155 SNV: p.F63S .
OVK18 Deletion: p.S280HfsTer5 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info 
N.A.  LDD0241  [1]
DBIA
 Probe Info 
C149(0.94); C136(0.95)  LDD1492  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C136(0.98)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C136(1.06)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C160(0.99); C137(1.14); C136(1.07)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C135(0.95)  LDD1510  [2]
 LDCM0259  AC14 HEK-293T C149(1.06)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C149(0.99); C136(0.95)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C136(1.00)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C136(0.94)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C160(1.32); C137(1.10); C136(0.84)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C136(0.98)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C135(0.96)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C149(1.05); C135(1.06)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C149(1.19)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C149(0.98); C136(0.95)  LDD1522  [2]
 LDCM0285  AC25 HEK-293T C136(0.99)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C136(0.97)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C160(0.96); C137(1.01); C136(0.99)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C135(1.01)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C149(1.00); C135(1.01)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C160(1.08); C137(1.00); C136(1.04)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C149(1.09)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C149(0.94); C136(0.96)  LDD1531  [2]
 LDCM0294  AC33 HEK-293T C136(1.05)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C136(1.03)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C160(1.05); C137(1.09); C136(1.06)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C135(0.93)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C149(1.04); C135(1.08)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C149(1.19)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C149(1.08); C136(0.94)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C135(0.96)  LDD1540  [2]
 LDCM0303  AC41 HEK-293T C136(1.05)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C136(1.00)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C160(1.08); C137(1.04); C136(1.08)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C135(0.89)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C149(0.97); C135(1.10)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C149(1.29)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C149(0.90); C136(1.03)  LDD1548  [2]
 LDCM0311  AC49 HEK-293T C136(1.07)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C149(1.01); C135(1.00)  LDD1551  [2]
 LDCM0313  AC50 HEK-293T C136(0.95)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C160(0.98); C137(1.05); C136(1.04)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C135(0.94)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C149(1.06); C135(1.09)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C149(1.12)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C149(0.97); C136(1.06)  LDD1557  [2]
 LDCM0320  AC57 HEK-293T C136(1.09)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C136(1.02)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C160(1.00); C137(1.06); C136(1.08)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C149(1.16)  LDD1562  [2]
 LDCM0324  AC60 HEK-293T C135(0.92)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C149(1.02); C135(1.08)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C149(1.19)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C149(0.95); C136(0.94)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C149(0.97); C136(1.05)  LDD1568  [2]
 LDCM0248  AKOS034007472 HEK-293T C149(1.03); C135(1.08)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C136(1.06)  LDD1570  [2]
 LDCM0367  CL1 HEK-293T C149(0.98); C135(0.97); C136(0.90)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C149(1.55)  LDD1572  [2]
 LDCM0369  CL100 HEK-293T C137(1.09); C136(1.02)  LDD1573  [2]
 LDCM0370  CL101 HEK-293T C149(0.92); C135(1.01); C136(0.98)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C135(1.08); C136(1.02)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C136(1.11)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C137(1.13); C136(1.01)  LDD1577  [2]
 LDCM0374  CL105 HEK-293T C149(0.92); C135(1.02); C136(0.91)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C135(1.08); C136(1.01)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C136(1.05)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C137(1.08); C136(1.01)  LDD1581  [2]
 LDCM0378  CL109 HEK-293T C149(0.97); C135(1.04); C136(0.96)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C149(0.96); C136(0.84)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C135(1.11); C136(0.98)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C136(0.94)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C137(1.01); C136(0.89)  LDD1586  [2]
 LDCM0383  CL113 HEK-293T C149(0.97); C135(0.98); C136(0.95)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C135(1.12); C136(1.08)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C136(0.99)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C137(1.13); C136(1.01)  LDD1590  [2]
 LDCM0387  CL117 HEK-293T C149(1.04); C135(1.06); C136(1.05)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C135(1.08); C136(1.14)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C136(1.00)  LDD1593  [2]
 LDCM0391  CL120 HEK-293T C137(1.01); C136(0.99)  LDD1595  [2]
 LDCM0392  CL121 HEK-293T C149(1.02); C135(1.09); C136(1.06)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C135(1.05); C136(1.09)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C136(1.05)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C137(1.26); C136(1.03)  LDD1599  [2]
 LDCM0396  CL125 HEK-293T C149(0.85); C135(1.14); C136(1.12)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C135(1.04); C136(1.13)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C136(1.04)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C137(1.10); C136(0.98)  LDD1603  [2]
 LDCM0400  CL13 HEK-293T C149(0.95); C135(0.97); C136(1.02)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C135(1.12); C136(1.04)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C136(0.95)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C137(1.07); C136(1.04)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C136(0.94)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C136(0.99)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C160(1.18); C137(1.09); C136(1.21)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C135(1.25); C136(1.03)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C135(1.00)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C149(1.24); C135(1.09)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C149(1.17)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C149(1.12); C136(0.90)  LDD1615  [2]
 LDCM0413  CL25 HEK-293T C149(0.88); C135(0.95); C136(1.05)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C135(1.08); C136(1.07)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C136(1.12)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C137(1.07); C136(0.97)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C136(1.01)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C136(0.94)  LDD1622  [2]
 LDCM0419  CL30 HEK-293T C136(0.97)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C160(1.14); C137(1.08); C136(1.06)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C135(0.99)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C149(1.32); C135(1.20)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C149(1.27)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C149(1.08); C136(0.89)  LDD1628  [2]
 LDCM0426  CL37 HEK-293T C149(0.93); C135(0.94); C136(1.02)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C136(0.99)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C137(1.14); C136(1.01)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C137(1.05); C136(0.89)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C136(0.95)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C136(0.98)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C160(1.03); C137(1.02); C136(0.92)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C135(0.90)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C149(1.19); C135(1.03)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C149(1.24)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C149(1.10); C136(0.93)  LDD1641  [2]
 LDCM0439  CL49 HEK-293T C149(0.96); C135(1.12); C136(1.04)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C136(1.02)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C135(1.12); C136(0.98)  LDD1645  [2]
 LDCM0443  CL52 HEK-293T C137(1.23); C136(0.96)  LDD1646  [2]
 LDCM0444  CL53 HEK-293T C136(0.98)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C136(0.97)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C160(1.17); C137(1.08); C136(1.06)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C135(0.90)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C149(1.08); C135(1.02)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C149(1.35)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C149(1.07); C136(0.98)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C136(0.98)  LDD1654  [2]
 LDCM0453  CL61 HEK-293T C149(0.91); C135(0.97); C136(1.09)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C135(1.03); C136(1.00)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C136(1.08)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C137(1.13); C136(0.94)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C136(0.98)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C136(0.94)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C160(1.10); C137(1.07); C136(1.11)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C135(0.94)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C149(1.08); C135(1.11)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C160(1.23); C137(1.05); C136(1.04)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C149(1.19)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C149(1.09); C136(0.96)  LDD1667  [2]
 LDCM0466  CL73 HEK-293T C149(0.93); C135(1.08); C136(0.97)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C135(1.07); C136(1.05)  LDD1670  [2]
 LDCM0469  CL76 HEK-293T C137(1.12); C136(0.98)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C136(0.95)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C136(1.04)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C160(1.15); C137(1.03); C136(1.09)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C135(0.87)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C135(0.98)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C149(1.09); C135(1.17)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C149(1.35)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C149(1.08); C136(0.86)  LDD1680  [2]
 LDCM0479  CL85 HEK-293T C149(0.79); C135(1.06); C136(1.15)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C135(1.05); C136(1.23)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C136(1.02)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C137(1.08); C136(1.02)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C136(1.03)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C149(1.13); C135(1.09)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C136(0.90)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C160(1.14); C137(0.97); C136(1.05)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C135(0.92)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C149(1.02); C135(1.06)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C149(1.12)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C149(1.14); C136(0.83)  LDD1693  [2]
 LDCM0492  CL97 HEK-293T C149(1.02); C135(1.00); C136(1.04)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C135(1.13); C136(1.04)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C136(0.96)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C136(1.07)  LDD1698  [2]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C146(1.70); C149(1.28)  LDD1702  [3]
 LDCM0468  Fragment33 HEK-293T C136(1.03)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C135(1.02); C136(0.99)  LDD1631  [2]
 LDCM0022  KB02 HEK-293T C149(0.94); C136(0.95)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C149(0.97); C136(1.13)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C149(1.07); C136(0.97)  LDD1502  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) . P49447
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein YIPF1 (YIPF1) YIP1 family Q9Y548

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761