Details of the Target

General Information of Target

Target ID LDTP12770
Target Name Syntabulin (SYBU)
Gene Name SYBU
Gene ID 55638
Synonyms
GOLSYN; KIAA1472; Syntabulin; Golgi-localized syntaphilin-related protein; Syntaxin-1-binding protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPFLLGLRQDKEACVGTNNQSYICDTGHCCGQSQCCNYYYELWWFWLVWTIIIILSCCCV
CHHRRAKHRLQAQQRQHEINLIAYREAHNYSALPFYFRFLPNYLLPPYEEVVNRPPTPPP
PYSAFQLQQQQLLPPQCGPAGGSPPGIDPTRGSQGAQSSPLSEPSRSSTRPPSIADPDPS
DLPVDRAATKAPGMEPSGSVAGLGELDPGAFLDKDAECREELLKDDSSEHGAPDSKEKTP
GRHRRFTGDSGIEVCVCNRGHHDDDLKEFNTLIDDALDGPLDFCDSCHVRPPGDEEEGLC
QSSEEQAREPGHPHLPRPPACLLLNTINEQDSPNSQSSSSPS
Target Bioclass
Other
Subcellular location
Golgi apparatus membrane; Single-pass membrane protein; Cytoplasm, cytoskeleton
Function
Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development.
Uniprot ID
Q9NX95
Ensemble ID
ENST00000276646.14
HGNC ID
HGNC:26011

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.M207V .
A549 SNV: p.N366K .
HEC1 SNV: p.A616V .
HEC1B SNV: p.A616V .
HGC27 SNV: p.P515L .
KYSE180 SNV: p.T79I .
LOXIMVI SNV: p.P521S .
MDAMB453 SNV: p.S537C .
NCIH1155 SNV: p.E457K .
SHP77 SNV: p.M1? .
TOV21G SNV: p.V13M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C36(1.99)  LDD3416  [1]
IA-alkyne
 Probe Info  		C389(0.80)  LDD2214  [2]
NAIA_5
 Probe Info  		N.A.  LDD2224  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C209(1.21)  LDD1508  [4]
 LDCM0237  AC12 HEK-293T C209(1.04); C116(1.08)  LDD1510  [4]
 LDCM0270  AC15 HEK-293T C209(1.16)  LDD1513  [4]
 LDCM0277  AC18 HEK-293T C209(0.93)  LDD1516  [4]
 LDCM0279  AC2 HEK-293T C209(1.05)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C209(1.19); C116(1.18)  LDD1519  [4]
 LDCM0283  AC23 HEK-293T C209(0.83)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C209(0.84)  LDD1523  [4]
 LDCM0286  AC26 HEK-293T C209(1.10)  LDD1525  [4]
 LDCM0288  AC28 HEK-293T C209(1.33); C116(1.03)  LDD1527  [4]
 LDCM0292  AC31 HEK-293T C209(0.98)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C209(0.85)  LDD1532  [4]
 LDCM0295  AC34 HEK-293T C209(1.09)  LDD1534  [4]
 LDCM0297  AC36 HEK-293T C209(1.09); C116(1.31)  LDD1536  [4]
 LDCM0300  AC39 HEK-293T C209(1.05)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C209(0.99); C116(1.15)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C209(1.04)  LDD1541  [4]
 LDCM0304  AC42 HEK-293T C209(1.16)  LDD1543  [4]
 LDCM0306  AC44 HEK-293T C209(1.06); C116(1.10)  LDD1545  [4]
 LDCM0309  AC47 HEK-293T C209(1.06)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C209(1.10)  LDD1549  [4]
 LDCM0313  AC50 HEK-293T C209(1.06)  LDD1552  [4]
 LDCM0315  AC52 HEK-293T C209(1.06); C116(1.02)  LDD1554  [4]
 LDCM0318  AC55 HEK-293T C209(0.94)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C209(1.06)  LDD1558  [4]
 LDCM0321  AC58 HEK-293T C209(1.23)  LDD1560  [4]
 LDCM0324  AC60 HEK-293T C209(1.09); C116(1.02)  LDD1563  [4]
 LDCM0327  AC63 HEK-293T C209(0.97)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C209(0.92)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C209(1.02)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C209(1.12)  LDD1569  [4]
 LDCM0275  AKOS034007705 HEK-293T C209(1.02)  LDD1514  [4]
 LDCM0630  CCW28-3 231MFP C389(0.80)  LDD2214  [2]
 LDCM0632  CL-Sc Hep-G2 C209(1.03); C318(0.58)  LDD2227  [3]
 LDCM0371  CL102 HEK-293T C209(1.11)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C209(0.96)  LDD1576  [4]
 LDCM0375  CL106 HEK-293T C209(1.08)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C209(0.74)  LDD1580  [4]
 LDCM0379  CL11 HEK-293T C209(1.13)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C209(0.92)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C209(1.00)  LDD1585  [4]
 LDCM0384  CL114 HEK-293T C209(1.02)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C209(0.73)  LDD1589  [4]
 LDCM0388  CL118 HEK-293T C209(1.00)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C209(1.07)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C209(1.02)  LDD1594  [4]
 LDCM0393  CL122 HEK-293T C209(1.13)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C209(0.82)  LDD1598  [4]
 LDCM0397  CL126 HEK-293T C209(1.00)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C209(0.94)  LDD1602  [4]
 LDCM0401  CL14 HEK-293T C209(1.13)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C209(0.85)  LDD1606  [4]
 LDCM0405  CL18 HEK-293T C209(1.07)  LDD1609  [4]
 LDCM0407  CL2 HEK-293T C209(1.12)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C209(1.10); C116(0.99)  LDD1612  [4]
 LDCM0411  CL23 HEK-293T C209(1.08)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C209(0.96)  LDD1616  [4]
 LDCM0414  CL26 HEK-293T C209(0.97)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C209(1.01)  LDD1619  [4]
 LDCM0418  CL3 HEK-293T C209(1.10)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C209(1.08)  LDD1623  [4]
 LDCM0421  CL32 HEK-293T C209(1.06); C116(1.13)  LDD1625  [4]
 LDCM0424  CL35 HEK-293T C209(0.96)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C209(0.99)  LDD1629  [4]
 LDCM0428  CL39 HEK-293T C209(1.30)  LDD1632  [4]
 LDCM0432  CL42 HEK-293T C209(1.05)  LDD1636  [4]
 LDCM0434  CL44 HEK-293T C209(0.89); C116(1.22)  LDD1638  [4]
 LDCM0437  CL47 HEK-293T C209(0.99)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C209(1.09)  LDD1642  [4]
 LDCM0441  CL50 HEK-293T C209(0.96)  LDD1645  [4]
 LDCM0445  CL54 HEK-293T C209(1.24)  LDD1648  [4]
 LDCM0447  CL56 HEK-293T C209(1.13); C116(1.07)  LDD1650  [4]
 LDCM0450  CL59 HEK-293T C209(1.14)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C209(1.10)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C209(1.02)  LDD1655  [4]
 LDCM0454  CL62 HEK-293T C209(1.01)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C209(0.89)  LDD1658  [4]
 LDCM0458  CL66 HEK-293T C209(1.11)  LDD1661  [4]
 LDCM0460  CL68 HEK-293T C209(1.15); C116(1.15)  LDD1663  [4]
 LDCM0464  CL71 HEK-293T C209(0.93)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C209(0.94)  LDD1668  [4]
 LDCM0467  CL74 HEK-293T C209(1.11)  LDD1670  [4]
 LDCM0471  CL78 HEK-293T C209(1.11)  LDD1674  [4]
 LDCM0473  CL8 HEK-293T C209(0.90); C116(1.35)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C209(1.21); C116(1.41)  LDD1677  [4]
 LDCM0477  CL83 HEK-293T C209(1.05)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C209(1.05)  LDD1681  [4]
 LDCM0480  CL86 HEK-293T C209(1.03)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C209(1.09)  LDD1684  [4]
 LDCM0485  CL90 HEK-293T C209(1.20)  LDD1688  [4]
 LDCM0487  CL92 HEK-293T C209(1.09); C116(1.17)  LDD1690  [4]
 LDCM0490  CL95 HEK-293T C209(1.04)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C209(1.04)  LDD1694  [4]
 LDCM0493  CL98 HEK-293T C209(0.94)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C209(1.10)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C209(0.96)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C209(0.86)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C209(0.91)  LDD1631  [4]
 LDCM0022  KB02 BRX211 C90(2.48)  LDD2268  [1]
 LDCM0023  KB03 BRX211 C90(2.98)  LDD2685  [1]
 LDCM0024  KB05 SCC-25 C36(1.99)  LDD3416  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402