Details of the Target

General Information of Target

Target ID LDTP12540
Target Name Dual specificity protein phosphatase 22 (DUSP22)
Gene Name DUSP22
Gene ID 56940
Synonyms
JSP1; LMWDSP2; MKPX; Dual specificity protein phosphatase 22; EC 3.1.3.16; EC 3.1.3.48; JNK-stimulatory phosphatase-1; JSP-1; Low molecular weight dual specificity phosphatase 2; LMW-DSP2; Mitogen-activated protein kinase phosphatase x; MAP kinase phosphatase x; MKP-x
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEGIKRRSVVSWKTGVFRNQVD
SETHCHAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPDCAGEVAEFLARHSNVNLTIFT
ARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENFVYNDNEPFKPWKGLKTNFRL
LKRRLRESLQ
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
Subcellular location
Cytoplasm
Function Activates the Jnk signaling pathway.
Uniprot ID
Q9NRW4
Ensemble ID
ENST00000344450.9
HGNC ID
HGNC:16077
ChEMBL ID
CHEMBL3924

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K18(0.87)  LDD0277  [1]
DBIA
 Probe Info  		C52(2.63)  LDD3339  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C124(1.30)  LDD1508  [6]
 LDCM0237  AC12 HEK-293T C124(1.10)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C124(1.17)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C124(0.94)  LDD1513  [6]
 LDCM0277  AC18 HEK-293T C124(1.15)  LDD1516  [6]
 LDCM0279  AC2 HEK-293T C124(0.99)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C124(0.99)  LDD1519  [6]
 LDCM0282  AC22 HEK-293T C124(1.05)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C124(0.99)  LDD1522  [6]
 LDCM0286  AC26 HEK-293T C124(1.28)  LDD1525  [6]
 LDCM0288  AC28 HEK-293T C124(0.97)  LDD1527  [6]
 LDCM0291  AC30 HEK-293T C124(1.00)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C124(1.08)  LDD1531  [6]
 LDCM0295  AC34 HEK-293T C124(1.13)  LDD1534  [6]
 LDCM0297  AC36 HEK-293T C124(1.04)  LDD1536  [6]
 LDCM0299  AC38 HEK-293T C124(0.97)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C124(0.99)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C124(1.12)  LDD1540  [6]
 LDCM0304  AC42 HEK-293T C124(1.16)  LDD1543  [6]
 LDCM0306  AC44 HEK-293T C124(1.05)  LDD1545  [6]
 LDCM0308  AC46 HEK-293T C124(1.04)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C124(0.95)  LDD1548  [6]
 LDCM0313  AC50 HEK-293T C124(1.11)  LDD1552  [6]
 LDCM0315  AC52 HEK-293T C124(1.10)  LDD1554  [6]
 LDCM0317  AC54 HEK-293T C124(0.98)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C124(0.98)  LDD1557  [6]
 LDCM0321  AC58 HEK-293T C124(0.89)  LDD1560  [6]
 LDCM0323  AC6 HEK-293T C124(1.12)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C124(0.98)  LDD1563  [6]
 LDCM0326  AC62 HEK-293T C124(0.99)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C124(1.01)  LDD1566  [6]
 LDCM0334  AC7 HEK-293T C124(1.00)  LDD1568  [6]
 LDCM0368  CL10 HEK-293T C124(1.30)  LDD1572  [6]
 LDCM0379  CL11 HEK-293T C124(1.12)  LDD1583  [6]
 LDCM0405  CL18 HEK-293T C124(1.00)  LDD1609  [6]
 LDCM0408  CL20 HEK-293T C124(1.05)  LDD1612  [6]
 LDCM0410  CL22 HEK-293T C124(1.03)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C124(1.11)  LDD1615  [6]
 LDCM0419  CL30 HEK-293T C124(1.41)  LDD1623  [6]
 LDCM0421  CL32 HEK-293T C124(1.17)  LDD1625  [6]
 LDCM0423  CL34 HEK-293T C124(1.04)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C124(1.16)  LDD1628  [6]
 LDCM0432  CL42 HEK-293T C124(1.31)  LDD1636  [6]
 LDCM0434  CL44 HEK-293T C124(0.99)  LDD1638  [6]
 LDCM0436  CL46 HEK-293T C124(1.07)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C124(1.10)  LDD1641  [6]
 LDCM0445  CL54 HEK-293T C124(0.94)  LDD1648  [6]
 LDCM0447  CL56 HEK-293T C124(1.01)  LDD1650  [6]
 LDCM0449  CL58 HEK-293T C124(0.98)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C124(1.14)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C124(1.12)  LDD1654  [6]
 LDCM0458  CL66 HEK-293T C124(1.03)  LDD1661  [6]
 LDCM0460  CL68 HEK-293T C124(0.98)  LDD1663  [6]
 LDCM0463  CL70 HEK-293T C124(1.11)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C124(1.11)  LDD1667  [6]
 LDCM0471  CL78 HEK-293T C124(1.21)  LDD1674  [6]
 LDCM0473  CL8 HEK-293T C124(1.37)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C124(1.03)  LDD1677  [6]
 LDCM0476  CL82 HEK-293T C124(1.02)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C124(1.18)  LDD1680  [6]
 LDCM0485  CL90 HEK-293T C124(1.50)  LDD1688  [6]
 LDCM0487  CL92 HEK-293T C124(0.95)  LDD1690  [6]
 LDCM0489  CL94 HEK-293T C124(1.09)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C124(1.17)  LDD1693  [6]
 LDCM0625  F8 Ramos C124(1.36); C52(0.75)  LDD2187  [7]
 LDCM0572  Fragment10 Ramos C124(7.79); C52(1.21)  LDD2189  [7]
 LDCM0573  Fragment11 Ramos C124(4.13); C52(0.31)  LDD2190  [7]
 LDCM0574  Fragment12 Ramos C124(10.58); C52(1.58)  LDD2191  [7]
 LDCM0575  Fragment13 Ramos C124(1.22); C52(1.09)  LDD2192  [7]
 LDCM0576  Fragment14 Ramos C124(8.39); C52(1.99)  LDD2193  [7]
 LDCM0579  Fragment20 Ramos C124(11.15); C52(2.09)  LDD2194  [7]
 LDCM0580  Fragment21 Ramos C124(1.21); C52(0.97)  LDD2195  [7]
 LDCM0582  Fragment23 Ramos C124(0.76); C52(1.50)  LDD2196  [7]
 LDCM0578  Fragment27 Ramos C124(0.82); C52(0.90)  LDD2197  [7]
 LDCM0586  Fragment28 Ramos C124(1.09); C52(0.30)  LDD2198  [7]
 LDCM0588  Fragment30 Ramos C124(1.44); C52(1.05)  LDD2199  [7]
 LDCM0589  Fragment31 Ramos C124(1.32); C52(1.12)  LDD2200  [7]
 LDCM0590  Fragment32 Ramos C124(4.08); C52(0.93)  LDD2201  [7]
 LDCM0468  Fragment33 Ramos C124(1.39); C52(1.00)  LDD2202  [7]
 LDCM0596  Fragment38 Ramos C124(2.68); C52(1.34)  LDD2203  [7]
 LDCM0566  Fragment4 Ramos C124(2.64); C52(1.03)  LDD2184  [7]
 LDCM0610  Fragment52 Ramos C124(1.82); C52(1.28)  LDD2204  [7]
 LDCM0614  Fragment56 Ramos C124(1.27); C52(1.13)  LDD2205  [7]
 LDCM0569  Fragment7 Ramos C124(3.65); C52(1.19)  LDD2186  [7]
 LDCM0571  Fragment9 Ramos C124(9.96); C52(1.95)  LDD2188  [7]
 LDCM0022  KB02 Ramos C124(8.20); C52(0.99)  LDD2182  [7]
 LDCM0023  KB03 Ramos C124(3.65); C52(1.35)  LDD2183  [7]
 LDCM0024  KB05 NALM-6 C52(2.63)  LDD3339  [2]
 LDCM0628  OTUB2-COV-1 HEK-293T C124(0.91)  LDD2207  [8]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
8 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.