Details of the Target

General Information of Target

Target ID LDTP12450
Target Name Neural proliferation differentiation and control protein 1 (NPDC1)
Gene Name NPDC1
Gene ID 56654
Synonyms
Neural proliferation differentiation and control protein 1; NPDC-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVAELYTQYNRVWIPDPEEVWKSAEIAKDYRVGDKVLRLLLEDGTELDYSVNPESLPPL
RNPDILVGENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDA
IIHAYSGQNMGDMDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFAT
VSKSGSNAHVEDKVLASNPITEAVGNAKTTRNDNSSRFGKYTEISFDEQNQIIGANMSTY
LLEKSRVVFQSENERNYHIFYQLCASAQQSEFKHLKLGSAEEFNYTRMGGNTVIEGVNDR
AEMVETQKTFTLLGFKEDFQMDVFKILAAILHLGNVQITAVGNERSSVSEDDSHLKVFCE
LLGLESGRVAQWLCNRKIVTSSETVVKPMTRPQAVNARDALAKKIYAHLFDFIVERINQA
LQFSGKQHTFIGVLDIYGFETFDVNSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEDI
PWTLIDFYDNQPVIDLIEAKMGILELLDEECLLPHGTDENWLQKLYNNFVNRNPLFEKPR
MSNTSFVIQHFADKVEYKCEGFLEKNRDTVYDMLVEILRASKFHLCANFFQENPTPPSPF
GSMITVKSAKQVIKPNSKHFRTTVGSKFRSSLYLLMETLNATTPHYVRCIKPNDEKLPFE
FDSKRIVQQLRACGVLETIRISAQSYPSRWTYIEFYSRYGILMTKQELSFSDKKEVCKVV
LHRLIQDSNQYQFGKTKIFFRAGQVAYLEKLRLDKLRQSCVMVQKHMRGWLQRKKFLRER
RAALIIQQYFRGQQTVRKAITAVALKEAWAAIIIQKHCRGYLVRSLYQLIRMATITMQAY
SRGFLARRRYRKMLEEHKAVILQKYARAWLARRRFQSIRRFVLNIQLTYRVQRLQKKLED
QNKENHGLVEKLTSLAALRAGDVEKIQKLEAELEKAATHRRNYEEKGKRYRDAVEEKLAK
LQKHNSELETQKEQIQLKLQEKTEELKEKMDNLTKQLFDDVQKEERQRMLLEKSFELKTQ
DYEKQIQSLKEEIKALKDEKMQLQHLVEGEHVTSDGLKAEVARLSKQVKTISEFEKEIEL
LQAQKIDVEKHVQSQKREMREKMSEITKQLLESYDIEDVRSRLSVEDLEHLNEDGELWFA
YEGLKKATRVLESHFQSQKDCYEKEIEALNFKVVHLSQEINHLQKLFREENDINESIRHE
VTRLTSENMMIPDFKQQISELEKQKQDLEIRLNEQAEKMKGKLEELSNQLHRSQEEEGTQ
RKALEAQNEIHTKEKEKLIDKIQEMQEASDHLKKQFETESEVKCNFRQEASRLTLENRDL
EEELDMKDRVIKKLQDQVKTLSKTIGKANDVHSSSGPKEYLGMLQYKREDEAKLIQNLIL
DLKPRGVVVNMIPGLPAHILFMCVRYADSLNDANMLKSLMNSTINGIKQVVKEHLEDFEM
LSFWLSNTCHFLNCLKQYSGEEEFMKHNSPQQNKNCLNNFDLSEYRQILSDVAIRIYHQF
IIIMEKNIQPIIVPGMLEYESLQGISGLKPTGFRKRSSSIDDTDGYTMTSVLQQLSYFYT
TMCQNGLDPELVRQAVKQLFFLIGAVTLNSLFLRKDMCSCRKGMQIRCNISYLEEWLKDK
NLQNSLAKETLEPLSQAAWLLQVKKTTDSDAKEIYERCTSLSAVQIIKILNSYTPIDDFE
KRVTPSFVRKVQALLNSREDSSQLMLDTKYLFQVTFPFTPSPHALEMIQIPSSFKLGFLN
RL
Target Bioclass
Other
Family
NPDC1/cab-1 family
Subcellular location
Membrane
Function Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation.
Uniprot ID
Q9NQX5
Ensemble ID
ENST00000371601.5
HGNC ID
HGNC:7899

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C260(1.85)  LDD3493  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C66(1.12)  LDD1508  [2]
 LDCM0259  AC14 HEK-293T C66(1.01)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C66(1.03)  LDD1513  [2]
 LDCM0277  AC18 HEK-293T C66(1.16)  LDD1516  [2]
 LDCM0279  AC2 HEK-293T C66(1.18)  LDD1518  [2]
 LDCM0282  AC22 HEK-293T C66(1.29)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C66(1.07)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C66(0.99)  LDD1523  [2]
 LDCM0286  AC26 HEK-293T C66(1.08)  LDD1525  [2]
 LDCM0291  AC30 HEK-293T C66(1.26)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C66(1.03)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C66(0.88)  LDD1532  [2]
 LDCM0295  AC34 HEK-293T C66(1.09)  LDD1534  [2]
 LDCM0299  AC38 HEK-293T C66(1.17)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C66(1.22)  LDD1539  [2]
 LDCM0302  AC40 HEK-293T C66(0.86)  LDD1541  [2]
 LDCM0304  AC42 HEK-293T C66(1.10)  LDD1543  [2]
 LDCM0308  AC46 HEK-293T C66(1.13)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C66(1.01)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C66(0.88)  LDD1549  [2]
 LDCM0313  AC50 HEK-293T C66(1.21)  LDD1552  [2]
 LDCM0317  AC54 HEK-293T C66(1.24)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C66(1.01)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C66(0.99)  LDD1558  [2]
 LDCM0321  AC58 HEK-293T C66(1.17)  LDD1560  [2]
 LDCM0323  AC6 HEK-293T C66(1.38)  LDD1562  [2]
 LDCM0326  AC62 HEK-293T C66(1.22)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C66(1.12)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C66(1.09)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C66(1.09)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C66(0.93)  LDD1569  [2]
 LDCM0275  AKOS034007705 HEK-293T C66(0.91)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C260(1.16); C66(0.89)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C66(1.08)  LDD1572  [2]
 LDCM0370  CL101 HEK-293T C260(1.07); C66(0.99)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C260(1.02)  LDD1575  [2]
 LDCM0374  CL105 HEK-293T C260(0.99); C66(1.01)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C260(0.98)  LDD1579  [2]
 LDCM0378  CL109 HEK-293T C260(0.99); C66(1.33)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C66(1.03)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C260(1.03)  LDD1584  [2]
 LDCM0383  CL113 HEK-293T C260(1.01); C66(1.15)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C260(1.12)  LDD1588  [2]
 LDCM0387  CL117 HEK-293T C260(1.19); C66(1.23)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C260(1.06)  LDD1592  [2]
 LDCM0390  CL12 HEK-293T C66(0.89)  LDD1594  [2]
 LDCM0392  CL121 HEK-293T C260(1.32); C66(0.98)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C260(1.05)  LDD1597  [2]
 LDCM0396  CL125 HEK-293T C260(1.28); C66(1.13)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C260(1.05)  LDD1601  [2]
 LDCM0400  CL13 HEK-293T C260(1.13); C66(0.92)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C260(1.04)  LDD1605  [2]
 LDCM0405  CL18 HEK-293T C66(1.32)  LDD1609  [2]
 LDCM0407  CL2 HEK-293T C260(1.18)  LDD1611  [2]
 LDCM0410  CL22 HEK-293T C66(1.18)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C66(0.95)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C66(0.99)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C260(0.89); C66(1.16)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C260(1.01)  LDD1618  [2]
 LDCM0419  CL30 HEK-293T C66(0.98)  LDD1623  [2]
 LDCM0423  CL34 HEK-293T C66(1.09)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C66(1.04)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C66(0.88)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C260(1.27); C66(1.08)  LDD1630  [2]
 LDCM0432  CL42 HEK-293T C66(1.27)  LDD1636  [2]
 LDCM0436  CL46 HEK-293T C66(0.93)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C66(1.11)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C66(0.94)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C260(1.21); C66(1.43)  LDD1643  [2]
 LDCM0441  CL50 HEK-293T C260(1.11)  LDD1645  [2]
 LDCM0445  CL54 HEK-293T C66(1.16)  LDD1648  [2]
 LDCM0449  CL58 HEK-293T C66(1.09)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C66(1.04)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C66(1.17)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C66(0.86)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C260(1.16); C66(1.08)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C260(1.11)  LDD1657  [2]
 LDCM0458  CL66 HEK-293T C66(1.01)  LDD1661  [2]
 LDCM0463  CL70 HEK-293T C66(1.40)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C66(1.01)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C66(0.98)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C260(1.07); C66(0.86)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C260(1.06)  LDD1670  [2]
 LDCM0471  CL78 HEK-293T C66(1.03)  LDD1674  [2]
 LDCM0476  CL82 HEK-293T C66(1.29)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C66(1.18)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C66(0.92)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C260(1.31); C66(1.16)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C260(1.24)  LDD1683  [2]
 LDCM0485  CL90 HEK-293T C66(1.16)  LDD1688  [2]
 LDCM0489  CL94 HEK-293T C66(1.15)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C66(1.17)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C66(0.96)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C260(0.94); C66(1.06)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C260(1.02)  LDD1696  [2]
 LDCM0427  Fragment51 HEK-293T C260(0.97)  LDD1631  [2]
 LDCM0022  KB02 HEK-293T C66(0.60)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C66(0.93)  LDD1497  [2]
 LDCM0024  KB05 ZR-75-1 C260(1.85)  LDD3493  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myelin and lymphocyte protein (MAL) MAL family P21145
MyoD family inhibitor (MDFI) MDFI family Q99750
Membrane-spanning 4-domains subfamily A member 13 (MS4A13) MS4A family Q5J8X5
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Paired immunoglobulin-like type 2 receptor alpha (PILRA) . Q9UKJ1
Other
Click To Hide/Show 22 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
KH domain-containing, RNA-binding, signal transduction-associated protein 2 (KHDRBS2) KHDRBS family Q5VWX1
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-5 (KRTAP10-5) KRTAP type 10 family P60370
Keratin-associated protein 10-6 (KRTAP10-6) KRTAP type 10 family P60371
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 12-2 (KRTAP12-2) KRTAP type 12 family P59991
Keratin-associated protein 12-3 (KRTAP12-3) KRTAP type 12 family P60328
Keratin-associated protein 2-4 (KRTAP2-4) KRTAP type 2 family Q9BYR9
Keratin-associated protein 4-1 (KRTAP4-1) KRTAP type 4 family Q9BYQ7
Keratin-associated protein 4-4 (KRTAP4-4) KRTAP type 4 family Q9BYR3
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Keratin-associated protein 9-3 (KRTAP9-3) KRTAP type 9 family Q9BYQ3
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Emerin (EMD) . P50402
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
RNA-binding motif protein, Y chromosome, family 1 member F/J (RBMY1F; RBMY1J) . Q15415
TPA-induced transmembrane protein (TTMP) . Q5BVD1

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402