Details of the Target

General Information of Target

Target ID LDTP12132
Target Name Adhesion G protein-coupled receptor L3 (ADGRL3)
Gene Name ADGRL3
Gene ID 23284
Synonyms
KIAA0768; LEC3; LPHN3; Adhesion G protein-coupled receptor L3; Calcium-independent alpha-latrotoxin receptor 3; CIRL-3; Latrophilin-3; Lectomedin-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGTRKKVHAFVRVKPTDDFAHEMIRYGDDKRSIDIHLKKDIRRGVVNNQQTDWSFKLDGV
LHDASQDLVYETVAKDVVSQALDGYNGTIMCYGQTGAGKTYTMMGATENYKHRGILPRAL
QQVFRMIEERPTHAITVRVSYLEIYNESLFDLLSTLPYVGPSVTPMTIVENPQGVFIKGL
SVHLTSQEEDAFSLLFEGETNRIIASHTMNKNSSRSHCIFTIYLEAHSRTLSEEKYITSK
INLVDLAGSERLGKSGSEGQVLKEATYINKSLSFLEQAIIALGDQKRDHIPFRQCKLTHA
LKDSLGGNCNMVLVTNIYGEAAQLEETLSSLRFASRMKLVTTEPAINEKYDAERMVKNLE
KELALLKQELAIHDSLTNRTFVTYDPMDEIQIAEINSQVRRYLEGTLDEIDIISLRQIKE
VFNQFRVVLSQQEQEVESTLRRKYTLIDRNDFAAISAIQKAGLVDVDGHLVGEPEGQNFG
LGVAPFSTKPGKKAKSKKTFKEPLSSLARKEGASSPVNGKDLDYVSTSKTQLVPSSKDGD
VKDMLSRDRETSSIEPLPSDSPKEELRPIRPDTPPSKPVAFEEFKNEQGSEINRIFKENK
SILNERRKRASETTQHINAIKREIDVTKEALNFQKSLREKQGKYENKGLMIIDEEEFLLI
LKLKDLKKQYRSEYQDLRDLRAEIQYCQHLVDQCRHRLLMEFDIWYNESFVIPEDMQMAL
KPGGSIRPGMVPVNRIVSLGEDDQDKFSQLQQRVLPEGPDSISFYNAKVKIEQKHNYLKT
MMGLQQAHRK
Target Type
Literature-reported
Target Bioclass
GPCR
Family
G-protein coupled receptor 2 family, LN-TM7 subfamily
Subcellular location
Cell membrane
Function
Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.
TTD ID
T77125
Uniprot ID
Q9HAR2
DrugMap ID
TTQST3U
Ensemble ID
ENST00000512091.6
HGNC ID
HGNC:20974

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C135(1.46)  LDD3369  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1385(1.05)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C135(1.70)  LDD1508  [2]
 LDCM0237  AC12 HEK-293T C1385(1.13)  LDD1510  [2]
 LDCM0270  AC15 HEK-293T C1385(1.12); C1120(0.97)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C1385(1.05)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C135(1.32)  LDD1516  [2]
 LDCM0279  AC2 HEK-293T C135(0.95)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C1385(1.09)  LDD1519  [2]
 LDCM0283  AC23 HEK-293T C1385(1.08); C1120(1.01)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C135(1.24); C1385(0.96)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C1385(1.08)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C135(1.76)  LDD1525  [2]
 LDCM0288  AC28 HEK-293T C1385(1.10)  LDD1527  [2]
 LDCM0292  AC31 HEK-293T C1385(1.05); C1120(1.00)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C135(1.17); C1385(1.01)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C1385(1.16)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C135(1.12)  LDD1534  [2]
 LDCM0297  AC36 HEK-293T C1385(1.17)  LDD1536  [2]
 LDCM0300  AC39 HEK-293T C1385(1.20); C1120(1.03)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C1385(0.94)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C135(0.98); C1385(1.05)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C1385(1.08)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C135(1.00)  LDD1543  [2]
 LDCM0306  AC44 HEK-293T C1385(1.19)  LDD1545  [2]
 LDCM0309  AC47 HEK-293T C1385(1.15); C1120(0.87)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C135(0.93); C1385(0.98)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C1385(1.11)  LDD1550  [2]
 LDCM0313  AC50 HEK-293T C135(1.22)  LDD1552  [2]
 LDCM0315  AC52 HEK-293T C1385(1.03)  LDD1554  [2]
 LDCM0318  AC55 HEK-293T C1385(1.15); C1120(0.98)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C135(1.12); C1385(1.05)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C1385(1.15)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C135(1.12)  LDD1560  [2]
 LDCM0324  AC60 HEK-293T C1385(1.08)  LDD1563  [2]
 LDCM0327  AC63 HEK-293T C1385(1.15); C1120(0.99)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C135(0.90); C1385(0.96)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C1385(1.11); C1120(0.96)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C135(1.09); C1385(0.88)  LDD1569  [2]
 LDCM0356  AKOS034007680 HEK-293T C1385(1.20)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C135(1.09); C1385(1.04)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C1385(1.06)  LDD1571  [2]
 LDCM0370  CL101 HEK-293T C1385(1.08)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C1385(1.08)  LDD1575  [2]
 LDCM0374  CL105 HEK-293T C1385(0.63)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C1385(1.05)  LDD1579  [2]
 LDCM0378  CL109 HEK-293T C1385(1.04)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C1385(1.13); C1120(1.11)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C1385(1.04)  LDD1584  [2]
 LDCM0383  CL113 HEK-293T C1385(1.15)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C1385(1.03)  LDD1588  [2]
 LDCM0387  CL117 HEK-293T C1385(1.21)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C1385(1.08)  LDD1592  [2]
 LDCM0390  CL12 HEK-293T C135(1.05); C1385(0.99)  LDD1594  [2]
 LDCM0392  CL121 HEK-293T C1385(1.12)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C1385(1.10)  LDD1597  [2]
 LDCM0396  CL125 HEK-293T C1385(1.19)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C1385(1.08)  LDD1601  [2]
 LDCM0400  CL13 HEK-293T C1385(1.12)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C1385(1.19)  LDD1605  [2]
 LDCM0404  CL17 HEK-293T C1385(1.01)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C135(1.14)  LDD1609  [2]
 LDCM0407  CL2 HEK-293T C1385(1.14)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C1385(1.13)  LDD1612  [2]
 LDCM0411  CL23 HEK-293T C1385(1.17); C1120(1.01)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C135(1.00); C1385(0.94)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C1385(1.02)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C1385(1.08)  LDD1618  [2]
 LDCM0417  CL29 HEK-293T C1385(1.14)  LDD1621  [2]
 LDCM0419  CL30 HEK-293T C135(1.48)  LDD1623  [2]
 LDCM0421  CL32 HEK-293T C1385(1.13)  LDD1625  [2]
 LDCM0424  CL35 HEK-293T C1385(1.27); C1120(1.08)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C135(1.58); C1385(0.92)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C1385(1.08)  LDD1630  [2]
 LDCM0431  CL41 HEK-293T C1385(1.02)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C135(1.25)  LDD1636  [2]
 LDCM0434  CL44 HEK-293T C1385(1.02)  LDD1638  [2]
 LDCM0437  CL47 HEK-293T C1385(1.25); C1120(1.13)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C135(1.20); C1385(0.94)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C1385(1.07)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C1385(1.06)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C1385(1.13)  LDD1645  [2]
 LDCM0444  CL53 HEK-293T C1385(1.05)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C135(1.22)  LDD1648  [2]
 LDCM0447  CL56 HEK-293T C1385(1.17)  LDD1650  [2]
 LDCM0450  CL59 HEK-293T C1385(1.18); C1120(1.15)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C135(1.43)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C135(1.27); C1385(1.08)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C1385(0.95)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C1385(1.13)  LDD1657  [2]
 LDCM0457  CL65 HEK-293T C1385(1.12)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C135(1.07)  LDD1661  [2]
 LDCM0460  CL68 HEK-293T C1385(1.22)  LDD1663  [2]
 LDCM0464  CL71 HEK-293T C1385(1.38); C1120(1.06)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C135(1.30); C1385(1.03)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C1385(0.96)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C1385(1.00)  LDD1670  [2]
 LDCM0470  CL77 HEK-293T C1385(0.99)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C135(1.04)  LDD1674  [2]
 LDCM0473  CL8 HEK-293T C1385(0.92)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C1385(1.14)  LDD1677  [2]
 LDCM0477  CL83 HEK-293T C1385(1.20); C1120(1.08)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C135(1.04); C1385(0.97)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C1385(1.14)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C1385(1.04)  LDD1683  [2]
 LDCM0483  CL89 HEK-293T C1385(1.04)  LDD1686  [2]
 LDCM0485  CL90 HEK-293T C135(1.53)  LDD1688  [2]
 LDCM0487  CL92 HEK-293T C1385(1.01)  LDD1690  [2]
 LDCM0490  CL95 HEK-293T C1385(1.16); C1120(1.39)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C135(1.26); C1385(1.09)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C1385(1.07)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C1385(0.96)  LDD1696  [2]
 LDCM0427  Fragment51 HEK-293T C1385(1.06)  LDD1631  [2]
 LDCM0022  KB02 KURAMOCHI C135(3.07)  LDD2432  [1]
 LDCM0023  KB03 Caov-3 C135(1.19)  LDD2712  [1]
 LDCM0024  KB05 OAW-42 C135(1.46)  LDD3369  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402