Details of the Target

General Information of Target

Target ID LDTP12127
Target Name Transcription factor COE2 (EBF2)
Gene Name EBF2
Gene ID 64641
Synonyms
COE2; Transcription factor COE2; Early B-cell factor 2; EBF-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNGFSTEEDSREGPPAAPAAAAPGYGQSCCLIEDGERCVRPAGNASFSKRVQKSISQKKL
KLDIDKSVRHLYICDFHKNFIQSVRNKRKRKTSDDGGDSPEHDTDIPEVDLFQLQVNTLR
RYKRHYKLQTRPGFNKAQLAETVSRHFRNIPVNEKETLAYFIYMVKSNKSRLDQKSEGGK
QLE
Target Bioclass
Transcription factor
Family
COE family
Subcellular location
Nucleus
Function
Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.
Uniprot ID
Q9HAK2
Ensemble ID
ENST00000520164.6
HGNC ID
HGNC:19090

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HG3 SNV: p.F69I DBIA    Probe Info 
MEWO SNV: p.P253L; p.P298S; p.A337T; p.E400K .
NUGC3 SNV: p.R151L .
RPMI7951 SNV: p.M149I .
SKMEL24 SNV: p.D178N .
SNU5 SNV: p.R241Q .
SW1990 SNV: p.Y109F
Substitution: p.Q112_L113delinsHF		 .
TOV21G Insertion: p.G550RfsTer41 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C250(2.13)  LDD3339  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C254(0.88)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C254(1.23)  LDD1509  [4]
 LDCM0259  AC14 HEK-293T C254(1.02)  LDD1512  [4]
 LDCM0277  AC18 HEK-293T C254(0.83)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C254(0.97)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C254(0.93)  LDD1518  [4]
 LDCM0282  AC22 HEK-293T C254(0.93)  LDD1521  [4]
 LDCM0284  AC24 HEK-293T C254(1.24)  LDD1523  [4]
 LDCM0286  AC26 HEK-293T C254(1.07)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C254(1.05)  LDD1526  [4]
 LDCM0290  AC3 HEK-293T C254(0.96)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C254(1.02)  LDD1530  [4]
 LDCM0293  AC32 HEK-293T C254(1.00)  LDD1532  [4]
 LDCM0295  AC34 HEK-293T C254(1.07)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C254(1.06)  LDD1535  [4]
 LDCM0299  AC38 HEK-293T C254(0.96)  LDD1538  [4]
 LDCM0302  AC40 HEK-293T C254(1.26)  LDD1541  [4]
 LDCM0304  AC42 HEK-293T C254(0.90)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C254(1.17)  LDD1544  [4]
 LDCM0308  AC46 HEK-293T C254(1.02)  LDD1547  [4]
 LDCM0310  AC48 HEK-293T C254(1.42)  LDD1549  [4]
 LDCM0313  AC50 HEK-293T C254(0.95)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C254(1.16)  LDD1553  [4]
 LDCM0317  AC54 HEK-293T C254(1.02)  LDD1556  [4]
 LDCM0319  AC56 HEK-293T C254(1.61)  LDD1558  [4]
 LDCM0321  AC58 HEK-293T C254(0.85)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C254(1.12)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C254(1.10)  LDD1562  [4]
 LDCM0326  AC62 HEK-293T C254(1.08)  LDD1565  [4]
 LDCM0328  AC64 HEK-293T C254(0.96)  LDD1567  [4]
 LDCM0345  AC8 HEK-293T C254(1.15)  LDD1569  [4]
 LDCM0275  AKOS034007705 HEK-293T C254(1.40)  LDD1514  [4]
 LDCM0368  CL10 HEK-293T C254(1.04)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C254(1.11)  LDD1573  [4]
 LDCM0373  CL104 HEK-293T C254(1.13)  LDD1577  [4]
 LDCM0377  CL108 HEK-293T C254(0.90)  LDD1581  [4]
 LDCM0382  CL112 HEK-293T C254(1.09)  LDD1586  [4]
 LDCM0386  CL116 HEK-293T C254(1.45)  LDD1590  [4]
 LDCM0390  CL12 HEK-293T C254(1.67)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C254(1.12)  LDD1595  [4]
 LDCM0395  CL124 HEK-293T C254(0.96)  LDD1599  [4]
 LDCM0399  CL128 HEK-293T C254(0.94)  LDD1603  [4]
 LDCM0403  CL16 HEK-293T C254(1.24)  LDD1607  [4]
 LDCM0405  CL18 HEK-293T C254(1.03)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C254(1.11)  LDD1610  [4]
 LDCM0410  CL22 HEK-293T C254(1.18)  LDD1614  [4]
 LDCM0412  CL24 HEK-293T C254(1.43)  LDD1616  [4]
 LDCM0416  CL28 HEK-293T C254(1.31)  LDD1620  [4]
 LDCM0419  CL30 HEK-293T C254(1.01)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C254(1.43)  LDD1624  [4]
 LDCM0423  CL34 HEK-293T C254(1.11)  LDD1627  [4]
 LDCM0425  CL36 HEK-293T C254(1.77)  LDD1629  [4]
 LDCM0429  CL4 HEK-293T C254(1.44)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C254(1.04)  LDD1634  [4]
 LDCM0432  CL42 HEK-293T C254(0.87)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C254(1.39)  LDD1637  [4]
 LDCM0436  CL46 HEK-293T C254(1.07)  LDD1640  [4]
 LDCM0438  CL48 HEK-293T C254(1.46)  LDD1642  [4]
 LDCM0443  CL52 HEK-293T C254(1.41)  LDD1646  [4]
 LDCM0445  CL54 HEK-293T C254(0.90)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C254(1.38)  LDD1649  [4]
 LDCM0449  CL58 HEK-293T C254(1.00)  LDD1652  [4]
 LDCM0451  CL6 HEK-293T C254(0.98)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C254(1.48)  LDD1655  [4]
 LDCM0456  CL64 HEK-293T C254(0.98)  LDD1659  [4]
 LDCM0458  CL66 HEK-293T C254(1.05)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C254(1.29)  LDD1662  [4]
 LDCM0462  CL7 HEK-293T C254(1.25)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C254(1.12)  LDD1666  [4]
 LDCM0465  CL72 HEK-293T C254(1.71)  LDD1668  [4]
 LDCM0469  CL76 HEK-293T C254(0.91)  LDD1672  [4]
 LDCM0471  CL78 HEK-293T C254(0.98)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C254(1.32)  LDD1675  [4]
 LDCM0476  CL82 HEK-293T C254(1.09)  LDD1679  [4]
 LDCM0478  CL84 HEK-293T C254(1.13)  LDD1681  [4]
 LDCM0482  CL88 HEK-293T C254(1.18)  LDD1685  [4]
 LDCM0485  CL90 HEK-293T C254(0.72)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C254(1.12)  LDD1689  [4]
 LDCM0489  CL94 HEK-293T C254(1.01)  LDD1692  [4]
 LDCM0491  CL96 HEK-293T C254(1.00)  LDD1694  [4]
 LDCM0022  KB02 HEK-293T C254(0.81)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C254(0.88)  LDD1497  [4]
 LDCM0024  KB05 NALM-6 C250(2.13)  LDD3339  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TNF receptor-associated factor 1 (TRAF1) . Q13077

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402