Details of the Target

General Information of Target

Target ID LDTP12115
Target Name Zinc finger matrin-type protein 3 (ZMAT3)
Gene Name ZMAT3
Gene ID 64393
Synonyms
PAG608; WIG1; Zinc finger matrin-type protein 3; Zinc finger protein WIG-1; p53-activated gene 608 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSVSNQQFAGGCAKAAEEAPEEAPEDAARAADEPQLLHGAGICKWFNVRMGFGFLSMTA
RAGVALDPPVDVFVHQSKLHMEGFRSLKEGEAVEFTFKKSAKGLESIRVTGPGGVFCIGS
ERRPKGKSMQKRRSKGDRCYNCGGLDHHAKECKLPPQPKKCHFCQSISHMVASCPLKAQQ
GPSAQGKPTYFREEEEEIHSPTLLPEAQN
Target Bioclass
Other
Subcellular location
Nucleus
Function
Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus.
Uniprot ID
Q9HA38
Ensemble ID
ENST00000311417.7
HGNC ID
HGNC:29983

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGR1 SNV: p.K135Ter .
MEC1 SNV: p.A7T .
NCIH1793 SNV: p.G221C .
YSCCC SNV: p.E266D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C107(1.53)  LDD3419  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C149(1.01)  LDD1510  [2]
 LDCM0270  AC15 HEK-293T C149(0.93)  LDD1513  [2]
 LDCM0280  AC20 HEK-293T C149(0.97)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C149(0.94); C67(0.99)  LDD1520  [2]
 LDCM0283  AC23 HEK-293T C149(0.90)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C149(1.06)  LDD1523  [2]
 LDCM0288  AC28 HEK-293T C149(1.01)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C149(0.97); C67(1.02)  LDD1528  [2]
 LDCM0292  AC31 HEK-293T C149(0.94)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C149(1.06)  LDD1532  [2]
 LDCM0297  AC36 HEK-293T C149(1.03)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C149(0.92); C67(1.11)  LDD1537  [2]
 LDCM0300  AC39 HEK-293T C149(0.89)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C149(0.92)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C149(1.18)  LDD1541  [2]
 LDCM0306  AC44 HEK-293T C149(0.96)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C149(0.93); C67(1.03)  LDD1546  [2]
 LDCM0309  AC47 HEK-293T C149(0.95)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C149(1.05)  LDD1549  [2]
 LDCM0312  AC5 HEK-293T C149(0.99); C67(1.09)  LDD1551  [2]
 LDCM0315  AC52 HEK-293T C149(0.96)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C149(0.90); C67(1.06)  LDD1555  [2]
 LDCM0318  AC55 HEK-293T C149(0.94)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C149(1.01)  LDD1558  [2]
 LDCM0324  AC60 HEK-293T C149(1.04)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C149(0.95); C67(1.02)  LDD1564  [2]
 LDCM0327  AC63 HEK-293T C149(1.11)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C149(1.07)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C149(0.92)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C149(1.05)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C149(0.98); C67(1.06)  LDD1511  [2]
 LDCM0275  AKOS034007705 HEK-293T C149(1.04)  LDD1514  [2]
 LDCM0379  CL11 HEK-293T C149(1.06)  LDD1583  [2]
 LDCM0390  CL12 HEK-293T C149(1.01)  LDD1594  [2]
 LDCM0408  CL20 HEK-293T C149(1.00)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C149(1.00); C67(0.96)  LDD1613  [2]
 LDCM0411  CL23 HEK-293T C149(1.06)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C149(1.03)  LDD1616  [2]
 LDCM0421  CL32 HEK-293T C149(1.05)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C149(1.23); C67(0.92)  LDD1626  [2]
 LDCM0424  CL35 HEK-293T C149(1.02)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C149(1.19)  LDD1629  [2]
 LDCM0434  CL44 HEK-293T C149(1.08)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C149(1.08); C67(1.00)  LDD1639  [2]
 LDCM0437  CL47 HEK-293T C149(1.07)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C149(1.01)  LDD1642  [2]
 LDCM0447  CL56 HEK-293T C149(1.04)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C149(0.96); C67(0.97)  LDD1651  [2]
 LDCM0450  CL59 HEK-293T C149(0.99)  LDD1653  [2]
 LDCM0452  CL60 HEK-293T C149(1.09)  LDD1655  [2]
 LDCM0460  CL68 HEK-293T C149(1.00)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C149(0.99); C67(1.00)  LDD1664  [2]
 LDCM0464  CL71 HEK-293T C149(1.07)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C149(1.10)  LDD1668  [2]
 LDCM0473  CL8 HEK-293T C149(1.31)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C149(1.02)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C149(1.02); C67(1.11)  LDD1678  [2]
 LDCM0477  CL83 HEK-293T C149(1.07)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C149(1.09)  LDD1681  [2]
 LDCM0484  CL9 HEK-293T C149(0.98); C67(1.11)  LDD1687  [2]
 LDCM0487  CL92 HEK-293T C149(1.05)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C149(1.03); C67(1.02)  LDD1691  [2]
 LDCM0490  CL95 HEK-293T C149(1.25)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C149(1.15)  LDD1694  [2]
 LDCM0022  KB02 C32 C107(1.75)  LDD2281  [1]
 LDCM0023  KB03 COLO 853 C107(1.09)  LDD2726  [1]
 LDCM0024  KB05 SH-4 C107(1.53)  LDD3419  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402