Details of the Target

General Information of Target

Target ID LDTP12086
Target Name Pantothenate kinase 3 (PANK3)
Gene Name PANK3
Gene ID 79646
Synonyms
Pantothenate kinase 3; hPanK3; EC 2.7.1.33; Pantothenic acid kinase 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVVPASLSGQDVGSFAYLTIKDRIPQILTKVIDTLHRHKSEFFEKHGEEGVEAEKKAIS
LLSKLRNELQTDKPFIPLVEKFVDTDIWNQYLEYQQSLLNESDGKSRWFYSPWLLVECYM
YRRIHEAIIQSPPIDYFDVFKESKEQNFYGSQESIIALCTHLQQLIRTIEDLDENQLKDE
FFKLLQISLWGNKCDLSLSGGESSSQNTNVLNSLEDLKPFILLNDMEHLWSLLSNCKKTR
EKASATRVYIVLDNSGFELVTDLILADFLLSSELATEVHFYGKTIPWFVSDTTIHDFNWL
IEQVKHSNHKWMSKCGADWEEYIKMGKWVYHNHIFWTLPHEYCAMPQVAPDLYAELQKAH
LILFKGDLNYRKLTGDRKWEFSVPFHQALNGFHPAPLCTIRTLKAEIQVGLQPGQGEQLL
ASEPSWWTTGKYGIFQYDGPL
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Type II pantothenate kinase family
Subcellular location
Cytoplasm
Function Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis.
TTD ID
T63183
Uniprot ID
Q9H999
DrugMap ID
TTFBUWA
Ensemble ID
ENST00000239231.7
HGNC ID
HGNC:19365
ChEMBL ID
CHEMBL3407328

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C141(0.92)  LDD3359  [1]
AHL-Pu-1
 Probe Info  		C112(20.00)  LDD0170  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C112(20.00)  LDD0170  [2]
 LDCM0226  AC11 HEK-293T C141(0.78)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C308(0.99)  LDD1510  [4]
 LDCM0278  AC19 HEK-293T C141(0.67)  LDD1517  [4]
 LDCM0280  AC20 HEK-293T C308(0.92)  LDD1519  [4]
 LDCM0284  AC24 HEK-293T C141(0.96)  LDD1523  [4]
 LDCM0287  AC27 HEK-293T C141(1.05)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C308(1.08)  LDD1527  [4]
 LDCM0290  AC3 HEK-293T C141(0.79)  LDD1529  [4]
 LDCM0293  AC32 HEK-293T C141(1.07)  LDD1532  [4]
 LDCM0296  AC35 HEK-293T C141(0.68)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C308(1.08)  LDD1536  [4]
 LDCM0301  AC4 HEK-293T C308(1.14)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C141(0.95)  LDD1541  [4]
 LDCM0305  AC43 HEK-293T C141(0.83)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C308(1.13)  LDD1545  [4]
 LDCM0310  AC48 HEK-293T C141(0.90)  LDD1549  [4]
 LDCM0314  AC51 HEK-293T C141(0.82)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C308(0.93)  LDD1554  [4]
 LDCM0319  AC56 HEK-293T C141(0.96)  LDD1558  [4]
 LDCM0322  AC59 HEK-293T C141(0.79)  LDD1561  [4]
 LDCM0324  AC60 HEK-293T C308(1.02)  LDD1563  [4]
 LDCM0328  AC64 HEK-293T C141(0.82)  LDD1567  [4]
 LDCM0345  AC8 HEK-293T C141(0.84)  LDD1569  [4]
 LDCM0275  AKOS034007705 HEK-293T C141(0.87)  LDD1514  [4]
 LDCM0390  CL12 HEK-293T C141(0.83)  LDD1594  [4]
 LDCM0406  CL19 HEK-293T C141(0.80)  LDD1610  [4]
 LDCM0408  CL20 HEK-293T C308(1.22)  LDD1612  [4]
 LDCM0412  CL24 HEK-293T C141(0.82)  LDD1616  [4]
 LDCM0420  CL31 HEK-293T C141(0.66)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C308(1.18)  LDD1625  [4]
 LDCM0425  CL36 HEK-293T C141(0.98)  LDD1629  [4]
 LDCM0433  CL43 HEK-293T C141(1.18)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C308(1.11)  LDD1638  [4]
 LDCM0438  CL48 HEK-293T C141(1.23)  LDD1642  [4]
 LDCM0446  CL55 HEK-293T C141(0.78)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C308(1.20)  LDD1650  [4]
 LDCM0452  CL60 HEK-293T C141(0.87)  LDD1655  [4]
 LDCM0459  CL67 HEK-293T C141(0.65)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C308(1.28)  LDD1663  [4]
 LDCM0462  CL7 HEK-293T C141(0.84)  LDD1665  [4]
 LDCM0465  CL72 HEK-293T C141(1.09)  LDD1668  [4]
 LDCM0472  CL79 HEK-293T C141(0.78)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C308(0.95)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C308(1.33)  LDD1677  [4]
 LDCM0478  CL84 HEK-293T C141(1.00)  LDD1681  [4]
 LDCM0486  CL91 HEK-293T C141(0.57)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C308(1.15)  LDD1690  [4]
 LDCM0491  CL96 HEK-293T C141(1.12)  LDD1694  [4]
 LDCM0625  F8 Ramos C308(1.26)  LDD2187  [5]
 LDCM0573  Fragment11 Ramos C308(13.26)  LDD2190  [5]
 LDCM0566  Fragment4 Ramos C308(1.13)  LDD2184  [5]
 LDCM0569  Fragment7 Ramos C308(1.00)  LDD2186  [5]
 LDCM0022  KB02 HCC1143 C308(1.99)  LDD2336  [1]
 LDCM0023  KB03 AN3-CA C141(2.14)  LDD2681  [1]
 LDCM0024  KB05 NCI-H23 C141(0.92)  LDD3359  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578