Details of the Target

General Information of Target

Target ID LDTP12037
Target Name Zinc finger protein 696 (ZNF696)
Gene Name ZNF696
Gene ID 79943
Synonyms
Zinc finger protein 696
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MTEVVPSSALSEVSLRLLCHDDIDTVKHLCGDWFPIEYPDSWYRDITSNKKFFSLAATYR
GAIVGMIVAEIKNRTKIHKEDGDILASNFSVDTQVAYILSLGVVKEFRKHGIGSLLLESL
KDHISTTAQDHCKAIYLHVLTTNNTAINFYENRDFKQHHYLPYYYSIRGVLKDGFTYVLY
INGGHPPWTILDYIQHLGSALASLSPCSIPHRVYRQAHSLLCSFLPWSGISSKSGIEYSR
TM
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q9H7X3
Ensemble ID
ENST00000330143.8
HGNC ID
HGNC:25872

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C74(2.13)  LDD3331  [1]
IA-alkyne
 Probe Info  		N.A.  LDD2241  [2]
NAIA_5
 Probe Info  		N.A.  LDD2224  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C136(1.06); C74(1.07)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C136(1.11); C74(1.00)  LDD1508  [5]
 LDCM0270  AC15 HEK-293T C136(1.31)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C136(1.01); C74(1.03)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C136(1.02); C74(1.17)  LDD1516  [5]
 LDCM0279  AC2 HEK-293T C136(1.09); C74(0.94)  LDD1518  [5]
 LDCM0283  AC23 HEK-293T C136(0.89)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C136(1.07)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C136(1.01); C74(0.91)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C136(0.96); C74(0.97)  LDD1525  [5]
 LDCM0292  AC31 HEK-293T C136(0.95)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C136(0.96)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C136(1.13); C74(1.01)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C136(1.40); C74(1.01)  LDD1534  [5]
 LDCM0300  AC39 HEK-293T C136(1.04)  LDD1539  [5]
 LDCM0302  AC40 HEK-293T C136(1.03)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C136(1.16); C74(1.14)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C136(1.20); C74(1.02)  LDD1543  [5]
 LDCM0309  AC47 HEK-293T C136(1.12)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C136(1.02)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C136(1.11); C74(1.09)  LDD1550  [5]
 LDCM0313  AC50 HEK-293T C136(1.23); C74(1.00)  LDD1552  [5]
 LDCM0318  AC55 HEK-293T C136(1.12)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C136(0.95)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C136(1.05); C74(1.04)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C136(1.03); C74(1.00)  LDD1560  [5]
 LDCM0327  AC63 HEK-293T C136(1.15)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C136(0.99)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C136(1.00)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C136(1.04)  LDD1569  [5]
 LDCM0356  AKOS034007680 HEK-293T C136(1.13); C74(1.08)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C136(1.09)  LDD1514  [5]
 LDCM0367  CL1 HEK-293T C136(1.08); C74(1.00)  LDD1571  [5]
 LDCM0369  CL100 HEK-293T C74(0.96)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C136(0.90); C74(1.05)  LDD1574  [5]
 LDCM0371  CL102 HEK-293T C74(0.95)  LDD1575  [5]
 LDCM0373  CL104 HEK-293T C74(1.06)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C136(0.80); C74(1.03)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C74(1.07)  LDD1579  [5]
 LDCM0377  CL108 HEK-293T C74(1.14)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C136(1.15); C74(0.96)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C136(0.86)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C74(0.96)  LDD1584  [5]
 LDCM0382  CL112 HEK-293T C74(1.06)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C136(1.04); C74(0.96)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C74(1.01)  LDD1588  [5]
 LDCM0386  CL116 HEK-293T C74(1.17)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C136(0.92); C74(0.97)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C74(1.05)  LDD1592  [5]
 LDCM0390  CL12 HEK-293T C136(1.06)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C74(1.07)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C136(0.88); C74(0.99)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C74(1.12)  LDD1597  [5]
 LDCM0395  CL124 HEK-293T C74(0.99)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C136(1.02); C74(1.07)  LDD1600  [5]
 LDCM0397  CL126 HEK-293T C74(1.02)  LDD1601  [5]
 LDCM0399  CL128 HEK-293T C74(1.05)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C136(1.10); C74(1.10)  LDD1604  [5]
 LDCM0401  CL14 HEK-293T C74(1.10)  LDD1605  [5]
 LDCM0403  CL16 HEK-293T C74(1.10)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C136(1.12); C74(0.95)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C136(1.21); C74(0.98)  LDD1609  [5]
 LDCM0407  CL2 HEK-293T C74(1.15)  LDD1611  [5]
 LDCM0411  CL23 HEK-293T C136(1.22)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C136(1.09)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C136(0.82); C74(0.89)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C74(1.00)  LDD1618  [5]
 LDCM0416  CL28 HEK-293T C74(0.97)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C136(1.21); C74(0.96)  LDD1621  [5]
 LDCM0419  CL30 HEK-293T C136(1.03); C74(1.00)  LDD1623  [5]
 LDCM0424  CL35 HEK-293T C136(1.14)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C136(1.06)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C136(0.89); C74(0.99)  LDD1630  [5]
 LDCM0429  CL4 HEK-293T C74(1.04)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C74(1.15)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C136(1.01); C74(1.01)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C136(0.96); C74(1.05)  LDD1636  [5]
 LDCM0437  CL47 HEK-293T C136(1.15)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C136(1.05)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C136(0.88); C74(1.07)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C136(1.05); C74(1.24)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C74(1.07)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C74(1.17)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C136(1.01); C74(0.96)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C136(1.44); C74(0.87)  LDD1648  [5]
 LDCM0450  CL59 HEK-293T C136(1.10)  LDD1653  [5]
 LDCM0451  CL6 HEK-293T C136(1.08); C74(0.93)  LDD1654  [5]
 LDCM0452  CL60 HEK-293T C136(1.05)  LDD1655  [5]
 LDCM0453  CL61 HEK-293T C136(0.93); C74(1.08)  LDD1656  [5]
 LDCM0454  CL62 HEK-293T C74(1.06)  LDD1657  [5]
 LDCM0456  CL64 HEK-293T C74(1.00)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C136(1.12); C74(1.10)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C136(1.37); C74(1.05)  LDD1661  [5]
 LDCM0464  CL71 HEK-293T C136(1.19)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C136(1.11)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C136(0.68); C74(0.98)  LDD1669  [5]
 LDCM0467  CL74 HEK-293T C74(1.03)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C74(1.04)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C136(1.08); C74(0.99)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C136(1.08); C74(0.98)  LDD1674  [5]
 LDCM0477  CL83 HEK-293T C136(0.87)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C136(1.03)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C136(0.84); C74(0.95)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C74(1.05)  LDD1683  [5]
 LDCM0482  CL88 HEK-293T C74(0.98)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C136(1.05); C74(1.15)  LDD1686  [5]
 LDCM0485  CL90 HEK-293T C136(1.11); C74(0.86)  LDD1688  [5]
 LDCM0490  CL95 HEK-293T C136(1.20)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C136(0.98)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C136(0.86); C74(0.96)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C74(1.03)  LDD1696  [5]
 LDCM0427  Fragment51 HEK-293T C74(0.96)  LDD1631  [5]
 LDCM0022  KB02 HEK-293T C136(1.02)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C136(0.98)  LDD1497  [5]
 LDCM0024  KB05 MKN-1 C74(2.13)  LDD3331  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dual specificity protein phosphatase CDC14B (CDC14B) Protein-tyrosine phosphatase family O60729
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Syntaxin-1A (STX1A) Syntaxin family Q16623
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 526 (ZNF526) Krueppel C2H2-type zinc-finger protein family Q8TF50
Other
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Cyclin-D1-binding protein 1 (CCNDBP1) CCNDBP1 family O95273
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Progranulin (GRN) Granulin family P28799
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-5 (KRTAP10-5) KRTAP type 10 family P60370
Keratin-associated protein 10-6 (KRTAP10-6) KRTAP type 10 family P60371
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 12-2 (KRTAP12-2) KRTAP type 12 family P59991
Keratin-associated protein 12-3 (KRTAP12-3) KRTAP type 12 family P60328
Keratin-associated protein 4-12 (KRTAP4-12) KRTAP type 4 family Q9BQ66
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Keratin-associated protein 9-2 (KRTAP9-2) KRTAP type 9 family Q9BYQ4
Teneurin-4 (TENM4) Tenascin family Q6N022
Brorin (VWC2) . Q2TAL6
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Keratin-associated protein 17-1 (KRTAP17-1) . Q9BYP8
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402