Details of the Target

General Information of Target

Target ID LDTP11736
Target Name Coiled-coil domain-containing protein 8 (CCDC8)
Gene Name CCDC8
Gene ID 83987
Synonyms
Coiled-coil domain-containing protein 8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAATLGPLGSWQQWRRCLSARDGSRMLLLLLLLGSGQGPQQVGAGQTFEYLKREHSLSKP
YQGVGTGSSSLWNLMGNAMVMTQYIRLTPDMQSKQGALWNRVPCFLRDWELQVHFKIHGQ
GKKNLHGDGLAIWYTKDRMQPGPVFGNMDKFVGLGVFVDTYPNEEKQQERVFPYISAMVN
NGSLSYDHERDGRPTELGGCTAIVRNLHYDTFLVIRYVKRHLTIMMDIDGKHEWRDCIEV
PGVRLPRGYYFGTSSITGDLSDNHDVISLKLFELTVERTPEEEKLHRDVFLPSVDNMKLP
EMTAPLPPLSGLALFLIVFFSLVFSVFAIVIGIILYNKWQEQSRKRFY
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Required for localization of CUL7 to the centrosome.
Uniprot ID
Q9H0W5
Ensemble ID
ENST00000307522.5
HGNC ID
HGNC:25367

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C256(4.08)  LDD3323  [1]
AHL-Pu-1
 Probe Info  		C256(3.91)  LDD0169  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
VSF
 Probe Info  		N.A.  LDD0007  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C256(3.91)  LDD0169  [2]
 LDCM0215  AC10 HEK-293T C256(0.73)  LDD1508  [7]
 LDCM0237  AC12 HEK-293T C256(1.23)  LDD1510  [7]
 LDCM0270  AC15 HEK-293T C256(1.01)  LDD1513  [7]
 LDCM0277  AC18 HEK-293T C256(0.88)  LDD1516  [7]
 LDCM0279  AC2 HEK-293T C256(0.62)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C256(1.11)  LDD1519  [7]
 LDCM0283  AC23 HEK-293T C256(1.25)  LDD1522  [7]
 LDCM0286  AC26 HEK-293T C256(0.89)  LDD1525  [7]
 LDCM0288  AC28 HEK-293T C256(1.08)  LDD1527  [7]
 LDCM0292  AC31 HEK-293T C256(1.01)  LDD1531  [7]
 LDCM0295  AC34 HEK-293T C256(0.82)  LDD1534  [7]
 LDCM0297  AC36 HEK-293T C256(0.91)  LDD1536  [7]
 LDCM0300  AC39 HEK-293T C256(0.86)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C256(1.10)  LDD1540  [7]
 LDCM0304  AC42 HEK-293T C256(0.89)  LDD1543  [7]
 LDCM0306  AC44 HEK-293T C256(1.14)  LDD1545  [7]
 LDCM0309  AC47 HEK-293T C256(1.14)  LDD1548  [7]
 LDCM0313  AC50 HEK-293T C256(0.81)  LDD1552  [7]
 LDCM0315  AC52 HEK-293T C256(0.96)  LDD1554  [7]
 LDCM0318  AC55 HEK-293T C256(1.22)  LDD1557  [7]
 LDCM0321  AC58 HEK-293T C256(0.65)  LDD1560  [7]
 LDCM0324  AC60 HEK-293T C256(1.14)  LDD1563  [7]
 LDCM0327  AC63 HEK-293T C256(1.42)  LDD1566  [7]
 LDCM0334  AC7 HEK-293T C256(1.27)  LDD1568  [7]
 LDCM0367  CL1 HEK-293T C256(1.03)  LDD1571  [7]
 LDCM0369  CL100 HEK-293T C256(1.05)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C256(1.04)  LDD1574  [7]
 LDCM0372  CL103 HEK-293T C256(0.96)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C256(1.14)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C256(0.94)  LDD1578  [7]
 LDCM0376  CL107 HEK-293T C256(0.94)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C256(0.97)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C256(0.95)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C256(1.18)  LDD1583  [7]
 LDCM0381  CL111 HEK-293T C256(0.89)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C256(1.10)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C256(1.18)  LDD1587  [7]
 LDCM0385  CL115 HEK-293T C256(0.86)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C256(1.14)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C256(0.95)  LDD1591  [7]
 LDCM0389  CL119 HEK-293T C256(0.91)  LDD1593  [7]
 LDCM0391  CL120 HEK-293T C256(1.07)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C256(1.04)  LDD1596  [7]
 LDCM0394  CL123 HEK-293T C256(0.95)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C256(1.18)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C256(1.07)  LDD1600  [7]
 LDCM0398  CL127 HEK-293T C256(0.99)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C256(1.04)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C256(1.14)  LDD1604  [7]
 LDCM0402  CL15 HEK-293T C256(0.96)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C256(0.99)  LDD1607  [7]
 LDCM0405  CL18 HEK-293T C256(1.07)  LDD1609  [7]
 LDCM0408  CL20 HEK-293T C256(1.39)  LDD1612  [7]
 LDCM0411  CL23 HEK-293T C256(1.16)  LDD1615  [7]
 LDCM0413  CL25 HEK-293T C256(0.84)  LDD1617  [7]
 LDCM0415  CL27 HEK-293T C256(0.79)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C256(1.13)  LDD1620  [7]
 LDCM0418  CL3 HEK-293T C256(0.91)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C256(0.97)  LDD1623  [7]
 LDCM0421  CL32 HEK-293T C256(1.24)  LDD1625  [7]
 LDCM0424  CL35 HEK-293T C256(1.29)  LDD1628  [7]
 LDCM0426  CL37 HEK-293T C256(0.99)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C256(0.91)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C256(1.09)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C256(1.05)  LDD1634  [7]
 LDCM0432  CL42 HEK-293T C256(0.65)  LDD1636  [7]
 LDCM0434  CL44 HEK-293T C256(1.36)  LDD1638  [7]
 LDCM0437  CL47 HEK-293T C256(1.05)  LDD1641  [7]
 LDCM0439  CL49 HEK-293T C256(1.09)  LDD1643  [7]
 LDCM0443  CL52 HEK-293T C256(1.10)  LDD1646  [7]
 LDCM0445  CL54 HEK-293T C256(0.80)  LDD1648  [7]
 LDCM0447  CL56 HEK-293T C256(0.99)  LDD1650  [7]
 LDCM0450  CL59 HEK-293T C256(1.17)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C256(0.77)  LDD1654  [7]
 LDCM0453  CL61 HEK-293T C256(1.00)  LDD1656  [7]
 LDCM0455  CL63 HEK-293T C256(0.83)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C256(1.06)  LDD1659  [7]
 LDCM0458  CL66 HEK-293T C256(0.71)  LDD1661  [7]
 LDCM0460  CL68 HEK-293T C256(1.21)  LDD1663  [7]
 LDCM0464  CL71 HEK-293T C256(1.12)  LDD1667  [7]
 LDCM0466  CL73 HEK-293T C256(0.95)  LDD1669  [7]
 LDCM0469  CL76 HEK-293T C256(1.05)  LDD1672  [7]
 LDCM0471  CL78 HEK-293T C256(0.91)  LDD1674  [7]
 LDCM0473  CL8 HEK-293T C256(0.88)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C256(1.10)  LDD1677  [7]
 LDCM0477  CL83 HEK-293T C256(0.98)  LDD1680  [7]
 LDCM0479  CL85 HEK-293T C256(0.95)  LDD1682  [7]
 LDCM0481  CL87 HEK-293T C256(0.91)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C256(1.10)  LDD1685  [7]
 LDCM0485  CL90 HEK-293T C256(0.89)  LDD1688  [7]
 LDCM0487  CL92 HEK-293T C256(1.15)  LDD1690  [7]
 LDCM0490  CL95 HEK-293T C256(0.97)  LDD1693  [7]
 LDCM0492  CL97 HEK-293T C256(0.93)  LDD1695  [7]
 LDCM0494  CL99 HEK-293T C256(0.99)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C256(0.92)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C256(0.92)  LDD1671  [7]
 LDCM0022  KB02 HEK-293T C256(1.06)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C256(1.05)  LDD1497  [7]
 LDCM0024  KB05 SKMEL24 C256(4.08)  LDD3323  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ankyrin repeat family A protein 2 (ANKRA2) . Q9H9E1

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402