Details of the Target

General Information of Target

Target ID LDTP11613
Target Name Zinc finger protein 407 (ZNF407)
Gene Name ZNF407
Gene ID 55628
Synonyms
KIAA1703; Zinc finger protein 407
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAATLLMAGSQAPVTFEDMAMYLTREEWRPLDAAQRDLYRDVMQENYGNVVSLDFEIRSE
NEVNPKQEISEDVQFGTTSERPAENAEENPESEEGFESGDRSERQWGDLTAEEWVSYPLQ
PVTDLLVHKEVHTGIRYHICSHCGKAFSQISDLNRHQKTHTGDRPYKCYECGKGFSRSSH
LIQHQRTHTGERPYDCNECGKSFGRSSHLIQHQTIHTGEKPHKCNECGKSFCRLSHLIQH
QRTHSGEKPYECEECGKSFSRSSHLAQHQRTHTGEKPYECNECGRGFSERSDLIKHYRVH
TGERPYKCDECGKNFSQNSDLVRHRRAHTGEKPYHCNECGENFSRISHLVQHQRTHTGEK
PYECNACGKSFSRSSHLITHQKIHTGEKPYECNECWRSFGERSDLIKHQRTHTGEKPYEC
VQCGKGFTQSSNLITHQRVHTGEKPYECTECEKSFSRSSALIKHKRVHTD
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q9C0G0
Ensemble ID
ENST00000299687.10
HGNC ID
HGNC:19904

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.A2051T DBIA    Probe Info 
EFO27 Deletion: p.G926VfsTer14 DBIA    Probe Info 
HCT15 SNV: p.V323M DBIA    Probe Info 
HEC1 SNV: p.A2112V DBIA    Probe Info 
HEC1B SNV: p.S97Y .
HT115 SNV: p.R871Q .
HT29 SNV: p.D79E DBIA    Probe Info 
IGROV1 Deletion: p.P170RfsTer13
SNV: p.Y1006H		 .
Ishikawa (Heraklio) 02 ER SNV: p.K1540E .
JHH7 SNV: p.P2044R .
KASUMI1 SNV: p.H1736R .
KNS42 SNV: p.M1647T .
LN18 SNV: p.L1701P DBIA    Probe Info 
MCC26 SNV: p.Q1199E .
MDAMB468 SNV: p.E1711G .
MEWO SNV: p.F557Y; p.S2164F .
MFE319 SNV: p.C191R DBIA    Probe Info 
NCIH1155 SNV: p.A440T .
ONS76 SNV: p.K1120E .
OVK18 SNV: p.H463Q .
PC9 SNV: p.H611Q .
RKO Deletion: p.S54QfsTer11 DBIA    Probe Info 
SW1271 SNV: p.P44R .
TE10 SNV: p.E2192Q .
TE11 SNV: p.A1838T DBIA    Probe Info 
TOV21G SNV: p.A2121S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C1230(4.63)  LDD0170  [1]
DBIA
 Probe Info  		C1753(5.85)  LDD0209  [2]
Acrolein
 Probe Info  		H984(0.00); H1509(0.00)  LDD0227  [3]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C1230(4.63)  LDD0170  [1]
 LDCM0284  AC24 HEK-293T C1250(1.02); C483(0.75)  LDD1523  [5]
 LDCM0293  AC32 HEK-293T C1250(0.89); C483(0.79)  LDD1532  [5]
 LDCM0302  AC40 HEK-293T C1250(1.05); C483(0.88)  LDD1541  [5]
 LDCM0310  AC48 HEK-293T C1250(1.05); C483(0.86)  LDD1549  [5]
 LDCM0319  AC56 HEK-293T C1250(0.88); C483(0.94)  LDD1558  [5]
 LDCM0328  AC64 HEK-293T C1250(0.97); C483(1.04)  LDD1567  [5]
 LDCM0345  AC8 HEK-293T C1250(1.10); C483(0.79)  LDD1569  [5]
 LDCM0275  AKOS034007705 HEK-293T C1250(0.91); C483(0.87)  LDD1514  [5]
 LDCM0369  CL100 HEK-293T C1753(1.04)  LDD1573  [5]
 LDCM0372  CL103 HEK-293T C1250(1.11)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C1753(1.15)  LDD1577  [5]
 LDCM0376  CL107 HEK-293T C1250(1.09)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C1753(1.11)  LDD1581  [5]
 LDCM0381  CL111 HEK-293T C1250(1.08)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C1753(1.17)  LDD1586  [5]
 LDCM0385  CL115 HEK-293T C1250(1.07)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C1753(1.06)  LDD1590  [5]
 LDCM0389  CL119 HEK-293T C1250(1.16)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C1250(1.14); C483(0.82)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C1753(1.08)  LDD1595  [5]
 LDCM0394  CL123 HEK-293T C1250(1.21)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C1753(1.10)  LDD1599  [5]
 LDCM0398  CL127 HEK-293T C1250(1.17)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C1753(1.04)  LDD1603  [5]
 LDCM0402  CL15 HEK-293T C1250(1.16)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C1753(1.09)  LDD1607  [5]
 LDCM0412  CL24 HEK-293T C1250(1.09); C483(0.85)  LDD1616  [5]
 LDCM0415  CL27 HEK-293T C1250(1.07)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C1753(1.11)  LDD1620  [5]
 LDCM0418  CL3 HEK-293T C1250(1.18)  LDD1622  [5]
 LDCM0425  CL36 HEK-293T C1250(1.09); C483(0.78)  LDD1629  [5]
 LDCM0428  CL39 HEK-293T C1250(1.11)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C1753(1.11)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C1753(1.10)  LDD1634  [5]
 LDCM0438  CL48 HEK-293T C1250(1.01); C483(0.98)  LDD1642  [5]
 LDCM0443  CL52 HEK-293T C1753(1.12)  LDD1646  [5]
 LDCM0452  CL60 HEK-293T C1250(1.12); C483(0.86)  LDD1655  [5]
 LDCM0455  CL63 HEK-293T C1250(1.12)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C1753(1.07)  LDD1659  [5]
 LDCM0465  CL72 HEK-293T C1250(1.06); C483(0.80)  LDD1668  [5]
 LDCM0469  CL76 HEK-293T C1753(0.95)  LDD1672  [5]
 LDCM0478  CL84 HEK-293T C1250(1.06); C483(0.88)  LDD1681  [5]
 LDCM0481  CL87 HEK-293T C1250(1.12)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C1753(1.03)  LDD1685  [5]
 LDCM0491  CL96 HEK-293T C1250(1.10); C483(0.65)  LDD1694  [5]
 LDCM0494  CL99 HEK-293T C1250(1.05)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C1250(1.07)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C1250(1.03)  LDD1671  [5]
 LDCM0022  KB02 HEK-293T C1753(1.01)  LDD1492  [5]
 LDCM0023  KB03 Jurkat C1753(5.85)  LDD0209  [2]
 LDCM0024  KB05 SKMEL24 C779(1.68)  LDD3323  [6]
 LDCM0109  NEM HeLa H984(0.00); H1509(0.00)  LDD0227  [3]

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840