Details of the Target

General Information of Target

Target ID LDTP11582
Target Name Tripartite motif-containing protein 6 (TRIM6)
Gene Name TRIM6
Gene ID 117854
Synonyms
RNF89; Tripartite motif-containing protein 6; EC 2.3.2.27; RING finger protein 89; RING-type E3 ubiquitin transferase TRIM6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAVGPRTGPGTGAEALALAAELQGEATCSICLELFREPVSVECGHSFCRACIGRCWERP
GAGSVGAATRAPPFPLPCPQCREPARPSQLRPNRQLAAVATLLRRFSLPAAAPGEHGSQA
AAARAAAARCGQHGEPFKLYCQDDGRAICVVCDRAREHREHAVLPLDEAVQEAKELLESR
LRVLKKELEDCEVFRSTEKKESKELLKQMAAEQEKVGAEFQALRAFLVEQEGRLLGRLEE
LSREVAQKQNENLAQLGVEITQLSKLSSQIQETAQKPDLDFLQEFKSTLSRCSNVPGPKP
TTVSSEMKNKVWNVSLKTFVLKGMLKKFKEDLRGELEKEEKVELTLDPDTANPRLILSLD
LKGVRLGERAQDLPNHPCRFDTNTRVLASCGFSSGRHHWEVEVGSKDGWAFGVARESVRR
KGLTPFTPEEGVWALQLNGGQYWAVTSPERSPLSCGHLSRVRVALDLEVGAVSFYAVEDM
RHLYTFRVNFQERVFPLFSVCSTGTYLRIWP
Target Bioclass
Enzyme
Family
TRIM/RBCC family
Subcellular location
Cytoplasm
Function
E3 ubiquitin ligase that plays a crucial role in the activation of the IKBKE-dependent branch of the type I interferon signaling pathway. In concert with the ubiquitin-conjugating E2 enzyme UBE2K, synthesizes unanchored 'Lys-48'-linked polyubiquitin chains that promote the oligomerization and autophosphorylation of IKBKE leading to stimulation of an antiviral response. Ubiquitinates also MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells. Promotes the association of unanchored 'Lys-48'-polyubiquitin chains with DHX16 leading to enhanced RIGI-mediated innate antiviral immune response.; (Microbial infection) Ubiquitinates ebolavirus protein VP35 leading to enhanced viral transcriptase activity.
Uniprot ID
Q9C030
Ensemble ID
ENST00000278302.9
HGNC ID
HGNC:16277

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C335(1.16)  LDD1509  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C335(1.16)  LDD1509  [1]
 LDCM0259  AC14 HEK-293T C335(0.95)  LDD1512  [1]
 LDCM0278  AC19 HEK-293T C335(1.28)  LDD1517  [1]
 LDCM0282  AC22 HEK-293T C335(0.97)  LDD1521  [1]
 LDCM0284  AC24 HEK-293T C335(0.83)  LDD1523  [1]
 LDCM0287  AC27 HEK-293T C335(0.97)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C335(1.00)  LDD1529  [1]
 LDCM0291  AC30 HEK-293T C335(1.21)  LDD1530  [1]
 LDCM0293  AC32 HEK-293T C335(0.75)  LDD1532  [1]
 LDCM0296  AC35 HEK-293T C335(0.97)  LDD1535  [1]
 LDCM0299  AC38 HEK-293T C335(1.18)  LDD1538  [1]
 LDCM0302  AC40 HEK-293T C335(1.02)  LDD1541  [1]
 LDCM0305  AC43 HEK-293T C335(1.05)  LDD1544  [1]
 LDCM0308  AC46 HEK-293T C335(1.15)  LDD1547  [1]
 LDCM0310  AC48 HEK-293T C335(0.92)  LDD1549  [1]
 LDCM0314  AC51 HEK-293T C335(0.89)  LDD1553  [1]
 LDCM0317  AC54 HEK-293T C335(1.06)  LDD1556  [1]
 LDCM0319  AC56 HEK-293T C335(0.93)  LDD1558  [1]
 LDCM0322  AC59 HEK-293T C335(1.01)  LDD1561  [1]
 LDCM0323  AC6 HEK-293T C335(1.10)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C335(1.00)  LDD1565  [1]
 LDCM0328  AC64 HEK-293T C335(0.83)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C335(0.88)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C335(0.96)  LDD1514  [1]
 LDCM0368  CL10 HEK-293T C335(1.48)  LDD1572  [1]
 LDCM0369  CL100 HEK-293T C335(0.88)  LDD1573  [1]
 LDCM0371  CL102 HEK-293T C335(1.10)  LDD1575  [1]
 LDCM0373  CL104 HEK-293T C335(0.93)  LDD1577  [1]
 LDCM0375  CL106 HEK-293T C335(0.91)  LDD1579  [1]
 LDCM0377  CL108 HEK-293T C335(0.85)  LDD1581  [1]
 LDCM0380  CL110 HEK-293T C335(1.08)  LDD1584  [1]
 LDCM0382  CL112 HEK-293T C335(0.99)  LDD1586  [1]
 LDCM0384  CL114 HEK-293T C335(1.15)  LDD1588  [1]
 LDCM0386  CL116 HEK-293T C335(0.82)  LDD1590  [1]
 LDCM0388  CL118 HEK-293T C335(0.94)  LDD1592  [1]
 LDCM0390  CL12 HEK-293T C335(0.99)  LDD1594  [1]
 LDCM0391  CL120 HEK-293T C335(1.08)  LDD1595  [1]
 LDCM0393  CL122 HEK-293T C335(1.10)  LDD1597  [1]
 LDCM0395  CL124 HEK-293T C335(1.01)  LDD1599  [1]
 LDCM0397  CL126 HEK-293T C335(1.01)  LDD1601  [1]
 LDCM0399  CL128 HEK-293T C335(0.81)  LDD1603  [1]
 LDCM0401  CL14 HEK-293T C335(1.07)  LDD1605  [1]
 LDCM0403  CL16 HEK-293T C335(1.02)  LDD1607  [1]
 LDCM0406  CL19 HEK-293T C335(1.09)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C335(0.92)  LDD1611  [1]
 LDCM0410  CL22 HEK-293T C335(1.39)  LDD1614  [1]
 LDCM0412  CL24 HEK-293T C335(1.13)  LDD1616  [1]
 LDCM0414  CL26 HEK-293T C335(1.04)  LDD1618  [1]
 LDCM0416  CL28 HEK-293T C335(0.82)  LDD1620  [1]
 LDCM0420  CL31 HEK-293T C335(1.13)  LDD1624  [1]
 LDCM0423  CL34 HEK-293T C335(1.10)  LDD1627  [1]
 LDCM0425  CL36 HEK-293T C335(1.17)  LDD1629  [1]
 LDCM0429  CL4 HEK-293T C335(0.94)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C335(0.96)  LDD1634  [1]
 LDCM0433  CL43 HEK-293T C335(0.95)  LDD1637  [1]
 LDCM0436  CL46 HEK-293T C335(1.11)  LDD1640  [1]
 LDCM0438  CL48 HEK-293T C335(1.18)  LDD1642  [1]
 LDCM0441  CL50 HEK-293T C335(0.95)  LDD1645  [1]
 LDCM0443  CL52 HEK-293T C335(1.11)  LDD1646  [1]
 LDCM0446  CL55 HEK-293T C335(1.22)  LDD1649  [1]
 LDCM0449  CL58 HEK-293T C335(1.36)  LDD1652  [1]
 LDCM0452  CL60 HEK-293T C335(1.19)  LDD1655  [1]
 LDCM0454  CL62 HEK-293T C335(1.06)  LDD1657  [1]
 LDCM0456  CL64 HEK-293T C335(1.06)  LDD1659  [1]
 LDCM0459  CL67 HEK-293T C335(1.05)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C335(1.13)  LDD1665  [1]
 LDCM0463  CL70 HEK-293T C335(1.18)  LDD1666  [1]
 LDCM0465  CL72 HEK-293T C335(0.96)  LDD1668  [1]
 LDCM0467  CL74 HEK-293T C335(0.95)  LDD1670  [1]
 LDCM0469  CL76 HEK-293T C335(0.75)  LDD1672  [1]
 LDCM0472  CL79 HEK-293T C335(1.06)  LDD1675  [1]
 LDCM0476  CL82 HEK-293T C335(1.13)  LDD1679  [1]
 LDCM0478  CL84 HEK-293T C335(1.00)  LDD1681  [1]
 LDCM0480  CL86 HEK-293T C335(1.01)  LDD1683  [1]
 LDCM0482  CL88 HEK-293T C335(0.96)  LDD1685  [1]
 LDCM0486  CL91 HEK-293T C335(1.04)  LDD1689  [1]
 LDCM0489  CL94 HEK-293T C335(1.30)  LDD1692  [1]
 LDCM0491  CL96 HEK-293T C335(0.95)  LDD1694  [1]
 LDCM0493  CL98 HEK-293T C335(1.04)  LDD1696  [1]
 LDCM0427  Fragment51 HEK-293T C335(0.97)  LDD1631  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402