Details of the Target

General Information of Target

Target ID LDTP11150
Target Name Autophagy-related protein 101 (ATG101)
Gene Name ATG101
Gene ID 60673
Synonyms
C12orf44; Autophagy-related protein 101
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSQPRTPEQALDTPGDCPPGRRDEDAGEGIQCSQRMLSFSDALLSIIATVMILPVTHTEI
SPEQQFDRSVQRLLATRIAVYLMTFLIVTVAWAAHTRLFQVVGKTDDTLALLNLACMMTI
TFLPYTFSLMVTFPDVPLGIFLFCVCVIAIGVVQALIVGYAFHFPHLLSPQIQRSAHRAL
YRRHVLGIVLQGPALCFAAAIFSLFFVPLSYLLMVTVILLPYVSKVTGWCRDRLLGHREP
SAHPVEVFSFDLHEPLSKERVEAFSDGVYAIVATLLILDICEDNVPDPKDVKERFSGSLV
AALSATGPRFLAYFGSFATVGLLWFAHHSLFLHVRKATRAMGLLNTLSLAFVGGLPLAYQ
QTSAFARQPRDELERVRVSCTIIFLASIFQLAMWTTALLHQAETLQPSVWFGGREHVLMF
AKLALYPCASLLAFASTCLLSRFSVGIFHLMQIAVPCAFLLLRLLVGLALATLRVLRGLA
RPEHPPPAPTGQDDPQSQLLPAPC
Target Bioclass
Transporter and channel
Family
ATG101 family
Subcellular location
Cytoplasm
Function Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.
Uniprot ID
Q9BSB4
Ensemble ID
ENST00000336854.9
HGNC ID
HGNC:25679

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K84(8.12)  LDD0277  [2]
DBIA
 Probe Info  		C116(1.72)  LDD3331  [3]
BTD
 Probe Info  		C149(0.24)  LDD2116  [4]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C116(0.92)  LDD1507  [8]
 LDCM0226  AC11 HEK-293T C116(1.13)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C116(0.99)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C116(0.90)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C116(0.84)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C116(1.04)  LDD1515  [8]
 LDCM0278  AC19 HEK-293T C116(0.79)  LDD1517  [8]
 LDCM0280  AC20 HEK-293T C116(1.00)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C116(0.92)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C116(0.96)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C116(0.96)  LDD1522  [8]
 LDCM0285  AC25 HEK-293T C116(1.13)  LDD1524  [8]
 LDCM0287  AC27 HEK-293T C116(1.08)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C116(1.01)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C116(1.01)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C116(1.04)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C116(0.93)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C116(0.98)  LDD1531  [8]
 LDCM0294  AC33 HEK-293T C116(1.00)  LDD1533  [8]
 LDCM0296  AC35 HEK-293T C116(1.23)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C116(1.09)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C116(0.98)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C116(1.01)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C116(0.91)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C116(0.97)  LDD1540  [8]
 LDCM0303  AC41 HEK-293T C116(0.97)  LDD1542  [8]
 LDCM0305  AC43 HEK-293T C116(0.99)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C116(0.98)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C116(0.95)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C116(0.89)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C116(1.02)  LDD1548  [8]
 LDCM0311  AC49 HEK-293T C116(1.15)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C116(1.04)  LDD1551  [8]
 LDCM0314  AC51 HEK-293T C116(0.99)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C116(0.91)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C116(1.02)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C116(0.89)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C116(1.00)  LDD1557  [8]
 LDCM0320  AC57 HEK-293T C116(0.95)  LDD1559  [8]
 LDCM0322  AC59 HEK-293T C116(1.16)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C116(0.96)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C116(0.99)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C116(1.02)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C116(0.98)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C116(0.94)  LDD1566  [8]
 LDCM0334  AC7 HEK-293T C116(1.08)  LDD1568  [8]
 LDCM0248  AKOS034007472 HEK-293T C116(1.07)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C116(0.98)  LDD1570  [8]
 LDCM0156  Aniline NCI-H1299 13.05  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C116(1.03)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C116(0.80)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C116(1.07)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C116(1.13)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C116(0.89)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C116(0.79)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C116(1.01)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C116(1.10)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C116(0.95)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C116(1.14)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C116(1.02)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C116(1.18)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C116(0.93)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C116(0.89)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C116(0.77)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C116(0.94)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C116(1.12)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C116(0.87)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C116(0.91)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C116(0.96)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C116(1.18)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C116(1.04)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C116(1.03)  LDD1593  [8]
 LDCM0391  CL120 HEK-293T C116(0.90)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C116(1.00)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C116(1.04)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C116(0.68)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C116(1.00)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C116(1.07)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C116(0.93)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C116(0.78)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C116(1.06)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C116(0.95)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C116(1.16)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C116(0.70)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C116(1.31)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C116(0.86)  LDD1608  [8]
 LDCM0406  CL19 HEK-293T C116(1.03)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C116(1.12)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C116(1.09)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C116(0.95)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C116(0.96)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C116(1.01)  LDD1615  [8]
 LDCM0413  CL25 HEK-293T C116(1.11)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C116(0.97)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C116(0.80)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C116(0.99)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C116(1.03)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C116(0.87)  LDD1622  [8]
 LDCM0420  CL31 HEK-293T C116(0.94)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C116(1.05)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C116(0.97)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C116(0.97)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C116(0.98)  LDD1628  [8]
 LDCM0426  CL37 HEK-293T C116(1.20)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C116(0.98)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C116(0.99)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C116(1.02)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C116(0.99)  LDD1635  [8]
 LDCM0433  CL43 HEK-293T C116(1.17)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C116(0.97)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C116(0.81)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C116(0.95)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C116(0.92)  LDD1641  [8]
 LDCM0439  CL49 HEK-293T C116(1.18)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C116(1.10)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C116(1.02)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C116(1.13)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C116(0.98)  LDD1647  [8]
 LDCM0446  CL55 HEK-293T C116(0.98)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C116(0.97)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C116(0.92)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C116(0.92)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C116(0.98)  LDD1653  [8]
 LDCM0453  CL61 HEK-293T C116(1.21)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C116(1.14)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C116(0.93)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C116(1.07)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C116(0.99)  LDD1660  [8]
 LDCM0459  CL67 HEK-293T C116(0.93)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C116(1.00)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C116(0.98)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C116(1.21)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C116(1.11)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C116(0.99)  LDD1667  [8]
 LDCM0466  CL73 HEK-293T C116(1.09)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C116(1.00)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C116(1.07)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C116(0.97)  LDD1673  [8]
 LDCM0472  CL79 HEK-293T C116(0.96)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C116(0.86)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C116(1.07)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C116(1.09)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C116(1.10)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C116(0.93)  LDD1680  [8]
 LDCM0479  CL85 HEK-293T C116(1.11)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C116(1.08)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C116(1.04)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C116(1.03)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C116(1.26)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C116(1.05)  LDD1687  [8]
 LDCM0486  CL91 HEK-293T C116(1.04)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C116(0.96)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C116(0.86)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C116(0.99)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C116(0.81)  LDD1693  [8]
 LDCM0492  CL97 HEK-293T C116(1.08)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C116(1.01)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C116(0.78)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C116(0.76)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C116(1.35)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C116(1.05)  LDD1631  [8]
 LDCM0022  KB02 HEK-293T C116(1.10)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C116(1.04)  LDD1497  [8]
 LDCM0024  KB05 MKN-1 C116(1.72)  LDD3331  [3]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C149(0.24)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C149(0.29)  LDD2118  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C149(0.32)  LDD2124  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Autophagy-related protein 101 (ATG101) ATG101 family Q9BSB4
Autophagy-related protein 13 (ATG13) ATG13 family O75143
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RB1-inducible coiled-coil protein 1 (RB1CC1) ATG17 family Q8TDY2
Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C) ATG8 family Q9BXW4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402