Details of the Target

General Information of Target

Target ID LDTP10844
Target Name Sodium/hydrogen exchanger 7 (SLC9A7)
Gene Name SLC9A7
Gene ID 84679
Synonyms
NHE7; Sodium/hydrogen exchanger 7; Na(+)/H(+) exchanger 7; NHE-7; Solute carrier family 9 member 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAAVEAAAPMGALWGLVHDFVVGQQEGPADQVAADVKSGNYTVLQVVEALGSSLENP
EPRTRARAIQLLSQVLLHCHTLLLEKEVVHLILFYENRLKDHHLVIPSVLQGLKALSLCV
ALPPGLAVSVLKAIFQEVHVQSLPQVDRHTVYNIITNFMRTREEELKSLGADFTFGFIQV
MDGEKDPRNLLVAFRIVHDLISRDYSLGPFVEELFEVTSCYFPIDFTPPPNDPHGIQRED
LILSLRAVLASTPRFAEFLLPLLIEKVDSEVLSAKLDSLQTLNACCAVYGQKELKDFLPS
LWASIRREVFQTASERVEAEGLAALHSLTACLSRSVLRADAEDLLDSFLSNILQDCRHHL
CEPDMKLVWPSAKLLQAAAGASARACDSVTSNVLPLLLEQFHKHSQSSQRRTILEMLLGF
LKLQQKWSYEDKDQRPLNGFKDQLCSLVFMALTDPSTQLQLVGIRTLTVLGAQPDLLSYE
DLELAVGHLYRLSFLKEDSQSCRVAALEASGTLAALYPVAFSSHLVPKLAEELRVGESNL
TNGDEPTQCSRHLCCLQALSAVSTHPSIVKETLPLLLQHLWQVNRGNMVAQSSDVIAVCQ
SLRQMAEKCQQDPESCWYFHQTAIPCLLALAVQASMPEKEPSVLRKVLLEDEVLAAMVSV
IGTATTHLSPELAAQSVTHIVPLFLDGNVSFLPENSFPSRFQPFQDGSSGQRRLIALLMA
FVCSLPRNVEIPQLNQLMRELLELSCCHSCPFSSTAAAKCFAGLLNKHPAGQQLDEFLQL
AVDKVEAGLGSGPCRSQAFTLLLWVTKALVLRYHPLSSCLTARLMGLLSDPELGPAAADG
FSLLMSDCTDVLTRAGHAEVRIMFRQRFFTDNVPALVQGFHAAPQDVKPNYLKGLSHVLN
RLPKPVLLPELPTLLSLLLEALSCPDCVVQLSTLSCLQPLLLEAPQVMSLHVDTLVTKFL
NLSSSPSMAVRIAALQCMHALTRLPTPVLLPYKPQVIRALAKPLDDKKRLVRKEAVSARG
EWFLLGSPGS
Target Bioclass
Transporter and channel
Family
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
Subcellular location
Golgi apparatus, trans-Golgi network membrane
Function Golgi Na(+), K(+)/(H+) antiporter. Mediates the electoneutral influx of Na(+) or K(+) in exchange for H(+). May contribute to the regulation of Golgi apparatus volume and pH.
Uniprot ID
Q96T83
Ensemble ID
ENST00000328306.4
HGNC ID
HGNC:17123

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C132(0.87)  LDD3318  [1]
IA-alkyne
 Probe Info  		C132(2.32)  LDD2183  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C132(0.97)  LDD1507  [3]
 LDCM0215  AC10 PaTu 8988t C132(1.42)  LDD1094  [4]
 LDCM0226  AC11 PaTu 8988t C132(0.95)  LDD1105  [4]
 LDCM0237  AC12 PaTu 8988t C132(1.38)  LDD1116  [4]
 LDCM0259  AC14 PaTu 8988t C132(1.30)  LDD1138  [4]
 LDCM0270  AC15 PaTu 8988t C132(1.62)  LDD1149  [4]
 LDCM0276  AC17 HEK-293T C132(0.88)  LDD1515  [3]
 LDCM0281  AC21 HEK-293T C132(1.01)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C132(0.93)  LDD1521  [3]
 LDCM0285  AC25 PaTu 8988t C132(1.17)  LDD1164  [4]
 LDCM0286  AC26 PaTu 8988t C132(1.14)  LDD1165  [4]
 LDCM0287  AC27 PaTu 8988t C132(1.68)  LDD1166  [4]
 LDCM0288  AC28 PaTu 8988t C132(1.15)  LDD1167  [4]
 LDCM0289  AC29 PaTu 8988t C132(1.18)  LDD1168  [4]
 LDCM0291  AC30 PaTu 8988t C132(1.16)  LDD1170  [4]
 LDCM0292  AC31 PaTu 8988t C132(1.28)  LDD1171  [4]
 LDCM0293  AC32 PaTu 8988t C132(0.84)  LDD1172  [4]
 LDCM0294  AC33 PaTu 8988t C132(0.92)  LDD1173  [4]
 LDCM0295  AC34 PaTu 8988t C132(1.37)  LDD1174  [4]
 LDCM0298  AC37 HEK-293T C132(1.06)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C132(0.95)  LDD1538  [3]
 LDCM0303  AC41 HEK-293T C132(1.06)  LDD1542  [3]
 LDCM0307  AC45 HEK-293T C132(1.04)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C132(1.04)  LDD1547  [3]
 LDCM0311  AC49 HEK-293T C132(1.00)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C132(1.01)  LDD1551  [3]
 LDCM0316  AC53 HEK-293T C132(1.04)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C132(1.04)  LDD1556  [3]
 LDCM0320  AC57 HEK-293T C132(0.95)  LDD1559  [3]
 LDCM0323  AC6 PaTu 8988t C132(1.99)  LDD1202  [4]
 LDCM0325  AC61 HEK-293T C132(1.10)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C132(0.97)  LDD1565  [3]
 LDCM0334  AC7 PaTu 8988t C132(1.62)  LDD1213  [4]
 LDCM0345  AC8 PaTu 8988t C132(1.61)  LDD1224  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C132(1.68)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C132(2.38)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C132(1.28)  LDD1154  [4]
 LDCM0367  CL1 HEK-293T C132(0.88)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C132(1.13)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C132(0.81)  LDD1573  [3]
 LDCM0370  CL101 PaTu 8988t C132(0.89)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C132(1.51)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C132(1.95)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C132(1.16)  LDD1252  [4]
 LDCM0374  CL105 HEK-293T C132(0.91)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C132(1.08)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C132(1.07)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C132(0.69)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C132(0.86)  LDD1582  [3]
 LDCM0380  CL110 HEK-293T C132(1.00)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C132(1.00)  LDD1585  [3]
 LDCM0382  CL112 PaTu 8988t C132(1.20)  LDD1261  [4]
 LDCM0383  CL113 PaTu 8988t C132(0.60)  LDD1262  [4]
 LDCM0384  CL114 PaTu 8988t C132(1.03)  LDD1263  [4]
 LDCM0385  CL115 PaTu 8988t C132(1.05)  LDD1264  [4]
 LDCM0386  CL116 PaTu 8988t C132(0.86)  LDD1265  [4]
 LDCM0387  CL117 HEK-293T C132(0.85)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C132(1.29)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C132(1.07)  LDD1593  [3]
 LDCM0391  CL120 HEK-293T C132(1.13)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C132(0.91)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C132(0.91)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C132(1.17)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C132(1.06)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C132(0.87)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C132(1.01)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C132(1.09)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C132(0.97)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C132(1.08)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C132(1.01)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C132(1.20)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C132(1.03)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C132(1.06)  LDD1608  [3]
 LDCM0407  CL2 HEK-293T C132(1.08)  LDD1611  [3]
 LDCM0409  CL21 HEK-293T C132(0.99)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C132(1.11)  LDD1614  [3]
 LDCM0413  CL25 HEK-293T C132(0.80)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C132(0.89)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C132(1.04)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C132(0.98)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C132(0.82)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C132(0.94)  LDD1622  [3]
 LDCM0420  CL31 PaTu 8988t C132(1.19)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C132(1.14)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C132(1.33)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C132(1.25)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C132(0.96)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C132(0.62)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C132(1.65)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C132(1.32)  LDD1307  [4]
 LDCM0429  CL4 HEK-293T C132(0.87)  LDD1633  [3]
 LDCM0430  CL40 PaTu 8988t C132(1.67)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C132(1.19)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C132(1.22)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C132(1.13)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C132(1.34)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C132(1.64)  LDD1314  [4]
 LDCM0436  CL46 HEK-293T C132(1.21)  LDD1640  [3]
 LDCM0439  CL49 HEK-293T C132(0.81)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C132(1.12)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C132(1.21)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C132(0.92)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C132(0.89)  LDD1647  [3]
 LDCM0448  CL57 HEK-293T C132(1.16)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C132(1.07)  LDD1652  [3]
 LDCM0453  CL61 PaTu 8988t C132(1.92)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C132(2.40)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C132(1.59)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C132(2.11)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C132(2.02)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C132(2.08)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C132(2.12)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C132(2.05)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C132(2.53)  LDD1340  [4]
 LDCM0463  CL70 PaTu 8988t C132(2.28)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C132(2.48)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C132(1.76)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C132(1.55)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C132(3.13)  LDD1346  [4]
 LDCM0469  CL76 PaTu 8988t C132(1.25)  LDD1348  [4]
 LDCM0470  CL77 PaTu 8988t C132(1.97)  LDD1349  [4]
 LDCM0471  CL78 PaTu 8988t C132(1.81)  LDD1350  [4]
 LDCM0472  CL79 PaTu 8988t C132(1.88)  LDD1351  [4]
 LDCM0474  CL80 PaTu 8988t C132(1.49)  LDD1353  [4]
 LDCM0475  CL81 PaTu 8988t C132(1.88)  LDD1354  [4]
 LDCM0476  CL82 PaTu 8988t C132(1.86)  LDD1355  [4]
 LDCM0477  CL83 PaTu 8988t C132(2.00)  LDD1356  [4]
 LDCM0478  CL84 PaTu 8988t C132(2.01)  LDD1357  [4]
 LDCM0479  CL85 PaTu 8988t C132(1.31)  LDD1358  [4]
 LDCM0480  CL86 PaTu 8988t C132(1.88)  LDD1359  [4]
 LDCM0481  CL87 PaTu 8988t C132(1.63)  LDD1360  [4]
 LDCM0482  CL88 PaTu 8988t C132(2.93)  LDD1361  [4]
 LDCM0483  CL89 PaTu 8988t C132(1.78)  LDD1362  [4]
 LDCM0484  CL9 HEK-293T C132(1.11)  LDD1687  [3]
 LDCM0485  CL90 PaTu 8988t C132(2.08)  LDD1364  [4]
 LDCM0488  CL93 HEK-293T C132(1.09)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C132(1.11)  LDD1692  [3]
 LDCM0492  CL97 HEK-293T C132(0.86)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C132(1.06)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C132(1.16)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C132(1.47)  LDD1698  [3]
 LDCM0625  F8 Ramos C132(1.07)  LDD2187  [2]
 LDCM0573  Fragment11 Ramos C132(13.32)  LDD2190  [2]
 LDCM0574  Fragment12 Ramos C132(2.23)  LDD2191  [2]
 LDCM0575  Fragment13 Ramos C132(0.93)  LDD2192  [2]
 LDCM0580  Fragment21 Ramos C132(0.66)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C132(0.68)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C132(0.89)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C132(1.21)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C132(1.03)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C132(0.59)  LDD2200  [2]
 LDCM0590  Fragment32 Ramos C132(1.52)  LDD2201  [2]
 LDCM0468  Fragment33 PaTu 8988t C132(1.97)  LDD1347  [4]
 LDCM0596  Fragment38 Ramos C132(1.26)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C132(0.68)  LDD2184  [2]
 LDCM0427  Fragment51 PaTu 8988t C132(1.95)  LDD1306  [4]
 LDCM0614  Fragment56 Ramos C132(1.12)  LDD2205  [2]
 LDCM0569  Fragment7 Ramos C132(2.54)  LDD2186  [2]
 LDCM0022  KB02 HEK-293T C132(0.97)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C132(1.00)  LDD1497  [3]
 LDCM0024  KB05 MELHO C132(0.87)  LDD3318  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Secretory carrier-associated membrane protein 2 (SCAMP2) SCAMP family O15127

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.