Details of the Target

General Information of Target

Target ID LDTP10733
Target Name Proton myo-inositol cotransporter (SLC2A13)
Gene Name SLC2A13
Gene ID 114134
Synonyms
Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter; Hmit; H(+)-myo-inositol symporter; Solute carrier family 2 member 13
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNRFGTRLVGATATSSPPPKARSNENLDKIDMSLDDIIKLNRKEGKKQNFPRLNRRLLQQ
SGAQQFRMRVRWGIQQNSGFGKTSLNRRGRVMPGKRRPNGVITGLAARKTTGIRKGISPM
NRPPLSDKNIEQYFPVLKRKANLLRQNEGQRKPVAVLKRPSQLSRKNNIPANFTRSGNKL
NHQKDTRQATFLFRRGLKVQAQLNTEQLLDDVVAKRTRQWRTSTTNGGILTVSIDNPGAV
QCPVTQKPRLTRTAVPSFLTKREQSDVKKVPKGVPLQFDINSVGKQTGMTLNERFGILKE
QRATLTYNKGGSRFVTVG
Target Bioclass
Transporter and channel
Family
Major facilitator superfamily, Sugar transporter (TC 2.A.1.1) family
Subcellular location
Cell membrane
Function H(+)-myo-inositol cotransporter. Can also transport related stereoisomers.
Uniprot ID
Q96QE2
Ensemble ID
ENST00000280871.9
HGNC ID
HGNC:15956

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C39(3.03)  LDD0168  [1]
DBIA
 Probe Info  		C314(0.90)  LDD1507  [2]
IPM
 Probe Info  		N.A.  LDD0025  [3]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [3]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C39(3.03)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C39(9.12)  LDD0169  [1]
 LDCM0214  AC1 HEK-293T C314(0.90)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C314(1.08)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C314(1.03)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C314(1.11)  LDD1510  [2]
 LDCM0270  AC15 HEK-293T C314(1.09)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C314(0.81)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C314(1.05)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C314(0.90)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C314(1.04)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C314(0.95)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C314(0.96)  LDD1520  [2]
 LDCM0283  AC23 HEK-293T C314(1.08)  LDD1522  [2]
 LDCM0285  AC25 HEK-293T C314(0.92)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C314(0.95)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C314(0.89)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C314(0.95)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C314(0.96)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C314(1.02)  LDD1529  [2]
 LDCM0292  AC31 HEK-293T C314(1.14)  LDD1531  [2]
 LDCM0294  AC33 HEK-293T C314(0.98)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C314(1.24)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C314(0.95)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C314(0.92)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C314(0.98)  LDD1537  [2]
 LDCM0300  AC39 HEK-293T C314(1.12)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C314(0.92)  LDD1540  [2]
 LDCM0303  AC41 HEK-293T C314(0.88)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C314(1.43)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C314(0.90)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C314(1.00)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C314(1.29)  LDD1546  [2]
 LDCM0309  AC47 HEK-293T C314(1.14)  LDD1548  [2]
 LDCM0311  AC49 HEK-293T C314(0.95)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C314(0.94)  LDD1551  [2]
 LDCM0313  AC50 HEK-293T C314(1.04)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C314(0.89)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C314(1.03)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C314(1.01)  LDD1555  [2]
 LDCM0318  AC55 HEK-293T C314(1.08)  LDD1557  [2]
 LDCM0320  AC57 HEK-293T C314(0.99)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C314(1.05)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C314(0.85)  LDD1561  [2]
 LDCM0324  AC60 HEK-293T C314(0.97)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C314(1.05)  LDD1564  [2]
 LDCM0327  AC63 HEK-293T C314(1.11)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C314(1.12)  LDD1568  [2]
 LDCM0248  AKOS034007472 HEK-293T C314(0.99)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C314(0.95)  LDD1570  [2]
 LDCM0369  CL100 HEK-293T C314(1.00)  LDD1573  [2]
 LDCM0372  CL103 HEK-293T C314(0.93)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C314(1.16)  LDD1577  [2]
 LDCM0376  CL107 HEK-293T C314(1.35)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C314(0.93)  LDD1581  [2]
 LDCM0379  CL11 HEK-293T C314(1.14)  LDD1583  [2]
 LDCM0381  CL111 HEK-293T C314(1.25)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C314(0.93)  LDD1586  [2]
 LDCM0385  CL115 HEK-293T C314(0.89)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C314(0.96)  LDD1590  [2]
 LDCM0389  CL119 HEK-293T C314(1.01)  LDD1593  [2]
 LDCM0391  CL120 HEK-293T C314(1.12)  LDD1595  [2]
 LDCM0394  CL123 HEK-293T C314(1.15)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C314(1.06)  LDD1599  [2]
 LDCM0398  CL127 HEK-293T C314(0.95)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C314(1.00)  LDD1603  [2]
 LDCM0402  CL15 HEK-293T C314(1.50)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C314(1.18)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C314(1.28)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C314(1.16)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C314(0.98)  LDD1610  [2]
 LDCM0408  CL20 HEK-293T C314(1.06)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C314(1.39)  LDD1613  [2]
 LDCM0411  CL23 HEK-293T C314(1.13)  LDD1615  [2]
 LDCM0415  CL27 HEK-293T C314(0.98)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C314(1.06)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C314(0.94)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C314(1.05)  LDD1622  [2]
 LDCM0419  CL30 HEK-293T C314(1.07)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C314(0.96)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C314(0.96)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C314(1.24)  LDD1626  [2]
 LDCM0424  CL35 HEK-293T C314(1.11)  LDD1628  [2]
 LDCM0428  CL39 HEK-293T C314(0.96)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C314(1.12)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C314(0.93)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C314(1.01)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C314(1.17)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C314(0.97)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C314(1.23)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C314(1.16)  LDD1639  [2]
 LDCM0437  CL47 HEK-293T C314(1.30)  LDD1641  [2]
 LDCM0440  CL5 HEK-293T C314(0.93)  LDD1644  [2]
 LDCM0443  CL52 HEK-293T C314(0.94)  LDD1646  [2]
 LDCM0444  CL53 HEK-293T C314(1.26)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C314(1.20)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C314(1.03)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C314(1.17)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C314(1.06)  LDD1651  [2]
 LDCM0450  CL59 HEK-293T C314(1.13)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C314(1.00)  LDD1654  [2]
 LDCM0455  CL63 HEK-293T C314(0.93)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C314(1.10)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C314(0.85)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C314(1.08)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C314(1.01)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C314(1.01)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C314(1.38)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C314(1.00)  LDD1665  [2]
 LDCM0464  CL71 HEK-293T C314(1.05)  LDD1667  [2]
 LDCM0469  CL76 HEK-293T C314(1.10)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C314(1.10)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C314(1.16)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C314(1.01)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C314(1.80)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C314(0.94)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C314(1.13)  LDD1678  [2]
 LDCM0477  CL83 HEK-293T C314(1.23)  LDD1680  [2]
 LDCM0481  CL87 HEK-293T C314(0.96)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C314(0.95)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C314(1.02)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C314(1.14)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C314(1.23)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C314(0.86)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C314(1.02)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C314(1.29)  LDD1691  [2]
 LDCM0490  CL95 HEK-293T C314(1.12)  LDD1693  [2]
 LDCM0494  CL99 HEK-293T C314(0.92)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C314(0.90)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C314(1.02)  LDD1671  [2]
 LDCM0022  KB02 A2058 C314(2.18)  LDD2253  [5]
 LDCM0023  KB03 A2058 C314(2.91)  LDD2670  [5]
 LDCM0024  KB05 COLO-679 C314(4.52)  LDD3139  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome P450 4F2 (CYP4F2) Cytochrome P450 family P78329
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Optineurin (OPTN) . Q96CV9
Proteolipid protein 2 (PLP2) . Q04941

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840