Details of the Target

General Information of Target

Target ID LDTP10516
Target Name Apoptosis-stimulating of p53 protein 1 (PPP1R13B)
Gene Name PPP1R13B
Gene ID 23368
Synonyms
ASPP1; KIAA0771; Apoptosis-stimulating of p53 protein 1; Protein phosphatase 1 regulatory subunit 13B
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAHFVQGTSRMIAAESSTEHKECAEPSTRKNLMNSLEQKIRCLEKQRKELLEVNQQWDQQ
FRSMKELYERKVAELKTKLDAAERFLSTREKDPHQRQRKDDRQREDDRQRDLTRDRLQRE
EKEKERLNEELHELKEENKLLKGKNTLANKEKEHYECEIKRLNKALQDALNIKCSFSEDC
LRKSRVEFCHEEMRTEMEVLKQQVQIYEEDFKKERSDRERLNQEKEELQQINETSQSQLN
RLNSQIKACQMEKEKLEKQLKQMYCPPCNCGLVFHLQDPWVPTGPGAVQKQREHPPDYQW
YALDQLPPDVQHKANGLSSVKKVHP
Target Bioclass
Other
Family
ASPP family
Subcellular location
Cytoplasm
Function
Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.
Uniprot ID
Q96KQ4
Ensemble ID
ENST00000202556.14
HGNC ID
HGNC:14950

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1005(1.21)  LDD0812  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1005(1.21)  LDD0812  [1]
 LDCM0215  AC10 PaTu 8988t C1005(0.71); C995(0.71)  LDD1094  [1]
 LDCM0226  AC11 PaTu 8988t C1005(0.70); C995(0.70)  LDD1105  [1]
 LDCM0237  AC12 PaTu 8988t C1005(0.67); C995(0.67)  LDD1116  [1]
 LDCM0246  AC128 HEK-293T C1005(0.74)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C1005(1.04)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C1005(0.99)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C1005(0.97)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C1005(0.96)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C1005(1.17)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C1005(1.13)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C1005(1.07)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C1005(1.34)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C1005(1.34)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C1005(1.24)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C1005(1.36)  LDD0856  [1]
 LDCM0259  AC14 PaTu 8988t C1005(0.73); C995(0.73)  LDD1138  [1]
 LDCM0260  AC140 HEK-293T C1005(1.07)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C1005(1.47)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C1005(1.33)  LDD0860  [1]
 LDCM0270  AC15 PaTu 8988t C1005(0.77); C995(0.77)  LDD1149  [1]
 LDCM0276  AC17 HEK-293T C1005(1.81)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C1005(1.50)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C1005(1.54)  LDD0876  [1]
 LDCM0279  AC2 HEK-293T C1005(1.51)  LDD0877  [1]
 LDCM0280  AC20 HEK-293T C1005(1.89)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C1005(1.40)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C1005(1.85)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C1005(1.78)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C1005(1.64)  LDD0882  [1]
 LDCM0285  AC25 HEK-293T C1005(1.58)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C1005(1.72)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C1005(1.62)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C1005(1.30)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C1005(1.81)  LDD0887  [1]
 LDCM0290  AC3 HEK-293T C1005(1.18)  LDD0888  [1]
 LDCM0291  AC30 HEK-293T C1005(1.79)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C1005(1.45)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C1005(1.66)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C1005(1.76)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C1005(1.84)  LDD0893  [1]
 LDCM0296  AC35 HEK-293T C1005(0.90)  LDD0894  [1]
 LDCM0297  AC36 HEK-293T C1005(1.22)  LDD0895  [1]
 LDCM0298  AC37 HEK-293T C1005(1.25)  LDD0896  [1]
 LDCM0299  AC38 HEK-293T C1005(1.11)  LDD0897  [1]
 LDCM0300  AC39 HEK-293T C1005(1.22)  LDD0898  [1]
 LDCM0301  AC4 HEK-293T C1005(1.12)  LDD0899  [1]
 LDCM0302  AC40 HEK-293T C1005(1.43)  LDD0900  [1]
 LDCM0303  AC41 HEK-293T C1005(1.18)  LDD0901  [1]
 LDCM0304  AC42 HEK-293T C1005(1.28)  LDD0902  [1]
 LDCM0305  AC43 HEK-293T C1005(1.19)  LDD0903  [1]
 LDCM0306  AC44 HEK-293T C1005(1.30)  LDD0904  [1]
 LDCM0307  AC45 HEK-293T C1005(1.14)  LDD0905  [1]
 LDCM0308  AC46 HEK-293T C1005(1.02)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C1005(1.17)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C1005(1.36)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C1005(1.33)  LDD0909  [1]
 LDCM0312  AC5 HEK-293T C1005(1.31)  LDD0910  [1]
 LDCM0313  AC50 HEK-293T C1005(1.43)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C1005(1.51)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C1005(1.58)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C1005(1.11)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C1005(1.45)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C1005(1.30)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C1005(1.39)  LDD0917  [1]
 LDCM0323  AC6 PaTu 8988t C1005(0.92); C995(0.92)  LDD1202  [1]
 LDCM0332  AC68 HEK-293T C1005(1.55)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C1005(1.93)  LDD0931  [1]
 LDCM0334  AC7 PaTu 8988t C1005(1.10); C995(1.10)  LDD1213  [1]
 LDCM0335  AC70 HEK-293T C1005(1.29)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C1005(1.31)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C1005(1.98)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C1005(2.02)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C1005(1.49)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C1005(1.68)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C1005(1.55)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C1005(1.74)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C1005(1.15)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C1005(1.42)  LDD0942  [1]
 LDCM0345  AC8 PaTu 8988t C1005(1.44); C995(1.44)  LDD1224  [1]
 LDCM0346  AC80 HEK-293T C1005(1.74)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C1005(2.72)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C1005(1.87)  LDD0946  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C1005(0.74); C995(0.74)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C1005(0.61); C995(0.61)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C1005(0.90); C995(0.90)  LDD1154  [1]
 LDCM0367  CL1 PaTu 8988t C1005(1.26); C995(1.26)  LDD1246  [1]
 LDCM0368  CL10 PaTu 8988t C1005(0.72); C995(0.72)  LDD1247  [1]
 LDCM0369  CL100 HEK-293T C1005(1.29)  LDD0967  [1]
 LDCM0370  CL101 PaTu 8988t C1005(1.24); C995(1.24)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C1005(0.92); C995(0.92)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C1005(0.90); C995(0.90)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C1005(0.77); C995(0.77)  LDD1252  [1]
 LDCM0374  CL105 HEK-293T C1005(1.31)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C1005(1.47)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C1005(1.44)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C1005(1.41)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C1005(1.32)  LDD0976  [1]
 LDCM0379  CL11 PaTu 8988t C1005(1.61); C995(1.61)  LDD1258  [1]
 LDCM0380  CL110 HEK-293T C1005(1.48)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C1005(1.33)  LDD0979  [1]
 LDCM0382  CL112 HEK-293T C1005(1.61)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C1005(1.71)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C1005(2.08)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C1005(1.88)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C1005(2.08)  LDD0984  [1]
 LDCM0387  CL117 HEK-293T C1005(0.89)  LDD0985  [1]
 LDCM0388  CL118 HEK-293T C1005(1.01)  LDD0986  [1]
 LDCM0389  CL119 HEK-293T C1005(1.37)  LDD0987  [1]
 LDCM0390  CL12 PaTu 8988t C1005(1.06); C995(1.06)  LDD1269  [1]
 LDCM0391  CL120 HEK-293T C1005(1.52)  LDD0989  [1]
 LDCM0392  CL121 HEK-293T C1005(1.35)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C1005(1.31)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C1005(0.99)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C1005(1.24)  LDD0993  [1]
 LDCM0400  CL13 PaTu 8988t C1005(0.84); C995(0.84)  LDD1279  [1]
 LDCM0401  CL14 PaTu 8988t C1005(1.03); C995(1.03)  LDD1280  [1]
 LDCM0402  CL15 PaTu 8988t C1005(0.95); C995(0.95)  LDD1281  [1]
 LDCM0403  CL16 PaTu 8988t C1005(0.73); C995(0.73)  LDD1282  [1]
 LDCM0404  CL17 PaTu 8988t C1005(0.70); C995(0.70)  LDD1283  [1]
 LDCM0405  CL18 PaTu 8988t C1005(0.68); C995(0.68)  LDD1284  [1]
 LDCM0406  CL19 PaTu 8988t C1005(0.63); C995(0.63)  LDD1285  [1]
 LDCM0407  CL2 PaTu 8988t C1005(0.94); C995(0.94)  LDD1286  [1]
 LDCM0408  CL20 PaTu 8988t C1005(0.68); C995(0.68)  LDD1287  [1]
 LDCM0409  CL21 PaTu 8988t C1005(0.78); C995(0.78)  LDD1288  [1]
 LDCM0410  CL22 PaTu 8988t C1005(0.58); C995(0.58)  LDD1289  [1]
 LDCM0411  CL23 PaTu 8988t C1005(0.70); C995(0.70)  LDD1290  [1]
 LDCM0412  CL24 PaTu 8988t C1005(0.78); C995(0.78)  LDD1291  [1]
 LDCM0413  CL25 PaTu 8988t C1005(0.71); C995(0.71)  LDD1292  [1]
 LDCM0414  CL26 PaTu 8988t C1005(0.69); C995(0.69)  LDD1293  [1]
 LDCM0415  CL27 PaTu 8988t C1005(0.67); C995(0.67)  LDD1294  [1]
 LDCM0416  CL28 PaTu 8988t C1005(0.77); C995(0.77)  LDD1295  [1]
 LDCM0417  CL29 PaTu 8988t C1005(0.77); C995(0.77)  LDD1296  [1]
 LDCM0418  CL3 PaTu 8988t C1005(1.21); C995(1.21)  LDD1297  [1]
 LDCM0419  CL30 PaTu 8988t C1005(0.65); C995(0.65)  LDD1298  [1]
 LDCM0420  CL31 HEK-293T C1005(1.61)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C1005(1.67)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C1005(1.46)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C1005(1.22)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C1005(1.59)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C1005(0.98)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C1005(1.38)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C1005(2.26)  LDD1026  [1]
 LDCM0429  CL4 PaTu 8988t C1005(1.28); C995(1.28)  LDD1308  [1]
 LDCM0430  CL40 HEK-293T C1005(1.51)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C1005(2.22)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C1005(1.72)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C1005(1.84)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C1005(1.61)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C1005(1.35)  LDD1033  [1]
 LDCM0440  CL5 PaTu 8988t C1005(0.88); C995(0.88)  LDD1319  [1]
 LDCM0451  CL6 PaTu 8988t C1005(0.69); C995(0.69)  LDD1330  [1]
 LDCM0453  CL61 PaTu 8988t C1005(1.27); C995(1.27)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C1005(1.41); C995(1.41)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C1005(1.40); C995(1.40)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C1005(0.95); C995(0.95)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C1005(0.83); C995(0.83)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C1005(0.81); C995(0.81)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C1005(0.67); C995(0.67)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C1005(0.77); C995(0.77)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C1005(0.87); C995(0.87)  LDD1340  [1]
 LDCM0462  CL7 PaTu 8988t C1005(1.03); C995(1.03)  LDD1341  [1]
 LDCM0463  CL70 PaTu 8988t C1005(0.87); C995(0.87)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C1005(1.19); C995(1.19)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C1005(1.52); C995(1.52)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C1005(0.78); C995(0.78)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C1005(1.71); C995(1.71)  LDD1346  [1]
 LDCM0473  CL8 PaTu 8988t C1005(1.24); C995(1.24)  LDD1352  [1]
 LDCM0484  CL9 PaTu 8988t C1005(0.68); C995(0.68)  LDD1363  [1]
 LDCM0486  CL91 HEK-293T C1005(1.21)  LDD1084  [1]
 LDCM0487  CL92 HEK-293T C1005(1.27)  LDD1085  [1]
 LDCM0488  CL93 HEK-293T C1005(1.44)  LDD1086  [1]
 LDCM0489  CL94 HEK-293T C1005(1.88)  LDD1087  [1]
 LDCM0490  CL95 HEK-293T C1005(1.74)  LDD1088  [1]
 LDCM0491  CL96 HEK-293T C1005(1.92)  LDD1089  [1]
 LDCM0492  CL97 HEK-293T C1005(1.51)  LDD1090  [1]
 LDCM0493  CL98 HEK-293T C1005(1.36)  LDD1091  [1]
 LDCM0494  CL99 HEK-293T C1005(1.20)  LDD1092  [1]
 LDCM0468  Fragment33 PaTu 8988t C1005(0.99); C995(0.99)  LDD1347  [1]
 LDCM0427  Fragment51 HEK-293T C1005(1.29)  LDD1025  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
Malonate--CoA ligase ACSF3, mitochondrial (ACSF3) ATP-dependent AMP-binding enzyme family Q4G176
Calpain-7 (CAPN7) Peptidase C2 family Q9Y6W3
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) PPP phosphatase family P62136
GTP-binding protein Di-Ras1 (DIRAS1) Di-Ras family O95057
Kinesin-like protein KIF9 (KIF9) Kinesin family Q9HAQ2
Tumor susceptibility gene 101 protein (TSG101) Ubiquitin-conjugating enzyme family Q99816
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Histone acetyltransferase p300 (EP300) . Q09472
RalA-binding protein 1 (RALBP1) . Q15311
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell division cycle 5-like protein (CDC5L) CEF1 family Q99459
Sal-like protein 1 (SALL1) Sal C2H2-type zinc-finger protein family Q9NSC2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B) . Q9P0W2
Other
Click To Hide/Show 39 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Deuterosome assembly protein 1 (DEUP1) CEP63 family Q05D60
Cyclin-dependent kinases regulatory subunit 1 (CKS1B) CKS family P61024
DNA mismatch repair protein Mlh1 (MLH1) DNA mismatch repair MutL/HexB family P40692
Protein FAM184A (FAM184A) FAM184 family Q8NB25
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
GAS2-like protein 2 (GAS2L2) GAS2 family Q8NHY3
DNA replication complex GINS protein SLD5 (GINS4) GINS4/SLD5 family Q9BRT9
Protein DGCR6L (DGCR6L) Gonadal family Q9BY27
Keratin, type I cytoskeletal 20 (KRT20) Intermediate filament family P35900
Keratin, type II cytoskeletal 4 (KRT4) Intermediate filament family P19013
Lamin-B1 (LMNB1) Intermediate filament family P20700
Lamin-B2 (LMNB2) Intermediate filament family Q03252
Peripherin (PRPH) Intermediate filament family P41219
Phakinin (BFSP2) Intermediate filament family Q13515
Liprin-alpha-3 (PPFIA3) Liprin family O75145
Protein Mis18-alpha (MIS18A) Mis18 family Q9NYP9
Kinetochore protein NDC80 homolog (NDC80) NDC80/HEC1 family O14777
NHS-like protein 2 (NHSL2) NHS family Q5HYW2
Nucleosome assembly protein 1-like 2 (NAP1L2) Nucleosome assembly protein (NAP) family Q9ULW6
Alpha-taxilin (TXLNA) Taxilin family P40222
T-cell leukemia/lymphoma protein 1A (TCL1A) TCL1 family P56279
Tektin-4 (TEKT4) Tektin family Q8WW24
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86
Coiled-coil domain-containing protein 184 (CCDC184) . Q52MB2
Golgin subfamily A member 1 (GOLGA1) . Q92805
Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1) . Q9BUJ2
Microspherule protein 1 (MCRS1) . Q96EZ8
Mirror-image polydactyly gene 1 protein (MIPOL1) . Q8TD10
Phostensin (PPP1R18) . Q6NYC8
Proline-rich protein 35 (PRR35) . P0CG20
RAS protein activator like-3 (RASAL3) . Q86YV0
Rho GTPase-activating protein 45 (ARHGAP45) . Q92619
Rhombotin-1 (LMO1) . P25800
Testis-expressed protein 12 (TEX12) . Q9BXU0
Testis-expressed protein 9 (TEX9) . Q8N6V9
TNF receptor-associated factor 1 (TRAF1) . Q13077
Uncharacterized protein C2orf42 (C2orf42) . Q9NWW7
ZZ-type zinc finger-containing protein 3 (ZZZ3) . Q8IYH5

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.