Details of the Target

General Information of Target

Target ID LDTP10494
Target Name RBPJ-interacting and tubulin-associated protein 1 (RITA1)
Gene Name RITA1
Gene ID 84934
Synonyms
C12orf52; RITA; RBPJ-interacting and tubulin-associated protein 1; RBPJ-interacting and tubulin-associated protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNYDSQQPPLPPLPYAGCRRASGFPALGRGGTVPVGVWGGAGQGREGRSWGEGPRGPGLG
RRDLSSADPAVLGATMESRCYGCAVKFTLFKKEYGCKNCGRAFCSGCLSFSAAVPRTGNT
QQKVCKQCHEVLTRGSSANASKWSPPQNYKKRVAALEAKQKPSTSQSQGLTRQDQMIAER
LARLRQENKPKLVPSQAEIEARLAALKDERQGSIPSTQEMEARLAALQGRVLPSQTPQPA
HHTPDTRTQAQQTQDLLTQLAAEVAIDESWKGGGPAASLQNDLNQGGPGSTNSKRQANWS
LEEEKSRLLAEAALELREENTRQERILALAKRLAMLRGQDPERVTLQDYRLPDSDDDEDE
ETAIQRVLQQLTEEASLDEASGFNIPAEQASRPWTQPRGAEPEAQDVDPRPEAEEEELPW
CCICNEDATLRCAGCDGDLFCARCFREGHDAFELKEHQTSAYSPPRAGQEH
Target Bioclass
Other
Family
RITA family
Subcellular location
Cytoplasm
Function
Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.
Uniprot ID
Q96K30
Ensemble ID
ENST00000548278.2
HGNC ID
HGNC:25925

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.T91PfsTer104 .
LOXIMVI SNV: p.P266L .
MOLT4 SNV: p.R162Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C80(2.01)  LDD3436  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C80(1.12); C110(1.00)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C80(1.23)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C80(0.98)  LDD1510  [3]
 LDCM0277  AC18 HEK-293T C80(0.99); C110(1.00)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C80(1.42)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C80(1.02); C110(1.07)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C80(1.11)  LDD1519  [3]
 LDCM0284  AC24 HEK-293T C80(0.89); C110(0.90)  LDD1523  [3]
 LDCM0286  AC26 HEK-293T C80(0.98); C110(1.10)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C80(0.99)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C80(1.06)  LDD1527  [3]
 LDCM0290  AC3 HEK-293T C80(1.19)  LDD1529  [3]
 LDCM0293  AC32 HEK-293T C80(0.93); C110(0.84)  LDD1532  [3]
 LDCM0295  AC34 HEK-293T C80(1.04); C110(1.16)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C80(1.10)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C80(1.06)  LDD1536  [3]
 LDCM0301  AC4 HEK-293T C80(1.08)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C80(0.92); C110(0.94)  LDD1541  [3]
 LDCM0304  AC42 HEK-293T C80(1.04); C110(0.99)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C80(1.13)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C80(1.23)  LDD1545  [3]
 LDCM0310  AC48 HEK-293T C80(1.03); C110(0.90)  LDD1549  [3]
 LDCM0313  AC50 HEK-293T C80(0.95); C110(1.06)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C80(1.14)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C80(1.08)  LDD1554  [3]
 LDCM0319  AC56 HEK-293T C80(0.97); C110(0.89)  LDD1558  [3]
 LDCM0321  AC58 HEK-293T C80(1.07); C110(1.14)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C80(1.16)  LDD1561  [3]
 LDCM0324  AC60 HEK-293T C80(1.09)  LDD1563  [3]
 LDCM0328  AC64 HEK-293T C80(0.89); C110(0.94)  LDD1567  [3]
 LDCM0345  AC8 HEK-293T C80(0.96); C110(0.93)  LDD1569  [3]
 LDCM0275  AKOS034007705 HEK-293T C80(0.92); C110(0.87)  LDD1514  [3]
 LDCM0369  CL100 HEK-293T C80(1.15)  LDD1573  [3]
 LDCM0371  CL102 HEK-293T C80(0.96)  LDD1575  [3]
 LDCM0373  CL104 HEK-293T C80(1.01)  LDD1577  [3]
 LDCM0375  CL106 HEK-293T C80(0.96)  LDD1579  [3]
 LDCM0377  CL108 HEK-293T C80(0.85)  LDD1581  [3]
 LDCM0380  CL110 HEK-293T C80(0.91)  LDD1584  [3]
 LDCM0382  CL112 HEK-293T C80(0.96)  LDD1586  [3]
 LDCM0384  CL114 HEK-293T C80(1.09)  LDD1588  [3]
 LDCM0386  CL116 HEK-293T C80(1.05)  LDD1590  [3]
 LDCM0388  CL118 HEK-293T C80(1.08)  LDD1592  [3]
 LDCM0390  CL12 HEK-293T C80(0.86); C110(0.98)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C80(1.12)  LDD1595  [3]
 LDCM0393  CL122 HEK-293T C80(1.13)  LDD1597  [3]
 LDCM0395  CL124 HEK-293T C80(0.87)  LDD1599  [3]
 LDCM0397  CL126 HEK-293T C80(0.97)  LDD1601  [3]
 LDCM0399  CL128 HEK-293T C80(1.06)  LDD1603  [3]
 LDCM0401  CL14 HEK-293T C80(0.90)  LDD1605  [3]
 LDCM0403  CL16 HEK-293T C80(1.09)  LDD1607  [3]
 LDCM0405  CL18 HEK-293T C80(0.97); C110(1.07)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C80(1.27)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C80(0.93)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C80(1.29)  LDD1612  [3]
 LDCM0412  CL24 HEK-293T C80(0.86); C110(0.85)  LDD1616  [3]
 LDCM0414  CL26 HEK-293T C80(0.95)  LDD1618  [3]
 LDCM0416  CL28 HEK-293T C80(1.17)  LDD1620  [3]
 LDCM0419  CL30 HEK-293T C80(0.97); C110(1.06)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C80(1.29)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C80(1.03)  LDD1625  [3]
 LDCM0425  CL36 HEK-293T C80(0.91); C110(0.97)  LDD1629  [3]
 LDCM0429  CL4 HEK-293T C80(1.19)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C80(1.08)  LDD1634  [3]
 LDCM0432  CL42 HEK-293T C80(0.97); C110(1.12)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C80(1.24)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C80(1.36)  LDD1638  [3]
 LDCM0438  CL48 HEK-293T C80(0.89); C110(0.96)  LDD1642  [3]
 LDCM0441  CL50 HEK-293T C80(0.97)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C80(1.13)  LDD1646  [3]
 LDCM0445  CL54 HEK-293T C80(1.05); C110(1.11)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C80(1.36)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C80(1.51)  LDD1650  [3]
 LDCM0451  CL6 HEK-293T C80(0.92); C110(1.26)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C80(0.97); C110(0.89)  LDD1655  [3]
 LDCM0454  CL62 HEK-293T C80(0.96)  LDD1657  [3]
 LDCM0456  CL64 HEK-293T C80(1.07)  LDD1659  [3]
 LDCM0458  CL66 HEK-293T C80(0.94); C110(1.11)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C80(1.42)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C80(1.47)  LDD1663  [3]
 LDCM0462  CL7 HEK-293T C80(1.18)  LDD1665  [3]
 LDCM0465  CL72 HEK-293T C80(1.00); C110(0.94)  LDD1668  [3]
 LDCM0467  CL74 HEK-293T C80(0.82)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C80(1.07)  LDD1672  [3]
 LDCM0471  CL78 HEK-293T C80(1.01); C110(1.13)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C80(1.35)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C80(1.00)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C80(1.13)  LDD1677  [3]
 LDCM0478  CL84 HEK-293T C80(0.91); C110(1.04)  LDD1681  [3]
 LDCM0480  CL86 HEK-293T C80(1.18)  LDD1683  [3]
 LDCM0482  CL88 HEK-293T C80(1.12)  LDD1685  [3]
 LDCM0485  CL90 HEK-293T C80(1.00); C110(1.20)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C80(1.26)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C80(1.00)  LDD1690  [3]
 LDCM0491  CL96 HEK-293T C80(0.92); C110(0.86)  LDD1694  [3]
 LDCM0493  CL98 HEK-293T C80(1.03)  LDD1696  [3]
 LDCM0427  Fragment51 HEK-293T C80(1.10)  LDD1631  [3]
 LDCM0022  KB02 Heraklio 02 ER- C80(1.46)  LDD2401  [1]
 LDCM0023  KB03 Heraklio 02 ER- C80(1.19)  LDD2818  [1]
 LDCM0024  KB05 SNG-M C80(2.01)  LDD3436  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
mRNA-decapping enzyme 1A (DCP1A) DCP1 family Q9NPI6
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Recombining binding protein suppressor of hairless (RBPJ) Su(H) family Q06330
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402