Details of the Target

General Information of Target

Target ID LDTP10312
Target Name Copine-2 (CPNE2)
Gene Name CPNE2
Gene ID 221184
Synonyms
Copine-2; Copine II
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGLAARLVLLAGAAALASGSQGDREPVYRDCVLQCEEQNCSGGALNHFRSRQPIYMSLA
GWTCRDDCKYECMWVTVGLYLQEGHKVPQFHGKWPFSRFLFFQEPASAVASFLNGLASLV
MLCRYRTFVPASSPMYHTCVAFAWVSLNAWFWSTVFHTRDTDLTEKMDYFCASTVILHSI
YLCCVRTVGLQHPAVVSAFRALLLLMLTVHVSYLSLIRFDYGYNLVANVAIGLVNVVWWL
AWCLWNQRRLPHVRKCVVVVLLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHVLFFS
FLEDDSLYLLKESEDKFKLD
Target Bioclass
Other
Family
Copine family
Subcellular location
Cytoplasm
Function Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties.
Uniprot ID
Q96FN4
Ensemble ID
ENST00000290776.13
HGNC ID
HGNC:2315

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HUH7 Substitution: p.R195T .
MEWO SNV: p.M450V DBIA    Probe Info 
MFE319 Deletion: p.T543PfsTer121 .
SKHEP1 SNV: p.M222I .
SKMEL2 SNV: p.G409S .
SNGM Deletion: p.T543PfsTer121 .
SW1116 SNV: p.D501Y .
TE4 SNV: p.Q533Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.43  LDD0403  [1]
DBIA
 Probe Info  		C14(1.72)  LDD3315  [2]
Acrolein
 Probe Info  		N.A.  LDD0232  [3]
IA-alkyne
 Probe Info  		C388(0.00); C48(0.00); C116(0.00)  LDD0165  [4]
STPyne
 Probe Info  		N.A.  LDD0009  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C116(0.95)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C116(1.07)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C116(0.80)  LDD1510  [6]
 LDCM0277  AC18 HEK-293T C116(0.86)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C116(0.87)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C116(0.99)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C116(0.82)  LDD1519  [6]
 LDCM0286  AC26 HEK-293T C116(0.91)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C116(1.15)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C116(0.85)  LDD1527  [6]
 LDCM0290  AC3 HEK-293T C116(1.01)  LDD1529  [6]
 LDCM0295  AC34 HEK-293T C116(0.88)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C116(0.95)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C116(0.88)  LDD1536  [6]
 LDCM0301  AC4 HEK-293T C116(1.03)  LDD1540  [6]
 LDCM0304  AC42 HEK-293T C116(0.88)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C116(0.99)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C116(0.82)  LDD1545  [6]
 LDCM0308  AC46 PaTu 8988t C116(0.96)  LDD1187  [7]
 LDCM0309  AC47 PaTu 8988t C116(1.00)  LDD1188  [7]
 LDCM0310  AC48 PaTu 8988t C116(1.02)  LDD1189  [7]
 LDCM0311  AC49 PaTu 8988t C116(0.97)  LDD1190  [7]
 LDCM0313  AC50 PaTu 8988t C116(1.06)  LDD1192  [7]
 LDCM0314  AC51 PaTu 8988t C116(0.98)  LDD1193  [7]
 LDCM0315  AC52 PaTu 8988t C116(1.03)  LDD1194  [7]
 LDCM0316  AC53 PaTu 8988t C116(1.04)  LDD1195  [7]
 LDCM0317  AC54 PaTu 8988t C116(1.19)  LDD1196  [7]
 LDCM0318  AC55 PaTu 8988t C116(0.94)  LDD1197  [7]
 LDCM0319  AC56 PaTu 8988t C116(0.88)  LDD1198  [7]
 LDCM0321  AC58 HEK-293T C116(0.91)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C116(0.92)  LDD1561  [6]
 LDCM0324  AC60 HEK-293T C116(0.88)  LDD1563  [6]
 LDCM0156  Aniline NCI-H1299 11.43  LDD0403  [1]
 LDCM0367  CL1 PaTu 8988t C48(1.04)  LDD1246  [7]
 LDCM0368  CL10 PaTu 8988t C48(0.65)  LDD1247  [7]
 LDCM0369  CL100 HEK-293T C116(0.90)  LDD1573  [6]
 LDCM0371  CL102 HEK-293T C116(0.99)  LDD1575  [6]
 LDCM0373  CL104 HEK-293T C116(0.89)  LDD1577  [6]
 LDCM0375  CL106 HEK-293T C116(0.94)  LDD1579  [6]
 LDCM0377  CL108 HEK-293T C116(0.91)  LDD1581  [6]
 LDCM0379  CL11 PaTu 8988t C48(1.00)  LDD1258  [7]
 LDCM0380  CL110 HEK-293T C116(0.96)  LDD1584  [6]
 LDCM0382  CL112 HEK-293T C116(0.80)  LDD1586  [6]
 LDCM0384  CL114 HEK-293T C116(1.10)  LDD1588  [6]
 LDCM0386  CL116 HEK-293T C116(0.86)  LDD1590  [6]
 LDCM0388  CL118 HEK-293T C116(1.01)  LDD1592  [6]
 LDCM0390  CL12 PaTu 8988t C48(1.00)  LDD1269  [7]
 LDCM0391  CL120 HEK-293T C116(0.94)  LDD1595  [6]
 LDCM0392  CL121 PaTu 8988t C116(1.06)  LDD1271  [7]
 LDCM0393  CL122 PaTu 8988t C116(0.83)  LDD1272  [7]
 LDCM0394  CL123 PaTu 8988t C116(1.11)  LDD1273  [7]
 LDCM0395  CL124 PaTu 8988t C116(1.00)  LDD1274  [7]
 LDCM0397  CL126 HEK-293T C116(0.90)  LDD1601  [6]
 LDCM0399  CL128 HEK-293T C116(0.89)  LDD1603  [6]
 LDCM0400  CL13 PaTu 8988t C48(0.50)  LDD1279  [7]
 LDCM0401  CL14 PaTu 8988t C48(0.35)  LDD1280  [7]
 LDCM0402  CL15 PaTu 8988t C48(0.81)  LDD1281  [7]
 LDCM0403  CL16 HEK-293T C116(1.01)  LDD1607  [6]
 LDCM0405  CL18 HEK-293T C116(1.02)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C116(1.14)  LDD1610  [6]
 LDCM0407  CL2 PaTu 8988t C48(0.87)  LDD1286  [7]
 LDCM0408  CL20 HEK-293T C116(1.22)  LDD1612  [6]
 LDCM0414  CL26 HEK-293T C116(1.08)  LDD1618  [6]
 LDCM0416  CL28 HEK-293T C116(0.96)  LDD1620  [6]
 LDCM0418  CL3 PaTu 8988t C48(1.20)  LDD1297  [7]
 LDCM0419  CL30 HEK-293T C116(1.03)  LDD1623  [6]
 LDCM0420  CL31 PaTu 8988t C116(1.11); C48(0.85)  LDD1299  [7]
 LDCM0421  CL32 PaTu 8988t C116(1.13); C48(0.74)  LDD1300  [7]
 LDCM0422  CL33 PaTu 8988t C116(1.11); C48(1.05)  LDD1301  [7]
 LDCM0423  CL34 PaTu 8988t C116(1.37); C48(0.70)  LDD1302  [7]
 LDCM0424  CL35 PaTu 8988t C116(1.28); C48(0.85)  LDD1303  [7]
 LDCM0425  CL36 PaTu 8988t C116(1.32); C48(0.26)  LDD1304  [7]
 LDCM0426  CL37 PaTu 8988t C116(1.43); C48(0.67)  LDD1305  [7]
 LDCM0428  CL39 PaTu 8988t C116(1.26); C48(0.75)  LDD1307  [7]
 LDCM0429  CL4 PaTu 8988t C48(1.13)  LDD1308  [7]
 LDCM0430  CL40 PaTu 8988t C116(1.23); C48(0.87)  LDD1309  [7]
 LDCM0431  CL41 PaTu 8988t C116(1.36); C48(0.79)  LDD1310  [7]
 LDCM0432  CL42 PaTu 8988t C116(1.44); C48(0.89)  LDD1311  [7]
 LDCM0433  CL43 PaTu 8988t C116(1.33); C48(0.72)  LDD1312  [7]
 LDCM0434  CL44 PaTu 8988t C116(1.30); C48(0.71)  LDD1313  [7]
 LDCM0435  CL45 PaTu 8988t C116(1.16); C48(0.61)  LDD1314  [7]
 LDCM0436  CL46 PaTu 8988t C116(0.95)  LDD1315  [7]
 LDCM0437  CL47 PaTu 8988t C116(1.08)  LDD1316  [7]
 LDCM0438  CL48 PaTu 8988t C116(0.98)  LDD1317  [7]
 LDCM0439  CL49 PaTu 8988t C116(1.02)  LDD1318  [7]
 LDCM0440  CL5 PaTu 8988t C48(0.61)  LDD1319  [7]
 LDCM0441  CL50 PaTu 8988t C116(1.05)  LDD1320  [7]
 LDCM0442  CL51 PaTu 8988t C116(1.02)  LDD1321  [7]
 LDCM0443  CL52 PaTu 8988t C116(1.13)  LDD1322  [7]
 LDCM0444  CL53 PaTu 8988t C116(1.13)  LDD1323  [7]
 LDCM0445  CL54 PaTu 8988t C116(1.12)  LDD1324  [7]
 LDCM0446  CL55 PaTu 8988t C116(1.03)  LDD1325  [7]
 LDCM0447  CL56 PaTu 8988t C116(0.83)  LDD1326  [7]
 LDCM0448  CL57 PaTu 8988t C116(1.14)  LDD1327  [7]
 LDCM0449  CL58 PaTu 8988t C116(1.12)  LDD1328  [7]
 LDCM0450  CL59 PaTu 8988t C116(1.02)  LDD1329  [7]
 LDCM0451  CL6 PaTu 8988t C48(0.74)  LDD1330  [7]
 LDCM0452  CL60 PaTu 8988t C116(1.18)  LDD1331  [7]
 LDCM0453  CL61 PaTu 8988t C48(0.80)  LDD1332  [7]
 LDCM0454  CL62 PaTu 8988t C48(0.90)  LDD1333  [7]
 LDCM0455  CL63 PaTu 8988t C48(0.95)  LDD1334  [7]
 LDCM0456  CL64 PaTu 8988t C48(1.03)  LDD1335  [7]
 LDCM0457  CL65 PaTu 8988t C48(0.86)  LDD1336  [7]
 LDCM0458  CL66 PaTu 8988t C48(0.67)  LDD1337  [7]
 LDCM0459  CL67 PaTu 8988t C48(0.76)  LDD1338  [7]
 LDCM0460  CL68 PaTu 8988t C48(0.72)  LDD1339  [7]
 LDCM0461  CL69 PaTu 8988t C48(0.82)  LDD1340  [7]
 LDCM0462  CL7 PaTu 8988t C48(0.76)  LDD1341  [7]
 LDCM0463  CL70 PaTu 8988t C48(0.85)  LDD1342  [7]
 LDCM0464  CL71 PaTu 8988t C48(1.11)  LDD1343  [7]
 LDCM0465  CL72 PaTu 8988t C48(1.44)  LDD1344  [7]
 LDCM0466  CL73 PaTu 8988t C48(0.73)  LDD1345  [7]
 LDCM0467  CL74 PaTu 8988t C48(1.35)  LDD1346  [7]
 LDCM0469  CL76 PaTu 8988t C116(1.18); C48(0.92)  LDD1348  [7]
 LDCM0470  CL77 PaTu 8988t C116(1.40); C48(0.85)  LDD1349  [7]
 LDCM0471  CL78 PaTu 8988t C116(1.52); C48(0.85)  LDD1350  [7]
 LDCM0472  CL79 PaTu 8988t C116(1.60); C48(0.86)  LDD1351  [7]
 LDCM0473  CL8 PaTu 8988t C48(0.75)  LDD1352  [7]
 LDCM0474  CL80 PaTu 8988t C116(1.51); C48(0.98)  LDD1353  [7]
 LDCM0475  CL81 PaTu 8988t C116(1.43); C48(0.83)  LDD1354  [7]
 LDCM0476  CL82 PaTu 8988t C116(1.68); C48(0.88)  LDD1355  [7]
 LDCM0477  CL83 PaTu 8988t C116(1.91); C48(0.68)  LDD1356  [7]
 LDCM0478  CL84 PaTu 8988t C116(1.20); C48(0.67)  LDD1357  [7]
 LDCM0479  CL85 PaTu 8988t C116(1.21); C48(0.87)  LDD1358  [7]
 LDCM0480  CL86 PaTu 8988t C116(1.49); C48(0.81)  LDD1359  [7]
 LDCM0481  CL87 PaTu 8988t C116(1.68); C48(0.62)  LDD1360  [7]
 LDCM0482  CL88 PaTu 8988t C116(1.65); C48(0.62)  LDD1361  [7]
 LDCM0483  CL89 PaTu 8988t C116(1.34); C48(0.56)  LDD1362  [7]
 LDCM0484  CL9 PaTu 8988t C48(0.64)  LDD1363  [7]
 LDCM0485  CL90 PaTu 8988t C116(1.35); C48(0.61)  LDD1364  [7]
 LDCM0486  CL91 HEK-293T C116(1.15)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C116(0.91)  LDD1690  [6]
 LDCM0493  CL98 HEK-293T C116(0.86)  LDD1696  [6]
 LDCM0468  Fragment33 PaTu 8988t C48(1.05)  LDD1347  [7]
 LDCM0427  Fragment51 PaTu 8988t C116(1.52); C48(0.75)  LDD1306  [7]
 LDCM0022  KB02 HEK-293T C116(0.99)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C116(0.92)  LDD1497  [6]
 LDCM0024  KB05 IGR39 C14(1.72)  LDD3315  [2]
 LDCM0109  NEM HeLa N.A.  LDD0232  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxynitrite isomerase THAP4 (THAP4) Nitrobindin family Q8WY91
Guanylate-binding protein 7 (GBP7) GB1/RHD3 GTPase family Q8N8V2
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
NEDD8-activating enzyme E1 catalytic subunit (UBA3) Ubiquitin-activating E1 family Q8TBC4
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) RAP1 family Q9NYB0
Proto-oncogene c-Rel (REL) . Q04864
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Meiosis-specific protein MEI4 (MEI4) MEI4L family A8MW99
Cancer/testis antigen 55 (CT55) . Q8WUE5
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
KATNB1-like protein 1 (KATNBL1) . Q9H079
PRKCA-binding protein (PICK1) . Q9NRD5
Vinexin (SORBS3) . O60504

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.