Details of the Target

General Information of Target

Target ID LDTP10280
Target Name HSPB1-associated protein 1 (HSPBAP1)
Gene Name HSPBAP1
Gene ID 79663
Synonyms
PASS1; HSPB1-associated protein 1; 27 kDa heat shock protein-associated protein 1; Protein associated with small stress protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLETLRERLLSVQQDFTSGLKTLSDKSREAKVKSKPRTVPFLPKYSAGLELLSRYEDTWA
ALHRRAKDCASAGELVDSEVVMLSAHWEKKKTSLVELQEQLQQLPALIADLESMTANLTH
LEASFEEVENNLLHLEDLCGQCELERCKHMQSQQLENYKKNKRKELETFKAELDAEHAQK
VLEMEHTQQMKLKERQKFFEEAFQQDMEQYLSTGYLQIAERREPIGSMSSMEVNVDMLEQ
MDLMDISDQEALDVFLNSGGEENTVLSPALGPESSTCQNEITLQVPNPSELRAKPPSSSS
TCTDSATRDISEGGESPVVQSDEEEVQVDTALATSHTDREATPDGGEDSDS
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function May play a role in cellular stress response.
Uniprot ID
Q96EW2
Ensemble ID
ENST00000306103.3
HGNC ID
HGNC:16389

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT SNV: p.S244R .
KYSE30 Substitution: p.S167F .
RCC10RGB SNV: p.D150N .
TFK1 SNV: p.S110N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C293(2.95)  LDD3393  [1]
AHL-Pu-1
 Probe Info  		C323(2.39)  LDD0170  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C323(2.39)  LDD0170  [2]
 LDCM0226  AC11 HEK-293T C362(1.21)  LDD1509  [4]
 LDCM0278  AC19 HEK-293T C362(1.19)  LDD1517  [4]
 LDCM0284  AC24 HEK-293T C362(0.94); C293(1.06)  LDD1523  [4]
 LDCM0287  AC27 HEK-293T C362(1.12)  LDD1526  [4]
 LDCM0290  AC3 HEK-293T C362(0.95)  LDD1529  [4]
 LDCM0293  AC32 HEK-293T C362(1.11); C293(1.17)  LDD1532  [4]
 LDCM0296  AC35 HEK-293T C362(1.00)  LDD1535  [4]
 LDCM0302  AC40 HEK-293T C362(1.30); C293(1.13)  LDD1541  [4]
 LDCM0305  AC43 HEK-293T C362(0.99)  LDD1544  [4]
 LDCM0310  AC48 HEK-293T C362(1.26); C293(1.25)  LDD1549  [4]
 LDCM0314  AC51 HEK-293T C362(0.92)  LDD1553  [4]
 LDCM0319  AC56 HEK-293T C362(1.04); C293(1.08)  LDD1558  [4]
 LDCM0322  AC59 HEK-293T C362(1.37)  LDD1561  [4]
 LDCM0328  AC64 HEK-293T C362(1.24); C293(1.20)  LDD1567  [4]
 LDCM0345  AC8 HEK-293T C362(1.20); C293(1.12)  LDD1569  [4]
 LDCM0275  AKOS034007705 HEK-293T C362(1.14); C293(1.12)  LDD1514  [4]
 LDCM0369  CL100 HEK-293T C362(1.01)  LDD1573  [4]
 LDCM0373  CL104 HEK-293T C362(0.98)  LDD1577  [4]
 LDCM0377  CL108 HEK-293T C362(1.10)  LDD1581  [4]
 LDCM0382  CL112 HEK-293T C362(1.02)  LDD1586  [4]
 LDCM0386  CL116 HEK-293T C362(1.14)  LDD1590  [4]
 LDCM0390  CL12 HEK-293T C362(1.39); C293(1.30)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C362(0.86)  LDD1595  [4]
 LDCM0395  CL124 HEK-293T C362(1.10)  LDD1599  [4]
 LDCM0399  CL128 HEK-293T C362(0.81)  LDD1603  [4]
 LDCM0403  CL16 HEK-293T C362(0.94)  LDD1607  [4]
 LDCM0406  CL19 HEK-293T C362(1.16)  LDD1610  [4]
 LDCM0412  CL24 HEK-293T C362(1.22); C293(1.23)  LDD1616  [4]
 LDCM0416  CL28 HEK-293T C362(0.84)  LDD1620  [4]
 LDCM0420  CL31 HEK-293T C362(1.02)  LDD1624  [4]
 LDCM0425  CL36 HEK-293T C362(1.06); C293(1.07)  LDD1629  [4]
 LDCM0429  CL4 HEK-293T C362(1.00)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C362(1.04)  LDD1634  [4]
 LDCM0433  CL43 HEK-293T C362(1.02)  LDD1637  [4]
 LDCM0438  CL48 HEK-293T C362(1.39); C293(1.28)  LDD1642  [4]
 LDCM0443  CL52 HEK-293T C362(1.10)  LDD1646  [4]
 LDCM0446  CL55 HEK-293T C362(1.12)  LDD1649  [4]
 LDCM0452  CL60 HEK-293T C362(1.70); C293(1.24)  LDD1655  [4]
 LDCM0456  CL64 HEK-293T C362(1.12)  LDD1659  [4]
 LDCM0459  CL67 HEK-293T C362(1.20)  LDD1662  [4]
 LDCM0462  CL7 HEK-293T C362(1.08)  LDD1665  [4]
 LDCM0465  CL72 HEK-293T C362(1.33); C293(1.24)  LDD1668  [4]
 LDCM0469  CL76 HEK-293T C362(0.84)  LDD1672  [4]
 LDCM0472  CL79 HEK-293T C362(1.15)  LDD1675  [4]
 LDCM0478  CL84 HEK-293T C362(1.96); C293(1.22)  LDD1681  [4]
 LDCM0482  CL88 HEK-293T C362(1.03)  LDD1685  [4]
 LDCM0486  CL91 HEK-293T C362(1.08)  LDD1689  [4]
 LDCM0491  CL96 HEK-293T C362(1.29); C293(1.28)  LDD1694  [4]
 LDCM0022  KB02 HEK-293T C293(1.00)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C293(1.18)  LDD1497  [4]
 LDCM0024  KB05 PaTu 8988t C293(2.95)  LDD3393  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-6 (CASP6) Peptidase C14A family P55212
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin-interacting protein 1 (HIP1) SLA2 family O00291
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NUT family member 1 (NUTM1) NUT family Q86Y26
Splicing regulator SDE2 (SDE2) SDE2 family Q6IQ49
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Gelsolin (GSN) Villin/gelsolin family P06396
Rho guanine nucleotide exchange factor 5 (ARHGEF5) . Q12774

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402