Details of the Target

General Information of Target

Target ID LDTP10235
Target Name Tripartite motif-containing protein 44 (TRIM44)
Gene Name TRIM44
Gene ID 54765
Synonyms
DIPB; Tripartite motif-containing protein 44; Protein DIPB
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDGKQGGMDGSKPAGPRDFPGIRLLSNPLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGW
AVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNL
LLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQR
ACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVP
PESPLAQLFLEREGPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLHL
Target Bioclass
Enzyme
Function May play a role in the process of differentiation and maturation of neuronal cells. May regulate the activity of TRIM17. Is a negative regulator of PAX6 expression.
Uniprot ID
Q96DX7
Ensemble ID
ENST00000299413.7
HGNC ID
HGNC:19016

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C179(0.92); C190(0.92)  LDD0078  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C179(1.01); C190(1.01)  LDD1093  [1]
 LDCM0215  AC10 PaTu 8988t C179(0.99); C190(0.99)  LDD1094  [1]
 LDCM0226  AC11 PaTu 8988t C179(0.99); C190(0.99)  LDD1105  [1]
 LDCM0237  AC12 PaTu 8988t C179(1.07); C190(1.07)  LDD1116  [1]
 LDCM0246  AC128 PaTu 8988t C179(1.14); C190(1.14)  LDD1125  [1]
 LDCM0247  AC129 PaTu 8988t C179(1.33); C190(1.33)  LDD1126  [1]
 LDCM0249  AC130 PaTu 8988t C179(0.94); C190(0.94)  LDD1128  [1]
 LDCM0250  AC131 PaTu 8988t C179(0.79); C190(0.79)  LDD1129  [1]
 LDCM0251  AC132 PaTu 8988t C179(0.78); C190(0.78)  LDD1130  [1]
 LDCM0252  AC133 PaTu 8988t C179(1.58); C190(1.58)  LDD1131  [1]
 LDCM0253  AC134 PaTu 8988t C179(1.20); C190(1.20)  LDD1132  [1]
 LDCM0254  AC135 PaTu 8988t C179(1.51); C190(1.51)  LDD1133  [1]
 LDCM0255  AC136 PaTu 8988t C179(1.76); C190(1.76)  LDD1134  [1]
 LDCM0256  AC137 PaTu 8988t C179(1.28); C190(1.28)  LDD1135  [1]
 LDCM0257  AC138 PaTu 8988t C179(1.47); C190(1.47)  LDD1136  [1]
 LDCM0258  AC139 PaTu 8988t C179(1.83); C190(1.83)  LDD1137  [1]
 LDCM0259  AC14 PaTu 8988t C179(1.07); C190(1.07)  LDD1138  [1]
 LDCM0260  AC140 PaTu 8988t C179(0.91); C190(0.91)  LDD1139  [1]
 LDCM0261  AC141 PaTu 8988t C179(1.45); C190(1.45)  LDD1140  [1]
 LDCM0262  AC142 PaTu 8988t C179(0.85); C190(0.85)  LDD1141  [1]
 LDCM0270  AC15 PaTu 8988t C179(1.23); C190(1.23)  LDD1149  [1]
 LDCM0276  AC17 PaTu 8988t C179(1.04); C190(1.04)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C179(1.11); C190(1.11)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C179(0.98); C190(0.98)  LDD1157  [1]
 LDCM0279  AC2 PaTu 8988t C179(1.24); C190(1.24)  LDD1158  [1]
 LDCM0280  AC20 PaTu 8988t C179(1.14); C190(1.14)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C179(1.03); C190(1.03)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C179(1.27); C190(1.27)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C179(1.24); C190(1.24)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C179(1.07); C190(1.07)  LDD1163  [1]
 LDCM0290  AC3 PaTu 8988t C179(0.96); C190(0.96)  LDD1169  [1]
 LDCM0296  AC35 PaTu 8988t C179(0.86); C190(0.86)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C179(0.91); C190(0.91)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C179(0.94); C190(0.94)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C179(1.04); C190(1.04)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C179(0.99); C190(0.99)  LDD1179  [1]
 LDCM0301  AC4 PaTu 8988t C179(0.85); C190(0.85)  LDD1180  [1]
 LDCM0302  AC40 PaTu 8988t C179(1.13); C190(1.13)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C179(0.94); C190(0.94)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C179(1.03); C190(1.03)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C179(1.03); C190(1.03)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C179(1.35); C190(1.35)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C179(1.05); C190(1.05)  LDD1186  [1]
 LDCM0312  AC5 PaTu 8988t C179(1.22); C190(1.22)  LDD1191  [1]
 LDCM0323  AC6 PaTu 8988t C179(0.96); C190(0.96)  LDD1202  [1]
 LDCM0334  AC7 PaTu 8988t C179(0.84); C190(0.84)  LDD1213  [1]
 LDCM0345  AC8 PaTu 8988t C179(0.92); C190(0.92)  LDD1224  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C179(0.92); C190(0.92)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C179(1.14); C190(1.14)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C179(1.15); C190(1.15)  LDD1154  [1]
 LDCM0020  ARS-1620 HCC44 C179(0.92); C190(0.92)  LDD0078  [1]
 LDCM0367  CL1 PaTu 8988t C179(1.19); C190(1.19)  LDD1246  [1]
 LDCM0368  CL10 PaTu 8988t C179(1.27); C190(1.27)  LDD1247  [1]
 LDCM0369  CL100 PaTu 8988t C179(0.91); C190(0.91)  LDD1248  [1]
 LDCM0370  CL101 PaTu 8988t C179(0.88); C190(0.88)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C179(0.97); C190(0.97)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C179(1.08); C190(1.08)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C179(0.87); C190(0.87)  LDD1252  [1]
 LDCM0374  CL105 PaTu 8988t C179(1.04); C190(1.04)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C179(1.02); C190(1.02)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C179(0.98); C190(0.98)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C179(0.96); C190(0.96)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C179(0.87); C190(0.87)  LDD1257  [1]
 LDCM0379  CL11 PaTu 8988t C179(1.09); C190(1.09)  LDD1258  [1]
 LDCM0380  CL110 PaTu 8988t C179(1.00); C190(1.00)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C179(1.27); C190(1.27)  LDD1260  [1]
 LDCM0387  CL117 PaTu 8988t C179(0.85); C190(0.85)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C179(1.04); C190(1.04)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C179(1.07); C190(1.07)  LDD1268  [1]
 LDCM0390  CL12 PaTu 8988t C179(1.17); C190(1.17)  LDD1269  [1]
 LDCM0391  CL120 PaTu 8988t C179(1.00); C190(1.00)  LDD1270  [1]
 LDCM0400  CL13 PaTu 8988t C179(1.32); C190(1.32)  LDD1279  [1]
 LDCM0401  CL14 PaTu 8988t C179(1.24); C190(1.24)  LDD1280  [1]
 LDCM0402  CL15 PaTu 8988t C179(1.11); C190(1.11)  LDD1281  [1]
 LDCM0407  CL2 PaTu 8988t C179(0.92); C190(0.92)  LDD1286  [1]
 LDCM0418  CL3 PaTu 8988t C179(1.01); C190(1.01)  LDD1297  [1]
 LDCM0420  CL31 PaTu 8988t C179(0.70); C190(0.70)  LDD1299  [1]
 LDCM0421  CL32 PaTu 8988t C179(0.85); C190(0.85)  LDD1300  [1]
 LDCM0422  CL33 PaTu 8988t C179(0.79); C190(0.79)  LDD1301  [1]
 LDCM0423  CL34 PaTu 8988t C179(0.90); C190(0.90)  LDD1302  [1]
 LDCM0424  CL35 PaTu 8988t C179(0.82); C190(0.82)  LDD1303  [1]
 LDCM0425  CL36 PaTu 8988t C179(0.92); C190(0.92)  LDD1304  [1]
 LDCM0426  CL37 PaTu 8988t C179(0.96); C190(0.96)  LDD1305  [1]
 LDCM0428  CL39 PaTu 8988t C179(0.74); C190(0.74)  LDD1307  [1]
 LDCM0429  CL4 PaTu 8988t C179(1.05); C190(1.05)  LDD1308  [1]
 LDCM0430  CL40 PaTu 8988t C179(0.88); C190(0.88)  LDD1309  [1]
 LDCM0431  CL41 PaTu 8988t C179(0.70); C190(0.70)  LDD1310  [1]
 LDCM0432  CL42 PaTu 8988t C179(0.85); C190(0.85)  LDD1311  [1]
 LDCM0433  CL43 PaTu 8988t C179(1.03); C190(1.03)  LDD1312  [1]
 LDCM0434  CL44 PaTu 8988t C179(0.81); C190(0.81)  LDD1313  [1]
 LDCM0435  CL45 PaTu 8988t C179(0.73); C190(0.73)  LDD1314  [1]
 LDCM0440  CL5 PaTu 8988t C179(1.13); C190(1.13)  LDD1319  [1]
 LDCM0451  CL6 PaTu 8988t C179(1.02); C190(1.02)  LDD1330  [1]
 LDCM0453  CL61 PaTu 8988t C179(1.11); C190(1.11)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C179(0.83); C190(0.83)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C179(0.81); C190(0.81)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C179(0.95); C190(0.95)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C179(0.84); C190(0.84)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C179(0.80); C190(0.80)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C179(1.02); C190(1.02)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C179(1.19); C190(1.19)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C179(1.29); C190(1.29)  LDD1340  [1]
 LDCM0462  CL7 PaTu 8988t C179(1.06); C190(1.06)  LDD1341  [1]
 LDCM0463  CL70 PaTu 8988t C179(1.13); C190(1.13)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C179(0.84); C190(0.84)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C179(0.92); C190(0.92)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C179(1.25); C190(1.25)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C179(1.10); C190(1.10)  LDD1346  [1]
 LDCM0469  CL76 PaTu 8988t C179(0.84); C190(0.84)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C179(0.96); C190(0.96)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C179(0.92); C190(0.92)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C179(0.85); C190(0.85)  LDD1351  [1]
 LDCM0473  CL8 PaTu 8988t C179(0.94); C190(0.94)  LDD1352  [1]
 LDCM0474  CL80 PaTu 8988t C179(0.83); C190(0.83)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C179(1.02); C190(1.02)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C179(0.86); C190(0.86)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C179(1.04); C190(1.04)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C179(0.81); C190(0.81)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C179(0.79); C190(0.79)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C179(0.80); C190(0.80)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C179(1.12); C190(1.12)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C179(0.93); C190(0.93)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C179(1.05); C190(1.05)  LDD1362  [1]
 LDCM0484  CL9 PaTu 8988t C179(1.43); C190(1.43)  LDD1363  [1]
 LDCM0485  CL90 PaTu 8988t C179(0.72); C190(0.72)  LDD1364  [1]
 LDCM0486  CL91 PaTu 8988t C179(1.01); C190(1.01)  LDD1365  [1]
 LDCM0487  CL92 PaTu 8988t C179(1.02); C190(1.02)  LDD1366  [1]
 LDCM0488  CL93 PaTu 8988t C179(1.00); C190(1.00)  LDD1367  [1]
 LDCM0489  CL94 PaTu 8988t C179(1.12); C190(1.12)  LDD1368  [1]
 LDCM0490  CL95 PaTu 8988t C179(1.16); C190(1.16)  LDD1369  [1]
 LDCM0491  CL96 PaTu 8988t C179(1.13); C190(1.13)  LDD1370  [1]
 LDCM0492  CL97 PaTu 8988t C179(1.12); C190(1.12)  LDD1371  [1]
 LDCM0493  CL98 PaTu 8988t C179(1.50); C190(1.50)  LDD1372  [1]
 LDCM0494  CL99 PaTu 8988t C179(1.02); C190(1.02)  LDD1373  [1]
 LDCM0468  Fragment33 PaTu 8988t C179(1.18); C190(1.18)  LDD1347  [1]
 LDCM0427  Fragment51 PaTu 8988t C179(1.08); C190(1.08)  LDD1306  [1]
 LDCM0021  THZ1 HCT 116 C179(1.18); C190(1.18)  LDD2173  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.