Details of the Target

General Information of Target

Target ID LDTP10080
Target Name Mitochondrial outer membrane protein SLC25A46 (SLC25A46)
Gene Name SLC25A46
Gene ID 91137
Synonyms
TB1; Mitochondrial outer membrane protein SLC25A46; Solute carrier family 25 member 46
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAVGVRGRYELPPCSGPGWLLSLSALLSVAARGAFATTHWVVTEDGKIQQQVDSPMNL
KHPHDLVILMRQEATVNYLKELEKQLVAQKIHIEENEDRDTGLEQRHNKEDPDCIKAKVP
LGDLDLYDGTYITLESKDISPEDYIDTESPVPPDPEQPDCTKILELPYSIHAFQHLRGVQ
ERVNLSAPLLPKEDPIFTYLSKRLGRSIDDIGHLIHEGLQKNTSSWVLYNMASFYWRIKN
EPYQVVECAMRALHFSSRHNKDIALVNLANVLHRAHFSADAAVVVHAALDDSDFFTSYYT
LGNIYAMLGEYNHSVLCYDHALQARPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLN
ELKEYQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQLGNHQICRLVNQQHS
LHCQWDQPVRYHRGDIFENVDYVQFGEDSSTSSMMSVNFDVQSNQSDINDSVKSSPVAHS
ILWIWGRDSDAYRDKQHILWPKRADCTESYPRVPVGGELPTYFLPPENKGLRIHELSSDD
YSTEEEAQTPDCSITDFRKSHTLSYLVKELEVRMDLKAKMPDDHARKILLSRINNYTIPE
EEIGSFLFHAINKPNAPIWLILNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQDVPLVN
LANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALKLTT
KCPECENSLKLIRCMQFYPFLYNITSSVCSGTVVEESNGSDEMENSDETKMSEEILALVD
EFQQAWPLEGFGGALEMKGRRLDLQGIRVLKKGPQDGVARSSCYGDCRSEDDEATEWITF
QVKRVKKPKGDHKKTPGKKVETGQIENGHRYQANLEITGPKVASPGPQGKKRDYQRLGWP
SPDECLKLRWVELTAIVSTWLAVSSKNIDITEHIDFATPIQQPAMEPLCNGNLPTSMHTL
DHLHGVSNRASLHYTGESQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWVLSSM
AALYWRVKGQGKKAIDCLRQALHYAPHQMKDVPLISLANILHNAKLWNDAVIVATMAVEI
APHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHLMLKKGRRS
P
Target Bioclass
Transporter and channel
Family
Mitochondrial carrier (TC 2.A.29) family
Subcellular location
Mitochondrion outer membrane
Function
Transmembrane protein of the mitochondrial outer membrane that controls mitochondrial organization. May regulate the assembly of the MICOS (mitochondrial contact site and cristae organizing system) complex which is essential to the biogenesis and dynamics of mitochondrial cristae, the inwards folds of the inner mitochondrial membrane. Through its interaction with the EMC (endoplasmic reticulum membrane protein complex), could regulate mitochondrial lipid homeostasis and thereby mitochondrial fission.
Uniprot ID
Q96AG3
Ensemble ID
ENST00000355943.8
HGNC ID
HGNC:25198

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.W57G .
JHH7 SNV: p.M147L .
JURLMK1 Deletion: p.T336QfsTer14 .
KPNYN SNV: p.A30P .
OSRC2 SNV: p.P76A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C93(7.23)  LDD3312  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
AOyne
 Probe Info  		13.80  LDD0443  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C239(1.02)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C239(1.00); C372(0.86)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C239(1.17)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C239(1.10)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C239(0.99)  LDD1512  [9]
 LDCM0276  AC17 HEK-293T C239(1.05)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C239(1.01); C372(0.78)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C239(1.06)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C239(0.97); C372(0.90)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C239(1.02)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C239(0.93)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C239(0.94)  LDD1521  [9]
 LDCM0284  AC24 HEK-293T C239(0.93)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C239(1.07)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C239(1.08); C372(0.82)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C239(1.02)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C239(1.12)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C239(1.12)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C239(1.09)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C239(1.03)  LDD1530  [9]
 LDCM0293  AC32 HEK-293T C239(0.97)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C239(1.08)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C239(0.99); C372(0.99)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C239(1.09)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C239(1.00)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C239(1.05)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C239(0.98)  LDD1538  [9]
 LDCM0301  AC4 HEK-293T C239(1.02)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C239(0.88)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C239(0.94)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C239(1.03); C372(1.03)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C239(1.14)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C239(0.99)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C239(1.00)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C239(0.99)  LDD1547  [9]
 LDCM0310  AC48 HEK-293T C239(0.97)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C239(1.04)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C239(0.95)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C239(1.13); C372(1.04)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C239(1.09)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C239(1.05)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C239(0.97)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C239(0.96)  LDD1556  [9]
 LDCM0319  AC56 HEK-293T C239(0.91)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C239(1.20)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C239(1.06); C372(1.17)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C239(1.09)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C239(0.93)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C239(1.01)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C239(1.08)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C239(0.91)  LDD1565  [9]
 LDCM0328  AC64 HEK-293T C239(0.93)  LDD1567  [9]
 LDCM0345  AC8 HEK-293T C239(0.92)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C239(1.04)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C239(1.02)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C239(0.93)  LDD1514  [9]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0367  CL1 HEK-293T C239(1.02)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C239(1.21)  LDD1572  [9]
 LDCM0370  CL101 HEK-293T C239(0.96)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C239(1.06)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C239(1.01)  LDD1576  [9]
 LDCM0374  CL105 HEK-293T C239(0.98)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C239(0.96)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C239(0.93)  LDD1580  [9]
 LDCM0378  CL109 HEK-293T C239(1.08)  LDD1582  [9]
 LDCM0380  CL110 HEK-293T C239(1.18)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C239(0.93)  LDD1585  [9]
 LDCM0383  CL113 HEK-293T C239(0.99)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C239(1.21)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C239(1.04)  LDD1589  [9]
 LDCM0387  CL117 HEK-293T C239(0.95)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C239(0.97)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C239(1.01)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C239(1.17)  LDD1594  [9]
 LDCM0392  CL121 HEK-293T C239(0.95)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C239(1.00)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C239(1.09)  LDD1598  [9]
 LDCM0396  CL125 HEK-293T C239(0.97)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C239(1.00)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C239(0.97)  LDD1602  [9]
 LDCM0400  CL13 HEK-293T C239(1.07)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C239(0.95)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C239(1.15)  LDD1606  [9]
 LDCM0404  CL17 HEK-293T C239(1.31)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C239(1.07); C372(1.06)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C239(1.23)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C239(1.01)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C239(1.04)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C239(0.93)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C239(1.37)  LDD1614  [9]
 LDCM0412  CL24 HEK-293T C239(1.22)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C239(1.08)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C239(0.98)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C239(0.96)  LDD1619  [9]
 LDCM0417  CL29 HEK-293T C239(1.06)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C239(1.05)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C239(1.05); C372(0.89)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C239(1.12)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C239(1.06)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C239(1.03)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C239(1.28)  LDD1627  [9]
 LDCM0425  CL36 HEK-293T C239(1.18)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C239(0.96)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C239(0.95)  LDD1632  [9]
 LDCM0431  CL41 HEK-293T C239(1.00)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C239(0.98); C372(1.11)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C239(1.09)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C239(1.07)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C239(1.03)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C239(1.33)  LDD1640  [9]
 LDCM0438  CL48 HEK-293T C239(1.16)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C239(0.98)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C239(1.13)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C239(1.04)  LDD1645  [9]
 LDCM0444  CL53 HEK-293T C239(1.26)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C239(1.32); C372(1.09)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C239(1.14)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C239(1.02)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C239(0.96)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C239(1.16)  LDD1652  [9]
 LDCM0451  CL6 HEK-293T C239(1.21); C372(1.12)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C239(1.09)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C239(0.92)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C239(0.99)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C239(0.92)  LDD1658  [9]
 LDCM0457  CL65 HEK-293T C239(1.30)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C239(0.97); C372(0.99)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C239(1.06)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C239(1.01)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C239(0.33)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C239(1.20)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C239(1.20)  LDD1666  [9]
 LDCM0465  CL72 HEK-293T C239(1.09)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C239(0.96)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C239(0.97)  LDD1670  [9]
 LDCM0470  CL77 HEK-293T C239(1.32)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C239(1.08); C372(1.11)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C239(1.11)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C239(1.46)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C239(0.99)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C239(1.06)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C239(0.98)  LDD1679  [9]
 LDCM0478  CL84 HEK-293T C239(1.10)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C239(0.94)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C239(1.05)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C239(1.06)  LDD1684  [9]
 LDCM0483  CL89 HEK-293T C239(1.14)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C239(1.09)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C239(1.73); C372(1.05)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C239(1.03)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C239(1.03)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C239(1.19)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C239(1.16)  LDD1692  [9]
 LDCM0491  CL96 HEK-293T C239(1.04)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C239(0.96)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C239(1.03)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C239(0.93)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C239(0.93)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C239(0.98)  LDD1671  [9]
 LDCM0427  Fragment51 HEK-293T C239(0.89)  LDD1631  [9]
 LDCM0022  KB02 HEK-293T C372(0.89); C239(0.95)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C372(1.05); C239(1.01)  LDD1497  [9]
 LDCM0024  KB05 HMCB C93(7.23)  LDD3312  [1]
 LDCM0131  RA190 MM1.R C239(1.70)  LDD0304  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) Short-chain dehydrogenases/reductases (SDR) family Q8NBQ5
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Large neutral amino acids transporter small subunit 2 (SLC7A8) L-type amino acid transporter (LAT) (TC 2.A.3.8) family Q9UHI5
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Hippocampus abundant transcript-like protein 1 (MFSD14B) Major facilitator superfamily Q5SR56
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Solute carrier family 66 member 2 (SLC66A2) . Q8N2U9
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor expression-enhancing protein 2 (REEP2) DP1 family Q9BRK0
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
FUN14 domain-containing protein 1 (FUNDC1) FUN14 family Q8IVP5
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
Vacuolar ATPase assembly integral membrane protein VMA21 (VMA21) VMA21 family Q3ZAQ7
Four and a half LIM domains protein 3 (FHL3) . Q13643
Outer dense fiber protein 4 (ODF4) . Q2M2E3

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.