Details of the Target

General Information of Target

Target ID LDTP09905
Target Name Semaphorin-4D (SEMA4D)
Gene Name SEMA4D
Gene ID 10507
Synonyms
C9orf164; CD100; SEMAJ; Semaphorin-4D; A8; BB18; GR3; CD antigen CD100
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASD
VFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLY
ELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPK
LLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSN
GNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFTSLKDR
QGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGR
FGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPE
QAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRMLKFLEKT
MEIRGRKRTVWGAKQISATSLPTAISAQTPRPPMRRWSSVS
Target Type
Clinical trial
Target Bioclass
Immunoglobulin
Family
Semaphorin family
Subcellular location
Cell membrane
Function
Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling. Regulates GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner. Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA. Promotes the migration of cerebellar granule cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway.
TTD ID
T50823
Uniprot ID
Q92854
DrugMap ID
TT5UT28
Ensemble ID
ENST00000339861.8
HGNC ID
HGNC:10732
ChEMBL ID
CHEMBL4630887

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.A15V .
CCK81 SNV: p.H568R; p.F799V .
CHL1 SNV: p.T821I .
DU145 SNV: p.G65C .
IGROV1 Deletion: p.F235del .
JHH7 SNV: p.T528A .
KMRC3 Deletion: p.D151MfsTer47 .
LN229 SNV: p.D858Y .
MCC13 Substitution: p.S800F .
NCIH716 SNV: p.L55P .
OVK18 Substitution: p.A531S .
SUPT1 SNV: p.A130V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K766(0.57); K775(8.12)  LDD0277  [1]
OPA-S-S-alkyne
 Probe Info  		K104(0.58); K219(2.27)  LDD3494  [2]
BTD
 Probe Info  		C370(0.61)  LDD2140  [3]
DBIA
 Probe Info  		C708(0.79)  LDD1492  [4]
IA-alkyne
 Probe Info  		C370(0.00); C108(0.00); C281(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C281(0.00); C370(0.00)  LDD0037  [5]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C281(0.98)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C708(0.98)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C708(0.81); C624(0.91); C281(0.84); C370(1.15)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C708(0.73); C281(0.88)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C708(0.88)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C708(1.03); C281(0.96)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C281(1.06)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C708(0.94)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C708(1.19); C624(0.94); C281(1.20); C370(1.29)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C708(0.97)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C708(0.90); C281(1.21)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C708(1.08)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C708(0.88)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C708(0.90); C281(0.85)  LDD1522  [4]
 LDCM0285  AC25 HEK-293T C281(1.14)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C708(0.99)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C708(1.22); C624(0.96); C281(0.95); C370(1.08)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C708(0.71); C281(1.34)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C708(0.95)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C708(1.02); C624(0.95); C281(1.04); C370(1.03)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C708(0.90)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C708(1.01); C281(0.95)  LDD1531  [4]
 LDCM0294  AC33 HEK-293T C281(1.06)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C708(1.04)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C708(0.79); C624(1.06); C281(0.87); C370(1.13)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C708(0.85); C281(1.08)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C708(1.11)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C708(0.83)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C708(0.98); C281(0.84)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C708(0.78); C281(1.32)  LDD1540  [4]
 LDCM0303  AC41 HEK-293T C281(1.00)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C708(1.13)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C708(0.82); C624(1.01); C281(1.07); C370(1.04)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C708(1.17); C281(1.04)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C708(1.00)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C708(0.86)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C708(1.10); C281(0.87)  LDD1548  [4]
 LDCM0311  AC49 HEK-293T C281(0.90)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C708(0.94)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C708(1.02)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C708(0.87); C624(1.04); C281(0.86); C370(1.06)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C708(0.91); C281(1.02)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C708(1.18)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C708(0.99)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C708(1.19); C281(0.92)  LDD1557  [4]
 LDCM0320  AC57 HEK-293T C281(1.01)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C708(0.92)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C708(1.21); C624(1.03); C281(0.82); C370(0.99)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C708(0.97)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C708(0.78); C281(1.13)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C708(1.00)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C708(0.85)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C708(1.06); C281(1.03)  LDD1566  [4]
 LDCM0334  AC7 HEK-293T C708(1.05); C281(0.96)  LDD1568  [4]
 LDCM0248  AKOS034007472 HEK-293T C708(0.92)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C281(0.97)  LDD1570  [4]
 LDCM0367  CL1 HEK-293T C708(0.72); C624(1.07)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C708(1.09)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C708(0.95); C281(1.14)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C708(0.84); C624(1.00)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C708(1.09); C624(1.11)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C708(1.07); C281(0.94)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C708(1.16); C281(0.99)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C708(0.81); C624(0.88)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C708(1.22); C624(1.21)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C708(0.97); C281(1.07)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C708(0.81); C281(0.93)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C708(0.62); C624(1.08)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C708(2.26); C281(1.17)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C708(1.00); C624(1.06)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C708(0.91); C281(1.05)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C708(1.16); C281(0.96)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C708(0.90); C624(0.86)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C708(1.05); C624(0.91)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C708(0.88); C281(1.03)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C708(0.93); C281(0.91)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C708(0.77); C624(1.03)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C708(0.98); C624(1.00)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C708(0.91); C281(0.94)  LDD1593  [4]
 LDCM0391  CL120 HEK-293T C708(0.83); C281(0.99)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C708(0.98); C624(0.93)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C708(1.03); C624(0.94)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C708(0.79); C281(1.08)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C708(0.93); C281(0.98)  LDD1599  [4]
 LDCM0396  CL125 HEK-293T C708(0.77); C624(1.04)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C708(0.82); C624(1.10)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C708(0.86); C281(1.05)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C708(0.93); C281(1.01)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C708(0.71); C624(1.00)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C708(0.92); C624(0.95)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C708(0.93); C281(1.02)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C708(1.29); C281(1.19)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C281(1.38)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C708(1.31)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C708(1.31); C624(1.15); C281(0.81); C370(1.32)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C708(1.08); C624(1.03)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C708(1.48); C281(1.19)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C708(1.88)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C708(1.31)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C708(2.09); C281(0.84)  LDD1615  [4]
 LDCM0413  CL25 HEK-293T C708(0.82); C624(1.00)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C708(1.17); C624(1.16)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C708(0.78); C281(1.01)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C708(1.03); C281(1.07)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C281(1.16)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C708(1.16); C281(1.03)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C708(1.12)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C708(0.90); C624(0.97); C281(0.79); C370(1.17)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C708(1.44); C281(1.19)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C708(1.50)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C708(1.56)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C708(2.30); C281(0.80)  LDD1628  [4]
 LDCM0426  CL37 HEK-293T C708(0.77); C624(1.01)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C708(1.02); C281(1.02)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C708(1.38); C281(0.87)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C708(0.88); C281(1.01)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C281(0.93)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C708(1.29)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C708(1.37); C624(1.10); C281(0.99); C370(1.15)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C708(1.59); C281(1.61)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C708(1.34)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C708(1.30)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C708(1.98); C281(1.03)  LDD1641  [4]
 LDCM0439  CL49 HEK-293T C708(0.75); C624(0.92)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C281(1.07)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C708(0.99); C624(1.11)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C708(1.00); C281(1.12)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C281(1.03)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C708(1.06)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C708(1.25); C624(1.15); C281(0.85); C370(1.09)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C708(1.21); C281(1.19)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C708(1.47)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C708(1.45)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C708(1.64); C281(1.12)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C708(1.08)  LDD1654  [4]
 LDCM0453  CL61 HEK-293T C708(0.79); C624(0.88)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C708(0.84); C624(1.04)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C708(0.85); C281(0.90)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C708(1.20); C281(1.02)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C281(1.04)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C708(1.35)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C708(1.42); C624(1.01); C281(0.77); C370(1.15)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C708(1.15); C281(1.14)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C708(1.37)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C708(1.47); C624(1.00); C281(1.07); C370(1.11)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C708(1.32)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C708(1.56); C281(0.77)  LDD1667  [4]
 LDCM0466  CL73 HEK-293T C708(0.80); C624(1.05)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C708(0.87); C624(1.00)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C708(1.05); C281(0.92)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C281(1.29)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C708(1.05)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C708(1.00); C624(0.99); C281(1.12); C370(1.18)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C708(1.31); C281(1.10)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C708(1.14); C281(1.06)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C708(1.59)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C708(1.27)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C708(2.16); C281(0.98)  LDD1680  [4]
 LDCM0479  CL85 HEK-293T C708(0.67); C624(1.12)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C708(1.26); C624(1.31)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C708(0.97); C281(1.01)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C708(1.05); C281(1.17)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C281(1.15)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C708(1.80)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C708(0.94)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C708(1.64); C624(1.05); C281(1.07); C370(1.30)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C708(1.01); C281(1.13)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C708(1.33)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C708(1.17)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C708(1.56); C281(0.99)  LDD1693  [4]
 LDCM0492  CL97 HEK-293T C708(0.96); C624(1.08)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C708(1.16); C624(1.32)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C708(0.99); C281(1.11)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C708(0.86); C281(1.08)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C708(0.95); C281(1.07)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C708(0.87); C624(1.06)  LDD1631  [4]
 LDCM0022  KB02 HEK-293T C708(0.79)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C708(0.97)  LDD1497  [4]
 LDCM0024  KB05 HEK-293T C708(0.74)  LDD1502  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C370(0.61)  LDD2140  [3]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pepinemab Antibody DG1ED2
Vx-15 Antibody D0N1SH

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD028853
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