Details of the Target

General Information of Target

Target ID LDTP09637
Target Name Dynein light chain Tctex-type protein 2B (DYNLT2B)
Gene Name DYNLT2B
Gene ID 255758
Synonyms
TCTEX1D2; Dynein light chain Tctex-type protein 2B; Tctex1 domain-containing protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATSIGVSFSVGDGVPEAEKNAGEPENTYILRPVFQQRFRPSVVKDCIHAVLKEELANAE
YSPEEMPQLTKHLSENIKDKLKEMGFDRYKMVVQVVIGEQRGEGVFMASRCFWDADTDNY
THDVFMNDSLFCVVAAFGCFYY
Target Bioclass
Other
Family
Dynein light chain Tctex-type family
Subcellular location
Dynein axonemal particle
Function
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. Required for proper retrograde ciliary transport.
Uniprot ID
Q8WW35
Ensemble ID
ENST00000325318.10
HGNC ID
HGNC:28482

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C47(1.79)  LDD3376  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C47(1.05)  LDD1507  [2]
 LDCM0270  AC15 HEK-293T C47(0.97)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C47(0.98)  LDD1515  [2]
 LDCM0283  AC23 HEK-293T C47(0.98)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C47(0.93)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C47(1.06)  LDD1524  [2]
 LDCM0292  AC31 HEK-293T C47(0.96)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C47(0.96)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C47(1.00)  LDD1533  [2]
 LDCM0300  AC39 HEK-293T C47(1.00)  LDD1539  [2]
 LDCM0302  AC40 HEK-293T C47(0.92)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C47(0.90)  LDD1542  [2]
 LDCM0309  AC47 HEK-293T C47(0.98)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C47(1.04)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C47(1.04)  LDD1550  [2]
 LDCM0318  AC55 HEK-293T C47(1.07)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C47(0.94)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C47(1.05)  LDD1559  [2]
 LDCM0327  AC63 HEK-293T C47(1.06)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C47(1.00)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C47(1.02)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C47(1.04)  LDD1569  [2]
 LDCM0356  AKOS034007680 HEK-293T C47(1.02)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C47(1.04)  LDD1514  [2]
 LDCM0369  CL100 HEK-293T C47(0.94)  LDD1573  [2]
 LDCM0371  CL102 HEK-293T C47(1.02)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C47(0.97)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C47(0.87)  LDD1577  [2]
 LDCM0375  CL106 HEK-293T C47(0.92)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C47(0.90)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C47(0.98)  LDD1581  [2]
 LDCM0379  CL11 HEK-293T C47(1.08)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C47(0.97)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C47(1.02)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C47(0.81)  LDD1586  [2]
 LDCM0384  CL114 HEK-293T C47(0.87)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C47(1.09)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C47(1.04)  LDD1590  [2]
 LDCM0388  CL118 HEK-293T C47(1.02)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C47(1.10)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C47(1.08)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C47(0.96)  LDD1595  [2]
 LDCM0393  CL122 HEK-293T C47(0.90)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C47(0.80)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C47(0.88)  LDD1599  [2]
 LDCM0397  CL126 HEK-293T C47(0.89)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C47(0.96)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C47(1.01)  LDD1603  [2]
 LDCM0401  CL14 HEK-293T C47(0.90)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C47(0.92)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C47(0.92)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C47(0.89)  LDD1608  [2]
 LDCM0407  CL2 HEK-293T C47(1.01)  LDD1611  [2]
 LDCM0411  CL23 HEK-293T C47(1.22)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C47(1.11)  LDD1616  [2]
 LDCM0414  CL26 HEK-293T C47(0.98)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C47(0.96)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C47(0.91)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C47(0.99)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C47(1.13)  LDD1622  [2]
 LDCM0424  CL35 HEK-293T C47(1.00)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C47(1.12)  LDD1629  [2]
 LDCM0428  CL39 HEK-293T C47(1.00)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C47(0.84)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C47(1.03)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C47(1.05)  LDD1635  [2]
 LDCM0437  CL47 HEK-293T C47(1.07)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C47(1.13)  LDD1642  [2]
 LDCM0440  CL5 HEK-293T C47(0.97)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C47(0.89)  LDD1645  [2]
 LDCM0443  CL52 HEK-293T C47(0.84)  LDD1646  [2]
 LDCM0444  CL53 HEK-293T C47(0.92)  LDD1647  [2]
 LDCM0450  CL59 HEK-293T C47(1.02)  LDD1653  [2]
 LDCM0452  CL60 HEK-293T C47(1.03)  LDD1655  [2]
 LDCM0454  CL62 HEK-293T C47(0.85)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C47(0.95)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C47(0.88)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C47(1.00)  LDD1660  [2]
 LDCM0464  CL71 HEK-293T C47(1.15)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C47(0.99)  LDD1668  [2]
 LDCM0467  CL74 HEK-293T C47(1.00)  LDD1670  [2]
 LDCM0469  CL76 HEK-293T C47(0.92)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C47(0.91)  LDD1673  [2]
 LDCM0477  CL83 HEK-293T C47(1.14)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C47(1.00)  LDD1681  [2]
 LDCM0480  CL86 HEK-293T C47(1.06)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C47(0.92)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C47(0.93)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C47(1.05)  LDD1686  [2]
 LDCM0490  CL95 HEK-293T C47(1.03)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C47(0.87)  LDD1694  [2]
 LDCM0493  CL98 HEK-293T C47(0.96)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C47(1.00)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C47(0.95)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C47(0.98)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C47(1.10)  LDD1631  [2]
 LDCM0022  KB02 786-O C47(1.53)  LDD2247  [1]
 LDCM0023  KB03 786-O C47(1.91)  LDD2664  [1]
 LDCM0024  KB05 ONS-76 C47(1.79)  LDD3376  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402