Details of the Target

General Information of Target

Target ID LDTP09029
Target Name Zinc finger and BTB domain-containing protein 38 (ZBTB38)
Gene Name ZBTB38
Gene ID 253461
Synonyms
Zinc finger and BTB domain-containing protein 38
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTVMSLSRDLKDDFHSDTVLSILNEQRIRGILCDVTIIVEDTKFKAHSNVLAASSLYFKN
IFWSHTICISSHVLELDDLKAEVFTEILNYIYSSTVVVKRQETVTDLAAAGKKLGISFLE
DLTDRNFSNSPGPYVFCITEKGVVKEEKNEKRHEEPAITNGPRITNAFSIIETENSNNMF
SPLDLRASFKKVSDSMRTASLCLERTDVCHEAEPVRTLAEHSYAVSSVAEAYRSQPVREH
DGSSPGNTGKENCEALAAKPKTCRKPKTFSIPQDSDSATENIPPPPVSNLEVNQERSPQP
AAVLTRSKSPNNEGDVHFSREDENQSSDVPGPPAAEVPPLVYNCSCCSKAFDSSTLLSAH
MQLHKPTQEPLVCKYCNKQFTTLNRLDRHEQICMRSSHMPIPGGNQRFLENYPTIGQNGG
SFTGPEPLLSENRIGEFSSTGSTLPDTDHMVKFVNGQMLYSCVVCKRSYVTLSSLRRHAN
VHSWRRTYPCHYCNKVFALAEYRTRHEIWHTGERRYQCIFCLETFMTYYILKNHQKSFHA
IDHRLSISKKTANGGLKPSVYPYKLYRLLPMKCKRAPYKSYRNSSYENARENSQMNESAP
GTYVVQNPHSSELPTLNFQDTVNTLTNSPAIPLETSACQDIPTSANVQNAEGTKWGEEAL
KMDLDNNFYSTEVSVSSTENAVSSDLRAGDVPVLSLSNSSENAASVISYSGSAPSVIVHS
SQFSSVIMHSNAIAAMTSSNHRAFSDPAVSQSLKDDSKPEPDKVGRFASRPKSIKEKKKT
TSHTRGEIPEESNYVADPGGSLSKTTNIAEETSKIETYIAKPALPGTSTNSNVAPLCQIT
VKIGNEAIVKRHILGSKLFYKRGRRPKYQMQEEPLPQGNDPEPSGDSPLGLCQSECMEMS
EVFDDASDQDSTDKPWRPYYNYKPKKKSRQLKKMRKVNWRKEHGNRSPSHKCKYPAELDC
AVGKAPQDKPFEEEETKEMPKLQCELCDGDKAVGAGNQGRPHRHLTSRPYACELCAKQFQ
SPSTLKMHMRCHTGEKPYQCKTCGRCFSVQGNLQKHERIHLGLKEFVCQYCNKAFTLNET
LKIHERIHTGEKRYHCQFCFQRFLYLSTKRNHEQRHIREHNGKGYACFQCPKICKTAAAL
GMHQKKHLFKSPSQQEKIGDVCHENSNPLENQHFIGSEDNDQKDNIQTGVENVVL
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner. Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication. Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons.
Uniprot ID
Q8NAP3
Ensemble ID
ENST00000321464.7
HGNC ID
HGNC:26636

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C209(2.02)  LDD3323  [1]
AHL-Pu-1
 Probe Info  		C209(3.33)  LDD0170  [2]
IPM
 Probe Info  		C209(0.00); C202(0.00)  LDD0147  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [3]
Acrolein
 Probe Info  		N.A.  LDD0217  [4]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C209(3.33)  LDD0170  [2]
 LDCM0320  AC57 PaTu 8988t C984(1.24); C987(1.24)  LDD1199  [5]
 LDCM0321  AC58 PaTu 8988t C984(0.99); C987(0.99)  LDD1200  [5]
 LDCM0322  AC59 PaTu 8988t C984(0.99); C987(0.99)  LDD1201  [5]
 LDCM0324  AC60 PaTu 8988t C984(1.02); C987(1.02)  LDD1203  [5]
 LDCM0325  AC61 PaTu 8988t C984(1.29); C987(1.29)  LDD1204  [5]
 LDCM0326  AC62 PaTu 8988t C984(1.16); C987(1.16)  LDD1205  [5]
 LDCM0327  AC63 PaTu 8988t C984(1.08); C987(1.08)  LDD1206  [5]
 LDCM0328  AC64 PaTu 8988t C984(1.23); C987(1.23)  LDD1207  [5]
 LDCM0329  AC65 PaTu 8988t C984(0.93); C987(0.93)  LDD1208  [5]
 LDCM0330  AC66 PaTu 8988t C984(1.13); C987(1.13)  LDD1209  [5]
 LDCM0331  AC67 PaTu 8988t C984(1.14); C987(1.14)  LDD1210  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0396  CL125 PaTu 8988t C984(1.01); C987(1.01)  LDD1275  [5]
 LDCM0397  CL126 PaTu 8988t C984(0.99); C987(0.99)  LDD1276  [5]
 LDCM0398  CL127 PaTu 8988t C984(0.92); C987(0.92)  LDD1277  [5]
 LDCM0399  CL128 PaTu 8988t C984(1.15); C987(1.15)  LDD1278  [5]
 LDCM0436  CL46 PaTu 8988t C984(1.06); C987(1.06)  LDD1315  [5]
 LDCM0437  CL47 PaTu 8988t C984(0.96); C987(0.96)  LDD1316  [5]
 LDCM0438  CL48 PaTu 8988t C984(1.03); C987(1.03)  LDD1317  [5]
 LDCM0439  CL49 PaTu 8988t C984(1.23); C987(1.23)  LDD1318  [5]
 LDCM0441  CL50 PaTu 8988t C984(1.11); C987(1.11)  LDD1320  [5]
 LDCM0442  CL51 PaTu 8988t C984(1.30); C987(1.30)  LDD1321  [5]
 LDCM0443  CL52 PaTu 8988t C984(1.21); C987(1.21)  LDD1322  [5]
 LDCM0444  CL53 PaTu 8988t C984(2.02); C987(2.02)  LDD1323  [5]
 LDCM0445  CL54 PaTu 8988t C984(1.21); C987(1.21)  LDD1324  [5]
 LDCM0446  CL55 PaTu 8988t C984(1.15); C987(1.15)  LDD1325  [5]
 LDCM0447  CL56 PaTu 8988t C984(1.26); C987(1.26)  LDD1326  [5]
 LDCM0448  CL57 PaTu 8988t C984(1.11); C987(1.11)  LDD1327  [5]
 LDCM0449  CL58 PaTu 8988t C984(0.99); C987(0.99)  LDD1328  [5]
 LDCM0450  CL59 PaTu 8988t C984(1.11); C987(1.11)  LDD1329  [5]
 LDCM0452  CL60 PaTu 8988t C984(1.00); C987(1.00)  LDD1331  [5]
 LDCM0453  CL61 PaTu 8988t C984(1.09); C987(1.09)  LDD1332  [5]
 LDCM0454  CL62 PaTu 8988t C984(1.08); C987(1.08)  LDD1333  [5]
 LDCM0455  CL63 PaTu 8988t C984(1.16); C987(1.16)  LDD1334  [5]
 LDCM0456  CL64 PaTu 8988t C984(1.21); C987(1.21)  LDD1335  [5]
 LDCM0457  CL65 PaTu 8988t C984(1.19); C987(1.19)  LDD1336  [5]
 LDCM0458  CL66 PaTu 8988t C984(1.12); C987(1.12)  LDD1337  [5]
 LDCM0459  CL67 PaTu 8988t C984(1.28); C987(1.28)  LDD1338  [5]
 LDCM0460  CL68 PaTu 8988t C984(1.25); C987(1.25)  LDD1339  [5]
 LDCM0461  CL69 PaTu 8988t C984(1.50); C987(1.50)  LDD1340  [5]
 LDCM0463  CL70 PaTu 8988t C984(1.36); C987(1.36)  LDD1342  [5]
 LDCM0464  CL71 PaTu 8988t C984(1.09); C987(1.09)  LDD1343  [5]
 LDCM0465  CL72 PaTu 8988t C984(1.17); C987(1.17)  LDD1344  [5]
 LDCM0466  CL73 PaTu 8988t C984(1.62); C987(1.62)  LDD1345  [5]
 LDCM0467  CL74 PaTu 8988t C984(1.25); C987(1.25)  LDD1346  [5]
 LDCM0469  CL76 PaTu 8988t C984(0.89); C987(0.89)  LDD1348  [5]
 LDCM0470  CL77 PaTu 8988t C984(0.89); C987(0.89)  LDD1349  [5]
 LDCM0471  CL78 PaTu 8988t C984(0.91); C987(0.91)  LDD1350  [5]
 LDCM0472  CL79 PaTu 8988t C984(1.09); C987(1.09)  LDD1351  [5]
 LDCM0474  CL80 PaTu 8988t C984(1.26); C987(1.26)  LDD1353  [5]
 LDCM0475  CL81 PaTu 8988t C984(1.03); C987(1.03)  LDD1354  [5]
 LDCM0476  CL82 PaTu 8988t C984(0.92); C987(0.92)  LDD1355  [5]
 LDCM0477  CL83 PaTu 8988t C984(1.56); C987(1.56)  LDD1356  [5]
 LDCM0478  CL84 PaTu 8988t C984(1.20); C987(1.20)  LDD1357  [5]
 LDCM0479  CL85 PaTu 8988t C984(0.92); C987(0.92)  LDD1358  [5]
 LDCM0480  CL86 PaTu 8988t C984(1.13); C987(1.13)  LDD1359  [5]
 LDCM0481  CL87 PaTu 8988t C984(1.63); C987(1.63)  LDD1360  [5]
 LDCM0482  CL88 PaTu 8988t C984(1.24); C987(1.24)  LDD1361  [5]
 LDCM0483  CL89 PaTu 8988t C984(1.12); C987(1.12)  LDD1362  [5]
 LDCM0485  CL90 PaTu 8988t C984(1.21); C987(1.21)  LDD1364  [5]
 LDCM0468  Fragment33 PaTu 8988t C984(1.33); C987(1.33)  LDD1347  [5]
 LDCM0022  KB02 8305C C960(1.92)  LDD2248  [1]
 LDCM0023  KB03 8305C C209(2.77); C960(2.08)  LDD2665  [1]
 LDCM0024  KB05 SKMEL24 C209(2.02)  LDD3323  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tripeptidyl-peptidase 1 (TPP1) . O14773
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-responsive transcription factor (CARF) . Q8N187

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.