Details of the Target

General Information of Target

Target ID LDTP08816
Target Name Voltage-dependent calcium channel beta subunit-associated regulatory protein (CBARP)
Gene Name CBARP
Gene ID 255057
Synonyms
C19orf26; Voltage-dependent calcium channel beta subunit-associated regulatory protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQPTATMATAATTTTTTTATVALTTSWDNATGRPTAEPDPILDNYVLLVVVMSLFVGGTL
VVLSGVLLLCKRCWDVHQRLNRAMEEAEKTTTTYLDNGTHPAQDPDFRGEDPECQDAETE
RFLSTSSTGRRVSFNEAALFEQSRKTQDKGRRYTLTEGDFHHLKNARLTHLHLPPLKIVT
IHECDSGEASSATTPHPATSPKATLAIFQPPGKALTGRSVGPSSALPGDPYNSAAGATDF
AEISPSASSDSGEGTSLDAGTRSTKAGGPGAAAGPGEAGPGSGAGTVLQFLTRLRRHASL
DGASPYFKVKKWKLEPSQRAASLDTRGSPKRHHFQRQRAASESTEQEEGDAPQEDFIQYI
ARAGDAVAFPHPRPFLASPPPALGRLEAAEAAGGASPDSPPERGAGSAGPEQQQPPLEPD
AERDAGPEQAQTSYRDLWSLRASLELHAAASDHSSSGNDRDSVRSGDSSGSGSGGAAPAF
PPPSPPAPRPKDGEARRLLQMDSGYASIEGRGAGDDTEPPAAPARPRSPRAWPRRPRRDY
SIDEKTDALFHEFLRHDPHFDDTPAAARHRARAHPHARKQWQRGRQHSDPGARAAPALAG
TPAPPAGAARPARAPLRRGDSVDGPPDGRTLGGAGDDPAIPVIEEEPGGGGCPGSGLCVL
PSGSVLDKLAAGLDERLFPPRLAEPVVATPALVAAAPTSPDHSPA
Target Bioclass
Transporter and channel
Subcellular location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Function
Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis.
Uniprot ID
Q8N350
Ensemble ID
ENST00000590083.5
HGNC ID
HGNC:28617

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C184(0.97)  LDD1514  [1]
NAIA_5
 Probe Info  		N.A.  LDD2225  [2]
TPP-AC
 Probe Info  		N.A.  LDD0427  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0284  AC24 HEK-293T C184(1.16)  LDD1523  [1]
 LDCM0293  AC32 HEK-293T C184(1.05)  LDD1532  [1]
 LDCM0302  AC40 HEK-293T C184(1.11)  LDD1541  [1]
 LDCM0310  AC48 HEK-293T C184(1.08)  LDD1549  [1]
 LDCM0319  AC56 HEK-293T C184(1.07)  LDD1558  [1]
 LDCM0328  AC64 HEK-293T C184(1.13)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C184(1.21)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C184(0.97)  LDD1514  [1]
 LDCM0020  ARS-1620 HCC44 C67(1.11)  LDD2171  [4]
 LDCM0369  CL100 HEK-293T C184(1.33)  LDD1573  [1]
 LDCM0373  CL104 HEK-293T C184(1.01)  LDD1577  [1]
 LDCM0377  CL108 HEK-293T C184(0.85)  LDD1581  [1]
 LDCM0382  CL112 HEK-293T C184(1.00)  LDD1586  [1]
 LDCM0386  CL116 HEK-293T C184(0.99)  LDD1590  [1]
 LDCM0390  CL12 HEK-293T C184(1.14)  LDD1594  [1]
 LDCM0391  CL120 HEK-293T C184(1.29)  LDD1595  [1]
 LDCM0395  CL124 HEK-293T C184(0.84)  LDD1599  [1]
 LDCM0399  CL128 HEK-293T C184(1.10)  LDD1603  [1]
 LDCM0403  CL16 HEK-293T C184(0.93)  LDD1607  [1]
 LDCM0412  CL24 HEK-293T C184(1.13)  LDD1616  [1]
 LDCM0416  CL28 HEK-293T C184(1.05)  LDD1620  [1]
 LDCM0425  CL36 HEK-293T C184(1.28)  LDD1629  [1]
 LDCM0429  CL4 HEK-293T C184(0.94)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C184(1.03)  LDD1634  [1]
 LDCM0438  CL48 HEK-293T C184(0.99)  LDD1642  [1]
 LDCM0443  CL52 HEK-293T C184(0.88)  LDD1646  [1]
 LDCM0452  CL60 HEK-293T C184(1.06)  LDD1655  [1]
 LDCM0456  CL64 HEK-293T C184(0.99)  LDD1659  [1]
 LDCM0465  CL72 HEK-293T C184(0.96)  LDD1668  [1]
 LDCM0469  CL76 HEK-293T C184(1.14)  LDD1672  [1]
 LDCM0478  CL84 HEK-293T C184(0.99)  LDD1681  [1]
 LDCM0482  CL88 HEK-293T C184(0.89)  LDD1685  [1]
 LDCM0491  CL96 HEK-293T C184(0.98)  LDD1694  [1]
 LDCM0021  THZ1 HCT 116 C67(1.11)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidylserine lipase ABHD16A (ABHD16A) ABHD16 family O95870
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium homeostasis modulator protein 6 (CALHM6) CALHM family Q5R3K3
Molybdate-anion transporter (MFSD5) Major facilitator superfamily Q6N075
Membrane-spanning 4-domains subfamily A member 13 (MS4A13) MS4A family Q5J8X5
Solute carrier family 35 member F6 (SLC35F6) SLC35F solute transporter family Q8N357
Zinc transporter ZIP9 (SLC39A9) ZIP transporter (TC 2.A.5) family Q9NUM3
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytoplasmic protein NCK2 (NCK2) . O43639
TRAF3-interacting JNK-activating modulator (TRAF3IP3) . Q9Y228

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.