Details of the Target

General Information of Target

Target ID LDTP08613
Target Name Kelch domain-containing protein 8B (KLHDC8B)
Gene Name KLHDC8B
Gene ID 200942
Synonyms
Kelch domain-containing protein 8B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAGGGRAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWL
ALAPLPTARAGAAAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGV
ATVERDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVL
GGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGPHNFYS
RPHFVNTVEMFDLEHGSWTKLPRSLRMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVE
SFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGGVAQGPSQAVEALCLRDGV
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells.
Uniprot ID
Q8IXV7
Ensemble ID
ENST00000332780.4
HGNC ID
HGNC:28557

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C20(1.15)  LDD3376  [1]
TFBX
 Probe Info  		C322(0.00); C320(0.00)  LDD0027  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C320(0.98); C322(0.98)  LDD0813  [3]
 LDCM0226  AC11 HEK-293T C320(0.93); C322(0.93)  LDD0824  [3]
 LDCM0237  AC12 HEK-293T C320(0.84); C322(0.84)  LDD0835  [3]
 LDCM0259  AC14 HEK-293T C320(0.87); C322(0.87)  LDD0857  [3]
 LDCM0270  AC15 HEK-293T C320(0.82); C322(0.82)  LDD0868  [3]
 LDCM0285  AC25 HEK-293T C320(0.96); C322(0.96)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C320(1.04); C322(1.04)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C320(0.95); C322(0.95)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C320(1.02); C322(1.02)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C320(0.88); C322(0.88)  LDD0887  [3]
 LDCM0291  AC30 HEK-293T C320(0.89); C322(0.89)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C320(0.91); C322(0.91)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C320(1.06); C322(1.06)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C320(0.90); C322(0.90)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C320(0.89); C322(0.89)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C320(0.95); C322(0.95)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C320(0.69); C322(0.69)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C320(1.04); C322(1.04)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C320(0.90); C322(0.90)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C320(1.43); C322(1.43)  LDD0898  [3]
 LDCM0302  AC40 HEK-293T C320(0.79); C322(0.79)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C320(1.00); C322(1.00)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C320(0.88); C322(0.88)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C320(0.85); C322(0.85)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C320(0.98); C322(0.98)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C320(1.01); C322(1.01)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C320(1.00); C322(1.00)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C320(0.88); C322(0.88)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C320(0.97); C322(0.97)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C320(0.87); C322(0.87)  LDD0909  [3]
 LDCM0313  AC50 HEK-293T C320(1.07); C322(1.07)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C320(1.15); C322(1.15)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C320(0.98); C322(0.98)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C320(0.96); C322(0.96)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C320(1.09); C322(1.09)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C320(1.12); C322(1.12)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C320(0.87); C322(0.87)  LDD0917  [3]
 LDCM0323  AC6 HEK-293T C320(0.90); C322(0.90)  LDD0921  [3]
 LDCM0334  AC7 HEK-293T C320(0.83); C322(0.83)  LDD0932  [3]
 LDCM0345  AC8 HEK-293T C320(0.73); C322(0.73)  LDD0943  [3]
 LDCM0248  AKOS034007472 HEK-293T C320(0.91); C322(0.91)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C320(0.82); C322(0.82)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C320(0.96); C322(0.96)  LDD0873  [3]
 LDCM0370  CL101 HEK-293T C320(1.02); C322(1.02)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C320(0.99); C322(0.99)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C320(0.77); C322(0.77)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C320(0.87); C322(0.87)  LDD0971  [3]
 LDCM0382  CL112 HEK-293T C320(1.10); C322(1.10)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C320(1.11); C322(1.11)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C320(1.03); C322(1.03)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C320(1.09); C322(1.09)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C320(0.98); C322(0.98)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C320(0.87); C322(0.87)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C320(0.93); C322(0.93)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C320(0.99); C322(0.99)  LDD0987  [3]
 LDCM0391  CL120 HEK-293T C320(0.97); C322(0.97)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C320(0.92); C322(0.92)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C320(1.08); C322(1.08)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C320(0.89); C322(0.89)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C320(0.97); C322(0.97)  LDD0993  [3]
 LDCM0436  CL46 HEK-293T C320(0.99); C322(0.99)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C320(0.95); C322(0.95)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C320(0.93); C322(0.93)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C320(1.01); C322(1.01)  LDD1037  [3]
 LDCM0441  CL50 HEK-293T C320(0.94); C322(0.94)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C320(1.18); C322(1.18)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C320(1.10); C322(1.10)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C320(0.87); C322(0.87)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C320(0.88); C322(0.88)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C320(0.82); C322(0.82)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C320(0.91); C322(0.91)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C320(1.10); C322(1.10)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C320(1.06); C322(1.06)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C320(0.99); C322(0.99)  LDD1048  [3]
 LDCM0452  CL60 HEK-293T C320(1.13); C322(1.13)  LDD1050  [3]
 LDCM0022  KB02 D283 Med C20(1.30)  LDD2312  [1]
 LDCM0023  KB03 D283 Med C20(1.24)  LDD2729  [1]
 LDCM0024  KB05 ONS-76 C20(1.15)  LDD3376  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.