Details of the Target

General Information of Target

Target ID LDTP07993
Target Name Magnesium transporter NIPA1 (NIPA1)
Gene Name NIPA1
Gene ID 123606
Synonyms
SPG6; Magnesium transporter NIPA1; Non-imprinted in Prader-Willi/Angelman syndrome region protein 1; Spastic paraplegia 6 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGTAAAAAAAAAAAAAGEGARSPSPAAVSLGLGVAVVSSLVNGSTFVLQKKGIVRAKRRG
TSYLTDIVWWAGTIAMAVGQIGNFLAYTAVPTVLVTPLGALGVPFGSILASYLLKEKLNI
LGKLGCLLSCAGSVVLIIHSPKSESVTTQAELEEKLTNPVFVGYLCIVLLMLLLLIFWIA
PAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDILHNNPSSQRALCLCLVLLAVLGCS
IIVQFRYINKALECFDSSVFGAIYYVVFTTLVLLASAILFREWSNVGLVDFLGMACGFTT
VSVGIVLIQVFKEFNFNLGEMNKSNMKTD
Target Bioclass
Transporter and channel
Family
NIPA family
Subcellular location
Cell membrane
Function Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Zn(2+) and Co(2+) but to a much less extent than Mg(2+).
Uniprot ID
Q7RTP0
Ensemble ID
ENST00000337435.9
HGNC ID
HGNC:17043

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FTC133 SNV: p.E18G .
HDMYZ SNV: p.E18G; p.A20G .
IM95 Deletion: p.K117SfsTer12 .
JEKO1 SNV: p.E18G .
LS123 SNV: p.T45A; p.K51N .
MEC1 SNV: p.A7S .
MOLT4 SNV: p.E18G .
NALM6 SNV: p.E18G; p.A100T .
REH SNV: p.E18G .
SKMEL3 SNV: p.T61I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C126(0.98); C130(0.98)  LDD1094  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 PaTu 8988t C126(0.98); C130(0.98)  LDD1094  [1]
 LDCM0216  AC100 PaTu 8988t C126(0.82); C130(0.82)  LDD1095  [1]
 LDCM0217  AC101 PaTu 8988t C126(0.88); C130(0.88)  LDD1096  [1]
 LDCM0218  AC102 PaTu 8988t C126(0.99); C130(0.99)  LDD1097  [1]
 LDCM0219  AC103 PaTu 8988t C126(0.89); C130(0.89)  LDD1098  [1]
 LDCM0220  AC104 PaTu 8988t C126(1.09); C130(1.09)  LDD1099  [1]
 LDCM0221  AC105 PaTu 8988t C126(0.99); C130(0.99)  LDD1100  [1]
 LDCM0222  AC106 PaTu 8988t C126(0.97); C130(0.97)  LDD1101  [1]
 LDCM0223  AC107 PaTu 8988t C126(1.08); C130(1.08)  LDD1102  [1]
 LDCM0224  AC108 PaTu 8988t C126(0.89); C130(0.89)  LDD1103  [1]
 LDCM0225  AC109 PaTu 8988t C126(0.90); C130(0.90)  LDD1104  [1]
 LDCM0226  AC11 PaTu 8988t C126(0.94); C130(0.94)  LDD1105  [1]
 LDCM0227  AC110 PaTu 8988t C126(0.86); C130(0.86)  LDD1106  [1]
 LDCM0228  AC111 PaTu 8988t C126(0.80); C130(0.80)  LDD1107  [1]
 LDCM0229  AC112 PaTu 8988t C126(0.88); C130(0.88)  LDD1108  [1]
 LDCM0230  AC113 PaTu 8988t C126(1.14); C130(1.14)  LDD1109  [1]
 LDCM0231  AC114 PaTu 8988t C126(1.22); C130(1.22)  LDD1110  [1]
 LDCM0232  AC115 PaTu 8988t C126(1.36); C130(1.36)  LDD1111  [1]
 LDCM0233  AC116 PaTu 8988t C126(1.02); C130(1.02)  LDD1112  [1]
 LDCM0234  AC117 PaTu 8988t C126(1.20); C130(1.20)  LDD1113  [1]
 LDCM0235  AC118 PaTu 8988t C126(0.91); C130(0.91)  LDD1114  [1]
 LDCM0236  AC119 PaTu 8988t C126(1.10); C130(1.10)  LDD1115  [1]
 LDCM0237  AC12 PaTu 8988t C126(0.96); C130(0.96)  LDD1116  [1]
 LDCM0238  AC120 PaTu 8988t C126(1.68); C130(1.68)  LDD1117  [1]
 LDCM0239  AC121 PaTu 8988t C126(1.56); C130(1.56)  LDD1118  [1]
 LDCM0240  AC122 PaTu 8988t C126(1.18); C130(1.18)  LDD1119  [1]
 LDCM0241  AC123 PaTu 8988t C126(1.04); C130(1.04)  LDD1120  [1]
 LDCM0242  AC124 PaTu 8988t C126(0.92); C130(0.92)  LDD1121  [1]
 LDCM0243  AC125 PaTu 8988t C126(0.87); C130(0.87)  LDD1122  [1]
 LDCM0244  AC126 PaTu 8988t C126(0.96); C130(0.96)  LDD1123  [1]
 LDCM0245  AC127 PaTu 8988t C126(1.13); C130(1.13)  LDD1124  [1]
 LDCM0246  AC128 PaTu 8988t C126(1.08); C130(1.08)  LDD1125  [1]
 LDCM0247  AC129 PaTu 8988t C126(0.95); C130(0.95)  LDD1126  [1]
 LDCM0249  AC130 PaTu 8988t C126(1.00); C130(1.00)  LDD1128  [1]
 LDCM0250  AC131 PaTu 8988t C126(1.06); C130(1.06)  LDD1129  [1]
 LDCM0251  AC132 PaTu 8988t C126(0.89); C130(0.89)  LDD1130  [1]
 LDCM0252  AC133 PaTu 8988t C126(1.06); C130(1.06)  LDD1131  [1]
 LDCM0253  AC134 PaTu 8988t C126(1.11); C130(1.11)  LDD1132  [1]
 LDCM0254  AC135 PaTu 8988t C126(1.07); C130(1.07)  LDD1133  [1]
 LDCM0255  AC136 PaTu 8988t C126(1.10); C130(1.10)  LDD1134  [1]
 LDCM0256  AC137 PaTu 8988t C126(1.19); C130(1.19)  LDD1135  [1]
 LDCM0257  AC138 PaTu 8988t C126(1.02); C130(1.02)  LDD1136  [1]
 LDCM0258  AC139 PaTu 8988t C126(1.07); C130(1.07)  LDD1137  [1]
 LDCM0259  AC14 PaTu 8988t C126(1.06); C130(1.06)  LDD1138  [1]
 LDCM0260  AC140 PaTu 8988t C126(0.98); C130(0.98)  LDD1139  [1]
 LDCM0261  AC141 PaTu 8988t C126(0.87); C130(0.87)  LDD1140  [1]
 LDCM0262  AC142 PaTu 8988t C126(1.12); C130(1.12)  LDD1141  [1]
 LDCM0263  AC143 PaTu 8988t C126(0.91); C130(0.91)  LDD1142  [1]
 LDCM0264  AC144 PaTu 8988t C126(1.02); C130(1.02)  LDD1143  [1]
 LDCM0265  AC145 PaTu 8988t C126(1.03); C130(1.03)  LDD1144  [1]
 LDCM0266  AC146 PaTu 8988t C126(1.12); C130(1.12)  LDD1145  [1]
 LDCM0267  AC147 PaTu 8988t C126(0.97); C130(0.97)  LDD1146  [1]
 LDCM0268  AC148 PaTu 8988t C126(1.04); C130(1.04)  LDD1147  [1]
 LDCM0269  AC149 PaTu 8988t C126(1.15); C130(1.15)  LDD1148  [1]
 LDCM0270  AC15 PaTu 8988t C126(0.99); C130(0.99)  LDD1149  [1]
 LDCM0271  AC150 PaTu 8988t C126(0.91); C130(0.91)  LDD1150  [1]
 LDCM0272  AC151 PaTu 8988t C126(1.10); C130(1.10)  LDD1151  [1]
 LDCM0273  AC152 PaTu 8988t C126(1.09); C130(1.09)  LDD1152  [1]
 LDCM0274  AC153 PaTu 8988t C126(1.15); C130(1.15)  LDD1153  [1]
 LDCM0621  AC154 PaTu 8988t C126(1.27); C130(1.27)  LDD2166  [1]
 LDCM0622  AC155 PaTu 8988t C126(1.00); C130(1.00)  LDD2167  [1]
 LDCM0623  AC156 PaTu 8988t C126(0.99); C130(0.99)  LDD2168  [1]
 LDCM0624  AC157 PaTu 8988t C126(1.39); C130(1.39)  LDD2169  [1]
 LDCM0277  AC18 HEK-293T C126(0.86)  LDD1516  [2]
 LDCM0279  AC2 HEK-293T C126(0.70)  LDD1518  [2]
 LDCM0286  AC26 HEK-293T C126(1.05)  LDD1525  [2]
 LDCM0295  AC34 HEK-293T C126(0.81)  LDD1534  [2]
 LDCM0304  AC42 HEK-293T C126(0.96)  LDD1543  [2]
 LDCM0313  AC50 HEK-293T C126(0.89)  LDD1552  [2]
 LDCM0321  AC58 HEK-293T C126(0.97)  LDD1560  [2]
 LDCM0323  AC6 PaTu 8988t C126(0.94); C130(0.94)  LDD1202  [1]
 LDCM0332  AC68 PaTu 8988t C126(1.10); C130(1.10)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C126(0.96); C130(0.96)  LDD1212  [1]
 LDCM0334  AC7 PaTu 8988t C126(1.09); C130(1.09)  LDD1213  [1]
 LDCM0335  AC70 PaTu 8988t C126(0.90); C130(0.90)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C126(1.03); C130(1.03)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C126(1.16); C130(1.16)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C126(1.03); C130(1.03)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C126(0.93); C130(0.93)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C126(0.91); C130(0.91)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C126(0.94); C130(0.94)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C126(0.89); C130(0.89)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C126(0.90); C130(0.90)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C126(0.96); C130(0.96)  LDD1223  [1]
 LDCM0345  AC8 PaTu 8988t C126(1.16); C130(1.16)  LDD1224  [1]
 LDCM0346  AC80 PaTu 8988t C126(0.84); C130(0.84)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C126(0.95); C130(0.95)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C126(1.06); C130(1.06)  LDD1227  [1]
 LDCM0349  AC83 PaTu 8988t C126(1.47); C130(1.47)  LDD1228  [1]
 LDCM0350  AC84 PaTu 8988t C126(1.66); C130(1.66)  LDD1229  [1]
 LDCM0351  AC85 PaTu 8988t C126(2.03); C130(2.03)  LDD1230  [1]
 LDCM0352  AC86 PaTu 8988t C126(1.70); C130(1.70)  LDD1231  [1]
 LDCM0353  AC87 PaTu 8988t C126(1.62); C130(1.62)  LDD1232  [1]
 LDCM0354  AC88 PaTu 8988t C126(1.70); C130(1.70)  LDD1233  [1]
 LDCM0355  AC89 PaTu 8988t C126(2.15); C130(2.15)  LDD1234  [1]
 LDCM0357  AC90 PaTu 8988t C126(1.86); C130(1.86)  LDD1236  [1]
 LDCM0358  AC91 PaTu 8988t C126(1.87); C130(1.87)  LDD1237  [1]
 LDCM0359  AC92 PaTu 8988t C126(1.81); C130(1.81)  LDD1238  [1]
 LDCM0360  AC93 PaTu 8988t C126(1.86); C130(1.86)  LDD1239  [1]
 LDCM0361  AC94 PaTu 8988t C126(1.50); C130(1.50)  LDD1240  [1]
 LDCM0362  AC95 PaTu 8988t C126(1.66); C130(1.66)  LDD1241  [1]
 LDCM0363  AC96 PaTu 8988t C126(1.50); C130(1.50)  LDD1242  [1]
 LDCM0364  AC97 PaTu 8988t C126(1.97); C130(1.97)  LDD1243  [1]
 LDCM0365  AC98 PaTu 8988t C126(0.84); C130(0.84)  LDD1244  [1]
 LDCM0366  AC99 PaTu 8988t C126(1.08); C130(1.08)  LDD1245  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C126(1.02); C130(1.02)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C126(1.36); C130(1.36)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C126(1.07); C130(1.07)  LDD1154  [1]
 LDCM0367  CL1 PaTu 8988t C126(0.88); C130(0.88)  LDD1246  [1]
 LDCM0368  CL10 PaTu 8988t C126(0.81); C130(0.81)  LDD1247  [1]
 LDCM0370  CL101 PaTu 8988t C126(0.98); C130(0.98)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C126(0.93); C130(0.93)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C126(0.90); C130(0.90)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C126(0.86); C130(0.86)  LDD1252  [1]
 LDCM0379  CL11 PaTu 8988t C126(0.77); C130(0.77)  LDD1258  [1]
 LDCM0390  CL12 PaTu 8988t C126(0.87); C130(0.87)  LDD1269  [1]
 LDCM0400  CL13 PaTu 8988t C126(1.01); C130(1.01)  LDD1279  [1]
 LDCM0401  CL14 PaTu 8988t C126(0.93); C130(0.93)  LDD1280  [1]
 LDCM0402  CL15 PaTu 8988t C126(0.76); C130(0.76)  LDD1281  [1]
 LDCM0405  CL18 HEK-293T C126(1.10)  LDD1609  [2]
 LDCM0407  CL2 PaTu 8988t C126(0.74); C130(0.74)  LDD1286  [1]
 LDCM0418  CL3 PaTu 8988t C126(0.59); C130(0.59)  LDD1297  [1]
 LDCM0419  CL30 HEK-293T C126(1.08)  LDD1623  [2]
 LDCM0429  CL4 PaTu 8988t C126(0.58); C130(0.58)  LDD1308  [1]
 LDCM0432  CL42 HEK-293T C126(0.89)  LDD1636  [2]
 LDCM0440  CL5 PaTu 8988t C126(0.87); C130(0.87)  LDD1319  [1]
 LDCM0445  CL54 HEK-293T C126(1.06)  LDD1648  [2]
 LDCM0451  CL6 PaTu 8988t C126(0.77); C130(0.77)  LDD1330  [1]
 LDCM0458  CL66 HEK-293T C126(0.96)  LDD1661  [2]
 LDCM0462  CL7 PaTu 8988t C126(0.94); C130(0.94)  LDD1341  [1]
 LDCM0469  CL76 PaTu 8988t C126(0.87); C130(0.87)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C126(0.68); C130(0.68)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C126(0.64); C130(0.64)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C126(0.68); C130(0.68)  LDD1351  [1]
 LDCM0473  CL8 PaTu 8988t C126(0.67); C130(0.67)  LDD1352  [1]
 LDCM0474  CL80 PaTu 8988t C126(0.52); C130(0.52)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C126(0.61); C130(0.61)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C126(0.71); C130(0.71)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C126(0.51); C130(0.51)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C126(0.72); C130(0.72)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C126(0.55); C130(0.55)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C126(0.60); C130(0.60)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C126(0.56); C130(0.56)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C126(0.54); C130(0.54)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C126(0.75); C130(0.75)  LDD1362  [1]
 LDCM0484  CL9 PaTu 8988t C126(0.87); C130(0.87)  LDD1363  [1]
 LDCM0485  CL90 PaTu 8988t C126(0.53); C130(0.53)  LDD1364  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Selenoprotein M (SELENOM) Selenoprotein M/F family Q8WWX9
Coiled-coil domain-containing protein 167 (CCDC167) . Q9P0B6

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402