Details of the Target

General Information of Target

Target ID LDTP07861
Target Name Bardet-Biedl syndrome 12 protein (BBS12)
Gene Name BBS12
Gene ID 166379
Synonyms
C4orf24; Bardet-Biedl syndrome 12 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVMACRVVNKRRHMGLQQLSSFAETGRTFLGPLKSSKFIIDEECHESVLISSTVRLLESL
DLTSAVGQLLNEAVQAQNNTYRTGISTLLFLVGAWSSAVEECLHLGVPISIIVSVMSEGL
NFCSEEVVSLHVPVHNIFDCMDSTKTFSQLETFSVSLCPFLQVPSDTDLIEELHGLKDVA
SQTLTISNLSGRPLKSYELFKPQTKVEADNNTSRTLKNSLLADTCCRQSILIHSRHFNRT
DNTEGVSKPDGFQEHVTATHKTYRCNDLVELAVGLSHGDHSSMKLVEEAVQLQYQNACVQ
QGNCTKPFMFDISRIFTCCLPGLPETSSCVCPGYITVVSVSNNPVIKELQNQPVRIVLIE
GDLTENYRHLGFNKSANIKTVLDSMRLQEDSSEELWANHVLQVLIQFKVNLVLVQGNVSE
RLIEKCINSKRLVIGSVNGSVMQAFAEAAGAVQVAYITQVNEDCVGDGVCVTFWRSSPLD
VVDRNNRIAILLKTEGINLVTAVLTNPVTAQMQIKEDRFWTCAYRLYYALKEEKVFLGGG
AVEFLCLSCLHILAEQSLKKENHACSGWLHNTSSWLASSLAIYRPTVLKFLANGWQKYLS
TLLYNTANYSSEFEASTYIQHHLQNATDSGSPSSYILNEYSKLNSRIFNSDISNKLEQIP
RVYDVVTPKIEAWRRALDLVLLVLQTDSEIITGHGHTQINSQELTGFLFL
Target Bioclass
Other
Family
TCP-1 chaperonin family, BBS12 subfamily
Subcellular location
Cell projection, cilium
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation.
Uniprot ID
Q6ZW61
Ensemble ID
ENST00000314218.8
HGNC ID
HGNC:26648

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C426(0.89)  LDD2090  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C426(0.44)  LDD2142  [1]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C426(0.87)  LDD2112  [1]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C426(1.27)  LDD2103  [1]
 LDCM0520  AKOS000195272 MDA-MB-231 C426(1.13)  LDD2113  [1]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C426(0.85)  LDD2102  [1]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C426(0.89)  LDD2090  [1]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C426(1.00)  LDD2092  [1]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C426(1.60)  LDD2094  [1]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C426(1.95)  LDD2096  [1]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C426(1.63)  LDD2098  [1]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C426(0.56)  LDD2100  [1]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C426(0.67)  LDD2101  [1]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C426(0.42)  LDD2104  [1]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C426(1.38)  LDD2105  [1]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C426(0.30)  LDD2106  [1]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C426(0.47)  LDD2110  [1]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C426(0.47)  LDD2114  [1]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C426(2.50)  LDD2116  [1]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C426(2.28)  LDD2118  [1]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C426(4.65)  LDD2122  [1]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C426(3.80)  LDD2124  [1]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C426(3.42)  LDD2126  [1]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C426(0.69)  LDD2141  [1]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C426(0.19)  LDD2145  [1]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C426(5.80)  LDD2149  [1]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C426(2.25)  LDD2151  [1]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C426(3.16)  LDD2153  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bardet-Biedl syndrome 7 protein (BBS7) . Q8IWZ6
Protein PTHB1 (BBS9) . Q3SYG4
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bardet-Biedl syndrome 10 protein (BBS10) TCP-1 chaperonin family Q8TAM1
Molecular chaperone MKKS (MKKS) TCP-1 chaperonin family Q9NPJ1

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761