Details of the Target

General Information of Target

Target ID LDTP07826
Target Name Major facilitator superfamily domain-containing protein 6 (MFSD6)
Gene Name MFSD6
Gene ID 54842
Synonyms
MMR2; Major facilitator superfamily domain-containing protein 6; Macrophage MHC class I receptor 2 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADDKVAILTDDEEEQKRKYVLADPFNGISREPEPPSNETPSSTETSAIPEEEIDWIEKH
CVKINNDLLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPF
WGVVADRFKKGKIVLLFSLLCWVLFNLGIGFVKPATLRCVPKIRPTTHPTNASHQLTILP
TNSSFTSFLTISPKMREKRNLLETRLNVSDTVTLPTAPNMNSEPTLQPQTGEITNRMMDL
TLNSSTATPVSPGSVTKETTTVIVTTTKSLPSDQVMLVYDQQEVEAIFLVILVVVIIGEF
FSASSVTIVDTVTLQYLGKHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIEVLIDGKGC
KPPEYRNYQIVFIVFGVLMTMALIVATQFRFRYNHFKNDDSKGKEVEIPQVERNNSTESS
EETPTTTSHSQAFNFWDLIKLLCSVQYGSVLFVAWFMGFGYGFVFTFLYWHLEDLNGTTT
LFGVCSVLSHVSELTAYFFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPME
VLQGVTHAAIWAACISYLSAAVPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAA
ATFRGIGMACLVILLLFALIQWLAVPDEEEDKTMLAERIPVPSSPVPIATIDLVQQQTED
VMPRIEPRLPPKKTKHQEEQEDVNKPAWGVSSSPWVTFVYALYQIKEMMQLTRDNRASEI
QPLQGTNENRENSPAGRAQPVPCETHSDPSRNQPSPDAAASQTQTSPAHPSVDPCTEESE
EQQAQLAAGGH
Target Bioclass
Transporter and channel
Family
Major facilitator superfamily, MFSD6 family
Subcellular location
Membrane
Uniprot ID
Q6ZSS7
Ensemble ID
ENST00000281416.11
HGNC ID
HGNC:24711

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C743(3.99)  LDD0168  [1]
IPM
 Probe Info  		C743(2.74)  LDD1701  [2]
DBIA
 Probe Info  		C743(1.15)  LDD1507  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C743(3.99)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C743(8.52)  LDD0169  [1]
 LDCM0214  AC1 HEK-293T C743(1.15)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C743(0.93)  LDD1508  [3]
 LDCM0237  AC12 HEK-293T C743(1.00)  LDD1510  [3]
 LDCM0270  AC15 HEK-293T C743(1.13)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C743(0.90)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C743(0.91)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C743(1.23)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C743(0.98)  LDD1519  [3]
 LDCM0283  AC23 HEK-293T C743(0.72)  LDD1522  [3]
 LDCM0285  AC25 HEK-293T C743(0.98)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C743(0.95)  LDD1525  [3]
 LDCM0288  AC28 HEK-293T C743(0.68)  LDD1527  [3]
 LDCM0292  AC31 HEK-293T C743(0.94)  LDD1531  [3]
 LDCM0294  AC33 HEK-293T C743(1.01)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C743(1.14)  LDD1534  [3]
 LDCM0297  AC36 HEK-293T C743(0.77)  LDD1536  [3]
 LDCM0300  AC39 HEK-293T C743(1.10)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C743(0.99)  LDD1540  [3]
 LDCM0303  AC41 HEK-293T C743(1.13)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C743(1.02)  LDD1543  [3]
 LDCM0306  AC44 HEK-293T C743(0.84)  LDD1545  [3]
 LDCM0309  AC47 HEK-293T C743(1.13)  LDD1548  [3]
 LDCM0311  AC49 HEK-293T C743(1.07)  LDD1550  [3]
 LDCM0313  AC50 HEK-293T C743(1.03)  LDD1552  [3]
 LDCM0315  AC52 HEK-293T C743(0.73)  LDD1554  [3]
 LDCM0318  AC55 HEK-293T C743(0.88)  LDD1557  [3]
 LDCM0320  AC57 HEK-293T C743(1.11)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C743(1.05)  LDD1560  [3]
 LDCM0324  AC60 HEK-293T C743(0.74)  LDD1563  [3]
 LDCM0327  AC63 HEK-293T C743(0.77)  LDD1566  [3]
 LDCM0334  AC7 HEK-293T C743(0.99)  LDD1568  [3]
 LDCM0356  AKOS034007680 HEK-293T C743(1.05)  LDD1570  [3]
 LDCM0367  CL1 HEK-293T C743(1.29)  LDD1571  [3]
 LDCM0369  CL100 HEK-293T C743(0.84)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C743(1.53)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C743(0.95)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C743(0.98)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C743(0.92)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C743(1.05)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C743(0.93)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C743(1.11)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C743(1.13)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C743(0.87)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C743(1.24)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C743(0.85)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C743(1.09)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C743(1.02)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C743(1.38)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C743(0.89)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C743(1.15)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C743(0.94)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C743(1.45)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C743(0.99)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C743(1.23)  LDD1593  [3]
 LDCM0391  CL120 HEK-293T C743(0.85)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C743(0.94)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C743(0.70)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C743(1.28)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C743(1.29)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C743(1.07)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C743(0.82)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C743(1.05)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C743(0.90)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C743(1.63)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C743(0.77)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C743(0.93)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C743(1.11)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C743(1.04)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C743(1.46)  LDD1609  [3]
 LDCM0407  CL2 HEK-293T C743(0.86)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C743(1.14)  LDD1612  [3]
 LDCM0411  CL23 HEK-293T C743(1.06)  LDD1615  [3]
 LDCM0413  CL25 HEK-293T C743(0.93)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C743(0.80)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C743(1.15)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C743(0.85)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C743(1.05)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C743(1.18)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C743(1.16)  LDD1623  [3]
 LDCM0421  CL32 HEK-293T C743(0.90)  LDD1625  [3]
 LDCM0424  CL35 HEK-293T C743(0.91)  LDD1628  [3]
 LDCM0426  CL37 HEK-293T C743(0.97)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C743(1.01)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C743(0.77)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C743(0.90)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C743(0.93)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C743(1.01)  LDD1636  [3]
 LDCM0434  CL44 HEK-293T C743(1.05)  LDD1638  [3]
 LDCM0437  CL47 HEK-293T C743(1.01)  LDD1641  [3]
 LDCM0439  CL49 HEK-293T C743(1.04)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C743(1.19)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C743(0.66)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C743(0.94)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C743(1.10)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C743(0.97)  LDD1648  [3]
 LDCM0447  CL56 HEK-293T C743(0.80)  LDD1650  [3]
 LDCM0450  CL59 HEK-293T C743(0.70)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C743(1.38)  LDD1654  [3]
 LDCM0453  CL61 HEK-293T C743(1.00)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C743(0.88)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C743(1.12)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C743(0.74)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C743(1.14)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C743(1.05)  LDD1661  [3]
 LDCM0460  CL68 HEK-293T C743(0.78)  LDD1663  [3]
 LDCM0464  CL71 HEK-293T C743(0.85)  LDD1667  [3]
 LDCM0466  CL73 HEK-293T C743(1.29)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C743(0.67)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C743(0.89)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C743(0.96)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C743(1.05)  LDD1674  [3]
 LDCM0473  CL8 HEK-293T C743(0.79)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C743(0.87)  LDD1677  [3]
 LDCM0477  CL83 HEK-293T C743(0.95)  LDD1680  [3]
 LDCM0479  CL85 HEK-293T C743(1.08)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C743(0.96)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C743(1.11)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C743(0.89)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C743(1.06)  LDD1686  [3]
 LDCM0485  CL90 HEK-293T C743(0.82)  LDD1688  [3]
 LDCM0487  CL92 HEK-293T C743(0.94)  LDD1690  [3]
 LDCM0490  CL95 HEK-293T C743(0.91)  LDD1693  [3]
 LDCM0492  CL97 HEK-293T C743(1.37)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C743(0.90)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C743(1.50)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C743(1.25)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C743(1.13)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C743(0.67)  LDD1631  [3]
 LDCM0023  KB03 MDA-MB-231 C743(2.74)  LDD1701  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (ALG8) ALG6/ALG8 glucosyltransferase family Q9BVK2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
NADH-cytochrome b5 reductase 3 (CYB5R3) Flavoprotein pyridine nucleotide cytochrome reductase family P00387
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Sphingosine-1-phosphate lyase 1 (SGPL1) Group II decarboxylase family O95470
Transporter and channel
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-secretase subunit APH-1A (APH1A) APH-1 family Q96BI3
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Synapse differentiation-inducing gene protein 1 (SYNDIG1) CD225/Dispanin family Q9H7V2
Gap junction alpha-8 protein (GJA8) Connexin family P48165
Gap junction beta-2 protein (GJB2) Connexin family P29033
Sodium-dependent glucose transporter 1 (MFSD4B) Major facilitator superfamily Q5TF39
Transmembrane protein 258 (TMEM258) OST5 family P61165
Small integral membrane protein 1 (SMIM1) SMIM1 family B2RUZ4
Transmembrane protein 179B (TMEM179B) TMEM179 family Q7Z7N9
Transmembrane protein 242 (TMEM242) TMEM242 family Q9NWH2
Translocator protein 2 (TSPO2) TspO/BZRP family Q5TGU0
Zinc transporter ZIP2 (SLC39A2) ZIP transporter (TC 2.A.5) family Q9NP94
Adiponectin (ADIPOQ) . Q15848
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor 42 (GPR42) G-protein coupled receptor 1 family O15529
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Programmed cell death 1 ligand 2 (PDCD1LG2) BTN/MOG family Q9BQ51
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein NKG7 (NKG7) PMP-22/EMP/MP20 family Q16617
Selenoprotein K (SELENOK) Selenoprotein K family Q9Y6D0
Protein shisa-like-1 (SHISAL1) Shisa family Q3SXP7
Syntaxin-12 (STX12) Syntaxin family Q86Y82
Lymphocyte antigen 6E (LY6E) . Q16553
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3
Uncharacterized protein C19orf18 (C19orf18) . Q8NEA5

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264