Details of the Target

General Information of Target

Target ID LDTP07782
Target Name RNA-binding protein MEX3B (MEX3B)
Gene Name MEX3B
Gene ID 84206
Synonyms
KIAA2009; RKHD3; RNF195; RNA-binding protein MEX3B; RING finger and KH domain-containing protein 3; RING finger protein 195
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPSSLFADLERNGSGGGGGGSSGGGETLDDQRALQLALDQLSLLGLDSDEGASLYDSEPR
KKSVNMTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFVVTGRKEDV
AMARREIISAAEHFSMIRASRNKNTALNGAVPGPPNLPGQTTIQVRVPYRVVGLVVGPKG
ATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEAHIALRTGGIIELTDEND
FHANGTDVGFDLHHGSGGSGPGSLWSKPTPSITPTPGRKPFSSYRNDSSSSLGSASTDSY
FGGGTSSSAAATQRLADYSPPSPALSFAHNGNNNNNGNGYTYTAGGEASVPSPDGCPELQ
PTFDPAPAPPPGAPLIWAQFERSPGGGPAAPVSSSCSSSASSSASSSSVVFPGGGASAPS
NANLGLLVHRRLHPGTSCPRLSPPLHMAPGAGEHHLARRVRSDPGGGGLAYAAYANGLGA
QLPGLQPSDTSGSSSSSSSSSSSSSSSSGLRRKGSRDCSVCFESEVIAALVPCGHNLFCM
ECANRICEKSEPECPVCHTAVTQAIRIFS
Target Bioclass
Other
Subcellular location
Nucleus
Function RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.
Uniprot ID
Q6ZN04
Ensemble ID
ENST00000329713.5
HGNC ID
HGNC:25297

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO320 SNV: p.N332D .
GB1 SNV: p.R314C .
HEC1B SNV: p.A243T .
HT SNV: p.Y471N .
HT115 SNV: p.R105C .
HT1197 SNV: p.I81V .
NCIH1793 SNV: p.Q188P .
OV90 SNV: p.R461C .
RKO Deletion: p.G346EfsTer181 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C69(3.12)  LDD0168  [1]
DBIA
 Probe Info  		C69(1.28); C438(0.97)  LDD1492  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C69(3.12)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C69(3.41)  LDD0169  [1]
 LDCM0214  AC1 HEK-293T C438(1.12)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C438(0.98)  LDD1508  [2]
 LDCM0237  AC12 HEK-293T C438(1.08)  LDD1510  [2]
 LDCM0276  AC17 HEK-293T C438(0.97)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C438(0.92)  LDD1516  [2]
 LDCM0279  AC2 HEK-293T C438(0.87)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C438(1.04)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C438(1.15)  LDD1520  [2]
 LDCM0284  AC24 HEK-293T C438(0.95)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C438(0.96)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C438(0.88)  LDD1525  [2]
 LDCM0288  AC28 HEK-293T C438(0.99)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C438(1.18)  LDD1528  [2]
 LDCM0293  AC32 HEK-293T C438(0.86)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C438(0.98)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C438(0.96)  LDD1534  [2]
 LDCM0297  AC36 HEK-293T C438(1.06)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C438(1.12)  LDD1537  [2]
 LDCM0301  AC4 HEK-293T C438(1.02)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C438(0.86)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C438(1.06)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C438(0.90)  LDD1543  [2]
 LDCM0306  AC44 HEK-293T C438(1.07)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C438(1.21)  LDD1546  [2]
 LDCM0310  AC48 HEK-293T C438(0.89)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C438(0.92)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C438(1.06)  LDD1551  [2]
 LDCM0313  AC50 HEK-293T C438(1.00)  LDD1552  [2]
 LDCM0315  AC52 HEK-293T C438(1.07)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C438(1.20)  LDD1555  [2]
 LDCM0319  AC56 HEK-293T C438(0.97)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C438(0.95)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C438(0.91)  LDD1560  [2]
 LDCM0324  AC60 HEK-293T C438(0.94)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C438(1.05)  LDD1564  [2]
 LDCM0328  AC64 HEK-293T C438(0.94)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C438(0.88)  LDD1569  [2]
 LDCM0248  AKOS034007472 HEK-293T C438(1.02)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C438(0.92)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C438(0.94)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C438(0.94)  LDD1571  [2]
 LDCM0370  CL101 HEK-293T C438(1.03)  LDD1574  [2]
 LDCM0374  CL105 HEK-293T C438(1.16)  LDD1578  [2]
 LDCM0378  CL109 HEK-293T C438(1.00)  LDD1582  [2]
 LDCM0383  CL113 HEK-293T C438(1.01)  LDD1587  [2]
 LDCM0387  CL117 HEK-293T C438(1.08)  LDD1591  [2]
 LDCM0390  CL12 HEK-293T C438(1.03)  LDD1594  [2]
 LDCM0392  CL121 HEK-293T C438(0.97)  LDD1596  [2]
 LDCM0396  CL125 HEK-293T C438(0.88)  LDD1600  [2]
 LDCM0400  CL13 HEK-293T C438(1.03)  LDD1604  [2]
 LDCM0404  CL17 HEK-293T C438(1.19)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C438(0.88)  LDD1609  [2]
 LDCM0408  CL20 HEK-293T C438(1.19)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C438(1.56)  LDD1613  [2]
 LDCM0412  CL24 HEK-293T C438(1.20)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C438(1.02)  LDD1617  [2]
 LDCM0417  CL29 HEK-293T C438(0.95)  LDD1621  [2]
 LDCM0419  CL30 HEK-293T C438(0.82)  LDD1623  [2]
 LDCM0421  CL32 HEK-293T C438(1.16)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C438(1.39)  LDD1626  [2]
 LDCM0425  CL36 HEK-293T C438(1.26)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C438(0.91)  LDD1630  [2]
 LDCM0431  CL41 HEK-293T C438(1.07)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C438(1.22)  LDD1636  [2]
 LDCM0434  CL44 HEK-293T C438(1.18)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C438(1.37)  LDD1639  [2]
 LDCM0438  CL48 HEK-293T C438(1.34)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C438(0.93)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C438(0.99)  LDD1644  [2]
 LDCM0444  CL53 HEK-293T C438(1.07)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C438(0.96)  LDD1648  [2]
 LDCM0447  CL56 HEK-293T C438(1.23)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C438(1.53)  LDD1651  [2]
 LDCM0451  CL6 HEK-293T C438(0.87)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C438(1.17)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C438(0.94)  LDD1656  [2]
 LDCM0457  CL65 HEK-293T C438(1.19)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C438(0.98)  LDD1661  [2]
 LDCM0460  CL68 HEK-293T C438(1.17)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C438(1.40)  LDD1664  [2]
 LDCM0465  CL72 HEK-293T C438(1.14)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C438(0.92)  LDD1669  [2]
 LDCM0470  CL77 HEK-293T C438(0.96)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C438(0.99)  LDD1674  [2]
 LDCM0473  CL8 HEK-293T C438(1.10)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C438(1.23)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C438(1.41)  LDD1678  [2]
 LDCM0478  CL84 HEK-293T C438(1.12)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C438(0.93)  LDD1682  [2]
 LDCM0483  CL89 HEK-293T C438(1.10)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C438(1.28)  LDD1687  [2]
 LDCM0485  CL90 HEK-293T C438(1.09)  LDD1688  [2]
 LDCM0487  CL92 HEK-293T C438(1.13)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C438(1.28)  LDD1691  [2]
 LDCM0491  CL96 HEK-293T C438(1.00)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C438(0.99)  LDD1695  [2]
 LDCM0022  KB02 HEK-293T C69(1.28); C438(0.97)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C69(1.07); C438(1.04)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C69(1.35); C438(0.93)  LDD1502  [2]

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004