Details of the Target
General Information of Target
Target ID | LDTP07432 | |||||
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Target Name | Mitochondrial sodium/calcium exchanger protein (SLC8B1) | |||||
Gene Name | SLC8B1 | |||||
Gene ID | 80024 | |||||
Synonyms |
NCKX6; NCLX; SLC24A6; Mitochondrial sodium/calcium exchanger protein; Na(+)/K(+)/Ca(2+)-exchange protein 6; Sodium/calcium exchanger protein, mitochondrial; Sodium/potassium/calcium exchanger 6; Solute carrier family 24 member 6; Solute carrier family 8 member B1
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3D Structure | ||||||
Sequence |
MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLN
VSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAK FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVL VTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFY VVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNC LHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWL FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR QGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVF SLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM |
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Target Type |
Literature-reported
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Target Bioclass |
Transporter and channel
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Family |
Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC24A subfamily
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Subcellular location |
Mitochondrion inner membrane
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Function |
Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion. Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes. Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses. Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity. Involved in B-lymphocyte chemotaxis. Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+).
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TTD ID | ||||||
Uniprot ID | ||||||
DrugMap ID | ||||||
Ensemble ID | ||||||
HGNC ID | ||||||
ChEMBL ID |
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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DBIA Probe Info |
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C123(0.97) | LDD1509 | [1] |
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
---|---|---|---|---|---|
LDCM0226 | AC11 | HEK-293T | C123(0.97) | LDD1509 | [1] |
LDCM0259 | AC14 | HEK-293T | C123(0.97) | LDD1512 | [1] |
LDCM0278 | AC19 | HEK-293T | C123(0.91) | LDD1517 | [1] |
LDCM0281 | AC21 | HEK-293T | C123(1.09) | LDD1520 | [1] |
LDCM0282 | AC22 | HEK-293T | C123(1.02) | LDD1521 | [1] |
LDCM0284 | AC24 | HEK-293T | C123(0.81) | LDD1523 | [1] |
LDCM0287 | AC27 | HEK-293T | C123(0.89) | LDD1526 | [1] |
LDCM0289 | AC29 | HEK-293T | C123(1.06) | LDD1528 | [1] |
LDCM0290 | AC3 | HEK-293T | C123(0.77) | LDD1529 | [1] |
LDCM0291 | AC30 | HEK-293T | C123(0.93) | LDD1530 | [1] |
LDCM0293 | AC32 | HEK-293T | C123(0.86) | LDD1532 | [1] |
LDCM0296 | AC35 | HEK-293T | C123(0.92) | LDD1535 | [1] |
LDCM0298 | AC37 | HEK-293T | C123(0.83) | LDD1537 | [1] |
LDCM0299 | AC38 | HEK-293T | C123(0.83) | LDD1538 | [1] |
LDCM0302 | AC40 | HEK-293T | C123(1.05) | LDD1541 | [1] |
LDCM0305 | AC43 | HEK-293T | C123(0.86) | LDD1544 | [1] |
LDCM0307 | AC45 | HEK-293T | C123(1.07) | LDD1546 | [1] |
LDCM0308 | AC46 | HEK-293T | C123(1.32) | LDD1547 | [1] |
LDCM0310 | AC48 | HEK-293T | C123(0.98) | LDD1549 | [1] |
LDCM0312 | AC5 | HEK-293T | C123(0.92) | LDD1551 | [1] |
LDCM0314 | AC51 | HEK-293T | C123(0.95) | LDD1553 | [1] |
LDCM0316 | AC53 | HEK-293T | C123(1.08) | LDD1555 | [1] |
LDCM0317 | AC54 | HEK-293T | C123(1.12) | LDD1556 | [1] |
LDCM0319 | AC56 | HEK-293T | C123(1.03) | LDD1558 | [1] |
LDCM0322 | AC59 | HEK-293T | C123(0.90) | LDD1561 | [1] |
LDCM0323 | AC6 | HEK-293T | C123(1.11) | LDD1562 | [1] |
LDCM0325 | AC61 | HEK-293T | C123(0.99) | LDD1564 | [1] |
LDCM0326 | AC62 | HEK-293T | C123(1.10) | LDD1565 | [1] |
LDCM0328 | AC64 | HEK-293T | C123(0.99) | LDD1567 | [1] |
LDCM0345 | AC8 | HEK-293T | C123(1.09) | LDD1569 | [1] |
LDCM0248 | AKOS034007472 | HEK-293T | C123(0.85) | LDD1511 | [1] |
LDCM0275 | AKOS034007705 | HEK-293T | C123(0.95) | LDD1514 | [1] |
LDCM0367 | CL1 | HEK-293T | C123(1.17) | LDD1571 | [1] |
LDCM0368 | CL10 | HEK-293T | C123(3.85) | LDD1572 | [1] |
LDCM0369 | CL100 | HEK-293T | C123(0.99) | LDD1573 | [1] |
LDCM0370 | CL101 | HEK-293T | C123(1.03) | LDD1574 | [1] |
LDCM0371 | CL102 | HEK-293T | C123(1.18) | LDD1575 | [1] |
LDCM0373 | CL104 | HEK-293T | C123(1.04) | LDD1577 | [1] |
LDCM0374 | CL105 | HEK-293T | C123(1.05) | LDD1578 | [1] |
LDCM0375 | CL106 | HEK-293T | C123(0.93) | LDD1579 | [1] |
LDCM0377 | CL108 | HEK-293T | C123(0.87) | LDD1581 | [1] |
LDCM0378 | CL109 | HEK-293T | C123(1.33) | LDD1582 | [1] |
LDCM0380 | CL110 | HEK-293T | C123(1.06) | LDD1584 | [1] |
LDCM0382 | CL112 | HEK-293T | C123(0.83) | LDD1586 | [1] |
LDCM0383 | CL113 | HEK-293T | C123(1.68) | LDD1587 | [1] |
LDCM0384 | CL114 | HEK-293T | C123(0.97) | LDD1588 | [1] |
LDCM0386 | CL116 | HEK-293T | C123(0.78) | LDD1590 | [1] |
LDCM0387 | CL117 | HEK-293T | C123(0.92) | LDD1591 | [1] |
LDCM0388 | CL118 | HEK-293T | C123(0.89) | LDD1592 | [1] |
LDCM0390 | CL12 | HEK-293T | C123(0.97) | LDD1594 | [1] |
LDCM0391 | CL120 | HEK-293T | C123(0.77) | LDD1595 | [1] |
LDCM0392 | CL121 | HEK-293T | C123(1.18) | LDD1596 | [1] |
LDCM0393 | CL122 | HEK-293T | C123(1.08) | LDD1597 | [1] |
LDCM0395 | CL124 | HEK-293T | C123(1.06) | LDD1599 | [1] |
LDCM0396 | CL125 | HEK-293T | C123(1.32) | LDD1600 | [1] |
LDCM0397 | CL126 | HEK-293T | C123(0.93) | LDD1601 | [1] |
LDCM0399 | CL128 | HEK-293T | C123(1.13) | LDD1603 | [1] |
LDCM0400 | CL13 | HEK-293T | C123(1.01) | LDD1604 | [1] |
LDCM0401 | CL14 | HEK-293T | C123(0.76) | LDD1605 | [1] |
LDCM0403 | CL16 | HEK-293T | C123(0.83) | LDD1607 | [1] |
LDCM0406 | CL19 | HEK-293T | C123(0.98) | LDD1610 | [1] |
LDCM0407 | CL2 | HEK-293T | C123(0.93) | LDD1611 | [1] |
LDCM0409 | CL21 | HEK-293T | C123(1.35) | LDD1613 | [1] |
LDCM0410 | CL22 | HEK-293T | C123(1.28) | LDD1614 | [1] |
LDCM0412 | CL24 | HEK-293T | C123(0.99) | LDD1616 | [1] |
LDCM0413 | CL25 | HEK-293T | C123(1.32) | LDD1617 | [1] |
LDCM0414 | CL26 | HEK-293T | C123(0.89) | LDD1618 | [1] |
LDCM0416 | CL28 | HEK-293T | C123(0.61) | LDD1620 | [1] |
LDCM0420 | CL31 | HEK-293T | C123(1.00) | LDD1624 | [1] |
LDCM0422 | CL33 | HEK-293T | C123(5.33) | LDD1626 | [1] |
LDCM0423 | CL34 | HEK-293T | C123(1.16) | LDD1627 | [1] |
LDCM0425 | CL36 | HEK-293T | C123(0.96) | LDD1629 | [1] |
LDCM0426 | CL37 | HEK-293T | C123(1.22) | LDD1630 | [1] |
LDCM0429 | CL4 | HEK-293T | C123(1.24) | LDD1633 | [1] |
LDCM0430 | CL40 | HEK-293T | C123(0.88) | LDD1634 | [1] |
LDCM0433 | CL43 | HEK-293T | C123(0.98) | LDD1637 | [1] |
LDCM0435 | CL45 | HEK-293T | C123(1.18) | LDD1639 | [1] |
LDCM0436 | CL46 | HEK-293T | C123(1.20) | LDD1640 | [1] |
LDCM0438 | CL48 | HEK-293T | C123(0.98) | LDD1642 | [1] |
LDCM0439 | CL49 | HEK-293T | C123(0.97) | LDD1643 | [1] |
LDCM0441 | CL50 | HEK-293T | C123(1.02) | LDD1645 | [1] |
LDCM0443 | CL52 | HEK-293T | C123(0.99) | LDD1646 | [1] |
LDCM0446 | CL55 | HEK-293T | C123(0.71) | LDD1649 | [1] |
LDCM0448 | CL57 | HEK-293T | C123(1.88) | LDD1651 | [1] |
LDCM0449 | CL58 | HEK-293T | C123(0.98) | LDD1652 | [1] |
LDCM0452 | CL60 | HEK-293T | C123(1.12) | LDD1655 | [1] |
LDCM0453 | CL61 | HEK-293T | C123(1.03) | LDD1656 | [1] |
LDCM0454 | CL62 | HEK-293T | C123(0.74) | LDD1657 | [1] |
LDCM0456 | CL64 | HEK-293T | C123(0.93) | LDD1659 | [1] |
LDCM0459 | CL67 | HEK-293T | C123(0.77) | LDD1662 | [1] |
LDCM0461 | CL69 | HEK-293T | C123(1.04) | LDD1664 | [1] |
LDCM0462 | CL7 | HEK-293T | C123(1.12) | LDD1665 | [1] |
LDCM0463 | CL70 | HEK-293T | C123(1.08) | LDD1666 | [1] |
LDCM0465 | CL72 | HEK-293T | C123(1.13) | LDD1668 | [1] |
LDCM0466 | CL73 | HEK-293T | C123(1.05) | LDD1669 | [1] |
LDCM0467 | CL74 | HEK-293T | C123(0.81) | LDD1670 | [1] |
LDCM0469 | CL76 | HEK-293T | C123(0.73) | LDD1672 | [1] |
LDCM0472 | CL79 | HEK-293T | C123(0.86) | LDD1675 | [1] |
LDCM0475 | CL81 | HEK-293T | C123(0.93) | LDD1678 | [1] |
LDCM0476 | CL82 | HEK-293T | C123(1.27) | LDD1679 | [1] |
LDCM0478 | CL84 | HEK-293T | C123(1.68) | LDD1681 | [1] |
LDCM0479 | CL85 | HEK-293T | C123(0.84) | LDD1682 | [1] |
LDCM0480 | CL86 | HEK-293T | C123(0.98) | LDD1683 | [1] |
LDCM0482 | CL88 | HEK-293T | C123(0.93) | LDD1685 | [1] |
LDCM0484 | CL9 | HEK-293T | C123(1.15) | LDD1687 | [1] |
LDCM0486 | CL91 | HEK-293T | C123(0.75) | LDD1689 | [1] |
LDCM0488 | CL93 | HEK-293T | C123(1.32) | LDD1691 | [1] |
LDCM0489 | CL94 | HEK-293T | C123(1.41) | LDD1692 | [1] |
LDCM0491 | CL96 | HEK-293T | C123(1.04) | LDD1694 | [1] |
LDCM0492 | CL97 | HEK-293T | C123(1.30) | LDD1695 | [1] |
LDCM0493 | CL98 | HEK-293T | C123(0.80) | LDD1696 | [1] |
LDCM0427 | Fragment51 | HEK-293T | C123(0.85) | LDD1631 | [1] |