Details of the Target

General Information of Target

Target ID LDTP07381
Target Name Vasorin (VASN)
Gene Name VASN
Gene ID 114990
Synonyms
SLITL2; Vasorin; Protein slit-like 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCSRVPLLLPLLLLLALGPGVQGCPSGCQCSQPQTVFCTARQGTTVPRDVPPDTVGLYVF
ENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETF
RGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLRLPRLLLLDLSHNS
LLALEPGILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPPVIRGLRG
LTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPF
NCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCPATTTTATVPT
TRPVVREPTALSSSLAPTWLSPTEPATEAPSPPSTAPPTVGPVPQPQDCPPSTCLNGGTC
HLGTRHHLACLCPEGFTGLYCESQMGQGTRPSPTPVTPRPPRSLTLGIEPVSPTSLRVGL
QRYLQGSSVQLRSLRLTYRNLSGPDKRLVTLRLPASLAEYTVTQLRPNATYSVCVMPLGP
GRVPEGEEACGEAHTPPAVHSNHAPVTQAREGNLPLLIAPALAAVLLAALAAVGAAYCVR
RGRAMAAAAQDKGQVGPGAGPLELEGVKVPLEPGPKATEGGGEALPSGSECEVPLMGFPG
PGLQSPLHAKPYI
Target Bioclass
Other
Subcellular location
Membrane
Function May act as an inhibitor of TGF-beta signaling.
Uniprot ID
Q6EMK4
Ensemble ID
ENST00000304735.4
HGNC ID
HGNC:18517

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K154(1.64); K333(1.84); K133(4.74); K506(5.10)  LDD3494  [1]
NAIA_5
 Probe Info  		C651(20.00)  LDD2227  [2]
Acrolein
 Probe Info  		N.A.  LDD0223  [3]
DBIA
 Probe Info  		C304(1.06)  LDD1095  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0216  AC100 PaTu 8988t C304(1.06)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C304(1.09)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C304(0.86)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C304(0.79)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C304(0.93)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C304(1.08)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C304(1.19)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C304(1.09)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C304(1.15)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C304(1.13)  LDD1104  [4]
 LDCM0227  AC110 PaTu 8988t C304(1.17)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C304(1.29)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C304(0.92)  LDD1108  [4]
 LDCM0230  AC113 PaTu 8988t C304(1.15)  LDD1109  [4]
 LDCM0231  AC114 PaTu 8988t C304(1.27)  LDD1110  [4]
 LDCM0232  AC115 PaTu 8988t C304(1.15)  LDD1111  [4]
 LDCM0233  AC116 PaTu 8988t C304(1.03)  LDD1112  [4]
 LDCM0234  AC117 PaTu 8988t C304(0.89)  LDD1113  [4]
 LDCM0235  AC118 PaTu 8988t C304(1.19)  LDD1114  [4]
 LDCM0236  AC119 PaTu 8988t C304(0.88)  LDD1115  [4]
 LDCM0238  AC120 PaTu 8988t C304(1.16)  LDD1117  [4]
 LDCM0239  AC121 PaTu 8988t C304(1.16)  LDD1118  [4]
 LDCM0240  AC122 PaTu 8988t C304(2.07)  LDD1119  [4]
 LDCM0241  AC123 PaTu 8988t C304(2.09)  LDD1120  [4]
 LDCM0242  AC124 PaTu 8988t C304(1.79)  LDD1121  [4]
 LDCM0243  AC125 PaTu 8988t C304(1.76)  LDD1122  [4]
 LDCM0244  AC126 PaTu 8988t C304(1.45)  LDD1123  [4]
 LDCM0245  AC127 PaTu 8988t C304(1.08)  LDD1124  [4]
 LDCM0246  AC128 PaTu 8988t C304(1.23)  LDD1125  [4]
 LDCM0247  AC129 PaTu 8988t C304(1.37)  LDD1126  [4]
 LDCM0249  AC130 PaTu 8988t C304(1.32)  LDD1128  [4]
 LDCM0250  AC131 PaTu 8988t C304(1.28)  LDD1129  [4]
 LDCM0251  AC132 PaTu 8988t C304(0.97)  LDD1130  [4]
 LDCM0252  AC133 PaTu 8988t C304(0.94)  LDD1131  [4]
 LDCM0253  AC134 PaTu 8988t C304(0.98)  LDD1132  [4]
 LDCM0254  AC135 PaTu 8988t C304(1.01)  LDD1133  [4]
 LDCM0255  AC136 PaTu 8988t C304(0.95)  LDD1134  [4]
 LDCM0256  AC137 PaTu 8988t C304(0.79)  LDD1135  [4]
 LDCM0257  AC138 PaTu 8988t C304(0.84)  LDD1136  [4]
 LDCM0258  AC139 PaTu 8988t C304(0.97)  LDD1137  [4]
 LDCM0260  AC140 PaTu 8988t C304(0.86)  LDD1139  [4]
 LDCM0261  AC141 PaTu 8988t C304(1.33)  LDD1140  [4]
 LDCM0262  AC142 PaTu 8988t C304(1.01)  LDD1141  [4]
 LDCM0296  AC35 PaTu 8988t C304(1.00)  LDD1175  [4]
 LDCM0297  AC36 PaTu 8988t C304(1.04)  LDD1176  [4]
 LDCM0298  AC37 PaTu 8988t C304(1.20)  LDD1177  [4]
 LDCM0299  AC38 PaTu 8988t C304(1.38)  LDD1178  [4]
 LDCM0300  AC39 PaTu 8988t C304(1.25)  LDD1179  [4]
 LDCM0302  AC40 PaTu 8988t C304(1.18)  LDD1181  [4]
 LDCM0303  AC41 PaTu 8988t C304(0.87)  LDD1182  [4]
 LDCM0304  AC42 PaTu 8988t C304(0.91)  LDD1183  [4]
 LDCM0305  AC43 PaTu 8988t C304(1.21)  LDD1184  [4]
 LDCM0306  AC44 PaTu 8988t C304(1.35)  LDD1185  [4]
 LDCM0307  AC45 PaTu 8988t C304(1.11)  LDD1186  [4]
 LDCM0308  AC46 PaTu 8988t C304(1.07)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C304(0.82)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C304(1.07)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C304(1.16)  LDD1190  [4]
 LDCM0313  AC50 PaTu 8988t C304(1.26)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C304(1.36)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C304(0.99)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C304(1.69)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C304(1.31)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C304(0.90)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C304(1.15)  LDD1198  [4]
 LDCM0332  AC68 PaTu 8988t C304(1.12)  LDD1211  [4]
 LDCM0333  AC69 PaTu 8988t C304(1.08)  LDD1212  [4]
 LDCM0335  AC70 PaTu 8988t C304(1.48)  LDD1214  [4]
 LDCM0336  AC71 PaTu 8988t C304(1.19)  LDD1215  [4]
 LDCM0337  AC72 PaTu 8988t C304(1.05)  LDD1216  [4]
 LDCM0338  AC73 PaTu 8988t C304(1.13)  LDD1217  [4]
 LDCM0339  AC74 PaTu 8988t C304(1.21)  LDD1218  [4]
 LDCM0340  AC75 PaTu 8988t C304(1.35)  LDD1219  [4]
 LDCM0341  AC76 PaTu 8988t C304(1.01)  LDD1220  [4]
 LDCM0342  AC77 PaTu 8988t C304(1.03)  LDD1221  [4]
 LDCM0343  AC78 PaTu 8988t C304(1.12)  LDD1222  [4]
 LDCM0344  AC79 PaTu 8988t C304(1.27)  LDD1223  [4]
 LDCM0346  AC80 PaTu 8988t C304(1.27)  LDD1225  [4]
 LDCM0347  AC81 PaTu 8988t C304(1.10)  LDD1226  [4]
 LDCM0348  AC82 PaTu 8988t C304(1.21)  LDD1227  [4]
 LDCM0365  AC98 PaTu 8988t C304(1.02)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C304(1.12)  LDD1245  [4]
 LDCM0632  CL-Sc Hep-G2 C651(20.00)  LDD2227  [2]
 LDCM0367  CL1 PaTu 8988t C304(0.95)  LDD1246  [4]
 LDCM0368  CL10 PaTu 8988t C304(0.79)  LDD1247  [4]
 LDCM0379  CL11 PaTu 8988t C304(0.62)  LDD1258  [4]
 LDCM0387  CL117 PaTu 8988t C304(1.01)  LDD1266  [4]
 LDCM0388  CL118 PaTu 8988t C304(1.00)  LDD1267  [4]
 LDCM0389  CL119 PaTu 8988t C304(1.07)  LDD1268  [4]
 LDCM0390  CL12 PaTu 8988t C304(0.87)  LDD1269  [4]
 LDCM0391  CL120 PaTu 8988t C304(1.06)  LDD1270  [4]
 LDCM0392  CL121 PaTu 8988t C304(1.15)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C304(1.25)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C304(0.84)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C304(1.07)  LDD1274  [4]
 LDCM0400  CL13 PaTu 8988t C304(1.31)  LDD1279  [4]
 LDCM0401  CL14 PaTu 8988t C304(1.31)  LDD1280  [4]
 LDCM0402  CL15 PaTu 8988t C304(0.70)  LDD1281  [4]
 LDCM0407  CL2 PaTu 8988t C304(0.76)  LDD1286  [4]
 LDCM0418  CL3 PaTu 8988t C304(0.85)  LDD1297  [4]
 LDCM0420  CL31 PaTu 8988t C304(1.02)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C304(1.19)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C304(1.17)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C304(0.81)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C304(0.86)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C304(1.16)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C304(1.40)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C304(1.03)  LDD1307  [4]
 LDCM0429  CL4 PaTu 8988t C304(1.07)  LDD1308  [4]
 LDCM0430  CL40 PaTu 8988t C304(0.99)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C304(0.88)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C304(1.37)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C304(1.56)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C304(1.88)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C304(1.28)  LDD1314  [4]
 LDCM0440  CL5 PaTu 8988t C304(1.33)  LDD1319  [4]
 LDCM0451  CL6 PaTu 8988t C304(0.89)  LDD1330  [4]
 LDCM0453  CL61 PaTu 8988t C304(1.13)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C304(1.14)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C304(1.10)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C304(0.94)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C304(1.28)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C304(1.08)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C304(1.22)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C304(1.01)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C304(1.33)  LDD1340  [4]
 LDCM0462  CL7 PaTu 8988t C304(0.88)  LDD1341  [4]
 LDCM0463  CL70 PaTu 8988t C304(0.99)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C304(1.08)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C304(1.00)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C304(1.30)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C304(1.12)  LDD1346  [4]
 LDCM0473  CL8 PaTu 8988t C304(0.90)  LDD1352  [4]
 LDCM0484  CL9 PaTu 8988t C304(1.27)  LDD1363  [4]
 LDCM0468  Fragment33 PaTu 8988t C304(1.17)  LDD1347  [4]
 LDCM0427  Fragment51 PaTu 8988t C304(1.72)  LDD1306  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein-glutamine gamma-glutamyltransferase K (TGM1) Transglutaminase family P22735
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Aquaporin-3 (AQP3) MIP/aquaporin (TC 1.A.8) family Q92482
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 837 (ZNF837) Krueppel C2H2-type zinc-finger protein family Q96EG3
Nuclear receptor subfamily 4 group A member 3 (NR4A3) Nuclear hormone receptor family Q92570
Other
Click To Hide/Show 35 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CUGBP Elav-like family member 5 (CELF5) CELF/BRUNOL family Q8N6W0
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Progranulin (GRN) Granulin family P28799
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-6 (KRTAP10-6) KRTAP type 10 family P60371
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 12-2 (KRTAP12-2) KRTAP type 12 family P59991
Keratin-associated protein 12-3 (KRTAP12-3) KRTAP type 12 family P60328
Keratin-associated protein 2-4 (KRTAP2-4) KRTAP type 2 family Q9BYR9
Keratin-associated protein 3-1 (KRTAP3-1) KRTAP type 3 family Q9BYR8
Keratin-associated protein 3-2 (KRTAP3-2) KRTAP type 3 family Q9BYR7
Keratin-associated protein 4-1 (KRTAP4-1) KRTAP type 4 family Q9BYQ7
Keratin-associated protein 4-11 (KRTAP4-11) KRTAP type 4 family Q9BYQ6
Keratin-associated protein 4-2 (KRTAP4-2) KRTAP type 4 family Q9BYR5
Keratin-associated protein 5-11 (KRTAP5-11) KRTAP type 5 family Q6L8G4
Keratin-associated protein 9-3 (KRTAP9-3) KRTAP type 9 family Q9BYQ3
Keratin-associated protein 9-8 (KRTAP9-8) KRTAP type 9 family Q9BYQ0
Late cornified envelope protein 1C (LCE1C) LCE family Q5T751
Late cornified envelope protein 2A (LCE2A) LCE family Q5TA79
Late cornified envelope protein 2C (LCE2C) LCE family Q5TA81
Late cornified envelope protein 2D (LCE2D) LCE family Q5TA82
Late cornified envelope protein 4A (LCE4A) LCE family Q5TA78
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Keratin-associated protein 11-1 (KRTAP11-1) PMG family Q8IUC1
Keratin-associated protein 26-1 (KRTAP26-1) PMG family Q6PEX3
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
Brorin (VWC2) . Q2TAL6
Calcium and integrin-binding family member 4 (CIB4) . A0PJX0
Keratin-associated protein 17-1 (KRTAP17-1) . Q9BYP8
Regulator of G-protein signaling 17 (RGS17) . Q9UGC6
Regulator of G-protein signaling 19 (RGS19) . P49795
Sperm mitochondrial-associated cysteine-rich protein (SMCP) . P49901

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060