Details of the Target

General Information of Target

Target ID LDTP06929
Target Name Zinc finger protein 385B (ZNF385B)
Gene Name ZNF385B
Gene ID 151126
Synonyms
ZNF533; Zinc finger protein 385B; Zinc finger protein 533
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNMANFLRGFEEKGIKNDRPEDQLSKEKKKILFSFCEVCNIQLNSAAQAQVHSNGKSHRK
RVKQLSDGQPPPPAQASPSSNSSTGSTCHTTTLPALVRTPTLMMQPSLDIKPFMSFPVDS
SSAVGLFPNFNTMDPVQKAVINHTFGVSIPPKKKQVISCNVCQLRFNSDSQAEAHYKGSK
HAKKVKALDATKNKPKMVPSKDSAKANPSCSITPITGNNSDKSEDKGKLKASSSSQPSSS
ESGSFLLKSGTTPLPPGAATSPSKSTNGAPGTVVESEEEKAKKLLYCSLCKVAVNSLSQL
EAHNTGSKHKTMVEARNGAGPIKSYPRPGSRLKMQNGSKGSGLQNKTFHCEICDVHVNSE
IQLKQHISSRRHKDRVAGKPLKPKYSPYNKLQRSPSILAAKLAFQKDMMKPLAPAFLSSP
LAAAAAVSSALSLPPRPSASLFQAPAIPPALLRPGHGPIRATPASILFAPY
Target Bioclass
Other
Subcellular location
Nucleus
Function May play a role in p53/TP53-mediated apoptosis.
Uniprot ID
Q569K4
Ensemble ID
ENST00000336917.9
HGNC ID
HGNC:26332

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C210(1.61)  LDD2182  [1]
DBIA
 Probe Info  		C210(1.46)  LDD0532  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C210(1.46)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C210(1.01)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C210(1.04)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C210(1.13)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C210(1.26)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C210(1.18)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C210(1.21)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C210(1.26)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C210(1.41)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C210(0.90)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C210(1.11)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C210(1.42)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C210(0.87)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C210(1.25)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C210(1.05)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C210(1.40)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C210(1.42)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C210(1.59)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C210(2.07)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C210(1.51)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C210(1.33)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C210(1.38)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C210(1.05)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C210(1.45)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C210(1.54)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C210(1.72)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C210(1.01)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C210(1.34)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C210(1.86)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C210(1.26)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C210(1.65)  LDD0562  [2]
 LDCM0259  AC14 HCT 116 C210(1.14)  LDD0576  [2]
 LDCM0270  AC15 HCT 116 C210(1.84)  LDD0587  [2]
 LDCM0276  AC17 HCT 116 C210(1.56)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C210(1.12)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C210(1.30)  LDD0595  [2]
 LDCM0280  AC20 HCT 116 C210(1.47)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C210(1.79)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C210(1.24)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C210(1.30)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C210(1.20)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C210(1.01)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C210(1.01)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C210(1.12)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C210(1.18)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C210(1.04)  LDD0606  [2]
 LDCM0291  AC30 HCT 116 C210(1.03)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C210(1.25)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C210(1.39)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C210(1.23)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C210(1.42)  LDD0612  [2]
 LDCM0323  AC6 HCT 116 C210(1.31)  LDD0640  [2]
 LDCM0332  AC68 HCT 116 C210(0.97)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C210(0.76)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C210(0.88)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C210(0.89)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C210(0.91)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C210(0.85)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C210(1.26)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C210(1.28)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C210(1.37)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C210(1.02)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C210(1.24)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C210(0.89)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C210(0.89)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C210(1.17)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C210(1.15)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C210(0.72)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C210(1.36)  LDD0665  [2]
 LDCM0365  AC98 HCT 116 C210(1.61)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C210(0.93)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C210(0.97)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C210(1.22)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C210(2.27)  LDD0592  [2]
 LDCM0370  CL101 HCT 116 C210(1.31)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C210(1.03)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C210(1.09)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C210(1.42)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C210(1.34)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C210(1.41)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C210(1.39)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C210(2.06)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C210(1.29)  LDD0695  [2]
 LDCM0380  CL110 HCT 116 C210(2.04)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C210(1.44)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C210(1.07)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C210(1.08)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C210(0.97)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C210(1.28)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C210(1.03)  LDD0703  [2]
 LDCM0625  F8 Ramos C210(1.41)  LDD2187  [1]
 LDCM0573  Fragment11 Ramos C210(11.45)  LDD2190  [1]
 LDCM0576  Fragment14 Ramos C210(0.80)  LDD2193  [1]
 LDCM0566  Fragment4 Ramos C210(1.00)  LDD2184  [1]
 LDCM0569  Fragment7 Ramos C210(1.21)  LDD2186  [1]
 LDCM0022  KB02 Ramos C210(1.61)  LDD2182  [1]
 LDCM0023  KB03 Ramos C210(1.10)  LDD2183  [1]
 LDCM0024  KB05 VCaP C225(2.83)  LDD3486  [3]

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840