Details of the Target

General Information of Target

Target ID LDTP06678
Target Name S-adenosylmethionine sensor upstream of mTORC1 (BMT2)
Gene Name BMT2
Gene ID 154743
Synonyms
C7orf60; SAMTOR; S-adenosylmethionine sensor upstream of mTORC1; Probable methyltransferase BMT2 homolog; EC 2.1.1.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPGAGGRNTARAQRAGSPNTPPPREQERKLEQEKLSGVVKSVHRRLRKKYREVGDFDKI
WREHCEDEETLCEYAVAMKNLADNHWAKTCEGEGRIEWCCSVCREYFQNGGKRKALEKDE
KRAVLATKTTPALNMHESSQLEGHLTNLSFTNPEFITELLQASGKIRLLDVGSCFNPFLK
FEEFLTVGIDIVPAVESVYKCDFLNLQLQQPLQLAQDAIDAFLKQLKNPIDSLPGELFHV
VVFSLLLSYFPSPYQRWICCKKAHELLVLNGLLLIITPDSSHQNRHAMMMKSWKIAIESL
GFKRFKYSKFSHMHLMAFRKISLKTTSDLVSRNYPGMLYIPQDFNSIEDEEYSNPSCYVR
SDIEDEQLAYGFTELPDAPYDSDSGESQASSIPFYELEDPILLLS
Target Bioclass
Enzyme
Family
BMT2 family
Function
S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential). {|HAMAP-Rule:MF_03044}.
Uniprot ID
Q1RMZ1
Ensemble ID
ENST00000297145.9
HGNC ID
HGNC:26475

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C174(2.19)  LDD3329  [1]
IA-alkyne
 Probe Info  		C90(17.61)  LDD1704  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 PaTu 8988t C174(0.77)  LDD1094  [3]
 LDCM0226  AC11 PaTu 8988t C174(0.76)  LDD1105  [3]
 LDCM0237  AC12 PaTu 8988t C174(0.70)  LDD1116  [3]
 LDCM0259  AC14 PaTu 8988t C174(0.97)  LDD1138  [3]
 LDCM0263  AC143 PaTu 8988t C174(1.02)  LDD1142  [3]
 LDCM0264  AC144 PaTu 8988t C174(1.10)  LDD1143  [3]
 LDCM0265  AC145 PaTu 8988t C174(0.99)  LDD1144  [3]
 LDCM0266  AC146 PaTu 8988t C174(0.88)  LDD1145  [3]
 LDCM0267  AC147 PaTu 8988t C174(0.85)  LDD1146  [3]
 LDCM0268  AC148 PaTu 8988t C174(1.20)  LDD1147  [3]
 LDCM0269  AC149 PaTu 8988t C174(1.24)  LDD1148  [3]
 LDCM0270  AC15 PaTu 8988t C174(0.84)  LDD1149  [3]
 LDCM0271  AC150 PaTu 8988t C174(0.93)  LDD1150  [3]
 LDCM0272  AC151 PaTu 8988t C174(1.10)  LDD1151  [3]
 LDCM0273  AC152 PaTu 8988t C174(1.04)  LDD1152  [3]
 LDCM0274  AC153 PaTu 8988t C174(1.08)  LDD1153  [3]
 LDCM0621  AC154 PaTu 8988t C174(0.90)  LDD2166  [3]
 LDCM0622  AC155 PaTu 8988t C174(0.93)  LDD2167  [3]
 LDCM0623  AC156 PaTu 8988t C174(1.01)  LDD2168  [3]
 LDCM0624  AC157 PaTu 8988t C174(0.86)  LDD2169  [3]
 LDCM0276  AC17 PaTu 8988t C174(1.02)  LDD1155  [3]
 LDCM0277  AC18 PaTu 8988t C174(0.86)  LDD1156  [3]
 LDCM0278  AC19 PaTu 8988t C174(1.13)  LDD1157  [3]
 LDCM0280  AC20 PaTu 8988t C174(1.04)  LDD1159  [3]
 LDCM0281  AC21 PaTu 8988t C174(1.03)  LDD1160  [3]
 LDCM0282  AC22 PaTu 8988t C174(0.96)  LDD1161  [3]
 LDCM0283  AC23 PaTu 8988t C174(1.01)  LDD1162  [3]
 LDCM0284  AC24 PaTu 8988t C174(1.12)  LDD1163  [3]
 LDCM0285  AC25 PaTu 8988t C174(1.10)  LDD1164  [3]
 LDCM0286  AC26 PaTu 8988t C174(1.22)  LDD1165  [3]
 LDCM0287  AC27 PaTu 8988t C174(1.15)  LDD1166  [3]
 LDCM0288  AC28 PaTu 8988t C174(1.15)  LDD1167  [3]
 LDCM0289  AC29 PaTu 8988t C174(1.13)  LDD1168  [3]
 LDCM0291  AC30 PaTu 8988t C174(1.09)  LDD1170  [3]
 LDCM0292  AC31 PaTu 8988t C174(1.03)  LDD1171  [3]
 LDCM0293  AC32 PaTu 8988t C174(1.03)  LDD1172  [3]
 LDCM0294  AC33 PaTu 8988t C174(1.06)  LDD1173  [3]
 LDCM0295  AC34 PaTu 8988t C174(1.00)  LDD1174  [3]
 LDCM0300  AC39 HEK-293T C90(0.96)  LDD1539  [4]
 LDCM0309  AC47 HEK-293T C90(0.96)  LDD1548  [4]
 LDCM0318  AC55 HEK-293T C90(1.06)  LDD1557  [4]
 LDCM0323  AC6 PaTu 8988t C174(0.81)  LDD1202  [3]
 LDCM0327  AC63 HEK-293T C90(1.03)  LDD1566  [4]
 LDCM0332  AC68 PaTu 8988t C174(1.21)  LDD1211  [3]
 LDCM0333  AC69 PaTu 8988t C174(1.22)  LDD1212  [3]
 LDCM0334  AC7 PaTu 8988t C174(0.86)  LDD1213  [3]
 LDCM0335  AC70 PaTu 8988t C174(1.23)  LDD1214  [3]
 LDCM0336  AC71 PaTu 8988t C174(1.15)  LDD1215  [3]
 LDCM0337  AC72 PaTu 8988t C174(1.16)  LDD1216  [3]
 LDCM0338  AC73 PaTu 8988t C174(1.39)  LDD1217  [3]
 LDCM0339  AC74 PaTu 8988t C174(1.22)  LDD1218  [3]
 LDCM0340  AC75 PaTu 8988t C174(1.24)  LDD1219  [3]
 LDCM0341  AC76 PaTu 8988t C174(1.17)  LDD1220  [3]
 LDCM0342  AC77 PaTu 8988t C174(1.17)  LDD1221  [3]
 LDCM0343  AC78 PaTu 8988t C174(1.24)  LDD1222  [3]
 LDCM0344  AC79 PaTu 8988t C174(1.25)  LDD1223  [3]
 LDCM0345  AC8 PaTu 8988t C174(0.84)  LDD1224  [3]
 LDCM0346  AC80 PaTu 8988t C174(1.41)  LDD1225  [3]
 LDCM0347  AC81 PaTu 8988t C174(1.23)  LDD1226  [3]
 LDCM0348  AC82 PaTu 8988t C174(1.32)  LDD1227  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C174(0.76)  LDD1127  [3]
 LDCM0356  AKOS034007680 PaTu 8988t C174(0.62)  LDD1235  [3]
 LDCM0275  AKOS034007705 PaTu 8988t C174(0.65)  LDD1154  [3]
 LDCM0369  CL100 HEK-293T C90(1.26)  LDD1573  [4]
 LDCM0370  CL101 PaTu 8988t C174(0.90)  LDD1249  [3]
 LDCM0371  CL102 PaTu 8988t C174(0.80)  LDD1250  [3]
 LDCM0372  CL103 PaTu 8988t C174(0.70)  LDD1251  [3]
 LDCM0373  CL104 PaTu 8988t C174(0.90)  LDD1252  [3]
 LDCM0374  CL105 PaTu 8988t C174(1.12)  LDD1253  [3]
 LDCM0375  CL106 PaTu 8988t C174(1.06)  LDD1254  [3]
 LDCM0376  CL107 PaTu 8988t C174(0.95)  LDD1255  [3]
 LDCM0377  CL108 PaTu 8988t C174(1.04)  LDD1256  [3]
 LDCM0378  CL109 PaTu 8988t C174(1.16)  LDD1257  [3]
 LDCM0379  CL11 HEK-293T C90(1.16)  LDD1583  [4]
 LDCM0380  CL110 PaTu 8988t C174(0.97)  LDD1259  [3]
 LDCM0381  CL111 PaTu 8988t C174(1.03)  LDD1260  [3]
 LDCM0382  CL112 PaTu 8988t C174(1.00)  LDD1261  [3]
 LDCM0383  CL113 PaTu 8988t C174(0.89)  LDD1262  [3]
 LDCM0384  CL114 PaTu 8988t C174(1.10)  LDD1263  [3]
 LDCM0385  CL115 PaTu 8988t C174(1.16)  LDD1264  [3]
 LDCM0386  CL116 PaTu 8988t C174(1.03)  LDD1265  [3]
 LDCM0391  CL120 HEK-293T C90(1.31)  LDD1595  [4]
 LDCM0395  CL124 HEK-293T C90(1.19)  LDD1599  [4]
 LDCM0399  CL128 HEK-293T C90(1.12)  LDD1603  [4]
 LDCM0403  CL16 HEK-293T C90(1.16)  LDD1607  [4]
 LDCM0411  CL23 HEK-293T C90(1.33)  LDD1615  [4]
 LDCM0416  CL28 HEK-293T C90(1.26)  LDD1620  [4]
 LDCM0424  CL35 HEK-293T C90(1.21)  LDD1628  [4]
 LDCM0429  CL4 HEK-293T C90(0.94)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C90(1.12)  LDD1634  [4]
 LDCM0437  CL47 HEK-293T C90(1.07)  LDD1641  [4]
 LDCM0443  CL52 HEK-293T C90(1.44)  LDD1646  [4]
 LDCM0450  CL59 HEK-293T C90(1.16)  LDD1653  [4]
 LDCM0456  CL64 HEK-293T C90(1.27)  LDD1659  [4]
 LDCM0464  CL71 HEK-293T C90(1.22)  LDD1667  [4]
 LDCM0469  CL76 HEK-293T C90(1.26)  LDD1672  [4]
 LDCM0477  CL83 HEK-293T C90(1.17)  LDD1680  [4]
 LDCM0482  CL88 HEK-293T C90(1.18)  LDD1685  [4]
 LDCM0490  CL95 HEK-293T C90(1.44)  LDD1693  [4]
 LDCM0022  KB02 T cell-activated C90(17.61)  LDD1704  [2]
 LDCM0023  KB03 697 C174(2.63)  LDD2662  [1]
 LDCM0024  KB05 RAW264.7 C174(2.19)  LDD3329  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402