Details of the Target

General Information of Target

Target ID LDTP06508
Target Name Zinc finger protein 124 (ZNF124)
Gene Name ZNF124
Gene ID 7678
Synonyms
Zinc finger protein 124; Zinc finger protein HZF-16
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSGHPGSWEMNSVAFEDVAVNFTQEEWALLDPSQKNLYRDVMQETFRNLASIGNKGEDQS
IEDQYKNSSRNLRHIISHSGNNPYGCEECGKKPCTCKQCQKTSLSVTRVHRDTVMHTGNG
HYGCTICEKVFNIPSSFQIHQRNHTGEKPYECMECGKALGFSRSLNRHKRIHTGEKRYEC
KQCGKAFSRSSHLRDHERTHTGEKPYECKHCGKAFRYSNCLHYHERTHTGEKPYVCMECG
KAFSCLSSLQGHIKAHAGEEPYPCKQCGKAFRYASSLQKHEKTHIAQKPYVCNNCGKGFR
CSSSLRDHERTHTGEKPYECQKCGKAFSRASTLWKHKKTHTGEKPYKCKKM
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q15973
Ensemble ID
ENST00000340684.10
HGNC ID
HGNC:12907

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C208(2.31)  LDD0170  [1]
IA-alkyne
 Probe Info  		C301(1.97)  LDD2182  [2]
DBIA
 Probe Info  		C220(0.91)  LDD1492  [3]
IPM
 Probe Info  		C245(0.00); C220(0.00)  LDD0147  [4]
HHS-465
 Probe Info  		K344(0.00); K347(0.00); Y346(0.00)  LDD2240  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C208(2.31)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C208(2.25)  LDD0171  [1]
 LDCM0215  AC10 HEK-293T C220(0.98)  LDD1508  [3]
 LDCM0277  AC18 HEK-293T C220(1.02)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C220(1.17)  LDD1518  [3]
 LDCM0284  AC24 HEK-293T C220(1.03)  LDD1523  [3]
 LDCM0286  AC26 HEK-293T C220(1.03)  LDD1525  [3]
 LDCM0293  AC32 HEK-293T C220(1.17)  LDD1532  [3]
 LDCM0295  AC34 HEK-293T C220(1.07)  LDD1534  [3]
 LDCM0302  AC40 HEK-293T C220(1.25)  LDD1541  [3]
 LDCM0304  AC42 HEK-293T C220(1.09)  LDD1543  [3]
 LDCM0310  AC48 HEK-293T C220(0.97)  LDD1549  [3]
 LDCM0313  AC50 HEK-293T C220(1.06)  LDD1552  [3]
 LDCM0319  AC56 HEK-293T C220(1.13)  LDD1558  [3]
 LDCM0321  AC58 HEK-293T C220(1.03)  LDD1560  [3]
 LDCM0328  AC64 HEK-293T C220(1.08)  LDD1567  [3]
 LDCM0345  AC8 HEK-293T C220(1.05)  LDD1569  [3]
 LDCM0275  AKOS034007705 HEK-293T C220(0.96)  LDD1514  [3]
 LDCM0390  CL12 HEK-293T C220(1.22)  LDD1594  [3]
 LDCM0405  CL18 HEK-293T C220(1.13)  LDD1609  [3]
 LDCM0412  CL24 HEK-293T C220(1.42)  LDD1616  [3]
 LDCM0419  CL30 HEK-293T C220(1.08)  LDD1623  [3]
 LDCM0425  CL36 HEK-293T C220(1.17)  LDD1629  [3]
 LDCM0432  CL42 HEK-293T C220(1.06)  LDD1636  [3]
 LDCM0438  CL48 HEK-293T C220(0.90)  LDD1642  [3]
 LDCM0445  CL54 HEK-293T C220(1.11)  LDD1648  [3]
 LDCM0451  CL6 HEK-293T C220(1.09)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C220(1.29)  LDD1655  [3]
 LDCM0458  CL66 HEK-293T C220(1.10)  LDD1661  [3]
 LDCM0465  CL72 HEK-293T C220(1.05)  LDD1668  [3]
 LDCM0471  CL78 HEK-293T C220(1.22)  LDD1674  [3]
 LDCM0478  CL84 HEK-293T C220(1.10)  LDD1681  [3]
 LDCM0485  CL90 HEK-293T C220(1.54)  LDD1688  [3]
 LDCM0491  CL96 HEK-293T C220(1.01)  LDD1694  [3]
 LDCM0625  F8 Ramos C301(1.51)  LDD2187  [2]
 LDCM0573  Fragment11 Ramos C301(1.38)  LDD2190  [2]
 LDCM0576  Fragment14 Ramos C301(0.90)  LDD2193  [2]
 LDCM0580  Fragment21 Ramos C301(2.58); C245(0.96)  LDD2195  [2]
 LDCM0578  Fragment27 Ramos C245(0.39)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C301(0.58); C245(2.53)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C301(1.80)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C301(0.94)  LDD2200  [2]
 LDCM0468  Fragment33 Ramos C301(1.63)  LDD2202  [2]
 LDCM0596  Fragment38 Ramos C245(1.42)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C245(0.67)  LDD2184  [2]
 LDCM0610  Fragment52 Ramos C301(0.75); C245(0.36)  LDD2204  [2]
 LDCM0569  Fragment7 Ramos C245(1.39)  LDD2186  [2]
 LDCM0022  KB02 HEK-293T C220(0.91)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C220(0.84)  LDD1497  [3]
 LDCM0024  KB05 HEK-293T C220(1.13)  LDD1502  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Glutaredoxin-3 (GLRX3) . O76003
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription regulator protein BACH2 (BACH2) BZIP family Q9BYV9
Zinc finger protein 526 (ZNF526) Krueppel C2H2-type zinc-finger protein family Q8TF50
Zinc finger protein 660 (ZNF660) Krueppel C2H2-type zinc-finger protein family Q6AZW8
Zinc finger protein 837 (ZNF837) Krueppel C2H2-type zinc-finger protein family Q96EG3
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
Golgin-45 (BLZF1) . Q9H2G9
Homeobox protein MOX-2 (MEOX2) . P50222
Transcription factor 4 (TCF4) . P15884
Other
Click To Hide/Show 31 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
Cyclin-D1-binding protein 1 (CCNDBP1) CCNDBP1 family O95273
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Progranulin (GRN) Granulin family P28799
Heat shock-related 70 kDa protein 2 (HSPA2) Heat shock protein 70 family P54652
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 10-5 (KRTAP10-5) KRTAP type 10 family P60370
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 12-3 (KRTAP12-3) KRTAP type 12 family P60328
Keratin-associated protein 4-2 (KRTAP4-2) KRTAP type 4 family Q9BYR5
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Protein LDOC1 (LDOC1) LDOC1 family O95751
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Serine/arginine repetitive matrix protein 4 (SRRM4) NSR100 family A7MD48
Synaptonemal complex central element protein 1 (SYCE1) SYCE family Q8N0S2
Axin-2 (AXIN2) . Q9Y2T1
Fibroblast growth factor receptor substrate 3 (FRS3) . O43559
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
Huntingtin-associated protein 1 (HAP1) . P54257
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
TNF receptor-associated factor 1 (TRAF1) . Q13077
Ubiquitin-like protein 5 (UBL5) . Q9BZL1

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010