Details of the Target

General Information of Target

Target ID LDTP06469
Target Name Zinc finger protein with KRAB and SCAN domains 8 (ZKSCAN8)
Gene Name ZKSCAN8
Gene ID 7745
Synonyms
ZNF192; Zinc finger protein with KRAB and SCAN domains 8; LD5-1; Zinc finger protein 192
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEESRKPSAPSPPDQTPEEDLVIVKVEEDHGWDQESSLHESNPLGQEVFRLRFRQLRYQ
ETLGPREALIQLRALCHQWLRPDLNTKEQILELLVLEQFLTILPEELQTLVKEHQLENGE
EVVTLLEDLERQIDILGRPVSARVHGHRVLWEEVVHSASAPEPPNTQLQSEATQHKSPVP
QESQERAMSTSQSPTRSQKGSSGDQEMTATLLTAGFQTLEKIEDMAVSLIREEWLLDPSQ
KDLCRDNRPENFRNMFSLGGETRSENRELASKQVISTGIQPHGETAAKCNGDVIRGLEHE
EARDLLGRLERQRGNPTQERRHKCDECGKSFAQSSGLVRHWRIHTGEKPYQCNVCGKAFS
YRSALLSHQDIHNKVKRYHCKECGKAFSQNTGLILHQRIHTGEKPYQCNQCGKAFSQSAG
LILHQRIHSGERPYECNECGKAFSHSSHLIGHQRIHTGEKPYECDECGKTFRRSSHLIGH
QRSHTGEKPYKCNECGRAFSQKSGLIEHQRIHTGERPYKCKECGKAFNGNTGLIQHLRIH
TGEKPYQCNECGKAFIQRSSLIRHQRIHSGEKSESISV
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q15776
Ensemble ID
ENST00000330236.7
HGNC ID
HGNC:12983

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BXPC3 SNV: p.N290Y .
CAL33 SNV: p.S446G .
COLO678 Insertion: p.L236FfsTer37 .
COLO800 SNV: p.A386V .
HCT15 SNV: p.R148M .
HT115 SNV: p.R143C .
HUH28 SNV: p.A10T .
JURKAT SNV: p.R342K .
MCAS SNV: p.E185K .
NCIH446 SNV: p.T513S .
NUGC3 SNV: p.T541I .
OVCAR8 SNV: p.R558S .
RL952 SNV: p.Y434C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C76(5.47)  LDD3376  [1]
IPM
 Probe Info  		N.A.  LDD0147  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C76(1.04)  LDD1510  [3]
 LDCM0270  AC15 HEK-293T C76(0.98)  LDD1513  [3]
 LDCM0280  AC20 HEK-293T C76(0.99)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C76(1.02)  LDD1520  [3]
 LDCM0283  AC23 HEK-293T C76(1.08)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C76(1.00)  LDD1523  [3]
 LDCM0288  AC28 HEK-293T C76(1.01)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C76(0.95)  LDD1528  [3]
 LDCM0292  AC31 HEK-293T C76(0.91)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C76(0.99)  LDD1532  [3]
 LDCM0297  AC36 HEK-293T C76(1.05)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C76(1.02)  LDD1537  [3]
 LDCM0300  AC39 HEK-293T C76(0.98)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C76(1.09)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C76(1.06)  LDD1541  [3]
 LDCM0306  AC44 HEK-293T C76(1.15)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C76(0.97)  LDD1546  [3]
 LDCM0309  AC47 HEK-293T C76(1.08)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C76(1.04)  LDD1549  [3]
 LDCM0312  AC5 HEK-293T C76(1.04)  LDD1551  [3]
 LDCM0315  AC52 HEK-293T C76(1.05)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C76(1.03)  LDD1555  [3]
 LDCM0318  AC55 HEK-293T C76(1.11)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C76(1.01)  LDD1558  [3]
 LDCM0324  AC60 HEK-293T C76(1.11)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C76(1.05)  LDD1564  [3]
 LDCM0327  AC63 HEK-293T C76(0.99)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C76(1.06)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C76(1.13)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C76(1.08)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C76(0.97)  LDD1511  [3]
 LDCM0275  AKOS034007705 HEK-293T C76(1.04)  LDD1514  [3]
 LDCM0367  CL1 HEK-293T C76(1.12)  LDD1571  [3]
 LDCM0370  CL101 HEK-293T C76(1.13)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C76(1.15)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C76(1.07)  LDD1576  [3]
 LDCM0374  CL105 HEK-293T C76(1.06)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C76(1.01)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C76(1.03)  LDD1580  [3]
 LDCM0378  CL109 HEK-293T C76(1.09)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C76(1.06)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C76(1.19)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C76(1.04)  LDD1585  [3]
 LDCM0383  CL113 HEK-293T C76(1.16)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C76(1.25)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C76(1.09)  LDD1589  [3]
 LDCM0387  CL117 HEK-293T C76(1.14)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C76(0.94)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C76(0.97)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C76(1.02)  LDD1594  [3]
 LDCM0392  CL121 HEK-293T C76(1.07)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C76(1.16)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C76(0.89)  LDD1598  [3]
 LDCM0396  CL125 HEK-293T C76(1.10)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C76(1.19)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C76(0.93)  LDD1602  [3]
 LDCM0400  CL13 HEK-293T C76(1.12)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C76(1.14)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C76(1.12)  LDD1606  [3]
 LDCM0407  CL2 HEK-293T C76(1.16)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C76(1.00)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C76(1.08)  LDD1613  [3]
 LDCM0411  CL23 HEK-293T C76(0.96)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C76(1.00)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C76(1.21)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C76(1.10)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C76(0.92)  LDD1619  [3]
 LDCM0418  CL3 HEK-293T C76(1.02)  LDD1622  [3]
 LDCM0421  CL32 HEK-293T C76(0.95)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C76(1.09)  LDD1626  [3]
 LDCM0424  CL35 HEK-293T C76(0.88)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C76(1.02)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C76(1.17)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C76(0.86)  LDD1632  [3]
 LDCM0434  CL44 HEK-293T C76(1.00)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C76(0.98)  LDD1639  [3]
 LDCM0437  CL47 HEK-293T C76(1.04)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C76(0.98)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C76(1.20)  LDD1643  [3]
 LDCM0441  CL50 HEK-293T C76(1.20)  LDD1645  [3]
 LDCM0447  CL56 HEK-293T C76(1.06)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C76(0.94)  LDD1651  [3]
 LDCM0450  CL59 HEK-293T C76(1.07)  LDD1653  [3]
 LDCM0452  CL60 HEK-293T C76(0.98)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C76(1.11)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C76(1.08)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C76(1.07)  LDD1658  [3]
 LDCM0460  CL68 HEK-293T C76(1.02)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C76(1.08)  LDD1664  [3]
 LDCM0464  CL71 HEK-293T C76(1.05)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C76(1.00)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C76(1.22)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C76(1.00)  LDD1670  [3]
 LDCM0473  CL8 HEK-293T C76(1.41)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C76(0.96)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C76(0.99)  LDD1678  [3]
 LDCM0477  CL83 HEK-293T C76(1.17)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C76(1.07)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C76(1.16)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C76(1.22)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C76(1.12)  LDD1684  [3]
 LDCM0484  CL9 HEK-293T C76(1.07)  LDD1687  [3]
 LDCM0487  CL92 HEK-293T C76(1.13)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C76(1.08)  LDD1691  [3]
 LDCM0490  CL95 HEK-293T C76(1.28)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C76(1.13)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C76(1.14)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C76(1.30)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C76(0.90)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C76(1.09)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C76(0.93)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C76(1.16)  LDD1631  [3]
 LDCM0022  KB02 HEK-293T C76(0.96)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C76(0.96)  LDD1497  [3]
 LDCM0024  KB05 ONS-76 C76(5.47)  LDD3376  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Huntingtin (HTT) Huntingtin family P42858
Protein mago nashi homolog (MAGOH) Mago nashi family P61326
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Progranulin (GRN) Granulin family P28799
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Prelamin-A/C (LMNA) Intermediate filament family P02545
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
Merlin (NF2) . P35240
RING finger protein 11 (RNF11) . Q9Y3C5
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402