Details of the Target

General Information of Target

Target ID LDTP05849
Target Name Putative nucleotidyltransferase MAB21L1 (MAB21L1)
Gene Name MAB21L1
Gene ID 4081
Synonyms
CAGR1; Putative nucleotidyltransferase MAB21L1; EC 2.7.7.-; Protein mab-21-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIAAQAKLVYHLNKYYNEKCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISSLNEMD
NRYEGLEVISPTEFEVVLYLNQMGVFNFVDDGSLPGCAVLKLSDGRKRSMSLWVEFITAS
GYLSARKIRSRFQTLVAQAVDKCSYRDVVKMVADTSEVKLRIRDRYVVQITPAFKCTGIW
PRSAAHWPLPHIPWPGPNRVAEVKAEGFNLLSKECHSLAGKQSSAESDAWVLQFAEAENR
LQMGGCRKKCLSILKTLRDRHLELPGQPLNNYHMKTLVSYECEKHPRESDWDESCLGDRL
NGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALENAAKQTWRLAREILTNPKSLEKL
Target Bioclass
Enzyme
Family
Mab-21 family
Subcellular location
Nucleus
Function
Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye. It is unclear whether it displays nucleotidyltransferase activity in vivo. Binds single-stranded RNA (ssRNA).
Uniprot ID
Q13394
Ensemble ID
ENST00000379919.6
HGNC ID
HGNC:6757

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C316(1.36)  LDD1507  [1]
IPM
 Probe Info  		N.A.  LDD0005  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C316(1.36)  LDD1507  [1]
 LDCM0259  AC14 HEK-293T C215(1.01)  LDD1512  [1]
 LDCM0276  AC17 HEK-293T C316(1.61)  LDD1515  [1]
 LDCM0282  AC22 HEK-293T C215(0.98)  LDD1521  [1]
 LDCM0284  AC24 HEK-293T C215(1.05)  LDD1523  [1]
 LDCM0285  AC25 HEK-293T C316(1.10)  LDD1524  [1]
 LDCM0291  AC30 HEK-293T C215(0.93)  LDD1530  [1]
 LDCM0293  AC32 HEK-293T C215(1.03)  LDD1532  [1]
 LDCM0294  AC33 HEK-293T C316(1.01)  LDD1533  [1]
 LDCM0299  AC38 HEK-293T C215(1.03)  LDD1538  [1]
 LDCM0302  AC40 HEK-293T C215(1.03)  LDD1541  [1]
 LDCM0303  AC41 HEK-293T C316(1.41)  LDD1542  [1]
 LDCM0308  AC46 HEK-293T C215(0.99)  LDD1547  [1]
 LDCM0310  AC48 HEK-293T C215(1.08)  LDD1549  [1]
 LDCM0311  AC49 HEK-293T C316(1.14)  LDD1550  [1]
 LDCM0317  AC54 HEK-293T C215(1.03)  LDD1556  [1]
 LDCM0319  AC56 HEK-293T C215(1.09)  LDD1558  [1]
 LDCM0320  AC57 HEK-293T C316(1.46)  LDD1559  [1]
 LDCM0323  AC6 HEK-293T C215(1.06)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C215(0.99)  LDD1565  [1]
 LDCM0328  AC64 HEK-293T C215(1.01)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C215(1.09)  LDD1569  [1]
 LDCM0356  AKOS034007680 HEK-293T C316(1.32)  LDD1570  [1]
 LDCM0275  AKOS034007705 HEK-293T C215(1.15)  LDD1514  [1]
 LDCM0367  CL1 HEK-293T C215(0.90)  LDD1571  [1]
 LDCM0368  CL10 HEK-293T C215(0.99)  LDD1572  [1]
 LDCM0369  CL100 HEK-293T C215(1.04)  LDD1573  [1]
 LDCM0370  CL101 HEK-293T C215(1.00)  LDD1574  [1]
 LDCM0371  CL102 HEK-293T C215(1.19)  LDD1575  [1]
 LDCM0373  CL104 HEK-293T C215(1.12)  LDD1577  [1]
 LDCM0374  CL105 HEK-293T C215(0.91)  LDD1578  [1]
 LDCM0375  CL106 HEK-293T C215(1.01)  LDD1579  [1]
 LDCM0377  CL108 HEK-293T C215(1.01)  LDD1581  [1]
 LDCM0378  CL109 HEK-293T C215(0.97)  LDD1582  [1]
 LDCM0380  CL110 HEK-293T C215(1.05)  LDD1584  [1]
 LDCM0382  CL112 HEK-293T C215(1.00)  LDD1586  [1]
 LDCM0383  CL113 HEK-293T C215(0.99)  LDD1587  [1]
 LDCM0384  CL114 HEK-293T C215(1.68)  LDD1588  [1]
 LDCM0386  CL116 HEK-293T C215(1.01)  LDD1590  [1]
 LDCM0387  CL117 HEK-293T C215(0.95)  LDD1591  [1]
 LDCM0388  CL118 HEK-293T C215(0.91)  LDD1592  [1]
 LDCM0390  CL12 HEK-293T C215(1.19)  LDD1594  [1]
 LDCM0391  CL120 HEK-293T C215(0.98)  LDD1595  [1]
 LDCM0392  CL121 HEK-293T C215(0.97)  LDD1596  [1]
 LDCM0393  CL122 HEK-293T C215(0.92)  LDD1597  [1]
 LDCM0395  CL124 HEK-293T C215(1.10)  LDD1599  [1]
 LDCM0396  CL125 HEK-293T C215(0.97)  LDD1600  [1]
 LDCM0397  CL126 HEK-293T C215(0.93)  LDD1601  [1]
 LDCM0399  CL128 HEK-293T C215(1.02)  LDD1603  [1]
 LDCM0400  CL13 HEK-293T C215(0.91)  LDD1604  [1]
 LDCM0401  CL14 HEK-293T C215(0.89)  LDD1605  [1]
 LDCM0403  CL16 HEK-293T C215(0.95)  LDD1607  [1]
 LDCM0404  CL17 HEK-293T C316(1.10)  LDD1608  [1]
 LDCM0407  CL2 HEK-293T C215(0.92)  LDD1611  [1]
 LDCM0410  CL22 HEK-293T C215(1.08)  LDD1614  [1]
 LDCM0412  CL24 HEK-293T C215(1.18)  LDD1616  [1]
 LDCM0413  CL25 HEK-293T C215(0.90)  LDD1617  [1]
 LDCM0414  CL26 HEK-293T C215(0.86)  LDD1618  [1]
 LDCM0416  CL28 HEK-293T C215(1.22)  LDD1620  [1]
 LDCM0417  CL29 HEK-293T C316(1.13)  LDD1621  [1]
 LDCM0423  CL34 HEK-293T C215(1.04)  LDD1627  [1]
 LDCM0425  CL36 HEK-293T C215(1.13)  LDD1629  [1]
 LDCM0426  CL37 HEK-293T C215(0.98)  LDD1630  [1]
 LDCM0429  CL4 HEK-293T C215(1.01)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C215(0.95)  LDD1634  [1]
 LDCM0431  CL41 HEK-293T C316(1.09)  LDD1635  [1]
 LDCM0436  CL46 HEK-293T C215(1.11)  LDD1640  [1]
 LDCM0438  CL48 HEK-293T C215(1.20)  LDD1642  [1]
 LDCM0439  CL49 HEK-293T C215(0.99)  LDD1643  [1]
 LDCM0440  CL5 HEK-293T C316(1.12)  LDD1644  [1]
 LDCM0441  CL50 HEK-293T C215(1.06)  LDD1645  [1]
 LDCM0443  CL52 HEK-293T C215(1.05)  LDD1646  [1]
 LDCM0444  CL53 HEK-293T C316(1.61)  LDD1647  [1]
 LDCM0449  CL58 HEK-293T C215(1.07)  LDD1652  [1]
 LDCM0452  CL60 HEK-293T C215(1.23)  LDD1655  [1]
 LDCM0453  CL61 HEK-293T C215(0.94)  LDD1656  [1]
 LDCM0454  CL62 HEK-293T C215(1.01)  LDD1657  [1]
 LDCM0456  CL64 HEK-293T C215(1.02)  LDD1659  [1]
 LDCM0457  CL65 HEK-293T C316(1.20)  LDD1660  [1]
 LDCM0463  CL70 HEK-293T C215(1.06)  LDD1666  [1]
 LDCM0465  CL72 HEK-293T C215(1.10)  LDD1668  [1]
 LDCM0466  CL73 HEK-293T C215(0.96)  LDD1669  [1]
 LDCM0467  CL74 HEK-293T C215(0.91)  LDD1670  [1]
 LDCM0469  CL76 HEK-293T C215(1.06)  LDD1672  [1]
 LDCM0470  CL77 HEK-293T C316(0.21)  LDD1673  [1]
 LDCM0476  CL82 HEK-293T C215(0.97)  LDD1679  [1]
 LDCM0478  CL84 HEK-293T C215(1.20)  LDD1681  [1]
 LDCM0479  CL85 HEK-293T C215(1.00)  LDD1682  [1]
 LDCM0480  CL86 HEK-293T C215(0.90)  LDD1683  [1]
 LDCM0482  CL88 HEK-293T C215(0.99)  LDD1685  [1]
 LDCM0483  CL89 HEK-293T C316(1.27)  LDD1686  [1]
 LDCM0489  CL94 HEK-293T C215(0.94)  LDD1692  [1]
 LDCM0491  CL96 HEK-293T C215(1.28)  LDD1694  [1]
 LDCM0492  CL97 HEK-293T C215(0.95)  LDD1695  [1]
 LDCM0493  CL98 HEK-293T C215(1.01)  LDD1696  [1]
 LDCM0427  Fragment51 HEK-293T C215(0.98)  LDD1631  [1]
 LDCM0022  KB02 HCC1806 C215(16.54)  LDD2341  [3]
 LDCM0023  KB03 HCC1806 C215(1.98)  LDD2758  [3]
 LDCM0024  KB05 CAL-51 C215(1.99)  LDD3122  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase SIAH1 (SIAH1) SINA (Seven in absentia) family Q8IUQ4

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840