Details of the Target

General Information of Target

Target ID LDTP05620
Target Name Nexilin (NEXN)
Gene Name NEXN
Gene ID 91624
Synonyms
Nexilin; F-actin-binding protein; Nelin
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MNDISQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQ
YIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKR
TEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYK
TSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKE
SLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAK
IFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEM
YKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEE
ENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLE
IKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRM
QFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSVVDSEPVR
FTVKVTGEPKPEITWWFEGEILQDGEDYQYIERGETYCLYLPETFPEDGGEYMCKAVNNK
GSAASTCILTIESKN
Target Bioclass
Immunoglobulin
Subcellular location
Cytoplasm, cytoskeleton
Function Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity.
Uniprot ID
Q0ZGT2
Ensemble ID
ENST00000330010.12
HGNC ID
HGNC:29557

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.L78I .
IGROV1 Deletion: p.R327GfsTer11 .
KYSE180 SNV: p.E338K .
NCIH1155 SNV: p.M77I .
NCIH661 SNV: p.K111Ter .
SH4 SNV: p.E267Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K103(10.00); K514(1.03); K97(5.88)  LDD0277  [1]
DBIA
 Probe Info  		C667(2.85)  LDD3312  [2]
Acrolein
 Probe Info  		N.A.  LDD0225  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C224(1.00)  LDD1507  [4]
 LDCM0237  AC12 HEK-293T C224(1.05)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C224(0.96)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C224(0.87)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C224(0.96)  LDD1515  [4]
 LDCM0280  AC20 HEK-293T C224(1.03)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C224(0.95)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C224(0.95)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C224(0.89)  LDD1522  [4]
 LDCM0285  AC25 HEK-293T C224(0.96)  LDD1524  [4]
 LDCM0288  AC28 HEK-293T C224(0.99)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C224(0.94)  LDD1528  [4]
 LDCM0291  AC30 HEK-293T C224(1.02)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C224(0.96)  LDD1531  [4]
 LDCM0294  AC33 HEK-293T C224(0.98)  LDD1533  [4]
 LDCM0297  AC36 HEK-293T C224(1.00)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C224(1.01)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C224(0.99)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C224(0.90)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C224(0.89)  LDD1540  [4]
 LDCM0303  AC41 HEK-293T C224(0.92)  LDD1542  [4]
 LDCM0306  AC44 HEK-293T C224(0.99)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C224(1.03)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C224(1.09)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C224(0.93)  LDD1548  [4]
 LDCM0311  AC49 HEK-293T C224(0.92)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C224(0.96)  LDD1551  [4]
 LDCM0315  AC52 HEK-293T C224(1.03)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C224(0.97)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C224(1.06)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C224(0.95)  LDD1557  [4]
 LDCM0320  AC57 HEK-293T C224(1.02)  LDD1559  [4]
 LDCM0323  AC6 HEK-293T C224(0.97)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C224(1.00)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C224(0.99)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C224(1.00)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C224(0.85)  LDD1566  [4]
 LDCM0334  AC7 HEK-293T C224(0.99)  LDD1568  [4]
 LDCM0248  AKOS034007472 HEK-293T C224(1.08)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C224(0.94)  LDD1570  [4]
 LDCM0368  CL10 HEK-293T C224(0.93)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C224(0.97)  LDD1573  [4]
 LDCM0373  CL104 HEK-293T C224(0.99)  LDD1577  [4]
 LDCM0377  CL108 HEK-293T C224(0.96)  LDD1581  [4]
 LDCM0379  CL11 HEK-293T C224(1.06)  LDD1583  [4]
 LDCM0382  CL112 HEK-293T C224(0.94)  LDD1586  [4]
 LDCM0386  CL116 HEK-293T C224(0.96)  LDD1590  [4]
 LDCM0391  CL120 HEK-293T C224(1.01)  LDD1595  [4]
 LDCM0395  CL124 HEK-293T C224(1.07)  LDD1599  [4]
 LDCM0399  CL128 HEK-293T C224(0.99)  LDD1603  [4]
 LDCM0403  CL16 HEK-293T C224(1.01)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C224(1.09)  LDD1608  [4]
 LDCM0408  CL20 HEK-293T C224(1.14)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C224(1.18)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C224(1.13)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C224(1.30)  LDD1615  [4]
 LDCM0416  CL28 HEK-293T C224(0.94)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C224(1.24)  LDD1621  [4]
 LDCM0421  CL32 HEK-293T C224(1.05)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C224(0.86)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C224(1.08)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C224(1.13)  LDD1628  [4]
 LDCM0429  CL4 HEK-293T C224(1.00)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C224(1.06)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C224(1.18)  LDD1635  [4]
 LDCM0434  CL44 HEK-293T C224(1.09)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C224(1.17)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C224(1.10)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C224(1.25)  LDD1641  [4]
 LDCM0440  CL5 HEK-293T C224(1.04)  LDD1644  [4]
 LDCM0443  CL52 HEK-293T C224(0.96)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C224(1.03)  LDD1647  [4]
 LDCM0447  CL56 HEK-293T C224(1.08)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C224(1.04)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C224(1.10)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C224(0.95)  LDD1653  [4]
 LDCM0456  CL64 HEK-293T C224(0.96)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C224(0.85)  LDD1660  [4]
 LDCM0460  CL68 HEK-293T C224(0.95)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C224(1.17)  LDD1664  [4]
 LDCM0463  CL70 HEK-293T C224(1.05)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C224(1.07)  LDD1667  [4]
 LDCM0469  CL76 HEK-293T C224(0.94)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C224(1.04)  LDD1673  [4]
 LDCM0473  CL8 HEK-293T C224(0.83)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C224(1.06)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C224(1.05)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C224(1.03)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C224(1.15)  LDD1680  [4]
 LDCM0482  CL88 HEK-293T C224(0.98)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C224(0.95)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C224(1.11)  LDD1687  [4]
 LDCM0487  CL92 HEK-293T C224(1.00)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C224(1.07)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C224(1.02)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C224(0.95)  LDD1693  [4]
 LDCM0022  KB02 42-MG-BA C667(3.39)  LDD2244  [2]
 LDCM0023  KB03 42-MG-BA C667(2.78)  LDD2661  [2]
 LDCM0024  KB05 HMCB C667(2.85)  LDD3312  [2]
 LDCM0109  NEM HeLa N.A.  LDD0225  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and SCAN domain-containing protein 22 (ZSCAN22) Krueppel C2H2-type zinc-finger protein family P10073
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RNA-binding protein FXR2 (FXR2) FMR1 family P51116

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402