Details of the Target

General Information of Target

Target ID LDTP05613
Target Name Break repair meiotic recombinase recruitment factor 1 (BRME1)
Gene Name BRME1
Gene ID 79173
Synonyms
C19orf57; Break repair meiotic recombinase recruitment factor 1; Pre-T/NK cell-associated protein 3B3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTKRKKLRTSGEGLCPPKPLKNPRLGDFYGDPQSSMLGCLHHPEEPEGKLGPVPSTQQHG
EEPGKAVSSSPDEETGSPCRLLRQPEKEPAPLPPSQNSFGRFVPQFAKSRKTVTRKEEMK
DEDRGSGAFSLETIAESSAQSPGCQLLVETLGVPLQEATELGDPTQADSARPEQSSQSPV
QAVPGSGDSQPDDPPDRGTGLSASQRASQDHLSEQGADDSKPETDRVPGDGGQKEHLPSI
DSEGEKPDRGAPQEGGAQRTAGAGLPGGPQEEGDGVPCTPASAPTSGPAPGLGPASWCLE
PGSVAQGSPDPQQTPSRMGREGEGTHSSLGCSSLGMVVIADLSTDPTELEERALEVAGPD
GQASAISPASPRRKAADGGHRRALPGCTSLTGETTGESGEAGQDGKPPGDVLVGPTASLA
LAPGSGESMMGAGDSGHASPDTGPCVNQKQEPGPAQEEAELGGQNLERDLEGFRVSPQAS
VVLEHREIADDPLQEPGAQQGIPDTTSELAGQRDHLPHSADQGTWADSLAVELDFLLDSQ
IQDALDASDFEAPPEQLFPSGNKPGPCWPGPSSHANGDPVAVAKAQPRTFVGIQASEASR
MEDATNVVRGLIVELSNLNRLIMGTHRDLEAFKRLNYRKTKLGGKAPLPYPSKGPGNIPR
GDPPWREL
Target Bioclass
Other
Subcellular location
Chromosome
Function
Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with and stabilization of the BRCA2:HSF2BP complex during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility.
Uniprot ID
Q0VDD7
Ensemble ID
ENST00000346736.6
HGNC ID
HGNC:28153

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.G358E .
CMK SNV: p.D72Y .
ICC4 SNV: p.Y650H .
JURKAT Deletion: p.D163TfsTer180
SNV: p.V531M		 .
ONS76 SNV: p.P32S .
SW1783 SNV: p.P23L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C79(2.50)  LDD2157  [1]
NAIA_5
 Probe Info  		C79(2.01)  LDD2227  [2]
DBIA
 Probe Info  		C79(0.95)  LDD1507  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C79(0.95)  LDD1507  [3]
 LDCM0226  AC11 HEK-293T C79(1.01)  LDD1509  [3]
 LDCM0259  AC14 HEK-293T C39(1.04)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C39(1.06)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C79(0.95)  LDD1515  [3]
 LDCM0278  AC19 HEK-293T C79(1.04)  LDD1517  [3]
 LDCM0281  AC21 HEK-293T C79(1.02)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C39(0.92)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C39(0.94)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C79(0.99); C39(1.14)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C79(1.14)  LDD1524  [3]
 LDCM0287  AC27 HEK-293T C79(1.09)  LDD1526  [3]
 LDCM0289  AC29 HEK-293T C79(0.97)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C79(0.98)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C39(1.06)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C39(1.21)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C79(1.07); C39(1.23)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C79(1.08)  LDD1533  [3]
 LDCM0296  AC35 HEK-293T C79(1.07)  LDD1535  [3]
 LDCM0298  AC37 HEK-293T C79(1.12)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C39(1.05)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C39(1.18)  LDD1539  [3]
 LDCM0302  AC40 HEK-293T C79(1.14); C39(1.19)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C79(0.95)  LDD1542  [3]
 LDCM0305  AC43 HEK-293T C79(1.11)  LDD1544  [3]
 LDCM0307  AC45 HEK-293T C79(1.05)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C39(1.12)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C39(1.12)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C79(0.93); C39(1.35)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C79(1.07)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C79(1.07)  LDD1551  [3]
 LDCM0314  AC51 HEK-293T C79(1.10)  LDD1553  [3]
 LDCM0316  AC53 HEK-293T C79(1.07)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C39(1.03)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C39(1.12)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C79(1.10); C39(1.08)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C79(0.92)  LDD1559  [3]
 LDCM0322  AC59 HEK-293T C79(1.07)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C39(0.98)  LDD1562  [3]
 LDCM0325  AC61 HEK-293T C79(0.94)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C39(1.01)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C39(1.07)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C79(1.06); C39(0.90)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C39(1.14)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C79(0.94); C39(1.13)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C79(1.15)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C79(0.98)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C79(1.07); C39(1.07)  LDD1514  [3]
 LDCM0632  CL-Sc Hep-G2 C79(2.01)  LDD2227  [2]
 LDCM0368  CL10 HEK-293T C39(1.07)  LDD1572  [3]
 LDCM0372  CL103 HEK-293T C39(0.92)  LDD1576  [3]
 LDCM0376  CL107 HEK-293T C39(1.05)  LDD1580  [3]
 LDCM0379  CL11 HEK-293T C39(1.11)  LDD1583  [3]
 LDCM0381  CL111 HEK-293T C39(1.06)  LDD1585  [3]
 LDCM0385  CL115 HEK-293T C39(0.85)  LDD1589  [3]
 LDCM0389  CL119 HEK-293T C39(0.91)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C79(1.25); C39(1.26)  LDD1594  [3]
 LDCM0394  CL123 HEK-293T C39(0.78)  LDD1598  [3]
 LDCM0398  CL127 HEK-293T C39(1.01)  LDD1602  [3]
 LDCM0402  CL15 HEK-293T C39(0.95)  LDD1606  [3]
 LDCM0404  CL17 HEK-293T C79(1.28)  LDD1608  [3]
 LDCM0406  CL19 HEK-293T C79(1.10)  LDD1610  [3]
 LDCM0409  CL21 HEK-293T C79(0.89)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C39(1.05)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C39(1.16)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C79(1.28); C39(1.01)  LDD1616  [3]
 LDCM0415  CL27 HEK-293T C39(0.88)  LDD1619  [3]
 LDCM0417  CL29 HEK-293T C79(1.13)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C39(0.90)  LDD1622  [3]
 LDCM0420  CL31 HEK-293T C79(0.97)  LDD1624  [3]
 LDCM0422  CL33 HEK-293T C79(1.04)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C39(0.95)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C39(0.99)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C79(1.14); C39(1.01)  LDD1629  [3]
 LDCM0428  CL39 HEK-293T C39(0.76)  LDD1632  [3]
 LDCM0431  CL41 HEK-293T C79(0.97)  LDD1635  [3]
 LDCM0433  CL43 HEK-293T C79(1.03)  LDD1637  [3]
 LDCM0435  CL45 HEK-293T C79(1.11)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C39(0.97)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C39(1.02)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C79(1.04); C39(1.12)  LDD1642  [3]
 LDCM0440  CL5 HEK-293T C79(1.03)  LDD1644  [3]
 LDCM0444  CL53 HEK-293T C79(0.89)  LDD1647  [3]
 LDCM0446  CL55 HEK-293T C79(1.10)  LDD1649  [3]
 LDCM0448  CL57 HEK-293T C79(0.94)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C39(0.86)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C39(1.13)  LDD1653  [3]
 LDCM0452  CL60 HEK-293T C79(0.97); C39(1.18)  LDD1655  [3]
 LDCM0455  CL63 HEK-293T C39(1.25)  LDD1658  [3]
 LDCM0457  CL65 HEK-293T C79(0.94)  LDD1660  [3]
 LDCM0459  CL67 HEK-293T C79(0.88)  LDD1662  [3]
 LDCM0461  CL69 HEK-293T C79(0.92)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C79(1.12)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C39(1.21)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C39(1.10)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C79(1.00); C39(1.09)  LDD1668  [3]
 LDCM0470  CL77 HEK-293T C79(0.98)  LDD1673  [3]
 LDCM0472  CL79 HEK-293T C79(1.05)  LDD1675  [3]
 LDCM0475  CL81 HEK-293T C79(1.02)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C39(1.14)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C39(1.05)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C79(1.13); C39(1.17)  LDD1681  [3]
 LDCM0481  CL87 HEK-293T C39(1.00)  LDD1684  [3]
 LDCM0483  CL89 HEK-293T C79(0.88)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C79(1.13)  LDD1687  [3]
 LDCM0486  CL91 HEK-293T C79(1.08)  LDD1689  [3]
 LDCM0488  CL93 HEK-293T C79(1.13)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C39(0.94)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C39(0.57)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C79(1.25); C39(1.38)  LDD1694  [3]
 LDCM0494  CL99 HEK-293T C39(0.91)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C39(0.86)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C39(0.92)  LDD1671  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
COP9 signalosome complex subunit 4 (COPS4) CSN4 family Q9BT78
Proteasome subunit alpha type-6 (PSMA6) Peptidase T1A family P60900
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Transthyretin (TTR) Transthyretin family P02766
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleoporin p58/p45 (NUP58) NUP58 family Q9BVL2
Syntaxin-binding protein 1 (STXBP1) STXBP/unc-18/SEC1 family P61764
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BRICK1 (BRK1) BRK1 family Q8WUW1
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
HAUS augmin-like complex subunit 3 (HAUS3) HAUS3 family Q68CZ6
Homer protein homolog 1 (HOMER1) Homer family Q86YM7
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cuticular Ha8 (KRT38) Intermediate filament family O76015
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
T-complex protein 1 subunit theta (CCT8) TCP-1 chaperonin family P50990
Alpha-catulin (CTNNAL1) Vinculin/alpha-catenin family Q9UBT7
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) . Q13155

References

1 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402