Details of the Target

General Information of Target

Target ID LDTP05565
Target Name Dematin (DMTN)
Gene Name DMTN
Gene ID 2039
Synonyms
DMT; EPB49; Dematin; Dematin actin-binding protein; Erythrocyte membrane protein band 4.9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERLQKQPLTSPGSVSPSRDSSVPGSPSSIVAKMDNQVLGYKDLAAIPKDKAILDIERPD
LMIYEPHFTYSLLEHVELPRSRERSLSPKSTSPPPSPEVWADSRSPGIISQASAPRTTGT
PRTSLPHFHHPETSRPDSNIYKKPPIYKQRESVGGSPQTKHLIEDLIIESSKFPAAQPPD
PNQPAKIETDYWPCPPSLAVVETEWRKRKASRRGAEEEEEEEDDDSGEEMKALRERQREE
LSKVTSNLGKMILKEEMEKSLPIRRKTRSLPDRTPFHTSLHQGTSKSSSLPAYGRTTLSR
LQSTEFSPSGSETGSPGLQNGEGQRGRMDRGNSLPCVLEQKIYPYEMLVVTNKGRTKLPP
GVDRMRLERHLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF
Target Bioclass
Other
Family
Villin/gelsolin family
Subcellular location
Cytoplasm
Function
Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.
Uniprot ID
Q08495
Ensemble ID
ENST00000265800.9
HGNC ID
HGNC:3382

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.I47T .
CHL1 SNV: p.L290F .
MOLT4 Deletion: p.P94HfsTer137 .
RKN SNV: p.E229D .
SKES1 SNV: p.N182K .
TE4 SNV: p.G214R .
TOV21G SNV: p.P17H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C194(1.10)  LDD3402  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C194(1.14)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C194(0.87)  LDD1508  [2]
 LDCM0237  AC12 HEK-293T C194(0.94)  LDD1510  [2]
 LDCM0276  AC17 HEK-293T C194(1.03)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C194(1.39)  LDD1516  [2]
 LDCM0279  AC2 HEK-293T C194(1.08)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C194(0.85)  LDD1519  [2]
 LDCM0284  AC24 HEK-293T C194(0.99)  LDD1523  [2]
 LDCM0285  AC25 HEK-293T C194(1.11)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C194(0.88)  LDD1525  [2]
 LDCM0288  AC28 HEK-293T C194(1.06)  LDD1527  [2]
 LDCM0293  AC32 HEK-293T C194(0.88)  LDD1532  [2]
 LDCM0294  AC33 HEK-293T C194(0.98)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C194(1.08)  LDD1534  [2]
 LDCM0297  AC36 HEK-293T C194(0.95)  LDD1536  [2]
 LDCM0301  AC4 HEK-293T C194(0.85)  LDD1540  [2]
 LDCM0302  AC40 HEK-293T C194(0.89)  LDD1541  [2]
 LDCM0303  AC41 HEK-293T C194(1.17)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C194(1.17)  LDD1543  [2]
 LDCM0306  AC44 HEK-293T C194(1.10)  LDD1545  [2]
 LDCM0310  AC48 HEK-293T C194(1.19)  LDD1549  [2]
 LDCM0311  AC49 HEK-293T C194(1.17)  LDD1550  [2]
 LDCM0313  AC50 HEK-293T C194(1.20)  LDD1552  [2]
 LDCM0315  AC52 HEK-293T C194(1.30)  LDD1554  [2]
 LDCM0319  AC56 HEK-293T C194(1.11)  LDD1558  [2]
 LDCM0320  AC57 HEK-293T C194(1.18)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C194(1.13)  LDD1560  [2]
 LDCM0324  AC60 HEK-293T C194(1.03)  LDD1563  [2]
 LDCM0328  AC64 HEK-293T C194(0.97)  LDD1567  [2]
 LDCM0345  AC8 HEK-293T C194(0.61)  LDD1569  [2]
 LDCM0356  AKOS034007680 HEK-293T C194(1.06)  LDD1570  [2]
 LDCM0275  AKOS034007705 HEK-293T C194(0.98)  LDD1514  [2]
 LDCM0369  CL100 HEK-293T C194(0.71)  LDD1573  [2]
 LDCM0372  CL103 HEK-293T C194(0.84)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C194(1.21)  LDD1577  [2]
 LDCM0376  CL107 HEK-293T C194(1.05)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C194(0.94)  LDD1581  [2]
 LDCM0381  CL111 HEK-293T C194(1.27)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C194(1.12)  LDD1586  [2]
 LDCM0385  CL115 HEK-293T C194(1.13)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C194(1.17)  LDD1590  [2]
 LDCM0389  CL119 HEK-293T C194(0.94)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C194(0.87)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C194(1.06)  LDD1595  [2]
 LDCM0394  CL123 HEK-293T C194(1.01)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C194(0.92)  LDD1599  [2]
 LDCM0398  CL127 HEK-293T C194(0.94)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C194(0.88)  LDD1603  [2]
 LDCM0402  CL15 HEK-293T C194(0.85)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C194(0.88)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C194(0.98)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C194(0.85)  LDD1609  [2]
 LDCM0408  CL20 HEK-293T C194(1.05)  LDD1612  [2]
 LDCM0412  CL24 HEK-293T C194(0.96)  LDD1616  [2]
 LDCM0415  CL27 HEK-293T C194(1.01)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C194(0.92)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C194(1.07)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C194(0.96)  LDD1622  [2]
 LDCM0419  CL30 HEK-293T C194(1.02)  LDD1623  [2]
 LDCM0421  CL32 HEK-293T C194(0.91)  LDD1625  [2]
 LDCM0425  CL36 HEK-293T C194(0.79)  LDD1629  [2]
 LDCM0428  CL39 HEK-293T C194(1.28)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C194(0.98)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C194(0.90)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C194(1.35)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C194(0.89)  LDD1636  [2]
 LDCM0434  CL44 HEK-293T C194(1.05)  LDD1638  [2]
 LDCM0438  CL48 HEK-293T C194(0.79)  LDD1642  [2]
 LDCM0440  CL5 HEK-293T C194(1.18)  LDD1644  [2]
 LDCM0443  CL52 HEK-293T C194(0.97)  LDD1646  [2]
 LDCM0444  CL53 HEK-293T C194(0.84)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C194(0.96)  LDD1648  [2]
 LDCM0447  CL56 HEK-293T C194(1.11)  LDD1650  [2]
 LDCM0451  CL6 HEK-293T C194(0.80)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C194(0.90)  LDD1655  [2]
 LDCM0455  CL63 HEK-293T C194(1.03)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C194(0.88)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C194(1.17)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C194(1.30)  LDD1661  [2]
 LDCM0460  CL68 HEK-293T C194(1.07)  LDD1663  [2]
 LDCM0465  CL72 HEK-293T C194(0.98)  LDD1668  [2]
 LDCM0469  CL76 HEK-293T C194(1.02)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C194(1.10)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C194(1.19)  LDD1674  [2]
 LDCM0473  CL8 HEK-293T C194(0.97)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C194(1.22)  LDD1677  [2]
 LDCM0478  CL84 HEK-293T C194(0.69)  LDD1681  [2]
 LDCM0481  CL87 HEK-293T C194(1.09)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C194(1.25)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C194(1.07)  LDD1686  [2]
 LDCM0485  CL90 HEK-293T C194(0.90)  LDD1688  [2]
 LDCM0487  CL92 HEK-293T C194(1.04)  LDD1690  [2]
 LDCM0491  CL96 HEK-293T C194(1.93)  LDD1694  [2]
 LDCM0494  CL99 HEK-293T C194(1.10)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C194(0.98)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C194(1.16)  LDD1671  [2]
 LDCM0022  KB02 EoL-1 C194(1.18)  LDD2324  [1]
 LDCM0023  KB03 COLO 320 C194(0.93)  LDD2720  [1]
 LDCM0024  KB05 REC-1 C194(1.10)  LDD3402  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402