Details of the Target

General Information of Target

Target ID LDTP05463
Target Name Collagen alpha-1(XIV) chain (COL14A1)
Gene Name COL14A1
Gene ID 7373
Synonyms
UND; Collagen alpha-1(XIV) chain; Undulin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKIFQRKMRYWLLPPFLAIVYFCTIVQGQVAPPTRLRYNVISHDSIQISWKAPRGKFGGY
KLLVTPTSGGKTNQLNLQNTATKAIIQGLMPDQNYTVQIIAYNKDKESKPAQGQFRIKDL
EKRKDPKPRVKVVDRGNGSRPSSPEEVKFVCQTPAIADIVILVDGSWSIGRFNFRLVRHF
LENLVTAFDVGSEKTRIGLAQYSGDPRIEWHLNAFSTKDEVIEAVRNLPYKGGNTLTGLA
LNYIFENSFKPEAGSRTGVSKIGILITDGKSQDDIIPPSRNLRESGVELFAIGVKNADVN
ELQEIASEPDSTHVYNVAEFDLMHTVVESLTRTLCSRVEEQDREIKASAHAITGPPTELI
TSEVTARSFMVNWTHAPGNVEKYRVVYYPTRGGKPDEVVVDGTVSSTVLKNLMSLTEYQI
AVFAIYAHTASEGLRGTETTLALPMASDLLLYDVTENSMRVKWDAVPGASGYLILYAPLT
EGLAGDEKEMKIGETHTDIELSGLLPNTEYTVTVYAMFGEEASDPVTGQETTLALSPPRN
LRISNVGSNSARLTWDPTSRQINGYRIVYNNADGTEINEVEVDPITTFPLKGLTPLTEYT
IAIFSIYDEGQSEPLTGVFTTEEVPAQQYLEIDEVTTDSFRVTWHPLSADEGLHKLMWIP
VYGGKTEEVVLKEEQDSHVIEGLEPGTEYEVSLLAVLDDGSESEVVTAVGTTLDSFWTEP
ATTIVPTTSVTSVFQTGIRNLVVGDETTSSLRVKWDISDSDVQQFRVTYMTAQGDPEEEV
IGTVMVPGSQNNLLLKPLLPDTEYKVTVTPIYTDGEGVSVSAPGKTLPSSGPQNLRVSEE
WYNRLRITWDPPSSPVKGYRIVYKPVSVPGPTLETFVGADINTILITNLLSGMDYNVKIF
ASQASGFSDALTGMVKTLFLGVTNLQAKHVEMTSLCAHWQVHRHATAYRVVIESLQDRQK
QESTVGGGTTRHCFYGLQPDSEYKISVYTKLQEIEGPSVSIMEKTQSLPTRPPTFPPTIP
PAKEVCKAAKADLVFMVDGSWSIGDENFNKIISFLYSTVGALNKIGTDGTQVAMVQFTDD
PRTEFKLNAYKTKETLLDAIKHISYKGGNTKTGKAIKYVRDTLFTAESGTRRGIPKVIVV
ITDGRSQDDVNKISREMQLDGYSIFAIGVADADYSELVSIGSKPSARHVFFVDDFDAFKK
IEDELITFVCETASATCPVVHKDGIDLAGFKMMEMFGLVEKDFSSVEGVSMEPGTFNVFP
CYQLHKDALVSQPTRYLHPEGLPSDYTISFLFRILPDTPQEPFALWEILNKNSDPLVGVI
LDNGGKTLTYFNYDQSGDFQTVTFEGPEIRKIFYGSFHKLHIVVSETLVKVVIDCKQVGE
KAMNASANITSDGVEVLGKMVRSRGPGGNSAPFQLQMFDIVCSTSWANTDKCCELPGLRD
DESCPDLPHSCSCSETNEVALGPAGPPGGPGLRGPKGQQGEPGPKGPDGPRGEIGLPGPQ
GPPGPQGPSGLSIQGMPGMPGEKGEKGDTGLPGPQGIPGGVGSPGRDGSPGQRGLPGKDG
SSGPPGPPGPIGIPGTPGVPGITGSMGPQGALGPPGVPGAKGERGERGDLQSQAMVRSVA
RQVCEQLIQSHMARYTAILNQIPSHSSSIRTVQGPPGEPGRPGSPGAPGEQGPPGTPGFP
GNAGVPGTPGERGLTGIKGEKGNPGVGTQGPRGPPGPAGPSGESRPGSPGPPGSPGPRGP
PGHLGVPGPQGPSGQPGYCDPSSCSAYGVRAPHPDQPEFTPVQDELEAMELWGPGV
Target Bioclass
Other
Family
Fibril-associated collagens with interrupted helices (FACIT) family
Subcellular location
Secreted, extracellular space, extracellular matrix
Function
Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors.
Uniprot ID
Q05707
Ensemble ID
ENST00000297848.8
HGNC ID
HGNC:2191

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R178W .
CAL27 SNV: p.T1216N .
CCK81 SNV: p.Q763H .
DU145 SNV: p.Q1272K .
HCT15 SNV: p.G966C .
HT1197 SNV: p.D1068G .
IGR1 SNV: p.D164N .
IPC298 SNV: p.G402E .
LN229 SNV: p.S1509I .
MCC26 SNV: p.P1714S DBIA    Probe Info 
MDAMB453 SNV: p.T728I .
MDST8 SNV: p.G1768C .
MFE319 Insertion: p.G1716WfsTer45
SNV: p.Q419H		 .
MOLT4 SNV: p.V1369A .
NALM6 SNV: p.A1115T .
NCIH661 Substitution: p.S981D .
PC14 SNV: p.V930I .
PC9 SNV: p.V930I .
RH41 SNV: p.Y1090Ter DBIA    Probe Info 
RKO Deletion: p.P852HfsTer5
SNV: p.G737R		 .
RL952 SNV: p.Y1262H .
SKMEL2 Substitution: p.G1602K .
TE4 SNV: p.M8K; p.G392C; p.R1604L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1261(2.90); C973(5.51); C1624(5.62)  LDD3401  [1]
TFBX
 Probe Info  		N.A.  LDD0148  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1217(1.04)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C1624(1.07); C1217(1.04)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C1624(1.13)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C1217(0.95)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C1624(0.92); C1217(1.09)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C1624(1.04); C1217(1.14)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C1217(1.19)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C1624(0.95); C1217(1.14)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C1624(1.45)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C1624(0.89); C1217(0.97)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C1217(1.03)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C1261(1.09); C1217(1.14)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C1624(1.36); C1217(1.11)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C1624(1.04); C1217(0.97)  LDD1522  [3]
 LDCM0285  AC25 HEK-293T C1217(1.12)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C1624(0.99); C1217(1.13)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C1624(1.16)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C1217(0.98)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C1261(1.08); C1217(1.03)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C1624(1.15)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C1624(1.26); C1217(1.10)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C1624(0.99); C1217(1.16)  LDD1531  [3]
 LDCM0294  AC33 HEK-293T C1217(1.15)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C1624(1.15); C1217(1.26)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C1624(1.32)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C1217(1.10)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C1261(1.07); C1217(0.84)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C1624(0.76); C1217(0.95)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C1624(1.13); C1217(1.03)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C1217(0.88)  LDD1540  [3]
 LDCM0303  AC41 HEK-293T C1217(1.07)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C1624(1.31); C1217(0.92)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C1624(1.06)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C1217(0.96)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C1261(1.16); C1217(1.01)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C1624(1.32); C1217(0.85)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C1624(1.44); C1217(0.90)  LDD1548  [3]
 LDCM0311  AC49 HEK-293T C1217(0.98)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C1261(1.26); C1217(0.81)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C1624(1.19); C1217(0.88)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C1624(1.09)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C1217(0.94)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C1261(1.21); C1217(1.05)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C1624(0.86); C1217(0.73)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C1624(0.97); C1217(0.94)  LDD1557  [3]
 LDCM0320  AC57 HEK-293T C1217(1.09)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C1624(1.39); C1217(1.02)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C1624(1.24)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C1624(1.00); C1217(1.09)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C1217(0.95)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C1261(1.13); C1217(0.92)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C1624(1.41); C1217(1.12)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C1624(1.41); C1217(0.92)  LDD1566  [3]
 LDCM0334  AC7 HEK-293T C1624(1.17); C1217(1.13)  LDD1568  [3]
 LDCM0248  AKOS034007472 HEK-293T C1261(1.20); C1217(1.07)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C1217(1.07)  LDD1570  [3]
 LDCM0367  CL1 HEK-293T C1217(0.92)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C1624(0.59); C1217(0.94)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C1217(1.01)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C1217(0.90)  LDD1574  [3]
 LDCM0372  CL103 HEK-293T C1217(0.80)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C1217(1.06)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C1217(1.02)  LDD1578  [3]
 LDCM0376  CL107 HEK-293T C1217(0.83)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C1217(1.20)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C1217(0.86)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C1624(0.50); C1217(0.96)  LDD1583  [3]
 LDCM0381  CL111 HEK-293T C1217(0.91)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C1217(1.03)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C1217(0.94)  LDD1587  [3]
 LDCM0385  CL115 HEK-293T C1217(0.88)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C1217(1.07)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C1217(0.90)  LDD1591  [3]
 LDCM0389  CL119 HEK-293T C1217(1.00)  LDD1593  [3]
 LDCM0391  CL120 HEK-293T C1217(0.89)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C1217(1.16)  LDD1596  [3]
 LDCM0394  CL123 HEK-293T C1217(0.85)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C1217(0.78)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C1217(1.23)  LDD1600  [3]
 LDCM0398  CL127 HEK-293T C1217(0.85)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C1217(1.00)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C1217(0.99)  LDD1604  [3]
 LDCM0402  CL15 HEK-293T C1217(0.98)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C1217(1.08)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C1217(1.00)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C1624(0.64); C1217(1.27)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C1624(0.62)  LDD1610  [3]
 LDCM0408  CL20 HEK-293T C1217(0.91)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C1261(1.03); C1217(0.70)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C1624(0.50); C1217(0.95)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C1624(0.45); C1217(1.17)  LDD1615  [3]
 LDCM0413  CL25 HEK-293T C1217(1.26)  LDD1617  [3]
 LDCM0415  CL27 HEK-293T C1217(0.90)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C1217(1.00)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C1217(1.22)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C1217(0.92)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C1624(0.65); C1217(0.90)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C1624(0.64)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C1217(1.05)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C1261(0.14); C1217(0.95)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C1624(0.50); C1217(0.78)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C1624(0.46); C1217(1.15)  LDD1628  [3]
 LDCM0426  CL37 HEK-293T C1217(1.18)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C1217(0.88)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C1217(1.02)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C1217(1.01)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C1217(1.02)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C1624(0.80); C1217(1.06)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C1624(0.75)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C1217(0.95)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C1261(1.21); C1217(1.04)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C1624(0.50); C1217(0.80)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C1624(0.51); C1217(1.06)  LDD1641  [3]
 LDCM0439  CL49 HEK-293T C1217(0.97)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C1217(1.31)  LDD1644  [3]
 LDCM0443  CL52 HEK-293T C1217(0.96)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C1217(1.09)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C1624(0.72); C1217(1.30)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C1624(0.71)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C1217(1.20)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C1261(1.08); C1217(1.04)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C1624(0.51); C1217(0.99)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C1624(0.48); C1217(1.22)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C1624(0.71); C1217(1.11)  LDD1654  [3]
 LDCM0453  CL61 HEK-293T C1217(1.00)  LDD1656  [3]
 LDCM0455  CL63 HEK-293T C1217(0.92)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C1217(0.92)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C1217(1.16)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C1624(0.89); C1217(0.72)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C1624(0.82)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C1217(0.98)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C1261(0.94); C1217(0.84)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C1624(0.68)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C1624(0.57); C1217(0.90)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C1624(0.44); C1217(1.25)  LDD1667  [3]
 LDCM0466  CL73 HEK-293T C1217(1.05)  LDD1669  [3]
 LDCM0469  CL76 HEK-293T C1217(1.11)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C1217(1.06)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C1624(0.93); C1217(1.04)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C1624(0.72)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C1217(1.23)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C1217(1.02)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C1261(1.15); C1217(1.03)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C1624(0.55); C1217(0.86)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C1624(0.63); C1217(1.13)  LDD1680  [3]
 LDCM0479  CL85 HEK-293T C1217(0.87)  LDD1682  [3]
 LDCM0481  CL87 HEK-293T C1217(0.91)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C1217(1.01)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C1217(1.28)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C1261(1.32); C1217(0.91)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C1624(0.98); C1217(1.05)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C1624(0.99)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C1217(0.89)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C1261(1.08); C1217(0.96)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C1624(0.81); C1217(0.82)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C1624(0.86); C1217(0.92)  LDD1693  [3]
 LDCM0492  CL97 HEK-293T C1217(0.97)  LDD1695  [3]
 LDCM0494  CL99 HEK-293T C1217(0.86)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C1217(0.79)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C1217(0.93)  LDD1671  [3]
 LDCM0022  KB02 HEK-293T C1261(0.98)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C1261(1.09)  LDD1497  [3]
 LDCM0024  KB05 RD C1261(2.90); C973(5.51); C1624(5.62)  LDD3401  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402