Details of the Target

General Information of Target

Target ID LDTP04731
Target Name Integrin alpha-1 (ITGA1)
Gene Name ITGA1
Gene ID 3672
Synonyms
Integrin alpha-1; CD49 antigen-like family member A; Laminin and collagen receptor; VLA-1; CD antigen CD49a
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPRPRARPGVAVACCWLLTVVLRCCVSFNVDVKNSMTFSGPVEDMFGYTVQQYENEEGK
WVLIGSPLVGQPKNRTGDVYKCPVGRGESLPCVKLDLPVNTSIPNVTEVKENMTFGSTLV
TNPNGGFLACGPLYAYRCGHLHYTTGICSDVSPTFQVVNSIAPVQECSTQLDIVIVLDGS
NSIYPWDSVTAFLNDLLERMDIGPKQTQVGIVQYGENVTHEFNLNKYSSTEEVLVAAKKI
VQRGGRQTMTALGIDTARKEAFTEARGARRGVKKVMVIVTDGESHDNHRLKKVIQDCEDE
NIQRFSIAILGSYNRGNLSTEKFVEEIKSIASEPTEKHFFNVSDELALVTIVKTLGERIF
ALEATADQSAASFEMEMSQTGFSAHYSQDWVMLGAVGAYDWNGTVVMQKASQIIIPRNTT
FNVESTKKNEPLASYLGYTVNSATASSGDVLYIAGQPRYNHTGQVIIYRMEDGNIKILQT
LSGEQIGSYFGSILTTTDIDKDSNTDILLVGAPMYMGTEKEEQGKVYVYALNQTRFEYQM
SLEPIKQTCCSSRQHNSCTTENKNEPCGARFGTAIAAVKDLNLDGFNDIVIGAPLEDDHG
GAVYIYHGSGKTIRKEYAQRIPSGGDGKTLKFFGQSIHGEMDLNGDGLTDVTIGGLGGAA
LFWSRDVAVVKVTMNFEPNKVNIQKKNCHMEGKETVCINATVCFDVKLKSKEDTIYEADL
QYRVTLDSLRQISRSFFSGTQERKVQRNITVRKSECTKHSFYMLDKHDFQDSVRITLDFN
LTDPENGPVLDDSLPNSVHEYIPFAKDCGNKEKCISDLSLHVATTEKDLLIVRSQNDKFN
VSLTVKNTKDSAYNTRTIVHYSPNLVFSGIEAIQKDSCESNHNITCKVGYPFLRRGEMVT
FKILFQFNTSYLMENVTIYLSATSDSEEPPETLSDNVVNISIPVKYEVGLQFYSSASEYH
ISIAANETVPEVINSTEDIGNEINIFYLIRKSGSFPMPELKLSISFPNMTSNGYPVLYPT
GLSSSENANCRPHIFEDPFSINSGKKMTTSTDHLKRGTILDCNTCKFATITCNLTSSDIS
QVNVSLILWKPTFIKSYFSSLNLTIRGELRSENASLVLSSSNQKRELAIQISKDGLPGRV
PLWVILLSAFAGLLLLMLLILALWKIGFFKRPLKKKMEK
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Family
Integrin alpha chain family
Subcellular location
Membrane
Function
Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.
TTD ID
T31818
Uniprot ID
P56199
DrugMap ID
TTPERWV
Ensemble ID
ENST00000282588.7
HGNC ID
HGNC:6134
ChEMBL ID
CHEMBL3682

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K1055(0.38); K1046(0.55); K849(0.92); K546(0.96)  LDD3494  [1]
DBIA
 Probe Info  		C567(2.66); C297(3.82)  LDD3346  [2]
IPM
 Probe Info  		C549(2.77)  LDD1701  [3]
Acrolein
 Probe Info  		C297(0.00); H860(0.00)  LDD0221  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
m-APA
 Probe Info  		H860(0.00); H285(0.00); H555(0.00)  LDD2231  [5]
IA-alkyne
 Probe Info  		C92(0.00); C756(0.00)  LDD0165  [6]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [4]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C550(1.31)  LDD1508  [7]
 LDCM0259  AC14 HEK-293T C25(1.09)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C25(1.06)  LDD1513  [7]
 LDCM0277  AC18 HEK-293T C550(1.06)  LDD1516  [7]
 LDCM0279  AC2 HEK-293T C550(1.31)  LDD1518  [7]
 LDCM0281  AC21 HEK-293T C25(1.03)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C25(1.01)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C25(1.01)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C25(0.98)  LDD1523  [7]
 LDCM0286  AC26 HEK-293T C550(1.17)  LDD1525  [7]
 LDCM0289  AC29 HEK-293T C25(0.99)  LDD1528  [7]
 LDCM0291  AC30 HEK-293T C25(1.02)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C25(0.97)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C25(0.98)  LDD1532  [7]
 LDCM0295  AC34 HEK-293T C550(1.12)  LDD1534  [7]
 LDCM0298  AC37 HEK-293T C25(0.94)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C25(1.06)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C25(1.12)  LDD1539  [7]
 LDCM0302  AC40 HEK-293T C25(0.92)  LDD1541  [7]
 LDCM0304  AC42 HEK-293T C550(1.05)  LDD1543  [7]
 LDCM0307  AC45 HEK-293T C25(1.01)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C25(1.11)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C25(1.03)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C25(0.98)  LDD1549  [7]
 LDCM0312  AC5 HEK-293T C25(0.90)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C550(1.23)  LDD1552  [7]
 LDCM0316  AC53 HEK-293T C25(1.04)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C25(0.98)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C25(1.07)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C25(1.00)  LDD1558  [7]
 LDCM0321  AC58 HEK-293T C550(1.00)  LDD1560  [7]
 LDCM0323  AC6 HEK-293T C25(0.96)  LDD1562  [7]
 LDCM0325  AC61 HEK-293T C25(0.95)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C25(1.06)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C25(1.02)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C25(1.02)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C25(1.07)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C25(0.91)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C25(0.98)  LDD1511  [7]
 LDCM0275  AKOS034007705 HEK-293T C25(0.96)  LDD1514  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0367  CL1 HEK-293T C92(1.07); C25(1.05)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C25(1.31)  LDD1572  [7]
 LDCM0370  CL101 HEK-293T C92(0.99); C25(1.01)  LDD1574  [7]
 LDCM0374  CL105 HEK-293T C92(1.03); C25(1.05)  LDD1578  [7]
 LDCM0378  CL109 HEK-293T C92(0.92); C25(1.01)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C25(1.26)  LDD1583  [7]
 LDCM0383  CL113 HEK-293T C92(1.05); C25(0.99)  LDD1587  [7]
 LDCM0387  CL117 HEK-293T C92(1.00); C25(1.06)  LDD1591  [7]
 LDCM0390  CL12 HEK-293T C25(1.09)  LDD1594  [7]
 LDCM0392  CL121 HEK-293T C92(1.15); C25(0.99)  LDD1596  [7]
 LDCM0396  CL125 HEK-293T C92(1.07); C25(1.00)  LDD1600  [7]
 LDCM0400  CL13 HEK-293T C92(1.10); C25(1.02)  LDD1604  [7]
 LDCM0405  CL18 HEK-293T C550(1.02)  LDD1609  [7]
 LDCM0409  CL21 HEK-293T C25(1.35)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C25(1.13)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C25(1.26)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C25(1.05)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C92(0.88); C25(1.02)  LDD1617  [7]
 LDCM0419  CL30 HEK-293T C550(1.02)  LDD1623  [7]
 LDCM0422  CL33 HEK-293T C25(1.34)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C25(1.31)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C25(1.14)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C25(1.21)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C92(0.84); C25(1.00)  LDD1630  [7]
 LDCM0432  CL42 HEK-293T C550(1.16)  LDD1636  [7]
 LDCM0435  CL45 HEK-293T C25(1.24)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C25(1.21)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C25(1.15)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C25(1.20)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C92(0.93); C25(1.04)  LDD1643  [7]
 LDCM0445  CL54 HEK-293T C550(1.02)  LDD1648  [7]
 LDCM0448  CL57 HEK-293T C25(1.10)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C25(1.21)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C25(1.26)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C550(1.36)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C25(1.05)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C92(0.88); C25(0.93)  LDD1656  [7]
 LDCM0458  CL66 HEK-293T C550(1.19)  LDD1661  [7]
 LDCM0461  CL69 HEK-293T C25(1.14)  LDD1664  [7]
 LDCM0463  CL70 HEK-293T C25(1.19)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C25(1.16)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C25(1.03)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C92(1.07); C25(1.10)  LDD1669  [7]
 LDCM0471  CL78 HEK-293T C550(1.05)  LDD1674  [7]
 LDCM0475  CL81 HEK-293T C25(1.04)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C25(1.13)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C25(1.10)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C25(1.14)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C92(0.93); C25(0.99)  LDD1682  [7]
 LDCM0484  CL9 HEK-293T C25(1.18)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C550(1.09)  LDD1688  [7]
 LDCM0488  CL93 HEK-293T C25(1.05)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C25(1.20)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C25(1.39)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C25(1.28)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C92(1.00); C25(1.09)  LDD1695  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C549(1.40)  LDD1702  [3]
 LDCM0107  IAA HeLa C297(0.00); H860(0.00)  LDD0221  [4]
 LDCM0022  KB02 HEK-293T C25(0.95)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C25(1.04)  LDD1497  [7]
 LDCM0024  KB05 NCI-H1666 C567(2.66); C297(3.82)  LDD3346  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [4]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
San-300 . D0B5VA

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402